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Select item 112846441.

The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Marina P. Volegova, Lauren E. Brown, Ushashi Banerjee, Ruben Dries, Bandana Sharma, Alyssa Kennedy, John A. Porco, Jr., Rani E. George

Cell Rep. Author manuscript; available in PMC 2024 Jul 29.

Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114134. Published online 2024 Apr 23. doi: 10.1016/j.celrep.2024.114134

PMCID:: PMC11284644

Abstract Article PDF–3.6M

Select item 110954742.

N-MYC impairs innate immune signaling in high-grade serous ovarian carcinoma

Alex Miranda, Swetansu Pattnaik, Phineas T. Hamilton, Monica Alvaro Fuss, Shreena Kalaria, Céline M. Laumont, Julian Smazynski, Monica Mesa, Allyson Banville, Xinpei Jiang, Russell Jenkins, Israel Cañadas, Brad H. Nelson

Sci Adv. 2024 May 17; 10(20): eadj5428. Published online 2024 May 15. doi: 10.1126/sciadv.adj5428

PMCID:: PMC11095474

Abstract Article PDF–9.3M

Select item 110305903.

MYCN as a target for cancer immunotherapy

Nourredine Himoudi, Mengyong Yan, Antigoni Papanastasiou, John Anderson

Cancer Immunol Immunother. 2008 May; 57(5): 693–700. Published online 2007 Nov 15. doi: 10.1007/s00262-007-0409-x

PMCID:: PMC11030590

Abstract Article PDF–438K

Select item 105508484.

Gain-of-function MYCN causes a megalencephaly-polydactyly syndrome manifesting mirror phenotypes of Feingold syndrome

Yosuke Nishio, Kohji Kato, Frederic Tran Mau-Them, Hiroshi Futagawa, Chloé Quélin, Saori Masuda, Antonio Vitobello, Shiomi Otsuji, Hossam H. Shawki, Hisashi Oishi, Christel Thauvin-Robinet, Toshiki Takenouchi, Kenjiro Kosaki, Yoshiyuki Takahashi, Shinji Saitoh

HGG Adv. 2023 Oct 12; 4(4): 100238. Published online 2023 Sep 14. doi: 10.1016/j.xhgg.2023.100238

PMCID:: PMC10550848

Abstract Article PDF–4.9M

Select item 105181175.

LncRNA AC142119.1 facilitates the progression of neuroblastoma by epigenetically initiating the transcription of MYCN

Rui Yang, Nanjing Liu, Ting Li, Fangjie Liu, Jun Zhang, Hui Zhao, Lin Zou, Xiaoyan He

J Transl Med. 2023; 21: 659. Published online 2023 Sep 23. doi: 10.1186/s12967-023-04535-3

PMCID:: PMC10518117

Abstract Article PDF–6.2M

Select item 103198046.

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E. Deubzer, Annette Künkele, Peter Lang, Jörg Fuchs, Anton G. Henssen, Angelika Eggert, Nikolaus Rajewsky, Falk Hertwig, Johannes H. Schulte

Nat Commun. 2023; 14: 3936. Published online 2023 Jul 4. doi: 10.1038/s41467-023-38747-4

PMCID:: PMC10319804

Abstract Article PDF–5.4M

Select item 101795537.

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma

Prasoon Agarwal, Aleksandra Glowacka, Loay Mahmoud, Wesam Bazzar, Lars-Gunnar Larsson, Mohammad Alzrigat

Int J Mol Sci. 2023 May; 24(9): 8141. Published online 2023 May 2. doi: 10.3390/ijms24098141

PMCID:: PMC10179553

Abstract Article PDF–3.4M

Select item 98173088.

Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome

Léa Guerrini-Rousseau, Arnault Tauziède-Espariat, David Castel, Etienne Rouleau, Philipp Sievers, Raphaël Saffroy, Kévin Beccaria, Thomas Blauwblomme, Lauren Hasty, Franck Bourdeaut, Jacques Grill, Pascale Varlet, Marie-Anne Debily

Acta Neuropathol Commun. 2023; 11: 3. Published online 2023 Jan 6. doi: 10.1186/s40478-022-01490-w

PMCID:: PMC9817308

Article PDF–695K

Select item 92822799.

An immature, dedifferentiated, and lineage-deconstrained cone precursor origin of N-Myc–initiated retinoblastoma

Hardeep P. Singh, Dominic W. H. Shayler, G. Esteban Fernandez, Matthew E. Thornton, Cheryl Mae Craft, Brendan H. Grubbs, David Cobrinik

Proc Natl Acad Sci U S A. 2022 Jul 12; 119(28): e2200721119. Published online 2022 Jul 8. doi: 10.1073/pnas.2200721119

PMCID:: PMC9282279

Abstract Article PDF–5.2M

Select item 927795510.

MYCN protein stability is a better prognostic indicator in neuroblastoma

Yi Yang, Jie Zhao, Yingwen Zhang, Tianyue Feng, Bo Yv, Jing Wang, Yijin Gao, Minzhi Yin, Jingyan Tang, Yanxin Li

BMC Pediatr. 2022; 22: 404. Published online 2022 Jul 11. doi: 10.1186/s12887-022-03449-1

PMCID:: PMC9277955

Abstract Article PDF–1.5M

Select item 911065811.

MYCN Directly Targets NeuroD1 to Promote Cellular Proliferation in Neuroblastoma

Fangjin Lu, Bin Mu, Ge Jin, Lin Zhu, Ping Mu

Oncol Res. 2021; 29(1): 1–10. Published online 2022 May 4. doi: 10.3727/096504021X16401852341873

PMCID:: PMC9110658

Abstract Article PDF–479K

Select item 904106812.

MYCN amplification plus 1p36 loss of heterozygosity predicts ultra high risk in bone marrow metastatic neuroblastoma

Zhi‐Xia Yue, Tian‐Yu Xing, Wen Zhao, Qian Zhao, Xi‐Si Wang, Yan Su, Chao Gao, Shu‐Guang Liu, Xiao‐Li Ma

Cancer Med. 2022 Apr; 11(8): 1837–1849. Published online 2022 Feb 9. doi: 10.1002/cam4.4583

PMCID:: PMC9041068

Abstract Article PDF–865K

Select item 883052213.

Urinary 3-Methoxytyramine Is a Biomarker for MYC Activity in Patients With Neuroblastoma

Iedan R. N. Verly, Yvette A. H. Matser, René Leen, Rutger Meinsma, Marta Fiocco, Jan Koster, Richard Volckmann, Dilara Savci-Heijink, Giuliana Cangemi, Sebastiano Barco, Linda J. Valentijn, Godelieve A. M. Tytgat, André B. P. van Kuilenburg

JCO Precis Oncol. 2022; 6: e2000447. Published online 2022 Jan 27. doi: 10.1200/PO.20.00447

PMCID:: PMC8830522

Abstract Article PDF–1.0M

Select item 837306814.

Targeting a noncanonical, hairpin-containing G-quadruplex structure from the MYCN gene

Mo Yang, Sakereh Carter, Shaifaly Parmar, Desta D Bume, David R Calabrese, Xiao Liang, Kamyar Yazdani, Man Xu, Zhihui Liu, Carol J Thiele, John S Schneekloth, Jr

Nucleic Acids Res. 2021 Aug 20; 49(14): 7856–7869. Published online 2021 Jul 21. doi: 10.1093/nar/gkab594

PMCID:: PMC8373068

Abstract Article PDF–4.6M

Select item 793839915.

MYCN gene polymorphisms and Wilms tumor susceptibility in Chinese children

Xiaokai Huang, Jie Zhao, Jinhong Zhu, Shanshan Chen, Wen Fu, Xiaoqian Tian, Susu Lou, Jichen Ruan, Jing He, Haixia Zhou

J Clin Lab Anal. 2019 Nov; 33(9): e22988. Published online 2019 Jul 25. doi: 10.1002/jcla.22988

PMCID:: PMC7938399

Abstract Article PDF–326K

Select item 766990616.

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche

Nat Commun. 2020; 11: 5823. Published online 2020 Nov 16. doi: 10.1038/s41467-020-19452-y

PMCID:: PMC7669906

Abstract Article PDF–2.8M

Select item 761600817.

Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification

Xiaoxiao Hu, Yilu Zhou, Charlotte Hill, Kai Chen, Cheng Cheng, Xiaowei Liu, Peiwen Duan, Yaoyao Gu, Yeming Wu, Rob M. Ewing, Zhongrong Li, Zhixiang Wu, Yihua Wang

Br J Cancer. 2024 May 27; 130(11): 1841–1854. Published online 2024 Mar 29. doi: 10.1038/s41416-024-02666-y

PMCID:: PMC7616008

Abstract Article PDF–4.6M

Select item 741588518.

MYCN Silencing by RNAi Induces Neurogenesis and Suppresses Proliferation in Models of Neuroblastoma with Resistance to Retinoic Acid

Ruhina Maeshima, Dale Moulding, Andrew W. Stoker, Stephen L. Hart

Nucleic Acid Ther. August 2020; 30(4): 237–248. Published online 2020 Aug 6. doi: 10.1089/nat.2019.0831

PMCID:: PMC7415885

Abstract Article PDF–733K

Select item 734635619.

High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma

Mark Raffeld, Zied Abdullaev, Svetlana D. Pack, Liqiang Xi, Sushma Nagaraj, Nicole Briceno, Elizabeth Vera, Stefania Pittaluga, Osorio Lopes Abath Neto, Martha Quezado, Kenneth Aldape, Terri S. Armstrong, Mark R. Gilbert

Acta Neuropathol Commun. 2020; 8: 101. Published online 2020 Jul 8. doi: 10.1186/s40478-020-00973-y

PMCID:: PMC7346356

Abstract Article PDF–5.2M

Select item 729566420.

Association of heterogeneous MYCN amplification with clinical features, biological characteristics, and outcomes in neuroblastoma: A report from the Children’s Oncology Group

Kevin Campbell, Arlene Naranjo, Emily Hibbitts, Julie M. Gastier-Foster, Rochelle Bagatell, Meredith S. Irwin, Hiroyuki Shimada, Michael Hogarty, Julie R. Park, Steven G. DuBois

Eur J Cancer. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Eur J Cancer. 2020 Jul; 133: 112–119. Published online 2020 May 31. doi: 10.1016/j.ejca.2020.04.007

PMCID:: PMC7295664

Abstract Article PDF–502K

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