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Select item 86000291.

KCND2 variants associated with global developmental delay differentially impair Kv4.2 channel gating

Yongqiang Zhang, Georgios Tachtsidis, Claudia Schob, Mahmoud Koko, Ulrike B S Hedrich, Holger Lerche, Johannes R Lemke, Arie van Haeringen, Claudia Ruivenkamp, Trine Prescott, Kristian Tveten, Thorsten Gerstner, Brianna Pruniski, Stephanie DiTroia, Grace E VanNoy, Heidi L Rehm, Heather McLaughlin, Hanno J Bolz, Ulrich Zechner, Emily Bryant, Tiffani McDonough, Stefan Kindler, Robert Bähring

Hum Mol Genet. 2021 Dec 1; 30(23): 2300–2314. Published online 2021 Jul 10. doi: 10.1093/hmg/ddab192

PMCID:: PMC8600029

Abstract Article PDF–1.4M

Select item 85662402.

Structural basis of gating modulation of Kv4 channel complexes

Yoshiaki Kise, Go Kasuya, Hiroyuki H. Okamoto, Daichi Yamanouchi, Kan Kobayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Koichi Nakajo, Osamu Nureki

Nature. 2021; 599(7883): 158–164. Published online 2021 Sep 22. doi: 10.1038/s41586-021-03935-z

PMCID:: PMC8566240

Abstract Article PDF–38M

Select item 58994403.

Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening

Meng-chin A. Lin, Stephen C. Cannon, Diane M. Papazian

Proc Natl Acad Sci U S A. 2018 Apr 10; 115(15): E3559–E3568. Published online 2018 Mar 26. doi: 10.1073/pnas.1717082115

PMCID:: PMC5899440

Abstract Article PDF–1.3M

Select item 48058694.

Intra- and Intersubunit Dynamic Binding in Kv4.2 Channel Closed-State Inactivation

Jessica Wollberg, Robert Bähring

Biophys J. 2016 Jan 5; 110(1): 157–175. Published online 2016 Jan 5. doi: 10.1016/j.bpj.2015.10.046

PMCID:: PMC4805869

Abstract Article PDF–3.5M

Select item 40493065.

Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation

Hane Lee, Meng-chin A. Lin, Harley I. Kornblum, Diane M. Papazian, Stanley F. Nelson

Hum Mol Genet. 2014 Jul 1; 23(13): 3481–3489. Published online 2014 Feb 5. doi: 10.1093/hmg/ddu056

PMCID:: PMC4049306

Abstract Article PDF–443K

Select item 26382016.

Dynamic Coupling of Voltage Sensor and Gate Involved in Closed-State Inactivation of Kv4.2 Channels

Jan Barghaan, Robert Bähring

J Gen Physiol. 2009 Feb; 133(2): 205–224. doi: 10.1085/jgp.200810073

PMCID:: PMC2638201

Abstract Article PDF–3.9M

Select item 22126967.

Role of N-Terminal Domain and Accessory Subunits in Controlling Deactivation-Inactivation Coupling of Kv4.2 Channels

Jan Barghaan, Magdalini Tozakidou, Heimo Ehmke, Robert Bähring

Biophys J. 2008 Feb 15; 94(4): 1276–1294. Published online 2007 Nov 2. doi: 10.1529/biophysj.107.111344

PMCID:: PMC2212696

Abstract Article PDF–1.7M

Select item 57920068.

Somatodendritic surface expression of epitope-tagged and KChIP binding-deficient Kv4.2 channels in hippocampal neurons

Helena Prechtel, Sven Hartmann, Daniel Minge, Robert Bähring

PLoS One. 2018; 13(1): e0191911. Published online 2018 Jan 31. doi: 10.1371/journal.pone.0191911

PMCID:: PMC5792006

Abstract Article PDF–15M

Select item 45662449.

Kv4.2 and Accessory Dipeptidyl Peptidase-like Protein 10 (DPP10) Subunit Preferentially Form a 4:2 (Kv4.2:DPP10) Channel Complex

Masahiro Kitazawa, Yoshihiro Kubo, Koichi Nakajo

J Biol Chem. 2015 Sep 11; 290(37): 22724–22733. Published online 2015 Jul 24. doi: 10.1074/jbc.M115.646794

PMCID:: PMC4566244

Abstract Article PDF–2.0M

Select item 449261410.

Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the I_to Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction

Shan-Feng Ma, Yan Luo, Ying-Jiong Ding, Ying Chen, Shi-Xin Pu, Hang-Jing Wu, Zhong-Feng Wang, Bei-Bei Tao, Wen-Wei Wang, Yi-Chun Zhu

Antioxid Redox Signal. 2015 Jul 10; 23(2): 129–147. doi: 10.1089/ars.2014.6094

PMCID:: PMC4492614

Abstract Article PDF–1.7M

Select item 396817611.

S-Glutathionylation of an Auxiliary Subunit Confers Redox Sensitivity to Kv4 Channel Inactivation

Henry H. Jerng, Paul J. Pfaffinger

PLoS One. 2014; 9(3): e93315. Published online 2014 Mar 27. doi: 10.1371/journal.pone.0093315

PMCID:: PMC3968176

Abstract Article PDF–1.6M

Select item 356372212.

Encephalitis and antibodies to DPPX, a subunit of Kv4.2 potassium channels

Anna Boronat, Jeffrey M. Gelfand, Nuria Gresa-Arribas, Hyo-Young Jeong, Michael Walsh, Kirk Roberts, Eugenia Martinez-Hernandez, Myrna R. Rosenfeld, Rita Balice-Gordon, Francesc Graus, Bernardo Rudy, Josep Dalmau

Ann Neurol. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Ann Neurol. 2013 Jan; 73(1): 120–128. Published online 2012 Dec 7. doi: 10.1002/ana.23756

PMCID:: PMC3563722

Abstract Article PDF–1.8M

Select item 326161813.

Mutant LGI1 Inhibits Seizure-Induced Trafficking of Kv4.2 Potassium Channels

Stephen E.P. Smith, Lin Xu, Michael R. Kasten, Matthew P. Anderson

J Neurochem. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: J Neurochem. 2012 Feb; 120(4): 611–621. doi: 10.1111/j.1471-4159.2011.07605.x

PMCID:: PMC3261618

Abstract Article PDF–1.1M

Select item 217125214.

Traffic of Kv4 K⁺ channels mediated by KChIP1 is via a novel post-ER vesicular pathway

Burcu Hasdemir, Daniel J. Fitzgerald, Ian A. Prior, Alexei V. Tepikin, Robert D. Burgoyne

J Cell Biol. 2005 Nov 7; 171(3): 459–469. doi: 10.1083/jcb.200506005

PMCID:: PMC2171252

Abstract Article PDF–2.8M

Select item 744350515.

Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3

Carolin Seifert, Stephan Storch, Robert Bähring

J Biol Chem. 2020 Aug 21; 295(34): 12099–12110. Published online 2020 Jul 7. doi: 10.1074/jbc.RA120.013828

PMCID:: PMC7443505

Abstract Article PDF–1.4M

Select item 677304716.

Localization and Enhanced Current Density of the Kv4.2 Potassium Channel by Interaction with the Actin-Binding Protein Filamin

Kevin Petrecca, David M. Miller, Alvin Shrier

J Neurosci. 2000 Dec 1; 20(23): 8736–8744. doi: 10.1523/JNEUROSCI.20-23-08736.2000

PMCID:: PMC6773047

Abstract Article PDF–675K

Select item 392327617.

Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study

Anne L.S. Chang, Gil Atzmon, Aviv Bergman, Samantha Brugmann, Scott X Atwood, Howard Y Chang, Nir Barzilai

J Invest Dermatol. 2014 Mar; 134(3): 651–657. Prepublished online 2013 Sep 13. Published online 2013 Oct 17. doi: 10.1038/jid.2013.381

PMCID:: PMC3923276

Abstract Article PDF–2.3M

Select item 373727018.

Functional Stoichiometry Underlying KChIP Regulation of Kv4.2 Functional Expression

Kumud Kunjilwar, Yan Qian, Paul J. Pfaffinger

J Neurochem. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: J Neurochem. 2013 Aug; 126(4): 462–472. Published online 2013 Jun 10. doi: 10.1111/jnc.12309

PMCID:: PMC3737270

Abstract Article PDF–2.0M

Select item 239746919.

I_SA Channel Complexes Include Four Subunits Each of DPP6 and Kv4.2

Heun Soh, Steve A. N. Goldstein

J Biol Chem. 2008 May 30; 283(22): 15072–15077. doi: 10.1074/jbc.M706964200

PMCID:: PMC2397469

Abstract Article PDF–254K

Select item 6013520.

A role for frequenin, a Ca²⁺-binding protein, as a regulator of Kv4 K⁺-currents

Tomoe Y. Nakamura, David J. Pountney, Ander Ozaita, Sumon Nandi, Stefanie Ueda, Bernardo Rudy, William A. Coetzee

Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22): 12808–12813. Published online 2001 Oct 16. doi: 10.1073/pnas.221168498

PMCID:: PMC60135

Abstract Article PDF–327K

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PMC Links for Gene (Select 3751) (40)
PMC
nl81a02.s1 NCI_CGAP_Br2 Homo sapiens cDNA clone IMAGE:1057034 3', mRNA sequence
nl81a02.s1 NCI_CGAP_Br2 Homo sapiens cDNA clone IMAGE:1057034 3', mRNA sequence
gi|2327801|gnl|dbEST|1207705|gb|AA5 .1|

Nucleotide
PREDICTED: Homo sapiens sorting nexin 22 (SNX22), transcript variant X2, mRNA
PREDICTED: Homo sapiens sorting nexin 22 (SNX22), transcript variant X2, mRNA
gi|2462545962|ref|XM_054378845.1|

Nucleotide
Mus musculus endosome-lysosome associated apoptosis and autophagy regulator 1 (E...
Mus musculus endosome-lysosome associated apoptosis and autophagy regulator 1 (Elapor1), transcript variant 1, mRNA
gi|1081677669|ref|NM_001346518.1|

Nucleotide
PREDICTED: Mus musculus endosome-lysosome associated apoptosis and autophagy reg...
PREDICTED: Mus musculus endosome-lysosome associated apoptosis and autophagy regulator 1 (Elapor1), transcript variant X4, mRNA
gi|1907150398|ref|XM_030252595.2|

Nucleotide

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