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Select item 106175871.

A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB

Avraham Bayer, Stephanie J. Child, Harmit S. Malik, Adam P. Geballe

J Virol. 2023 Oct; 97(10): e00830-23. Published online 2023 Oct 5. doi: 10.1128/jvi.00830-23

PMCID:: PMC10617587

Abstract Article PDF–1.6M

Select item 94335512.

MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus

Xiang-Wen Meng, Zhi-Luo Cheng, Zhi-Yuan Lu, Ya-Nan Tan, Xiao-Yi Jia, Min Zhang

Front Immunol. 2022; 13: 978851. Published online 2022 Aug 18. doi: 10.3389/fimmu.2022.978851

PMCID:: PMC9433551

Abstract Article PDF–8.4M

Select item 85512833.

High accumulation of Mx2 renders limited multiplication of oncolytic herpes simplex virus-1 in human tumor cells

Yong Ren, Meiling Chen, Guangxian Wu, Dongmei Ji, Grace Guoying Zhou, Pei-Gen Ren, Wenmin Fu

Sci Rep. 2021; 11: 21227. Published online 2021 Oct 27. doi: 10.1038/s41598-021-00691-y

PMCID:: PMC8551283

Abstract Article PDF–5.4M

Select item 80269194.

MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy

Marina Juraleviciute, Jérémie Nsengimana, Julia Newton‐Bishop, Gert J. Hendriks, Ana Slipicevic

Cancer Med. 2021 Apr; 10(8): 2840–2854. Published online 2021 Mar 18. doi: 10.1002/cam4.3846

PMCID:: PMC8026919

Abstract Article PDF–2.5M

Select item 76116615.

MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation

Gilberto Betancor, Jose M Jimenez-Guardeño, Steven Lynham, Robin Antrobus, Hataf Khan, Andrew Sobala, Matthew DJ Dicks, Michael H Malim

Nat Microbiol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Nat Microbiol. 2021 Aug 1; 6(8): 1031–1042. Published online 2021 Jul 19. doi: 10.1038/s41564-021-00937-5

Correction in:: Nat Microbiol. 2021 Aug 13

PMCID:: PMC7611661

Abstract Article PDF–3.5M

Select item 73910066.

The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction

Gilberto Betancor, Matthew D.J. Dicks, Jose M. Jimenez-Guardeño, Nabil H. Ali, Luis Apolonia, Michael H. Malim

Cell Rep. 2019 Nov 12; 29(7): 1923–1933.e3. Published online 2019 Nov 12. doi: 10.1016/j.celrep.2019.10.009

PMCID:: PMC7391006

Abstract Article

Select item 72993357.

MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface

Richard J Miles, Claire Kerridge, Laura Hilditch, Christopher Monit, David A Jacques, Greg J Towers

eLife. 2020; 9: e56910. Published online 2020 Jun 17. doi: 10.7554/eLife.56910

PMCID:: PMC7299335

Abstract Article PDF–2.9M

Select item 72642328.

Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma

Jiyeon Choi, Tongwu Zhang, Andrew Vu, Julien Ablain, Matthew M. Makowski, Leandro M. Colli, Mai Xu, Rebecca C. Hennessey, Jinhu Yin, Harriet Rothschild, Cathrin Gräwe, Michael A. Kovacs, Karen M. Funderburk, Myriam Brossard, John Taylor, Bogdan Pasaniuc, Raj Chari, Stephen J. Chanock, Clive J. Hoggart, Florence Demenais, Jennifer H. Barrett, Matthew H. Law, Mark M. Iles, Kai Yu, Michiel Vermeulen, Leonard I. Zon, Kevin M. Brown

Nat Commun. 2020; 11: 2718. Published online 2020 Jun 1. doi: 10.1038/s41467-020-16590-1

PMCID:: PMC7264232

Abstract Article PDF–1.9M

Select item 72126619.

Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid

Fengwen Xu, Fei Zhao, Xiaoxiao Zhao, Di Zhang, Xiaoman Liu, Siqi Hu, Shan Mei, Zhangling Fan, Yu Huang, Hong Sun, Liang Wei, Chao Wu, Quanjie Li, Jianwei Wang, Shan Cen, Chen Liang, Fei Guo

J Biol Chem. 2020 May 8; 295(19): 6447–6456. Published online 2020 Mar 26. doi: 10.1074/jbc.RA119.012439

PMCID:: PMC7212661

Abstract Article PDF–2.5M

Select item 718385710.

.MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid

Sarah Sierra Smaga, Chaoyi Xu, Brady James Summers, Katherine Marie Digianantonio, Juan R. Perilla, Yong Xiong

Structure. Author manuscript; available in PMC 2020 Apr 26.

Published in final edited form as: Structure. 2019 Aug 6; 27(8): 1234–1245.e5. Published online 2019 May 30. doi: 10.1016/j.str.2019.04.015

PMCID:: PMC7183857

Abstract Article PDF–2.2M

Select item 718010011.

MX2 is a novel regulator of cell cycle in melanoma cells

Marina Juraleviciute, Joanna Pozniak, Jérémie Nsengimana, Mark Harland, Juliette Randerson-Moor, Patrik Vernhoff, Assia Bassarova, Geir Frode Øy, Gunhild Trøen, Vivi Ann Flørenes, David Timothy Bishop, Meenhard Herlyn, Julia Newton-Bishop, Ana Slipicevic

Pigment Cell Melanoma Res. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Pigment Cell Melanoma Res. 2020 May; 33(3): 446–457. Published online 2019 Nov 13. doi: 10.1111/pcmr.12837

Correction in:: Pigment Cell Melanoma Res. 2021 Sep; 34(5): 994.

PMCID:: PMC7180100

Abstract Article PDF–1.8M

Select item 704433712.

The anti-viral dynamin family member MxB participates in mitochondrial integrity

Hong Cao, E. W. Krueger, Jing Chen, Kristina Drizyte-Miller, Mary E. Schulz, Mark A. McNiven

Nat Commun. 2020; 11: 1048. Published online 2020 Feb 26. doi: 10.1038/s41467-020-14727-w

PMCID:: PMC7044337

Abstract Article PDF–11M

Select item 626414513.

Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction

Matthew D. J. Dicks, Gilberto Betancor, Jose M. Jimenez-Guardeño, Lucie Pessel-Vivares, Luis Apolonia, Caroline Goujon, Michael H. Malim

PLoS Pathog. 2018 Nov; 14(11): e1007408. Published online 2018 Nov 29. doi: 10.1371/journal.ppat.1007408

PMCID:: PMC6264145

Abstract Article PDF–2.7M

Select item 609680214.

Human MxB Protein Is a Pan-herpesvirus Restriction Factor

Mirjam Schilling, Lorenzo Bulli, Sebastian Weigang, Laura Graf, Sebastian Naumann, Corinna Patzina, Valentina Wagner, Liane Bauersfeld, Caroline Goujon, Hartmut Hengel, Anne Halenius, Zsolt Ruzsics, Torsten Schaller, Georg Kochs

J Virol. 2018 Sep 1; 92(17): e01056-18. Prepublished online 2018 Jun 27. Published online 2018 Aug 16. doi: 10.1128/JVI.01056-18

PMCID:: PMC6096802

Abstract Article PDF–1.6M

Select item 595805715.

MxB is an interferon-induced restriction factor of human herpesviruses

Michel Crameri, Michael Bauer, Nicole Caduff, Raphael Walker, Fiona Steiner, Francesca D. Franzoso, Cornelia Gujer, Karin Boucke, Talissa Kucera, Andrea Zbinden, Christian Münz, Cornel Fraefel, Urs F. Greber, Jovan Pavlovic

Nat Commun. 2018; 9: 1980. Published online 2018 May 17. doi: 10.1038/s41467-018-04379-2