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Select item 109445991.

Single-cell transcriptomic sequencing data reveal aberrant DNA methylation in SMAD3 promoter region in tumor-associated fibroblasts affecting molecular mechanism of radiosensitivity in non-small cell lung cancer

Fushi Han, Shuzhen Chen, Kangwei Zhang, Kunming Zhang, Meng Wang, Peijun Wang

J Transl Med. 2024; 22: 288. Published online 2024 Mar 16. doi: 10.1186/s12967-024-05057-2

PMCID:: PMC10944599

Abstract Article PDF–9.9M

Select item 107244972.

A novel pathogenic variant located just upstream of the C‐terminal Ser423‐X‐Ser425 phosphorylation motif in SMAD3 causing Loeys–Dietz syndrome

Satoshi Ishii, Takayuki Fujiwara, Hiroki Yagi, Norifumi Takeda, Masahiko Ando, Haruo Yamauchi, Ryo Inuzuka, Yuki Taniguchi, Masaru Hatano, Issei Komuro

Mol Genet Genomic Med. 2023 Dec; 11(12): e2257. Published online 2023 Oct 20. doi: 10.1002/mgg3.2257

PMCID:: PMC10724497

Abstract Article PDF–7.6M

Select item 100857083.

SMAD3 promotes expression and activity of the androgen receptor in prostate cancer

Hee-Young Jeon, Majid Pornour, Hyunju Ryu, Sudeep Khadka, Rui Xu, Jihyun Jang, Deqiang Li, Hegang Chen, Arif Hussain, Ladan Fazli, Martin Gleave, Xuesen Dong, Furong Huang, Qianben Wang, Christopher Barbieri, Jianfei Qi

Nucleic Acids Res. 2023 Apr 11; 51(6): 2655–2670. Published online 2023 Feb 2. doi: 10.1093/nar/gkad043

PMCID:: PMC10085708

Abstract Article PDF–5.5M

Select item 91810974.

Smad3 Phospho-Isoform Signaling in Nonalcoholic Steatohepatitis

Takashi Yamaguchi, Katsunori Yoshida, Miki Murata, Kanehiko Suwa, Koichi Tsuneyama, Koichi Matsuzaki, Makoto Naganuma

Int J Mol Sci. 2022 Jun; 23(11): 6270. Published online 2022 Jun 3. doi: 10.3390/ijms23116270

PMCID:: PMC9181097

Abstract Article PDF–769K

Select item 90661015.

Smad3 Signatures in Renal Inflammation and Fibrosis

Wenjing Wu, Xiaoqin Wang, Xueqing Yu, Hui-Yao Lan

Int J Biol Sci. 2022; 18(7): 2795–2806. Published online 2022 Mar 28. doi: 10.7150/ijbs.71595

PMCID:: PMC9066101

Abstract Article PDF–1.2M

Select item 90039676.

Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway

Jiaojiao Xu, Luyao Ma, Danqing Wang, Jianhong Yang

BMC Mol Cell Biol. 2022; 23: 18. Published online 2022 Apr 12. doi: 10.1186/s12860-022-00416-7

PMCID:: PMC9003967

Abstract Article PDF–7.3M

Select item 84967267.

SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy

Chen Yang, Xiao-Cui Chen, Zhi-Hang Li, Hong-Luan Wu, Kai-Peng Jing, Xiao-Ru Huang, Lin Ye, Biao Wei, Hui-Yao Lan, Hua-Feng Liu

Autophagy. 2021; 17(9): 2325–2344. Published online 2020 Oct 12. doi: 10.1080/15548627.2020.1824694

PMCID:: PMC8496726

Abstract Article PDF–26M

Select item 79334848.

Endogenous SO₂-dependent Smad3 redox modification controls vascular remodeling

Yaqian Huang, Zongmin Li, Lulu Zhang, Huan Tang, Heng Zhang, Chu Wang, Selena Ying Chen, Dingfang Bu, Zaifeng Zhang, Zhigang Zhu, Piaoliu Yuan, Kun Li, Xiaoqi Yu, Wei Kong, Chaoshu Tang, Youngeun Jung, Renan B. Ferreira, Kate S. Carroll, Junbao Du, Jing Yang, Hongfang Jin

Redox Biol. 2021 May; 41: 101898. Published online 2021 Feb 18. doi: 10.1016/j.redox.2021.101898

PMCID:: PMC7933484

Abstract Article PDF–7.3M

Select item 77161169.

Definition of Smad3 Phosphorylation Events That Affect Malignant and Metastatic Behaviors in Breast Cancer Cells

Eunjin Bae, Misako Sato, Ran-Ju Kim, Mi-Kyung Kwak, Kazuhito Naka, Jungsoo Gim, Mitsutaka Kadota, Binwu Tang, Kathleen C. Flanders, Tae-Aug Kim, Sun-Hee Leem, Taesung Park, Fang Liu, Lalage M. Wakefield, Seong-Jin Kim, Akira Ooshima

Cancer Res. Author manuscript; available in PMC 2020 Dec 4.

Published in final edited form as: Cancer Res. 2014 Nov 1; 74(21): 6139–6149. Published online 2014 Sep 9. doi: 10.1158/0008-5472.CAN-14-0803

PMCID:: PMC7716116

Abstract Article PDF–2.2M

Select item 750747810.

Identification of novel splice mutation in SMAD3 in two Cypriot families with nonsyndromic thoracic aortic aneurysm. Two case reports

Anna Keravnou, Evy Bashiardes, Vassilis Barberis, Kyriaki Michailidou, Marinos Soteriou, George A. Tanteles, Marios A. Cariolou

Mol Genet Genomic Med. 2020 Sep; 8(9): e1378. Published online 2020 Jun 29. doi: 10.1002/mgg3.1378

PMCID:: PMC7507478

Abstract Article PDF–884K

Select item 731659611.

In vitro lineage-specific differentiation of vascular smooth muscle cells in response to SMAD3 deficiency: Implications for SMAD3-related thoracic aortic aneurysm

Jian Gong, Dong Zhou, Longtan Jiang, Ping Qiu, Dianna M. Milewicz, Y. Eugene Chen, Bo Yang

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Jul; 40(7): 1651–1663. Published online 2020 May 14. doi: 10.1161/ATVBAHA.120.313033

PMCID:: PMC7316596

Abstract Article PDF–2.0M

Select item 721681012.

Clinical and genetic data of 22 new patients with SMAD3 pathogenic variants and review of the literature

Bertrand Chesneau, Thomas Edouard, Yves Dulac, Hélène Colineaux, Maud Langeois, Nadine Hanna, Catherine Boileau, Pauline Arnaud, Nicolas Chassaing, Sophie Julia, Guillaume Jondeau, Aurélie Plancke, Philippe Khau Van Kien, Julie Plaisancié

Mol Genet Genomic Med. 2020 May; 8(5): e1132. Published online 2020 Mar 10. doi: 10.1002/mgg3.1132

PMCID:: PMC7216810

Abstract Article PDF–727K

Select item 720193213.

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway

Heeseog Kang, Smita Jha, Aleksandra Ivovic, Nadja Fratzl-Zelman, Zuoming Deng, Apratim Mitra, Wayne A. Cabral, Eric P. Hanson, Eileen Lange, Edward W. Cowen, James Katz, Paul Roschger, Klaus Klaushofer, Ryan K. Dale, Richard M. Siegel, Timothy Bhattacharyya, Joan C. Marini

J Exp Med. 2020 May 4; 217(5): e20191499. Published online 2020 Mar 31. doi: 10.1084/jem.20191499

PMCID:: PMC7201932

Abstract Article PDF–5.3M

Select item 719647614.

Novel SMAD3 p.Arg386Thr genetic variant co‐segregating with thoracic aortic aneurysm and dissection

Karolina Engström, Farkas Vánky, Malin Rehnberg, Cecilia Trinks, Jon Jonasson, Anna Green, Cecilia Gunnarsson

Mol Genet Genomic Med. 2020 Apr; 8(4): e1089. Published online 2020 Feb 5. doi: 10.1002/mgg3.1089

PMCID:: PMC7196476

Abstract Article PDF–969K

Select item 681706315.

Association between SMAD3 gene rs12901499 polymorphism and knee osteoarthritis in a Chinese population

Li Zhang, Limin Zhang, Haiqin Zhang, Wenjun Wang, You Zhao

J Clin Lab Anal. 2018 Jun; 32(5): e22383. Published online 2018 Jan 8. doi: 10.1002/jcla.22383

PMCID:: PMC6817063

Abstract Article PDF–251K

Select item 677166416.

Psychological well‐being in patients with aneurysms‐osteoarthritis syndrome

Lidia R. Bons, Allard T. van den Hoven, Ayda E. Damirchi, Denise van der Linde, Silvy Dekker, Robert M. Kauling, Ingrid M. B. H. van de Laar, Elisabeth M. W. J. Utens, Ricardo P. J. Budde, Jolien W. Roos‐Hesselink

Am J Med Genet A. 2019 Aug; 179(8): 1491–1497. Published online 2019 May 27. doi: 10.1002/ajmg.a.61209

PMCID:: PMC6771664

Abstract Article PDF–1.2M

Select item 625067917.

Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer

Qihan Fu, Qi Zhang, Yu Lou, Jiaqi Yang, Gang Nie, Qi Chen, Yiwen Chen, Jingying Zhang, Jianxin Wang, Tao Wei, Hao Qin, Xiaowei Dang, Xueli Bai, Tingbo Liang

Oncogene. 2018; 37(47): 6105–6118. Published online 2018 Jul 10. doi: 10.1038/s41388-018-0391-0

Correction in:: Oncogene. 2019; 38(28): 5740–5741.

PMCID:: PMC6250679

Abstract Article PDF–4.8M

Select item 617514518.

Results of next‐generation sequencing gene panel diagnostics including copy‐number variation analysis in 810 patients suspected of heritable thoracic aortic disorders

Eline Overwater, Luisa Marsili, Marieke J.H. Baars, Annette F. Baas, Irma van de Beek, Eelco Dulfer, Johanna M. van Hagen, Yvonne Hilhorst‐Hofstee, Marlies Kempers, Ingrid P. Krapels, Leonie A. Menke, Judith M.A. Verhagen, Kak K. Yeung, Petra J.G. Zwijnenburg, Maarten Groenink, Peter van Rijn, Marjan M. Weiss, Els Voorhoeve, J. Peter van Tintelen, Arjan C. Houweling, Alessandra Maugeri

Hum Mutat. 2018 Sep; 39(9): 1173–1192. Published online 2018 Jul 12. doi: 10.1002/humu.23565