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Select item 48981651.

Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line

Hitoshi Imamura, Sawako Yoshina, Katsunori Ikari, Keiji Miyazawa, Shigeki Momohara, Shohei Mitani

Mod Rheumatol. 2016 Jul 3; 26(4): 507–516. Published online 2016 Jan 4. doi: 10.3109/14397595.2015.1112481

PMCID:: PMC4898165

Abstract Article PDF–1.2M

Select item 47394132.

Genetic Variation in NFKBIE Is Associated With Increased Risk of Pneumococcal Meningitis in Children

Lene F. Lundbo, Zitta Barrella Harboe, Louise N. Clausen, Mads V. Hollegaard, Henrik T. Sørensen, David M. Hougaard, Helle B. Konradsen, Mette Nørgaard, Thomas Benfield

EBioMedicine. 2016 Jan; 3: 93–99. Published online 2015 Dec 2. doi: 10.1016/j.ebiom.2015.11.048

PMCID:: PMC4739413

Abstract Article PDF–251K

Select item 45894863.

Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway

A. Hunter Shain, Maria Garrido, Thomas Botton, Eric Talevich, Iwei Yeh, J. Zachary Sanborn, Jongsuk Chung, Nicholas J. Wang, Hojabr Kakavand, Graham J. Mann, John F. Thompson, Thomas Wiesner, Ritu Roy, Adam B. Olshen, Alexander Gagnon, Joe W. Gray, Nam Huh, Joe S. Hur, Klaus J. Busam, Richard A. Scolyer, Raymond J. Cho, Rajmohan Murali, Boris C. Bastian

Nat Genet. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nat Genet. 2015 Oct; 47(10): 1194–1199. Published online 2015 Sep 7. doi: 10.1038/ng.3382

PMCID:: PMC4589486

Article PDF–1.3M

Select item 112169884.

NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia

Alice Bonato, Supriya Chakraborty, Riccardo Bomben, Giulia Canarutto, Giulia Felician, Claudio Martines, Antonella Zucchetto, Federico Pozzo, Marija Vujovikj, Jerry Polesel, Annalisa Chiarenza, Maria Ilaria Del Principe, Giovanni Del Poeta, Giovanni D’Arena, Roberto Marasca, Agostino Tafuri, Luca Laurenti, Silvano Piazza, Aleksandar J. Dimovski, Valter Gattei, Dimitar G. Efremov

Leukemia. 2024; 38(7): 1511–1521. Published online 2024 Mar 15. doi: 10.1038/s41375-024-02224-8

PMCID:: PMC11216988

Abstract Article PDF–1.8M

Select item 44511255.

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Larry Mansouri, Lesley-Ann Sutton, Viktor Ljungström, Sina Bondza, Linda Arngården, Sujata Bhoi, Jimmy Larsson, Diego Cortese, Antonia Kalushkova, Karla Plevova, Emma Young, Rebeqa Gunnarsson, Elin Falk-Sörqvist, Peter Lönn, Alice F. Muggen, Xiao-Jie Yan, Birgitta Sander, Gunilla Enblad, Karin E. Smedby, Gunnar Juliusson, Chrysoula Belessi, Johan Rung, Nicholas Chiorazzi, Jonathan C. Strefford, Anton W. Langerak, Sarka Pospisilova, Frederic Davi, Mats Hellström, Helena Jernberg-Wiklund, Paolo Ghia, Ola Söderberg, Kostas Stamatopoulos, Mats Nilsson, Richard Rosenquist

J Exp Med. 2015 Jun 1; 212(6): 833–843. doi: 10.1084/jem.20142009

PMCID:: PMC4451125

Abstract Article PDF–2.0M

Select item 34416786.

Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-κB Pathway Are Associated with Rheumatoid Arthritis in Japanese

Keiko Myouzen, Yuta Kochi, Yukinori Okada, Chikashi Terao, Akari Suzuki, Katsunori Ikari, Tatsuhiko Tsunoda, Atsushi Takahashi, Michiaki Kubo, Atsuo Taniguchi, Fumihiko Matsuda, Koichiro Ohmura, Shigeki Momohara, Tsuneyo Mimori, Hisashi Yamanaka, Naoyuki Kamatani, Ryo Yamada, Yusuke Nakamura, Kazuhiko Yamamoto

PLoS Genet. 2012 Sep; 8(9): e1002949. Published online 2012 Sep 13. doi: 10.1371/journal.pgen.1002949

PMCID:: PMC3441678

Abstract Article PDF–1.1M

Select item 22994927.

Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: Identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility

Elena V. Komissarova, Ping Li, Ahmed N. Uddin, Xuyan Chen, Arthur Nadas, Toby G. Rossman

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2009 Jan 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2008 Jan 15; 226(2): 199–205. Published online 2007 Sep 15. doi: 10.1016/j.taap.2007.09.004

PMCID:: PMC2299492

Abstract Article PDF–380K

Select item 1918538.

VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells.

S M Curristin, K J Bird, R J Tubbs, A Ruddell

J Virol. 1997 Aug; 71(8): 5972–5981. doi: 10.1128/jvi.71.8.5972-5981.1997

PMCID:: PMC191853

Summary PDF–1.7M

Select item 474819.

I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif.

S Kumar, C Gélinas

Proc Natl Acad Sci U S A. 1993 Oct 1; 90(19): 8962–8966. doi: 10.1073/pnas.90.19.8962

PMCID:: PMC47481

Summary Page Browse PDF–1.4M

Select item 35862710.

Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.

S K Hansen, P A Baeuerle, F Blasi

Mol Cell Biol. 1994 Apr; 14(4): 2593–2603. doi: 10.1128/mcb.14.4.2593

PMCID:: PMC358627

Summary Page Browse PDF–2.9M

Select item 23246911.

A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.

Z Li, G J Nabel

Mol Cell Biol. 1997 Oct; 17(10): 6184–6190. doi: 10.1128/mcb.17.10.6184

PMCID:: PMC232469

Summary PDF–1.9M

Select item 116973812.

I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.

S T Whiteside, J C Epinat, N R Rice, A Israël

EMBO J. 1997 Mar 17; 16(6): 1413–1426. doi: 10.1093/emboj/16.6.1413

PMCID:: PMC1169738

Summary PDF–717K

Select item 307610413.

Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists

Sara J. Schonfeld, Parveen Bhatti, Elizabeth E. Brown, Martha S. Linet, Steven L. Simon, Robert M. Weinstock, Amy A. Hutchinson, Marilyn Stovall, Dale L. Preston, Bruce H. Alexander, Michele M. Doody, Alice J. Sigurdson

Cancer Causes Control. Author manuscript; available in PMC 2011 Apr 13.

Published in final edited form as: Cancer Causes Control. 2010 Nov; 21(11): 1857–1866. Published online 2010 Aug 15. doi: 10.1007/s10552-010-9613-7

PMCID:: PMC3076104

Abstract Article PDF–342K

Select item 567964114.

Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection

Benoit Besson, Florian Sonthonnax, Magalie Duchateau, Youcef Ben Khalifa, Florence Larrous, Hyeju Eun, Véronique Hourdel, Mariette Matondo, Julia Chamot-Rooke, Regis Grailhe, Hervé Bourhy

PLoS Pathog. 2017 Oct; 13(10): e1006697. Published online 2017 Oct 30. doi: 10.1371/journal.ppat.1006697

PMCID:: PMC5679641

Abstract Article PDF–8.5M

Select item 53450915.

Recruitment of IκBα to the hes1 promoter is associated with transcriptional repression

Cristina Aguilera, Ruben Hoya-Arias, Guy Haegeman, Lluís Espinosa, Anna Bigas

Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47): 16537–16542. Published online 2004 Nov 9. doi: 10.1073/pnas.0404429101

PMCID:: PMC534509

Abstract Article PDF–542K

Select item 281579216.

Maternal and Fetal Genetic Associations of PTGER3 and PON1 with Preterm Birth

Kelli K. Ryckman, Nils-Halvdan Morken, Marquitta J. White, Digna R. Velez, Ramkumar Menon, Stephen J. Fortunato, Per Magnus, Scott M. Williams, Bo Jacobsson

PLoS One. 2010; 5(2): e9040. Published online 2010 Feb 3. doi: 10.1371/journal.pone.0009040

PMCID:: PMC2815792

Abstract Article PDF–899K

Select item 291018417.

Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut

Kyoung-Mu Lee, Dalsu Baris, Yawei Zhang, H. Dean Hosgood, III, Idan Menashe, Meredith Yeager, Shelia Hoar Zahm, Sophia S. Wang, Mark P. Purdue, Stephen Chanock, Tongzhang Zheng, Nathaniel Rothman, Qing Lan

Am J Hematol. Author manuscript; available in PMC 2011 Aug 1.

Published in final edited form as: Am J Hematol. 2010 Aug; 85(8): 560–563. doi: 10.1002/ajh.21760

PMCID:: PMC2910184

Abstract Article PDF–310K

Select item 394409818.

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Yukinori Okada, Di Wu, Gosia Trynka, Towfique Raj, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Shinji Yoshida, Robert R. Graham, Arun Manoharan, Ward Ortmann, Tushar Bhangale, Joshua C. Denny, Robert J. Carroll, Anne E. Eyler, Jeffrey D. Greenberg, Joel M. Kremer, Dimitrios A. Pappas, Lei Jiang, Jian Yin, Lingying Ye, Ding-Feng Su, Jian Yang, Gang Xie, Ed Keystone, Harm-Jan Westra, Tõnu Esko, Andres Metspalu, Xuezhong Zhou, Namrata Gupta, Daniel Mirel, Eli A. Stahl, Dorothée Diogo, Jing Cui, Katherine Liao, Michael H. Guo, Keiko Myouzen, Takahisa Kawaguchi, Marieke J.H. Coenen, Piet L.C.M. van Riel, Mart A.F.J. van de Laar, Henk-Jan Guchelaar, Tom W.J. Huizinga, Philippe Dieudé, Xavier Mariette, S. Louis Bridges, Jr., Alexandra Zhernakova, Rene E.M. Toes, Paul P. Tak, Corinne Miceli-Richard, So-Young Bang, Hye-Soon Lee, Javier Martin, Miguel A. Gonzalez-Gay, Luis Rodriguez-Rodriguez, Solbritt Rantapää-Dahlqvist, Lisbeth Ärlestig, Hyon K. Choi, Yoichiro Kamatani, Pilar Galan, Mark Lathrop, the RACI consortium, the GARNET consortium, Steve Eyre, John Bowes, Anne Barton, Niek de Vries, Larry W. Moreland, Lindsey A. Criswell, Elizabeth W. Karlson, Atsuo Taniguchi, Ryo Yamada, Michiaki Kubo, Jun S. Liu, Sang-Cheol Bae, Jane Worthington, Leonid Padyukov, Lars Klareskog, Peter K. Gregersen, Soumya Raychaudhuri, Barbara E. Stranger, Philip L. De Jager, Lude Franke, Peter M. Visscher, Matthew A. Brown, Hisashi Yamanaka, Tsuneyo Mimori, Atsushi Takahashi, Huji Xu, Timothy W. Behrens, Katherine A. Siminovitch, Shigeki Momohara, Fumihiko Matsuda, Kazuhiko Yamamoto, Robert M. Plenge

Nature. Author manuscript; available in PMC 2014 Aug 20.

Published in final edited form as: Nature. 2014 Feb 20; 506(7488): 376–381. Published online 2013 Dec 25. doi: 10.1038/nature12873

PMCID:: PMC3944098

Abstract Article PDF–1.9M

Select item 482920319.

Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants

Digna R. Velez, Stephen Fortunato, Poul Thorsen, Salvatore J. Lombardi, Scott M. Williams, Ramkumar Menon

Am J Obstet Gynecol. Author manuscript; available in PMC 2016 Apr 12.

Published in final edited form as: Am J Obstet Gynecol. 2009 Feb; 200(2): 209.e1–209.27. Published online 2008 Nov 18. doi: 10.1016/j.ajog.2008.08.051

PMCID:: PMC4829203

Abstract Article PDF–164K

Select item 271485020.

Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants

Ramkumar Menon, Brad Pearce, Digna R Velez, Mario Merialdi, Scott M Williams, Stephen J Fortunato, Poul Thorsen

Reprod Biol Endocrinol. 2009; 7: 62. Published online 2009 Jun 15. doi: 10.1186/1477-7827-7-62

PMCID:: PMC2714850

Abstract Article PDF–8.4M

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