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Items: 1 to 20 of 192

1.
Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome
Adriana A. de Jesus, Guibin Chen, Dan Yang, Tomas Brdicka, Natasha M. Ruth, David Bennin, Dita Cebecauerova, Hana Malcova, Helen Freeman, Neil Martin, Karel Svojgr, Murray H. Passo, Farzana Bhuyan, Sara Alehashemi, Andre T. Rastegar, Katsiaryna Uss, Lela Kardava, Bernadette Marrero, Iris Duric, Ebun Omoyinmi, Petra Peldova, Chyi-Chia Richard Lee, David E. Kleiner, Colleen M. Hadigan, Stephen M. Hewitt, Stefania Pittaluga, Carmelo Carmona-Rivera, Katherine R. Calvo, Nirali Shah, Miroslava Balascakova, Danielle L. Fink, Radana Kotalova, Zuzana Parackova, Lucie Peterkova, Daniela Kuzilkova, Vit Campr, Lucie Sramkova, Angelique Biancotto, Stephen R. Brooks, Cameron Manes, Eric Meffre, Rebecca L. Harper, Hyesun Kuehn, Mariana J. Kaplan, Paul Brogan, Sergio D. Rosenzweig, Melinda Merchant, Zuoming Deng, Anna Huttenlocher, Susan L. Moir, Douglas B. Kuhns, Manfred Boehm, Karolina Skvarova Kramarzova, Raphaela Goldbach-Mansky
Nat Commun. 2023; 14: 1502. Published online 2023 Mar 17. doi: 10.1038/s41467-023-36941-y
PMCID:
PMC10022554
AbstractArticlePDF–5.3M
2.
Lyn regulates creatine uptake in an imatinib-resistant CML cell line
Denis O. Okumu, Lucas J. Aponte-Collazo, Brian J. Dewar, Nathan J. Cox, Michael P. East, Katherine Tech, Ian M. McDonald, Andrey P. Tikunov, Ekhson Holmuhamedov, Jeffrey M. Macdonald, Lee M. Graves
Biochim Biophys Acta Gen Subj. Author manuscript; available in PMC 2021 Apr 1.
Published in final edited form as: Biochim Biophys Acta Gen Subj. 2020 Apr; 1864(4): 129507. Published online 2019 Dec 24. doi: 10.1016/j.bbagen.2019.129507
PMCID:
PMC7055176
AbstractArticlePDF–1.1M
3.
Lyn regulates epithelial–mesenchymal transition in CS-exposed model through Smad2/3 signaling
Xiaobo Liang, Xiang He, Yin Li, Junyi Wang, Dehong Wu, Xiefang Yuan, Xiaoyun Wang, Guoping Li
Respir Res. 2019; 20: 201. Published online 2019 Sep 2. doi: 10.1186/s12931-019-1166-z
PMCID:
PMC6720409
AbstractArticlePDF–6.3M
4.
LYN expression predicts the response to dasatinib in a subpopulation of lung adenocarcinoma patients
Yu Jin Kim, Sungyoul Hong, Minjung Sung, Min Jeong Park, Kyungsoo Jung, Ka-Won Noh, Doo-Yi Oh, Mi-Sook Lee, Ensel Oh, Young Kee Shin, Yoon-La Choi
Oncotarget. 2016 Dec 13; 7(50): 82876–82888. Published online 2016 Oct 14. doi: 10.18632/oncotarget.12657
PMCID:
PMC5347739
AbstractArticlePDF–5.7M
5.
Tyrosine kinase LYN is an oncotarget in human cervical cancer: A quantitative proteomic based study
Shuaibin Liu, Xiaoming Hao, Xiaolan Ouyang, Xiaojing Dong, Yixuan Yang, Tinghe Yu, Jianguo Hu, Lina Hu
Oncotarget. 2016 Nov 15; 7(46): 75468–75481. Published online 2016 Sep 26. doi: 10.18632/oncotarget.12258
PMCID:
PMC5342753
AbstractArticlePDF–8.6M
6.
Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients
Antonia K. Roseweir, Tahir Qayyum, Zhi Lim, Rachel Hammond, Alasdair I. MacDonald, Sioban Fraser, Grenville M. Oades, Michael Aitchison, Robert J. Jones, Joanne Edwards
BMC Cancer. 2016; 16: 229. Published online 2016 Mar 16. doi: 10.1186/s12885-016-2254-9
PMCID:
PMC4794832
AbstractArticlePDF–2.6M
7.
Inhibition of Lyn is a promising treatment for mantle cell lymphoma with bortezomib resistance
Areumnuri Kim, Ki Moon Seong, Hye Jin Kang, Sunhoo Park, Seung-Sook Lee
Oncotarget. 2015 Nov 10; 6(35): 38225–38238. Published online 2015 Oct 21. doi: 10.18632/oncotarget.5425
PMCID:
PMC4741995
AbstractArticlePDF–1.9M
8.
LYN, a Key Gene From Bioinformatics Analysis, Contributes to Development and Progression of Esophageal Adenocarcinoma
Dabiao Liu
Med Sci Monit Basic Res. 2015; 21: 253–261. Published online 2015 Dec 21. doi: 10.12659/MSMBR.895463
PMCID:
PMC4701013
AbstractArticlePDF–1.2M
9.
Astaxanthin Improves Human Sperm Capacitation by Inducing Lyn Displacement and Activation
Alessandra Andrisani, Gabriella Donà, Elena Tibaldi, Anna Maria Brunati, Chiara Sabbadin, Decio Armanini, Gualtiero Alvisi, Salvatore Gizzo, Guido Ambrosini, Eugenio Ragazzi, Luciana Bordin
Mar Drugs. 2015 Sep; 13(9): 5533–5551. Published online 2015 Aug 25. doi: 10.3390/md13095533
PMCID:
PMC4584338
AbstractArticlePDF–1.8M
10.
LYN-activating mutations mediate antiestrogen resistance in estrogen receptor–positive breast cancer
Luis J. Schwarz, Emily M. Fox, Justin M. Balko, Joan T. Garrett, María Gabriela Kuba, Mónica Valeria Estrada, Ana María González-Angulo, Gordon B. Mills, Monica Red-Brewer, Ingrid A. Mayer, Vandana Abramson, Monica Rizzo, Mark C. Kelley, Ingrid M. Meszoely, Carlos L. Arteaga
J Clin Invest. 2014 Dec 1; 124(12): 5490–5502. Published online 2014 Nov 17. doi: 10.1172/JCI72573
PMCID:
PMC4348968
AbstractArticlePDF–6.6M
11.
Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells
Elena Chiricozzi, Maria Grazia Ciampa, Giuseppina Brasile, Federica Compostella, Alessandro Prinetti, Hitoshi Nakayama, Roudy C. Ekyalongo, Kazuhisa Iwabuchi, Sandro Sonnino, Laura Mauri
J Lipid Res. 2015 Jan; 56(1): 129–141. doi: 10.1194/jlr.M055319
PMCID:
PMC4274061
AbstractArticlePDF–1.2M
12.
Activation of Lyn Tyrosine Kinase through Decreased Membrane Cholesterol Levels during a Change in Its Membrane Distribution upon Cell Detachment
Takao Morinaga, Kohei Abe, Yuji Nakayama, Noritaka Yamaguchi, Naoto Yamaguchi
J Biol Chem. 2014 Sep 19; 289(38): 26327–26343. Published online 2014 Aug 7. doi: 10.1074/jbc.M114.580001
PMCID:
PMC4176202
AbstractArticlePDF–4.1M
13.
Phosphorylation of c-Cbl and p85 PI3K Driven by All-trans Retinoic Acid and CD38 Depends on Lyn Kinase Activity
Johanna Congleton, Miaoqing Shen, Robert MacDonald, Fabio Malavasi, Andrew Yen
Cell Signal. Author manuscript; available in PMC 2015 Jul 1.
Published in final edited form as: Cell Signal. 2014 Jul; 26(7): 1589–1597. Published online 2014 Mar 29. doi: 10.1016/j.cellsig.2014.03.021
PMCID:
PMC4039659
AbstractArticlePDF–2.9M
14.
Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer
S.E. Wheeler, E.M. Morariu, J.S. Bednash, C.G. Otte, R.R. Seethala, S.I. Chiosea, J.R. Grandis
Clin Cancer Res. Author manuscript; available in PMC 2013 May 15.
Published in final edited form as: Clin Cancer Res. 2012 May 15; 18(10): 2850–2860. Published online 2012 Apr 6. doi: 10.1158/1078-0432.CCR-11-2486
PMCID:
PMC3433855
AbstractArticlePDF–2.8M
15.
Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity
Lucia De Franceschi, Carlo Tomelleri, Alessandro Matte, Anna Maria Brunati, Petra H. Bovee-Geurts, Mariarita Bertoldi, Edwin Lasonder, Elena Tibaldi, Adrian Danek, Ruth H. Walker, Hans H. Jung, Benedikt Bader, Angela Siciliano, Emanuela Ferru, Narla Mohandas, Giel J. C. G. M. Bosman
Blood. 2011 Nov 17; 118(20): 5652–5663. Prepublished online 2011 Sep 27. doi: 10.1182/blood-2011-05-355339
PMCID:
PMC3217364
AbstractArticle
16.
Chemoattractant-induced Signaling via the Ras-ERK and PI3K-Akt Networks, along with Leukotriene C4 Release, Is Dependent upon the Tyrosine Kinase Lyn in IL-5- and IL-3-primed Human Blood Eosinophils
Yiming Zhu, Paul J. Bertics
J Immunol. Author manuscript; available in PMC 2012 Jan 1.
Published in final edited form as: J Immunol. 2011 Jan 1; 186(1): 516–526. Published online 2010 Nov 24. doi: 10.4049/jimmunol.1000955
PMCID:
PMC3156584
AbstractArticlePDF–980K
17.
Association Between Imatinib-Resistant BCR-ABL Mutation-Negative Leukemia and Persistent Activation of LYN Kinase
Ji Wu, Feng Meng, Ling-Yuan Kong, Zhenghong Peng, Yunming Ying, William G. Bornmann, Bryant G. Darnay, Betty Lamothe, Hanshi Sun, Moshe Talpaz, Nicholas J. Donato
J Natl Cancer Inst. 2008 Jul 2; 100(13): 926–939. Published online 2008 Jul 2. doi: 10.1093/jnci/djn188
PMCID:
PMC2902818
AbstractArticlePDF–845K
18.
LYN is a mediator of epithelial-mesenchymal transition and target of dasatinib in breast cancer
Yoon-La Choi, Melanie Bocanegra, Mi Jeong Kwon, Young Kee Shin, Seok Jin Nam, Jung-Hyun Yang, Jessica Kao, Andrew K. Godwin, Jonathan R. Pollack
Cancer Res. Author manuscript; available in PMC 2011 Mar 15.
Published in final edited form as: Cancer Res. 2010 Mar 15; 70(6): 2296–2306. Published online 2010 Mar 9. doi: 10.1158/0008-5472.CAN-09-3141
PMCID:
PMC2869247
AbstractArticlePDF–3.2M
19.
Genetic Associations of LYN with Systemic Lupus Erythematosus
Rufei Lu, Gabriel S. Vidal, Jennifer A Kelly, Angélica M Delgado-Vega, Xana Kim-Howard, Susan R Macwana, Nicolas Dominguez, Wendy Klein, Christian Burrell, Isaac T Harley, Kenneth M Kaufman, Gail R Bruner, Kathy L Moser, Patrick M Gaffney, Gary S Gilkeson, Edward K Wakeland, Quan-Zhen Li, Carl D Langefeld, Miranda C Marion, Jasmin Divers, Graciela S Alarcón, Elizabeth E Brown, Robert P Kimberly, Jeffery C Edberg, Rosalind Ramsey-Goldman, John D Reveille, Gerald McGwin, Jr., Luis M Vilá, Michelle A Petri, Sang-Cheol Bae, Soo-Kyung Cho, So-Young Bang, IL Kim, Chan-Bum Choi, Javier Martin, Timothy J Vyse, Joan T Merrill, John B Harley, Marta E Alarcón-Riquelme, Swapan K Nath, Judith A James, Joel M Guthridge
Genes Immun. Author manuscript; available in PMC 2010 Jan 1.
Published in final edited form as: Genes Immun. 2009 Jul; 10(5): 397–403. Published online 2009 Apr 16. doi: 10.1038/gene.2009.19
PMCID:
PMC2750001
AbstractArticlePDF–271K
20.
Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity
Finn Bauer, Kristian Schweimer, Heike Meiselbach, Silke Hoffmann, Paul Rösch, Heinrich Sticht
Protein Sci. 2005 Oct; 14(10): 2487–2498. doi: 10.1110/ps.051563605
PMCID:
PMC2253286
AbstractArticlePDF–623K

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