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Select item 99531331.

Acid Ceramidase Deficiency: Bridging Gaps between Clinical Presentation, Mouse Models, and Future Therapeutic Interventions

Annie Kleynerman, Jitka Rybova, Mary L. Faber, William M. McKillop, Thierry Levade, Jeffrey A. Medin

Biomolecules. 2023 Feb; 13(2): 274. Published online 2023 Feb 1. doi: 10.3390/biom13020274

PMCID:: PMC9953133

Abstract Article PDF–910K

Select item 82663292.

Acid ceramidase promotes senescent cell survival

Rachel Munk, Carlos Anerillas, Martina Rossi, Dimitrios Tsitsipatis, Jennifer L. Martindale, Allison B. Herman, Jen-Hao Yang, Jackson A. Roberts, Vijay R. Varma, Poonam R. Pandey, Madhav Thambisetty, Myriam Gorospe, Kotb Abdelmohsen

Aging (Albany NY) 2021 Jun 30; 13(12): 15750–15769. Published online 2021 Jun 8. doi: 10.18632/aging.203170

PMCID:: PMC8266329

Abstract Article PDF–1.9M

Select item 80819933.

N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production

Parmanand Malvi, Radoslav Janostiak, Arvindhan Nagarajan, Xuchen Zhang, Narendra Wajapeyee

Mol Metab. 2021 Jun; 48: 101217. Published online 2021 Mar 23. doi: 10.1016/j.molmet.2021.101217

PMCID:: PMC8081993

Abstract Article PDF–3.4M

Select item 77654214.

Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer

Rachael E. Clifford, Naren Govindarajah, David Bowden, Paul Sutton, Mark Glenn, Mahnaz Darvish-Damavandi, Simon Buczacki, Ultan McDermott, Zdzislaw Szulc, Besim Ogretmen, Jason L. Parsons, Dale Vimalachandran

Cells. 2020 Dec; 9(12): 2693. Published online 2020 Dec 15. doi: 10.3390/cells9122693

PMCID:: PMC7765421

Abstract Article PDF–2.2M

Select item 70845295.

Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content

Kalia Kyriakou, Carsten W. Lederer, Marina Kleanthous, Anthi Drousiotou, Anna Malekkou

Int J Mol Sci. 2020 Mar; 21(5): 1607. Published online 2020 Feb 26. doi: 10.3390/ijms21051607

PMCID:: PMC7084529

Abstract Article PDF–6.4M

Select item 66021376.

Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis

Shai White-Gilbertson, Ping Lu, James S. Norris, Christina Voelkel-Johnson

J Lipid Res. 2019 Jul; 60(7): 1225–1235. Published online 2019 Apr 15. doi: 10.1194/jlr.M092247

PMCID:: PMC6602137

Abstract Article PDF–1.5M

Select item 63142577.

Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress

Eriko Sugano, Genea Edwards, Saikat Saha, Lynda A. Wilmott, Richard C. Grambergs, Koushik Mondal, Hui Qi, Megan Stiles, Hiroshi Tomita, Nawajes Mandal

J Lipid Res. 2019 Jan; 60(1): 30–43. Published online 2018 Nov 9. doi: 10.1194/jlr.M082198

PMCID:: PMC6314257

Abstract Article PDF–1.4M

Select item 59155988.

Structural basis for the activation of acid ceramidase

Ahmad Gebai, Alexei Gorelik, Zixian Li, Katalin Illes, Bhushan Nagar

Nat Commun. 2018; 9: 1621. Published online 2018 Apr 24. doi: 10.1038/s41467-018-03844-2

PMCID:: PMC5915598

Abstract Article PDF–2.7M

Select item 58891099.

Whole-transcriptome sequencing in blood provides a diagnosis of spinal muscular atrophy with progressive myoclonic epilepsy

Kristin D. Kernohan, Laure Frésard, Zachary Zappala, Taila Hartley, Kevin S. Smith, Justin Wagner, Hongbin Xu, Arran McBride, Pierre R. Bourque, Care4Rare Canada Consortium, Steffany A. L. Bennett, David A. Dyment, Kym M. Boycott, Stephen B. Montgomery, Jodi Warman Chardon

Hum Mutat. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Hum Mutat. 2017 Jun; 38(6): 611–614. Published online 2017 Mar 28. doi: 10.1002/humu.23211

PMCID:: PMC5889109

Abstract Article PDF–508K

Select item 576577010.

Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro

Mariane Maffei Azuma, Pooja Balani, Heike Boisvert, Mindy Gil, Kenji Egashira, Tsuguno Yamaguchi, Hatice Hasturk, Margaret Duncan, Toshihisa Kawai, Alexandru Movila

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Jan 22.

Published in final edited form as: Biochem Biophys Res Commun. 2018 Jan 22; 495(4): 2383–2389. Published online 2017 Dec 24. doi: 10.1016/j.bbrc.2017.12.137

PMCID:: PMC5765770

Abstract Article PDF–693K

Select item 560202211.

Identification of ASAH1 as a susceptibility gene for familial keloids

Regie Lyn P Santos-Cortez, Ying Hu, Fanyue Sun, Fairouz Benahmed-Miniuk, Jian Tao, Jitendra K Kanaujiya, Samuel Ademola, Solomon Fadiora, Victoria Odesina, Deborah A Nickerson, Michael J Bamshad, Peter B Olaitan, Odunayo M Oluwatosin, Suzanne M Leal, Ernst J Reichenberger, University of Washington Center for Mendelian Genomics

Eur J Hum Genet. 2017 Oct; 25(10): 1155–1161. Published online 2017 Jul 26. doi: 10.1038/ejhg.2017.121

PMCID:: PMC5602022

Abstract Article PDF–1.4M

Select item 554712712.

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

Michele Lai, Natalia Realini, Marco La Ferla, Ilaria Passalacqua, Giulia Matteoli, Anand Ganesan, Mauro Pistello, Chiara Maria Mazzanti, Daniele Piomelli

Sci Rep. 2017; 7: 7411. Published online 2017 Aug 7. doi: 10.1038/s41598-017-07606-w

PMCID:: PMC5547127

Abstract Article PDF–2.7M

Select item 552869513.

Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer

Nicole Sänger, Eugen Ruckhäberle, Balazs Györffy, Knut Engels, Tomas Heinrich, Tanja Fehm, Anna Graf, Uwe Holtrich, Sven Becker, Thomas Karn

Mol Oncol. 2015 Jan; 9(1): 58–67. Published online 2014 Jul 31. doi: 10.1016/j.molonc.2014.07.016

PMCID:: PMC5528695

Abstract Article PDF–1.3M

Select item 534776314.

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Su-Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong-Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran, Jr

Oncotarget. 2016 Dec 13; 7(50): 83208–83222. Published online 2016 Nov 4. doi: 10.18632/oncotarget.13079

PMCID:: PMC5347763

Abstract Article PDF–4.3M

Select item 511004515.

ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study

Massimiliano Filosto, Massimo Aureli, Barbara Castellotti, Fabrizio Rinaldi, Domitilla Schiumarini, Manuela Valsecchi, Susanna Lualdi, Raffaella Mazzotti, Viviana Pensato, Silvia Rota, Cinzia Gellera, Mirella Filocamo, Alessandro Padovani

Eur J Hum Genet. 2016 Nov; 24(11): 1578–1583. Published online 2016 Mar 30. doi: 10.1038/ejhg.2016.28

PMCID:: PMC5110045

Abstract Article PDF–1.1M

Select item 473222416.

Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

Natalia Realini, Francesca Palese, Daniela Pizzirani, Silvia Pontis, Abdul Basit, Anders Bach, Anand Ganesan, Daniele Piomelli

J Biol Chem. 2016 Jan 29; 291(5): 2422–2434. Published online 2015 Nov 9. doi: 10.1074/jbc.M115.666909

PMCID:: PMC4732224

Abstract Article PDF–2.9M

Select item 378452217.

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

Joseph C. Cheng, Aiping Bai, Thomas H. Beckham, S. Tucker Marrison, Caroline L. Yount, Katherine Young, Ping Lu, Anne M. Bartlett, Bill X. Wu, Barry J. Keane, Kent E. Armeson, David T. Marshall, Thomas E. Keane, Michael T. Smith, E. Ellen Jones, Richard R. Drake, Jr., Alicja Bielawska, James S. Norris, Xiang Liu

J Clin Invest. 2013 Oct 1; 123(10): 4344–4358. Published online 2013 Sep 16. doi: 10.1172/JCI64791

PMCID:: PMC3784522

Abstract Article PDF–3.1M

Select item 362231818.

Acid ceramidase as a therapeutic target in metastatic prostate cancer

Luz Camacho, Óscar Meca-Cortés, José Luis Abad, Simón García, Nuria Rubio, Alba Díaz, Toni Celià-Terrassa, Francesca Cingolani, Raquel Bermudo, Pedro L. Fernández, Jerónimo Blanco, Antonio Delgado, Josefina Casas, Gemma Fabriàs, Timothy M. Thomson

J Lipid Res. 2013 May; 54(5): 1207–1220. doi: 10.1194/jlr.M032375

PMCID:: PMC3622318

Abstract Article PDF–1.4M

Select item 315106519.

Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine

Carmen Bedia, Josefina Casas, Nathalie Andrieu-Abadie, Gemma Fabriàs, Thierry Levade

J Biol Chem. 2011 Aug 12; 286(32): 28200–28209. Published online 2011 Jun 23. doi: 10.1074/jbc.M110.216382

PMCID:: PMC3151065

Abstract Article PDF–1.4M

Select item 310331820.

Genistein Stimulates MCF-7 Breast Cancer Cell Growth by Inducing Acid Ceramidase (ASAH1) Gene Expression

Natasha C. Lucki, Marion B. Sewer

J Biol Chem. 2011 Jun 3; 286(22): 19399–19409. Published online 2011 Apr 14. doi: 10.1074/jbc.M110.195826

PMCID:: PMC3103318

Abstract Article PDF–1.2M

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