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Select item 110350631.

Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA

Kanal Elamparithi Balu, Mitchell Gulkis, Danah Almohdar, Melike Çağlayan

J Biol Chem. 2024 May; 300(5): 107216. Published online 2024 Mar 24. doi: 10.1016/j.jbc.2024.107216

PMCID:: PMC11035063

Abstract Article PDF–3.4M

Select item 103479602.

The Association of DNA Ligase 1 Rs20579 Polymorphism With Lung Cancer Risk Among Taiwanese

SHANG-MIAO CHANG, YA-CHEN YANG, GUAN-LIANG CHEN, LI-HSIOU CHEN, TE-CHUN SHEN, YEN-FENG LIU, YUN-CHI WANG, CHIA-WEN TSAI, TE-CHUN HSIA, DA-TIAN BAU, WEN-SHIN CHANG

In Vivo. 2023 Jul-Aug; 37(4): 1504–1510. Published online 2023 Jul 3. doi: 10.21873/invivo.13235

PMCID:: PMC10347960

Abstract Article PDF–131K

Select item 80247093.

DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized and mismatch nucleotide insertion products in base excision repair

Pradnya Kamble, Kalen Hall, Mahesh Chandak, Qun Tang, Melike Çağlayan

J Biol Chem. 2021 Jan-Jun; 296: 100427. Published online 2021 Feb 16. doi: 10.1016/j.jbc.2021.100427

PMCID:: PMC8024709

Abstract Article PDF–4.3M

Select item 78975204.

LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency

Thomas J Jurkiw, Percy P Tumbale, Matthew J Schellenberg, Charlotte Cunningham-Rundles, R Scott Williams, Patrick J O’Brien

Nucleic Acids Res. 2021 Feb 22; 49(3): 1619–1630. Published online 2021 Jan 14. doi: 10.1093/nar/gkaa1297

PMCID:: PMC7897520

Abstract Article PDF–11M

Select item 78461895.

DNA ligase I variants fail in the ligation of mutagenic repair intermediates with mismatches and oxidative DNA damage

Qun Tang, Pradnya Kamble, Melike Çağlayan

Mutagenesis. 2020 Sep; 35(5): 391–404. Published online 2020 Sep 11. doi: 10.1093/mutage/geaa023

PMCID:: PMC7846189

Abstract Article PDF–3.9M

Select item 64118406.

DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase

Kate Liddiard, Brian Ruis, Yinan Kan, Kez Cleal, Kevin E Ashelford, Eric A Hendrickson, Duncan M Baird

Nucleic Acids Res. 2019 Mar 18; 47(5): 2402–2424. Published online 2018 Dec 21. doi: 10.1093/nar/gky1279

PMCID:: PMC6411840

Abstract Article PDF–2.4M

Select item 62646447.

Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies

Patrick Maffucci, Jose Chavez, Thomas J. Jurkiw, Patrick J. O’Brien, Jordan K. Abbott, Paul R. Reynolds, Austen Worth, Luigi D. Notarangelo, Kerstin Felgentreff, Patricia Cortes, Bertrand Boisson, Lin Radigan, Aurélie Cobat, Chitra Dinakar, Mohammad Ehlayel, Tawfeg Ben-Omran, Erwin W. Gelfand, Jean-Laurent Casanova, Charlotte Cunningham-Rundles

J Clin Invest. 2018 Dec 3; 128(12): 5489–5504. Published online 2018 Nov 5. doi: 10.1172/JCI99629

PMCID:: PMC6264644

Abstract Article PDF–7.1M

Select item 44950438.

Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells

Paolo Cremaschi, Matteo Oliverio, Valentina Leva, Silvia Bione, Roberta Carriero, Giulia Mazzucco, Andrea Palamidessi, Giorgio Scita, Giuseppe Biamonti, Alessandra Montecucco

PLoS One. 2015; 10(7): e0130561. Published online 2015 Jul 7. doi: 10.1371/journal.pone.0130561

PMCID:: PMC4495043

Abstract Article PDF–2.0M

Select item 38815519.

DNA ligase I, the replicative DNA ligase

Timothy R.L. Howes, Alan E. Tomkinson

Subcell Biochem. Author manuscript; available in PMC 2014 Jan 6.

Published in final edited form as: Subcell Biochem. 2012; 62: 10.1007/978-94-007-4572-8_17. doi: 10.1007/978-94-007-4572-8_17

PMCID:: PMC3881551

Abstract Article PDF–1.6M

Select item 312307310.

Kinetic Mechanism of Human DNA Ligase I Reveals Magnesium-dependent Changes in the Rate-limiting Step That Compromise Ligation Efficiency

Mark R. Taylor, John A. Conrad, Daniel Wahl, Patrick J. O'Brien

J Biol Chem. 2011 Jul 1; 286(26): 23054–23062. Published online 2011 May 10. doi: 10.1074/jbc.M111.248831

PMCID:: PMC3123073

Abstract Article PDF–2.1M

Select item 267693611.

A Case-Control Study of the Association of the Polymorphisms and Haplotypes of DNA Ligase I with Lung and Upper-Aerodigestive-Tract Cancers

Yuan-Chin Amy Lee, Hal Morgenstern, Sander Greenland, Donald P. Tashkin, Jeanette Papp, Janet Sinsheimer, Wei Cao, Mia Hashibe, Nai-Chieh Y. You, Jenny T. Mao, Wendy Cozen, Thomas M. Mack, Zuo-Feng Zhang

Int J Cancer. Author manuscript; available in PMC 2009 May 4.

Published in final edited form as: Int J Cancer. 2008 Apr 1; 122(7): 1630–1638. doi: 10.1002/ijc.23274

PMCID:: PMC2676936

Abstract Article PDF–121K

Select item 266329612.

DNA Ligase I Deficiency Leads to Replication-Dependent DNA Damage and Impacts Cell Morphology without Blocking Cell Cycle Progression

Samuela Soza, Valentina Leva, Riccardo Vago, Giovanni Ferrari, Giuliano Mazzini, Giuseppe Biamonti, Alessandra Montecucco

Mol Cell Biol. 2009 Apr; 29(8): 2032–2041. Published online 2009 Feb 17. doi: 10.1128/MCB.01730-08

PMCID:: PMC2663296

Abstract Article PDF–2.9M

Select item 39464713.

The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication.

A Montecucco, E Savini, F Weighardt, R Rossi, G Ciarrocchi, A Villa, G Biamonti

EMBO J. 1995 Nov 1; 14(21): 5379–5386. doi: 10.1002/j.1460-2075.1995.tb00222.x

PMCID:: PMC394647

Summary Page Browse PDF–2.3M

Select item 31401214.

Human DNA ligase I efficiently seals nicks in nucleosomes

David R. Chafin, Joseph M. Vitolo, Leigh A. Henricksen, Robert A. Bambara, Jeffrey J. Hayes

EMBO J. 2000 Oct 16; 19(20): 5492–5501. doi: 10.1093/emboj/19.20.5492

PMCID:: PMC314012

Abstract Article PDF–550K

Select item 5460015.

Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae.

D E Barnes, L H Johnston, K Kodama, A E Tomkinson, D D Lasko, T Lindahl

Proc Natl Acad Sci U S A. 1990 Sep; 87(17): 6679–6683. doi: 10.1073/pnas.87.17.6679

PMCID:: PMC54600

Summary Page Browse PDF–1.1M

Select item 5235216.

A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells.

J H Petrini, K G Huwiler, D T Weaver

Proc Natl Acad Sci U S A. 1991 Sep 1; 88(17): 7615–7619. doi: 10.1073/pnas.88.17.7615

PMCID:: PMC52352

Summary Page Browse PDF–1.3M

Select item 988113017.

Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity

Justin R McNally, Amanda M Ames, Suzanne J Admiraal, Patrick J O’Brien

Nucleic Acids Res. 2023 Jan 25; 51(2): 796–805. Published online 2023 Jan 10. doi: 10.1093/nar/gkac1263

PMCID:: PMC9881130

Abstract Article PDF–1.9M

Select item 834401618.

Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers

Reem Ali, Muslim Alabdullah, Mashael Algethami, Adel Alblihy, Islam Miligy, Ahmed Shoqafi, Katia A. Mesquita, Tarek Abdel-Fatah, Stephen YT Chan, Pei Wen Chiang, Nigel P Mongan, Emad A Rakha, Alan E Tomkinson, Srinivasan Madhusudan

Theranostics. 2021; 11(17): 8350–8361. Published online 2021 Jul 25. doi: 10.7150/thno.51456