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Select item 86494471.

Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma

Yishan Huo, Kainan Zhang, Songtao Han, Yangchun Feng, Yongxing Bao

J Int Med Res. 2021 Nov; 49(11): 03000605211059681. Published online 2021 Nov 24. doi: 10.1177/03000605211059681

PMCID:: PMC8649447

Abstract Article PDF–1.0M

Select item 80807222.

A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8⁺ T cells

Zijun Wang, Mou Peng

Sci Rep. 2021; 11: 9164. Published online 2021 Apr 28. doi: 10.1038/s41598-021-88676-9

PMCID:: PMC8080722

Abstract Article PDF–7.4M

Select item 54796073.

SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course

Nili Dezorella, Ben-Zion Katz, Mika Shapiro, Aaron Polliack, Chava Perry, Yair Herishanu

Haematologica. 2016 Dec; 101(12): 1553–1562. doi: 10.3324/haematol.2015.139154

PMCID:: PMC5479607

Abstract Article PDF–1.1M

Select item 42882614.

SRC Homology 2 Domain-containing Leukocyte Phosphoprotein of 76 kDa (SLP-76) N-terminal Tyrosine Residues Regulate a Dynamic Signaling Equilibrium Involving Feedback of Proximal T-cell Receptor (TCR) Signaling

Qinqin Ji, Yiyuan Ding, Arthur R. Salomon

Mol Cell Proteomics. 2015 Jan; 14(1): 30–40. Published online 2014 Oct 14. doi: 10.1074/mcp.M114.037861

PMCID:: PMC4288261

Abstract Article PDF–2.6M

Select item 38420375.

Complementary Phosphorylation Sites in the Adaptor Protein SLP-76 Promote Synergistic Activation of Natural Killer Cells

Hun Sik Kim, Eric O. Long

Sci Signal. Author manuscript; available in PMC 2013 Nov 27.

Published in final edited form as: Sci Signal. 2012 Jul 10; 5(232): 10.1126/scisignal.2002754. Published online 2012 Jul 10. doi: 10.1126/scisignal.2002754

PMCID:: PMC3842037

Abstract Article PDF–3.0M

Select item 37952526.

SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation

Hebin Liu, Youg Raj Thaker, Loren Stagg, Helga Schneider, John E. Ladbury, Christopher E. Rudd

J Biol Chem. 2013 Oct 11; 288(41): 29539–29549. Published online 2013 Aug 9. doi: 10.1074/jbc.M112.424846

PMCID:: PMC3795252

Abstract Article PDF–1.8M

Select item 34696227.

Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells

Lulu Cao, Yiyuan Ding, Norris Hung, Kebing Yu, Anna Ritz, Benjamin J. Raphael, Arthur R. Salomon

PLoS One. 2012; 7(10): e46725. Published online 2012 Oct 11. doi: 10.1371/journal.pone.0046725

PMCID:: PMC3469622

Abstract Article PDF–1.5M

Select item 21925218.

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

J Exp Med. 1996 Apr 1; 183(4): 1937–1943. doi: 10.1084/jem.183.4.1937

PMCID:: PMC2192521

Summary PDF–1.0M

Select item 62403009.

ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters

Juliana B. Lewis, Frank A. Scangarello, Joanne M. Murphy, Keith P. Eidell, Michelle O. Sodipo, Michael J. Ophir, Ryan Sargeant, Maria-Cristina Seminario, Stephen C. Bunnell

J Cell Sci. 2018 Nov 1; 131(21): jcs215517. Published online 2018 Nov 8. doi: 10.1242/jcs.215517

PMCID:: PMC6240300

Abstract Article

Select item 520102110.

Development of nanoscale structure in LAT-based signaling complexes

Valarie A. Barr, Eilon Sherman, Jason Yi, Itoro Akpan, Alexandre K. Rouquette-Jazdanian, Lawrence E. Samelson

J Cell Sci. 2016 Dec 15; 129(24): 4548–4562. doi: 10.1242/jcs.194886

PMCID:: PMC5201021

Abstract Article

Select item 390264011.

Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa (SLP-76) Is Required for Optimal CXCR4-Stimulated T Lymphocyte Firm Arrest to ICAM-1 Under Shear Flow

Dooyoung Lee, Jiyeon Kim, Rebecca G. Baker, Gary A. Koretzky, Daniel A. Hammer

Eur J Immunol. Author manuscript; available in PMC 2014 Jan 27.

Published in final edited form as: Eur J Immunol. 2012 Oct; 42(10): 2736–2743. Published online 2012 Sep 10. doi: 10.1002/eji.201142303

PMCID:: PMC3902640

Abstract Article PDF–1013K

Select item 381188712.

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

Nathan P. Coussens, Ryo Hayashi, Patrick H. Brown, Lakshmi Balagopalan, Andrea Balbo, Itoro Akpan, Jon C. D. Houtman, Valarie A. Barr, Peter Schuck, Ettore Appella, Lawrence E. Samelson

Mol Cell Biol. 2013 Nov; 33(21): 4140–4151. doi: 10.1128/MCB.00410-13

PMCID:: PMC3811887

Abstract Article PDF–2.4M

Select item 346451813.

Attenuation of T Cell Receptor Signaling by Serine Phosphorylation-mediated Lysine 30 Ubiquitination of SLP-76 Protein

Xiaohong Wang, Ju-Pi Li, Li-Li Chiu, Joung-Liang Lan, Der-Yuan Chen, Jonathan Boomer, Tse-Hua Tan

J Biol Chem. 2012 Oct 5; 287(41): 34091–34100. Published online 2012 Aug 17. doi: 10.1074/jbc.M112.371062

PMCID:: PMC3464518

Abstract Article PDF–3.7M

Select item 316096514.

Spatial Association of Signaling Proteins and F-Actin Effects on Cluster Assembly Analyzed via Photoactivation Localization Microscopy in T Cells

Chih-Jung Hsu, Tobias Baumgart

PLoS One. 2011; 6(8): e23586. Published online 2011 Aug 24. doi: 10.1371/journal.pone.0023586

PMCID:: PMC3160965

Abstract Article PDF–1.5M

Select item 221303615.

The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation

Christiane Gerke, Stanley Falkow, Yueh-hsiu Chien

J Exp Med. 2005 Feb 7; 201(3): 361–371. doi: 10.1084/jem.20041120

PMCID:: PMC2213036

Abstract Article PDF–2.5M

Select item 219328816.

Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane

Masamichi Ishiai, Mari Kurosaki, Kazunori Inabe, Andrew C. Chan, Kazuo Sugamura, Tomohiro Kurosaki

J Exp Med. 2000 Sep 18; 192(6): 847–856. doi: 10.1084/jem.192.6.847

PMCID:: PMC2193288

Abstract Article PDF–471K

Select item 219271117.

Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells

J Exp Med. 1996 Aug 1; 184(2): 457–463. doi: 10.1084/jem.184.2.457

PMCID:: PMC2192711

Summary PDF–1004K

Select item 215094018.

Expression, refolding and crystallizations of the Grb2-like (GADS) C-terminal SH3 domain complexed with a SLP-76 motif peptide

Alessandro Faravelli, Nazzareno Dimasi

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jan 1; 62(Pt 1): 52–55. Published online 2005 Dec 16. doi: 10.1107/S1744309105041023

PMCID:: PMC2150940

Abstract Article PDF–797K

Select item 187183819.

SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK

Yaron Bogin, Carmit Ainey, Dvora Beach, Deborah Yablonski

Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16): 6638–6643. Published online 2007 Apr 9. doi: 10.1073/pnas.0609771104

PMCID:: PMC1871838

Abstract Article PDF–737K

Select item 159284920.

CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76

Namir J. Hassan, Stephen J. Simmonds, Nicholas G. Clarkson, Sarah Hanrahan, Michael J. Puklavec, Martine Bomb, A. Neil Barclay, Marion H. Brown

Mol Cell Biol. 2006 Sep; 26(17): 6727–6738. doi: 10.1128/MCB.00688-06

Correction in:: Mol Cell Biol. 2009 Jun; 29(12): 3452.

Correction in:: Mol Cell Biol. 2019 Apr 1; 39(7): e00054-19.

PMCID:: PMC1592849

Abstract Article PDF–548K

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PMC Links for Gene (Select 3937) (87)
PMC
Poecilopsetta beanii recombination activating protein 1 (RAG1) gene, partial cds
Poecilopsetta beanii recombination activating protein 1 (RAG1) gene, partial cds
gi|529274467|gb|KF312001.1|

Nucleotide
Samariscus latus recombination activating protein 1 (RAG1) gene, partial cds
Samariscus latus recombination activating protein 1 (RAG1) gene, partial cds
gi|529274473|gb|KF312004.1|

Nucleotide
Arnoglossus laterna recombination activating protein 1 (RAG1) gene, partial cds
Arnoglossus laterna recombination activating protein 1 (RAG1) gene, partial cds
gi|529274439|gb|KF311987.1|

Nucleotide
lymphocyte cytosolic protein 2 isoform X1 [Homo sapiens]
lymphocyte cytosolic protein 2 isoform X1 [Homo sapiens]
gi|2462602481|ref|XP_054208550.1|

Protein

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