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Select item 82061581.

Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation

Jiancong Weng, Yingxi Yang, Dong Song, Ran Huo, Hao Li, Yiyun Chen, Yoonhee Nam, Qiuxia Zhou, Yuming Jiao, Weilun Fu, Zihan Yan, Jie Wang, Hongyuan Xu, Lin Di, Jie Li, Shuo Wang, Jizong Zhao, Jiguang Wang, Yong Cao

Am J Hum Genet. 2021 May 6; 108(5): 942–950. Published online 2021 Apr 22. doi: 10.1016/j.ajhg.2021.04.005

PMCID:: PMC8206158

Abstract Article PDF–3.2M

Select item 65580322.

Overexpression of MAP3K3 promotes tumour growth through activation of the NF-κB signalling pathway in ovarian carcinoma

Ying Zhang, Sha-Sha Wang, Lin Tao, Li-Juan Pang, Hong Zou, Wei-Hua Liang, Zheng Liu, Su-Liang Guo, Jin-Fang Jiang, Wen-Jie Zhang, Wei Jia, Feng Li

Sci Rep. 2019; 9: 8401. Published online 2019 Jun 10. doi: 10.1038/s41598-019-44835-7

PMCID:: PMC6558032

Abstract Article PDF–9.4M

Select item 63255803.

MiR‐194 regulates nasopharyngeal carcinoma progression by modulating MAP3K3 expression

Wei Yin, Lei Shi, Yanjiao Mao

FEBS Open Bio. 2019 Jan; 9(1): 43–52. Published online 2018 Nov 26. doi: 10.1002/2211-5463.12545

PMCID:: PMC6325580

Abstract Article PDF–1.5M

Select item 46506174.

MAP3K3 expression in tumor cells and tumor-infiltrating lymphocytes is correlated with favorable patient survival in lung cancer

Yanli He, Lihui Wang, Weijun Liu, Jinjie Zhong, Shengbin Bai, Zhuwen Wang, Dafydd G. Thomas, Jules Lin, Rishindra M. Reddy, Nithya Ramnath, Philip W. Carrott, William R. Lynch, Mark B. Orringer, Andrew C. Chang, David G. Beer, Guoan Chen

Sci Rep. 2015; 5: 11471. Published online 2015 Jun 19. doi: 10.1038/srep11471

PMCID:: PMC4650617

Abstract Article PDF–1.7M

Select item 43756285.

A Somatic MAP3K3 Mutation Is Associated with Verrucous Venous Malformation

Javier A. Couto, Matthew P. Vivero, Harry P.W. Kozakewich, Amir H. Taghinia, John B. Mulliken, Matthew L. Warman, Arin K. Greene

Am J Hum Genet. 2015 Mar 5; 96(3): 480–486. doi: 10.1016/j.ajhg.2015.01.007

PMCID:: PMC4375628

Abstract Article PDF–1.4M

Select item 38905846.

Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis

Raghibul Hasan, Rinu Sharma, Anoop Saraya, Tushar K Chattopadhyay, Siddartha DattaGupta, Paul G Walfish, Shyam S Chauhan, Ranju Ralhan

BMC Cancer. 2014; 14: 2. Published online 2014 Jan 2. doi: 10.1186/1471-2407-14-2

PMCID:: PMC3890584

Abstract Article PDF–1.0M

Select item 83310107.

Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis

Chao Yang, Jiang Shi, Jie Wang, Dexun Hao, Jinlu An, Junguang Jiang

Cell Cycle. 2021; 20(13): 1334–1346. Published online 2021 Jun 30. doi: 10.1080/15384101.2021.1941612

PMCID:: PMC8331010

Abstract Article PDF–3.6M

Select item 63650228.

miR-505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT-NFκB pathway in NSCLC cells

Huaping Tang, Weihong Lv, Wenxin Sun, Qiaojie Bi, Yueqin Hao

Int J Mol Med. 2019 Mar; 43(3): 1203–1216. Published online 2018 Dec 31. doi: 10.3892/ijmm.2018.4041

PMCID:: PMC6365022

Abstract Article PDF–2.3M

Select item 29234289.

MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival

Xiaofang Wang, Xing Chang, Valeria Facchinetti, Yuan Zhuang, Bing Su

J Immunol. Author manuscript; available in PMC 2010 Aug 18.

Published in final edited form as: J Immunol. 2009 Mar 15; 182(6): 3597–3608. doi: 10.4049/jimmunol.0803738

PMCID:: PMC2923428

Abstract Article PDF–1.3M

Select item 283294110.

Phosphorylation of Thr-516 and Ser-520 in the Kinase Activation Loop of MEKK3 Is Required for Lysophosphatidic Acid-mediated Optimal IκB Kinase β (IKKβ)/Nuclear Factor-κB (NF-κB) Activation

Wenjing Sun, Ningling Ge, Yang Yu, Susan Burlingame, Xiaonan Li, Ming Zhang, Shenglong Ye, Songbin Fu, Jianhua Yang

J Biol Chem. 2010 Mar 12; 285(11): 7911–7918. Published online 2010 Jan 12. doi: 10.1074/jbc.M109.051219

PMCID:: PMC2832941

Abstract Article PDF–1.7M

Select item 53397211.

Restoration of NF-κB Activation by Tumor Necrosis Factor Alpha Receptor Complex-Targeted MEKK3 in Receptor-Interacting Protein-Deficient Cells

Marzenna Blonska, Yun You, Romas Geleziunas, Xin Lin

Mol Cell Biol. 2004 Dec; 24(24): 10757–10765. doi: 10.1128/MCB.24.24.10757-10765.2004

PMCID:: PMC533972

Abstract Article PDF–493K

Select item 1047475112.

Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations

Bin Zhang, Rui He, Zigang Xu, Yujuan Sun, Li Wei, Li Li, Yuanxiang Liu, Wu Guo, Li Song, Huijun Wang, Zhimiao Lin, Lin Ma

Orphanet J Rare Dis. 2023; 18: 261. Published online 2023 Sep 1. doi: 10.1186/s13023-023-02860-w

PMCID:: PMC10474751

Abstract Article PDF–1.7M

Select item 1012000513.

Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease

Ketu Mishra-Gorur, Tanyeri Barak, Leon D. Kaulen, Octavian Henegariu, Sheng Chih Jin, Stephanie Marie Aguilera, Ezgi Yalbir, Gizem Goles, Sayoko Nishimura, Danielle Miyagishima, Lydia Djenoune, Selin Altinok, Devendra K. Rai, Stephen Viviano, Andrew Prendergast, Cynthia Zerillo, Kent Ozcan, Burcin Baran, Leman Sencar, Nukte Goc, Yanki Yarman, A. Gulhan Ercan-Sencicek, Kaya Bilguvar, Richard P. Lifton, Jennifer Moliterno, Angeliki Louvi, Shiaulou Yuan, Engin Deniz, Martina Brueckner, Murat Gunel

Proc Natl Acad Sci U S A. 2023 Apr 18; 120(16): e2214997120. Published online 2023 Apr 12. doi: 10.1073/pnas.2214997120

PMCID:: PMC10120005

Abstract Article PDF–9.8M

Select item 289837914.

Protein Phosphatase 2A Acts as a Mitogen-activated Protein Kinase Kinase Kinase 3 (MEKK3) Phosphatase to Inhibit Lysophosphatidic Acid-induced IκB Kinase β/Nuclear Factor-κB Activation

Wenjing Sun, Hao Wang, Xiumei Zhao, Yang Yu, Yihui Fan, Hao Wang, Xishan Wang, Xiongbin Lu, Guiyin Zhang, Songbin Fu, Jianhua Yang

J Biol Chem. 2010 Jul 9; 285(28): 21341–21348. Published online 2010 May 6. doi: 10.1074/jbc.M110.104224

PMCID:: PMC2898379

Abstract Article PDF–1.6M

Select item 455158215.

Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascade

Juan F. Linares, Angeles Duran, Miguel Reina-Campos, Pedro Aza-Blanc, Alex Campos, Jorge Moscat, Maria T. Diaz-Meco

Cell Rep. Author manuscript; available in PMC 2016 Aug 25.

Published in final edited form as: Cell Rep. 2015 Aug 25; 12(8): 1339–1352. Published online 2015 Aug 13. doi: 10.1016/j.celrep.2015.07.045

PMCID:: PMC4551582

Abstract Article PDF–2.2M

Select item 280436416.

PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation

Kazuhiro Nakamura, Adam J. Kimple, David P. Siderovski, Gary L. Johnson

J Biol Chem. 2010 Jan 15; 285(3): 2077–2089. Published online 2009 Nov 10. doi: 10.1074/jbc.M109.065102

PMCID:: PMC2804364

Abstract Article PDF–4.8M

Select item 267942917.

Cerebral Cavernous Malformation 2 Protein Promotes Smad Ubiquitin Regulatory Factor 1-mediated RhoA Degradation in Endothelial Cells

Lisa E. S. Crose, Thomas L. Hilder, Noah Sciaky, Gary L. Johnson

J Biol Chem. 2009 May 15; 284(20): 13301–13305. doi: 10.1074/jbc.C900009200

PMCID:: PMC2679429

Abstract Article PDF–528K

Select item 415653418.

A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose-tissue inflammation in obesity

Eloy D. Hernandez, Sang Jun Lee, Ji Young Kim, Angeles Duran, Juan F. Linares, Tomoko Yajima, Timo D. Müller, Matthias H. Tschöp, Steven R. Smith, Maria T. Diaz-Meco, Jorge Moscat

Cell Metab. Author manuscript; available in PMC 2015 Sep 2.

Published in final edited form as: Cell Metab. 2014 Sep 2; 20(3): 499–511. Published online 2014 Jul 17. doi: 10.1016/j.cmet.2014.06.008

PMCID:: PMC4156534

Abstract Article PDF–1.7M

Select item 604125719.

MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function

Jinqiu Lu, Liansheng Liu, Mingjie Zheng, Xiaoling Li, Ailing Wu, Qingzhe Wu, Cheng Liao, Jian Zou, Hai Song

Oncogene. 2018; 37(28): 3864–3878. Published online 2018 Apr 17. doi: 10.1038/s41388-018-0249-5

PMCID:: PMC6041257

Abstract Article PDF–2.4M

Select item 486403520.

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling

Zinan Zhou, Alan T. Tang, Weng-Yew Wong, Sharika Bamezai, Lauren M. Goddard, Robert Shenkar, Su Zhou, Jisheng Yang, Alexander C. Wright, Matthew Foley, J. Simon C. Arthur, Kevin J. Whitehead, Issam A. Awad, Dean Y. Li, Xiangjian Zheng, Mark L. Kahn

Nature. Author manuscript; available in PMC 2016 Sep 30.

Published in final edited form as: Nature. 2016 Apr 7; 532(7597): 122–126. Published online 2016 Mar 30. doi: 10.1038/nature17178

Correction in:: Nature. 2016 May 25; 536(7617): 488.

PMCID:: PMC4864035

Abstract Article PDF–3.0M

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