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Select item 109910851.

NF2 mutation status and tumor mutational burden correlate with immune cell infiltration in meningiomas

John W. Rutland, Corey M. Gill, Joshua Loewenstern, Hanane Arib, Margaret Pain, Melissa Umphlett, Yayoi Kinoshita, Russell B. McBride, Joshua Bederson, Michael Donovan, Robert Sebra, Raj K. Shrivastava, Mary Fowkes

Cancer Immunol Immunother. 2021 Jan; 70(1): 169–176. Published online 2020 Jul 13. doi: 10.1007/s00262-020-02671-z

PMCID:: PMC10991085

Abstract Article PDF–976K

Select item 105214032.

Meningiomas in patients with neurofibromatosis type 2 predominantly comprise ‘immunogenic subtype’ tumours characterised by macrophage infiltration

Yu Teranishi, Satoru Miyawaki, Masahiro Nakatochi, Atsushi Okano, Kenta Ohara, Hiroki Hongo, Daiichiro Ishigami, Yu Sakai, Daisuke Shimada, Shunsaku Takayanagi, Masako Ikemura, Daisuke Komura, Hiroto Katoh, Jun Mitsui, Shinichi Morishita, Tetsuo Ushiku, Shumpei Ishikawa, Hirofumi Nakatomi, Nobuhito Saito

Acta Neuropathol Commun. 2023; 11: 156. Published online 2023 Sep 26. doi: 10.1186/s40478-023-01645-3

PMCID:: PMC10521403

Abstract Article PDF–8.4M

Select item 103221443.

Comprehensive Genomic Profiling of NF2-Mutated Kidney Tumors Reveals Potential Targets for Therapy

Sean M Hacking, Dean Pavlick, Yihong Wang, Benedito A Carneiro, Matthew Mullally, Shaolei Lu, Mariana Canepa, Gennady Bratslavsky, Joseph Jacob, Andrea Necchi, Philippe E Spiess, Li Wang, Evgeny Yakirevich, Jeffrey Ross

Oncologist. 2023 Jul; 28(7): e508–e519. Published online 2023 Mar 14. doi: 10.1093/oncolo/oyad040

PMCID:: PMC10322144

Abstract Article PDF–24M

Select item 101226454.

Correlation between genotype and phenotype with special attention to hearing in 14 Japanese cases of NF2-related schwannomatosis

Naoki Oishi, Masaru Noguchi, Masato Fujioka, Kiyomitsu Nara, Koichiro Wasano, Hideki Mutai, Rie Kawakita, Ryota Tamura, Kosuke Karatsu, Yukina Morimoto, Masahiro Toda, Hiroyuki Ozawa, Tatsuo Matsunaga

Sci Rep. 2023; 13: 6595. Published online 2023 Apr 22. doi: 10.1038/s41598-023-33812-w

PMCID:: PMC10122645

Abstract Article PDF–1.6M

Select item 99429535.

Merlin tumor suppressor function is regulated by PIP₂-mediated dimerization

Robert F. Hennigan, Craig S. Thomson, Kye Stachowski, Nicolas Nassar, Nancy Ratner

PLoS One. 2023; 18(2): e0281876. Published online 2023 Feb 21. doi: 10.1371/journal.pone.0281876

PMCID:: PMC9942953

Abstract Article PDF–2.6M

Select item 91594536.

Origins of biallelic inactivation of NF2 in neurofibromatosis type 2

Lu Xue, Weiwei He, Yi Zhang, Zhigang Wang, Hongsai Chen, Zhe Chen, Weidong Zhu, Dongmei Liu, Huan Jia, Yi Jiang, Zhaoyan Wang, Hao Wu

Neuro Oncol. 2022 Jun; 24(6): 903–913. Published online 2021 Dec 16. doi: 10.1093/neuonc/noab287

PMCID:: PMC9159453

Abstract Article PDF–8.4M

Select item 81131657.

Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype

Catena Kresbach, Mario M. Dorostkar, Abigail K. Suwala, Annika K. Wefers, Leonille Schweizer, Lara Engertsberger, Brigitte Bison, Martin Mynarek, Katja Kloth-Stachnau, Michael Spohn, Andreas von Deimling, Martin Benesch, Christian Hagel, Viktor-F. Mautner, Stefan Rutkowski, Ulrich Schüller

Acta Neuropathol. 2021; 141(6): 971–974. Published online 2021 Apr 12. doi: 10.1007/s00401-021-02304-4

PMCID:: PMC8113165

Article PDF–3.9M

Select item 80959068.

NF2 Mutations in Secretory and Other Rare Variants of Meningiomas

Christian Hartmann, Jennifer Sieberns, Claire Gehlhaar, Matthias Simon, Werner Paulus, Andreas von Deimling

Brain Pathol. 2006 Jan; 16(1): 15–19. Published online 2006 Apr 5. doi: 10.1111/j.1750-3639.2006.tb00557.x

PMCID:: PMC8095906

Abstract Article PDF–203K

Select item 80954979.

Role of NF2 Haploinsufficiency in NF2‐associated Polyneuropathy

Clemens O. Hanemann, Ruth Diebold, Dieter Kaufmann

Brain Pathol. 2007 Oct; 17(4): 371–376. Published online 2007 Jul 26. doi: 10.1111/j.1750-3639.2007.00086.x

PMCID:: PMC8095497

Abstract Article PDF–296K

Select item 735062410.

Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated with Somatic NF2 Mutations

Pedram Argani, Victor E. Reuter, John N. Eble, Ljiljana Vlatkovic, Oksana Yaskiv, David Swanson, Brendan C. Dickson, Cristina R. Antonescu, Andres Matoso, Jeffrey Gagan, Doreen N. Palsgrove

Am J Surg Pathol. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Am J Surg Pathol. 2020 Jul; 44(7): 901–916. doi: 10.1097/PAS.0000000000001467

PMCID:: PMC7350624

Abstract Article PDF–3.7M

Select item 675606811.

The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling

Yan Cui, Susann Groth, Scott Troutman, Annemarie Carlstedt, Tobias Sperka, Lars Björn Riecken, Joseph L. Kissil, Hongchuan Jin, Helen Morrison

Oncogene. 2019; 38(36): 6370–6381. Published online 2019 Jul 16. doi: 10.1038/s41388-019-0883-6

PMCID:: PMC6756068

Abstract Article PDF–1.8M

Select item 671684512.

Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT

Gerhard Jungwirth, Rolf Warta, Christopher Beynon, Felix Sahm, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende, Christine Jungk

Acta Neuropathol Commun. 2019; 7: 140. Published online 2019 Aug 30. doi: 10.1186/s40478-019-0793-4

PMCID:: PMC6716845

Abstract Article PDF–1.8M

Select item 614897313.

Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer

Mateus S V Mota, William P Jackson, Sarah K Bailey, Praveen Vayalil, Aimee Landar, Jack W Rostas, III, Madhuri S Mulekar, Rajeev S Samant, Lalita A Shevde

Carcinogenesis. 2018 Sep; 39(9): 1165–1175. Published online 2018 Jun 9. doi: 10.1093/carcin/bgy078

PMCID:: PMC6148973

Abstract Article PDF–21M

Select item 599911114.

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2

The Synodos for NF2 Consortium, Robert Allaway, Steve P. Angus, Roberta L. Beauchamp, Jaishri O. Blakeley, Marga Bott, Sarah S. Burns, Annemarie Carlstedt, Long-Sheng Chang, Xin Chen, D. Wade Clapp, Patrick A. Desouza, Serkan Erdin, Cristina Fernandez-Valle, Justin Guinney, James F. Gusella, Stephen J. Haggarty, Gary L. Johnson, Salvatore La Rosa, Helen Morrison, Alejandra M. Petrilli, Scott R. Plotkin, Abhishek Pratap, Vijaya Ramesh, Noah Sciaky, Anat Stemmer-Rachamimov, Tim J. Stuhlmiller, Michael E. Talkowski, D. Bradley Welling, Charles W. Yates, Jon S. Zawistowski, Wen-Ning Zhao

PLoS One. 2018; 13(6): e0197350. Published online 2018 Jun 13. doi: 10.1371/journal.pone.0197350

PMCID:: PMC5999111

Abstract Article PDF–14M

Select item 597933315.

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma

Tatsuhiro Sato, Yoshitaka Sekido

Int J Mol Sci. 2018 Apr; 19(4): 988. Published online 2018 Mar 26. doi: 10.3390/ijms19040988

PMCID:: PMC5979333

Abstract Article PDF–7.7M

Select item 588939116.

Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

Krishna Chinthalapudi, Vinay Mandati, Jie Zheng, Andrew J. Sharff, Gerard Bricogne, Patrick R. Griffin, Joseph Kissil, Tina Izard

Nat Commun. 2018; 9: 1338. Published online 2018 Apr 6. doi: 10.1038/s41467-018-03648-4

PMCID:: PMC5889391

Abstract Article PDF–1.5M

Select item 554311817.

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

Sameer Agnihotri, Suganth Suppiah, Peter D. Tonge, Shahrzad Jalali, Arnavaz Danesh, Jeffery P. Bruce, Yasin Mamatjan, George Klironomos, Lior Gonen, Karolyn Au, Sheila Mansouri, Sharin Karimi, Felix Sahm, Andreas von Deimling, Michael D. Taylor, Normand J. Laperriere, Trevor J. Pugh, Kenneth D. Aldape, Gelareh Zadeh

Nat Commun. 2017; 8: 186. Published online 2017 Aug 4. doi: 10.1038/s41467-017-00174-7

PMCID:: PMC5543118

Abstract Article PDF–854K

Select item 551125418.

Differential NF2 Gene Status in Sporadic Vestibular Schwannomas and its Prognostic Impact on Tumour Growth Patterns

Hongsai Chen, Lu Xue, Hantao Wang, Zhaoyan Wang, Hao Wu

Sci Rep. 2017; 7: 5470. Published online 2017 Jul 14. doi: 10.1038/s41598-017-05769-0

PMCID:: PMC5511254

Abstract Article PDF–4.1M

Select item 525610019.

Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling

Shamik Das, William P. Jackson, Jeevan K. Prasain, Ann Hanna, Sarah K. Bailey, J. Allan Tucker, Sejong Bae, Landon S. Wilson, Rajeev S. Samant, Stephen Barnes, Lalita A. Shevde

Sci Rep. 2017; 7: 40773. Published online 2017 Jan 23. doi: 10.1038/srep40773

PMCID:: PMC5256100

Abstract Article PDF–1.3M

Select item 448441120.

Genetic/molecular alterations of meningiomas and the signaling pathways targeted

Patrícia Domingues, María González-Tablas, Álvaro Otero, Daniel Pascual, Laura Ruiz, David Miranda, Pablo Sousa, Jesús María Gonçalves, María Celeste Lopes, Alberto Orfao, María Dolores Tabernero

Oncotarget. 2015 May 10; 6(13): 10671–10688. Published online 2015 Apr 19. doi: 10.18632/oncotarget.3870

PMCID:: PMC4484411

Abstract Article PDF–1.5M

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