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Select item 93992921.

Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division

Luis Cedeno-Rosario, David Honda, Autumn M. Sunderland, Mark D. Lewandowski, William R. Taylor, Deborah N. Chadee

J Biol Chem. 2022 Aug; 298(8): 102263. Published online 2022 Jul 14. doi: 10.1016/j.jbc.2022.102263

PMCID:: PMC9399292

Abstract Article PDF–3.3M

Select item 90869962.

Mechanisms underlying melanoma invasion as a consequence of MLK3 loss

Henriette U. Balinda, Alanna Sedgwick, Crislyn D’Souza-Schorey

Exp Cell Res. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Cell Res. 2022 Jun 1; 415(1): 113106. Published online 2022 Mar 18. doi: 10.1016/j.yexcr.2022.113106

PMCID:: PMC9086996

Abstract Article PDF–2.7M

Select item 61201903.

Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3

Malgorzata E. Kokoszka, Stefanie L. Kall, Sehar Khosla, Jennifer E. McGinnis, Arnon Lavie, Brian K. Kay

J Biol Chem. 2018 Aug 31; 293(35): 13553–13565. Published online 2018 Jul 6. doi: 10.1074/jbc.RA117.000262

PMCID:: PMC6120190

Abstract Article PDF–2.3M

Select item 58388534.

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs

BMC Med Genomics. 2018; 11: 22. Published online 2018 Mar 5. doi: 10.1186/s12920-018-0339-9

PMCID:: PMC5838853

Abstract Article PDF–1.1M

Select item 39955755.

Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation

Sérgia Velho, Ana Pinto, Danilo Licastro, Maria José Oliveira, Filipa Sousa, Elia Stupka, Raquel Seruca

BMC Cancer. 2014; 14: 182. Published online 2014 Mar 14. doi: 10.1186/1471-2407-14-182

PMCID:: PMC3995575

Abstract Article PDF–874K

Select item 37501716.

Hepatitis C Virus NS5A Inhibits Mixed Lineage Kinase 3 to Block Apoptosis

Yutaka Amako, Zsofia Igloi, Jamel Mankouri, Arunas Kazlauskas, Kalle Saksela, Mark Dallas, Chris Peers, Mark Harris

J Biol Chem. 2013 Aug 23; 288(34): 24753–24763. Published online 2013 Jul 15. doi: 10.1074/jbc.M113.491985

PMCID:: PMC3750171

Abstract Article PDF–2.3M

Select item 33892807.

Mixed Lineage Kinase 3 is Required for Matrix Metalloproteinase Expression and Invasion in Ovarian Cancer Cells

Yu Zhan, Widian F. Abi Saab, Nidhi Modi, Amanda M. Stewart, Jinsong Liu, Deborah N. Chadee

Exp Cell Res. Author manuscript; available in PMC 2013 Aug 15.

Published in final edited form as: Exp Cell Res. 2012 Aug 15; 318(14): 1641–1648. Published online 2012 May 28. doi: 10.1016/j.yexcr.2012.05.002

PMCID:: PMC3389280

Abstract Article PDF–1.3M

Select item 31994938.

Mixed Lineage Kinase 3 Modulates β-Catenin Signaling in Cancer Cells

Ramesh P. Thylur, Subramanian Senthivinayagam, Edward M. Campbell, Velusamy Rangasamy, Nithyananda Thorenoor, Gautam Sondarva, Suneet Mehrotra, Prajna Mishra, Erin Zook, Phong T. Le, Ajay Rana, Basabi Rana

J Biol Chem. 2011 Oct 28; 286(43): 37470–37482. Published online 2011 Aug 31. doi: 10.1074/jbc.M111.298943

PMCID:: PMC3199493

Abstract Article PDF–5.4M

Select item 29631919.

Estrogen Negatively Regulates the Pro-apoptotic Function of Mixed Lineage Kinase 3 in Estrogen Receptor Positive Breast Cancer

Velusamy Rangasamy, Rajakishore Mishra, Suneet Mehrotra, Gautam Sondarva, Rajarshi S. Ray, Arundhati Rao, Malay Chatterjee, Basabi Rana, Ajay Rana

Cancer Res. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: Cancer Res. 2010 Feb 15; 70(4): 1731–1740. Published online 2010 Feb 9. doi: 10.1158/0008-5472.CAN-09-3492

PMCID:: PMC2963191

Abstract Article PDF–903K

Select item 283515110.

Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells

Hyukjin Cha, Surabhi Dangi, Carolyn E. Machamer, Paul Shapiro

Cell Signal. Author manuscript; available in PMC 2010 Mar 9.

Published in final edited form as: Cell Signal. 2006 Jan; 18(1): 93–104. Published online 2005 May 31. doi: 10.1016/j.cellsig.2005.03.028

PMCID:: PMC2835151

Abstract Article PDF–792K

Select item 280737411.

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

Sérgia Velho, Carla Oliveira, Joana Paredes, Sónia Sousa, Marina Leite, Paulo Matos, Fernanda Milanezi, Ana Sofia Ribeiro, Nuno Mendes, Danilo Licastro, Auli Karhu, Maria José Oliveira, Marjolijn Ligtenberg, Richard Hamelin, Fátima Carneiro, Annika Lindblom, Paivi Peltomaki, Sérgio Castedo, Simó Schwartz, Jr, Peter Jordan, Lauri A. Aaltonen, Robert M.W. Hofstra, Gianpaolo Suriano, Elia Stupka, Arsenio M. Fialho, Raquel Seruca

Hum Mol Genet. 2010 Feb 15; 19(4): 697–706. Published online 2009 Dec 3. doi: 10.1093/hmg/ddp536

PMCID:: PMC2807374

Abstract Article PDF–343K

Select item 950121812.

MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells

Anh Thu Ha, Jae Youl Cho, Daewon Kim

Int J Mol Sci. 2022 Sep; 23(18): 10874. Published online 2022 Sep 17. doi: 10.3390/ijms231810874

PMCID:: PMC9501218

Abstract Article PDF–2.0M

Select item 855360913.

MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

Sunil Kumar Singh, Sandeep Kumar, Navin Viswakarma, Daniel R. Principe, Subhasis Das, Gautam Sondarva, Rakesh Sathish Nair, Piush Srivastava, Subhash C. Sinha, Paul J. Grippo, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana

Oncogene. 2021; 40(43): 6153–6165. Published online 2021 Sep 13. doi: 10.1038/s41388-021-02007-w

PMCID:: PMC8553609

Abstract Article PDF–6.9M

Select item 756868614.

Mixed Lineage Kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-Activated Kinase 1

Subhasis Das, Rakesh Sathish Nair, Rajakishore Mishra, Gautam Sondarva, Navin Viswakarma, Hazem Abdelkarim, Vadim Gaponenko, Basabi Rana, Ajay Rana

Oncogene. Author manuscript; available in PMC 2020 Oct 17.

Published in final edited form as: Oncogene. 2019 May; 38(19): 3569–3584. Published online 2019 Jan 21. doi: 10.1038/s41388-019-0690-0

Correction in:: Oncogene. 2019 Sep 17

PMCID:: PMC7568686

Abstract Article PDF–1.8M

Select item 714938915.

Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity

Sandeep Kumar, Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Subhash C. Sinha, Rajyasree Emmadi, Kent Hoskins, Oana Danciu, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana

Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7961–7970. Published online 2020 Mar 24. doi: 10.1073/pnas.1921325117

PMCID:: PMC7149389

Abstract Article PDF–2.4M

Select item 709855416.

MLK3 is a newly identified microRNA-520b target that regulates liver cancer cell migration

Fei Zhang, Yu Zhu, Shuhua Wu, Guodong Hou, Nianxiang Wu, Lirun Qian, Dong Yang

PLoS One. 2020; 15(3): e0230716. Published online 2020 Mar 26. doi: 10.1371/journal.pone.0230716

PMCID:: PMC7098554

Abstract Article PDF–1.2M

Select item 541909517.

Mixed Lineage Kinase-3/JNK1 Axis Promotes Migration of Human Gastric Cancer Cells following Gastrin Stimulation

Prajna Mishra, Subramanian Senthivinayagam, Velusamy Rangasamy, Gautam Sondarva, Basabi Rana

Mol Endocrinol. March 1, 2010; 24(3): 598–607. doi: 10.1210/me.2009-0387

PMCID:: PMC5419095

Abstract Article

Select item 489100218.

Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11)

Kimberly A. Byrnes, Pornima Phatak, Daniel Mansour, Lan Xiao, Tongtong Zou, Jaladanki N. Rao, Douglas J. Turner, Jian-Ying Wang, James M. Donahue

Oncotarget. 2016 Feb 23; 7(8): 8756–8770. Published online 2015 Dec 24. doi: 10.18632/oncotarget.6752

PMCID:: PMC4891002

Abstract Article PDF–5.0M

Select item 457189219.

Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival

Subhasis Das, Gautam Sondarva, Navin Viswakarma, Rakesh Sathish Nair, Clodia Osipo, Guri Tzivion, Basabi Rana, Ajay Rana

J Biol Chem. 2015 Aug 28; 290(35): 21705–21712. Published online 2015 Jul 7. doi: 10.1074/jbc.M115.655563

PMCID:: PMC4571892

Abstract Article PDF–2.7M

Select item 329772220.

Defining MAP3Kinases Required for MDA-MB-231 Cell Tumor Growth and Metastasis

Mark R. Cronan, Kazuhiro Nakamura, Nancy L. Johnson, Deborah A. Granger, Bruce D. Cuevas, Jian-Guo Wang, Nigel Mackman, John E. Scott, Henrik G. Dohlman, Gary L. Johnson

Oncogene. Author manuscript; available in PMC 2013 Feb 23.

Published in final edited form as: Oncogene. 2012 Aug 23; 31(34): 3889–3900. Published online 2011 Dec 5. doi: 10.1038/onc.2011.544

PMCID:: PMC3297722

Abstract Article PDF–1.6M

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