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Select item 106455451.

Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants >5 kb from coding DNA

Sihao Xiao, Zhentian Kai, Daniel Murphy, Dongyang Li, Dilip Patel, Adrianna M. Bielowka, Maria E. Bernabeu-Herrero, Awatif Abdulmogith, Andrew D. Mumford, Sarah K. Westbury, Micheala A. Aldred, Neil Vargesson, Mark J. Caulfield, Genomics England Research Consortium, Claire L. Shovlin

Am J Hum Genet. 2023 Nov 2; 110(11): 1903–1918. Published online 2023 Oct 9. doi: 10.1016/j.ajhg.2023.09.005

PMCID:: PMC10645545

Abstract Article PDF–4.6M

Select item 104425102.

Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors

Dimuthu Alankarage, Annabelle Enriquez, Robert D Steine, Cathy Raggio, Megan Higgins, Di Milnes, David T Humphreys, Emma L Duncan, Duncan B Sparrow, Philip F Giampietro, Gavin Chapman, Sally L Dunwoodie

Differentiation. Author manuscript; available in PMC 2023 Aug 22.

Published in final edited form as: Differentiation. 2022 Nov-Dec; 128: 1–12. Published online 2022 Sep 24. doi: 10.1016/j.diff.2022.09.002

PMCID:: PMC10442510

Abstract Article PDF–1.6M

Select item 101786653.

SMAD4 Expression in Monocytes as a Potential Biomarker for Atherosclerosis Risk in Patients with Obstructive Sleep Apnea

Elena Díaz-García, Aldara García-Sánchez, David Sánz-Rubio, Enrique Alfaro, Cristina López-Fernández, Raquel Casitas, Eva Mañas Baena, Irene Cano-Pumarega, Pablo Cubero, Marta Marin-Oto, Eduardo López-Collazo, José María Marin, Francisco García-Río, Carolina Cubillos-Zapata

Int J Mol Sci. 2023 May; 24(9): 7900. Published online 2023 Apr 26. doi: 10.3390/ijms24097900

PMCID:: PMC10178665

Abstract Article PDF–1.2M

Select item 100533254.

Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling

Cong Tang, Mo Xiulei, Qiankun Niu, Alafate Wahafu, Xuan Yang, Min Qui, Andrey A. Ivanov, Yuhong Du, Haian Fu

Cell Chem Biol. Author manuscript; available in PMC 2023 Mar 29.

Published in final edited form as: Cell Chem Biol. 2021 May 20; 28(5): 636–647.e5. Published online 2020 Dec 15. doi: 10.1016/j.chembiol.2020.11.010

PMCID:: PMC10053325

Abstract Article PDF–1.9M

Select item 98306415.

Multiomics of Colorectal Cancer Organoids Reveals Putative Mediators of Cancer Progression Resulting from SMAD4 Inactivation

Jelmer J. Dijkstra, Hannah K. Neikes, Somayeh Rezaeifard, Xuhui Ma, Emile E. Voest, Daniele V. F. Tauriello, Michiel Vermeulen

J Proteome Res. 2023 Jan 6; 22(1): 138–151. Published online 2022 Nov 30. doi: 10.1021/acs.jproteome.2c00551

PMCID:: PMC9830641

Abstract Article PDF–5.3M

Select item 93093236.

SMAD4 rs10502913 is Significantly Associated with Chronic Obstructive Pulmonary Disease in a Chinese Han Population: A Case-Control Study

Zhifei Hou, Zhihui Yuan, Hao Wang, Kang Chang, Yong Gao

Int J Chron Obstruct Pulmon Dis. 2022; 17: 1623–1631. Published online 2022 Jul 19. doi: 10.2147/COPD.S362467

PMCID:: PMC9309323

Abstract Article PDF–442K

Select item 92006597.

SMAD4 Controls Cancer Cell Metabolism by Regulating Methylmalonic Aciduria Cobalamin Deficiency (cbl) B Type

Kyoung Song, Hun Seok Lee, Lina Jia, Chaithanya Chelakkot, Nirmal Rajasekaran, Young Kee Shin

Mol Cells. 2022 Jun 30; 45(6): 413–424. Published online 2022 Jun 3. doi: 10.14348/molcells.2022.0067

PMCID:: PMC9200659

Abstract Article PDF–15M

Select item 90143238.

Amelioration of ligamentum flavum hypertrophy using umbilical cord mesenchymal stromal cell-derived extracellular vesicles

Cheng Ma, Xin Qi, Yi-Fan Wei, Zhi Li, He-Long Zhang, He Li, Feng-Lei Yu, Ya-Nan Pu, Yong-Can Huang, Yong-Xin Ren

Bioact Mater. 2023 Jan; 19: 139–154. Published online 2022 Apr 8. doi: 10.1016/j.bioactmat.2022.03.042

PMCID:: PMC9014323

Abstract Article PDF–14M

Select item 90122879.

SMAD4 TGF-β–independent function preconditions naive CD8⁺ T cells to prevent severe chronic intestinal inflammation

Ramdane Igalouzene, Hector Hernandez-Vargas, Nicolas Benech, Alexandre Guyennon, David Bauché, Célia Barrachina, Emeric Dubois, Julien C. Marie, Saïdi M’Homa Soudja

J Clin Invest. 2022 Apr 15; 132(8): e151020. Published online 2022 Apr 15. doi: 10.1172/JCI151020

PMCID:: PMC9012287

Abstract Article PDF–5.7M

Select item 878961710.

A SMAD4‐modulated gene profile predicts disease‐free survival in stage II and III colorectal cancer

Bryan C. Szeglin, Chao Wu, Michael R. Marco, Hyun Sung Park, Zeda Zhang, Bing Zhang, Julio Garcia‐Aguilar, R. Daniel Beauchamp, X. Steven Chen, J. Joshua Smith

Cancer Rep (Hoboken) 2022 Jan; 5(1): e1423. Published online 2021 Jun 10. doi: 10.1002/cnr2.1423

PMCID:: PMC8789617

Abstract Article PDF–2.8M

Select item 877058811.

Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4

Sarah Ouahoud, Rutger J. Jacobs, Ludmilla L. Kodach, Philip W. Voorneveld, Lukas J. A. C. Hawinkels, Nikki L. Weil, Britt van Vliet, Ron M. Herings, Lennart R. A. van der Burg, Tom van Wezel, Hans Morreau, Marije Slingerland, Esther Bastiaannet, Hein Putter, James C. H. Hardwick

Br J Cancer. 2022 Feb 1; 126(2): 297–301. Published online 2021 Oct 26. doi: 10.1038/s41416-021-01604-6

PMCID:: PMC8770588

Abstract Article PDF–745K

Select item 850480612.

SMAD4 loss is associated with response to neoadjuvant chemotherapy plus hydroxychloroquine in patients with pancreatic adenocarcinoma

Naomi Fei, Sijin Wen, Rajesh Ramanathan, Melissa E. Hogg, Amer H. Zureikat, Michael T. Lotze, Nathan Bahary, Aatur D. Singhi, Herbert J. Zeh, Brian A. Boone

Clin Transl Sci. 2021 Sep; 14(5): 1822–1829. Published online 2021 May 18. doi: 10.1111/cts.13029

PMCID:: PMC8504806

Abstract Article PDF–492K

Select item 829966113.

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis

Tian Fang, Tingting Liang, Yizhuo Wang, Haitao Wu, Shuhan Liu, Linying Xie, Jiaying Liang, Chang Wang, Yehui Tan

BMC Gastroenterol. 2021; 21: 297. Published online 2021 Jul 23. doi: 10.1186/s12876-021-01864-9

PMCID:: PMC8299661

Abstract Article PDF–1.0M

Select item 826744314.

Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett’s Esophagus

Jovana R. Gotovac, Tanjina Kader, Julia V. Milne, Kenji M. Fujihara, Luis E. Lara-Gonzalez, Kylie L. Gorringe, Sangeetha N. Kalimuthu, Madawa W. Jayawardana, Cuong P. Duong, Wayne A. Phillips, Nicholas J. Clemons

Cell Mol Gastroenterol Hepatol. 2021; 12(2): 689–713. Published online 2021 Mar 25. doi: 10.1016/j.jcmgh.2021.03.008

PMCID:: PMC8267443

Abstract Article PDF–8.9M

Select item 816264515.

Association of SMAD4 loss with drug resistance in clinical cancer patients: A systematic meta-analysis

Wei Xu, Sau Har Lee, Fengjun Qiu, Li Zhou, Xiaoling Wang, Tingjie Ye, Xudong Hu

PLoS One. 2021; 16(5): e0250634. Published online 2021 May 28. doi: 10.1371/journal.pone.0250634

PMCID:: PMC8162645

Abstract Article PDF–2.4M

Select item 801783516.

Correlation between loss of Smad4 and clinical parameters of non-small cell lung cancer: an observational cohort study

Xiangjun Guo, Mengmeng Li, Xin Wang, Yun Pan, Jiashu Li

BMC Pulm Med. 2021; 21: 111. Published online 2021 Apr 1. doi: 10.1186/s12890-021-01480-z

PMCID:: PMC8017835

Abstract Article PDF–2.3M

Select item 784191317.

SMAD4 haploinsufficiency in small intestinal neuroendocrine tumors

Tobias Hofving, Erik Elias, Anna Rehammar, Linda Inge, Gülay Altiparmak, Marta Persson, Erik Kristiansson, Martin E. Johansson, Ola Nilsson, Yvonne Arvidsson

BMC Cancer. 2021; 21: 101. Published online 2021 Jan 28. doi: 10.1186/s12885-021-07786-9

PMCID:: PMC7841913

Abstract Article PDF–1.5M

Select item 737951618.

SMAD4 Is Essential for Human Cardiac Mesodermal Precursor Cell Formation

Jiejia Xu, Peter J. Gruber, Kenneth R. Chien

Stem Cells. 2019 Feb; 37(2): 216–225. Published online 2018 Dec 18. doi: 10.1002/stem.2943

PMCID:: PMC7379516

Abstract Article PDF–1.1M

Select item 733535519.

Pattern of invasion in human pancreatic cancer organoids is associated with loss of SMAD4 and clinical outcome

Wenjie Huang, Bernat Navarro-Serer, Yea Ji Jeong, Peter Chianchiano, Limin Xia, Claudio Luchini, Nicola Veronese, Cameron Dowiak, Tammy Ng, Maria A. Trujillo, Bo Huang, Michael J. Pflüger, Anne M. Macgregor-Das, Gemma Lionheart, Danielle Jones, Kohei Fujikura, Kim-Vy Nguyen-Ngoc, Neil M. Neumann, Vincent P. Groot, Alina Hasanain, A. Floortje van Oosten, Sandra E. Fischer, Steven Gallinger, Aatur D. Singhi, Amer H. Zureikat, Randall E. Brand, Matthias M. Gaida, Stefan Heinrich, Richard A. Burkhart, Jin He, Christopher L. Wolfgang, Michael G. Goggins, Elizabeth D. Thompson, Nicholas J. Roberts, Andrew J. Ewald, Laura D. Wood

Cancer Res. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Cancer Res. 2020 Jul 1; 80(13): 2804–2817. Published online 2020 May 6. doi: 10.1158/0008-5472.CAN-19-1523

PMCID:: PMC7335355

Abstract Article PDF–1.4M

Select item 722895020.

SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis

Xing Du, Qiqi Li, Liu Yang, Lu Liu, Qiuyu Cao, Qifa Li

Cell Death Dis. 2020 May; 11(5): 373. Published online 2020 May 15. doi: 10.1038/s41419-020-2578-x

PMCID:: PMC7228950

Abstract Article PDF–2.7M

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