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Select item 110067541.

Omenn Syndrome in Two Infants with Different Hypomorphic Variants in Janus Kinase 3

Christo Tsilifis, Jarmila Stremenova Spegarova, Ross Good, Helen Griffin, Karin R. Engelhardt, Sophie Graham, Stephen Hughes, Peter D. Arkwright, Sophie Hambleton, Andrew R. Gennery

J Clin Immunol. 2024; 44(4): 98. Published online 2024 Apr 10. doi: 10.1007/s10875-024-01699-5

PMCID:: PMC11006754

Abstract Article PDF–1.1M

Select item 109324052.

Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency

Clifford Liongue, Tarindhi Ratnayake, Faiza Basheer, Alister C. Ward

Int J Mol Sci. 2024 Mar; 25(5): 2977. Published online 2024 Mar 4. doi: 10.3390/ijms25052977

PMCID:: PMC10932405

Abstract Article PDF–1.2M

Select item 107814893.

Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement

Yingjing Zhao, Yuxue Mu, Yujia Zou, Zhijian He, Tianxing Lu, Xinhui Wang, Weihang Li, Bo Gao

Aging (Albany NY) 2023 Dec 31; 15(24): 14764–14790. Published online 2023 Dec 12. doi: 10.18632/aging.205289

PMCID:: PMC10781489

Abstract Article PDF–3.3M

Select item 94819624.

Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma

Qian Long, Chunyu Huang, Jinsheng Huang, Qi Meng, Yanjun Cheng, Yilin Li, Liru He, Miao Chen, Changlin Zhang, Xiaonan Wang, Wancui Zhu, Jin Peng, Dingbo Shi, Fufu Zheng, Pei Dong, Wuguo Deng

J Adv Res. 2022 Sep; 40: 153–166. Published online 2021 Dec 4. doi: 10.1016/j.jare.2021.11.016

PMCID:: PMC9481962

Abstract Article PDF–6.4M

Select item 91776795.

JAK3 Mutations and Mitochondrial Apoptosis Resistance in T-Cell Acute Lymphoblastic Leukemia

Kimberly Bodaar, Natsuko Yamagata, Anais Barthe, Jack Landrigan, Triona Ni Chonghaile, Melissa Burns, Kristen E. Stevenson, Meenakshi Devidas, Mignon L. Loh, Stephen P. Hunger, Brent Wood, Lewis B. Silverman, David T. Teachey, Jules P. Meijerink, Anthony Letai, Alejandro Gutierrez

Leukemia. Author manuscript; available in PMC 2022 Oct 11.

Published in final edited form as: Leukemia. 2022 Jun; 36(6): 1499–1507. Published online 2022 Apr 11. doi: 10.1038/s41375-022-01558-5

PMCID:: PMC9177679

Abstract Article PDF–1.4M

Select item 78748396.

Whole‐exome sequencing of T^‐B⁺ severe combined immunodeficiency in Egyptian infants, JAK3 predominance and novel variants

R. El Hawary, S. Meshaal, A.A. Mauracher, L. Opitz, D. Abd Elaziz, S. Lotfy, A. Eldash, J. Boutros, N. Galal, J. Pachlopnik Schmid, A. Elmarsafy

Clin Exp Immunol. 2021 Mar; 203(3): 448–457. Published online 2020 Nov 2. doi: 10.1111/cei.13536

PMCID:: PMC7874839

Abstract Article PDF–374K

Select item 77198087.

RNA Sequencing Keloid Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and JAK3-Skewing

Jianni Wu, Ester Del Duca, Michael Espino, Alyssa Gontzes, Inna Cueto, Ning Zhang, Yeriel D. Estrada, Ana B. Pavel, James G. Krueger, Emma Guttman-Yassky

Front Immunol. 2020; 11: 597741. Published online 2020 Nov 23. doi: 10.3389/fimmu.2020.597741

PMCID:: PMC7719808

Abstract Article PDF–6.8M

Select item 73431608.

Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene

Lorenza Mittempergher, Anna M. Piskorz, Astrid J. Bosma, Magali Michaut, G. Bea A. Wisman, Roelof J. C. Kluin, Marja Nieuwland, Wim Brugman, Kevin J. W. van der Ven, Francesco Marass, James Morris, Nitzan Rosenfeld, Mercedes Jimenez-Linan, Steven de Jong, Ate G. J. van der Zee, James D. Brenton, René Bernards

PLoS One. 2020; 15(7): e0235766. Published online 2020 Jul 8. doi: 10.1371/journal.pone.0235766

PMCID:: PMC7343160

Abstract Article PDF–2.1M

Select item 70159099.

A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis

Weili Miao, Lin Li, Xiaochuan Liu, Tianyu F. Qi, Lei Guo, Ming Huang, Yinsheng Wang

Sci Rep. 2020; 10: 2485. Published online 2020 Feb 12. doi: 10.1038/s41598-020-59572-5

PMCID:: PMC7015909

Abstract Article PDF–2.1M

Select item 680003710.

JAK3 variant, immune signatures, DNA methylation, and social determinants linked to survival racial disparities in head and neck cancer patients

Rafael Guerrero-Preston, Fahcina Lawson, Sebastian Rodriguez-Torres, Maartje G. Noordhuis, Francesca Pirini, Laura Manuel, Blanca Valle, Tal Hadar, Bianca Rivera, Oluwasina Folawiyo, Adriana Baez Bermejo, Luigi Marchionni, Wayne Koch, William H. Westra, Young Kim, James Eshleman, David Sidransky

Cancer Prev Res (Phila) Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: Cancer Prev Res (Phila). 2019 Apr; 12(4): 255–270. Published online 2019 Feb 18. doi: 10.1158/1940-6207.CAPR-17-0356

Correction in:: Cancer Prev Res (Phila). 2019 Jul; 12(7): 491–492.

PMCID:: PMC6800037

Abstract Article PDF–982K

Select item 675362011.

Recurrent somatic JAK3 mutations in NK-cell enteropathy

Wenbin Xiao, Gaurav K. Gupta, Jinjuan Yao, Yoon J. Jang, Liqiang Xi, Jeeyeon Baik, Allison Sigler, Anita Kumar, Alison J. Moskowitz, Maria E. Arcila, Mark Raffeld, Stefania Pittaluga, Ahmet Dogan, Elaine S. Jaffe

Blood. 2019 Sep 19; 134(12): 986–991. Prepublished online 2019 Aug 5. doi: 10.1182/blood.2019001443

PMCID:: PMC6753620

Article

Select item 616070012.

JAK3 mutations in Italian patients affected by SCID: New molecular aspects of a long‐known gene

Gigliola Di Matteo, Maria Chiriaco, Alessia Scarselli, Cristina Cifaldi, Susanna Livadiotti, Silvia Di Cesare, Valentina Ferradini, Alessandro Aiuti, Paolo Rossi, Andrea Finocchi, Caterina Cancrini

Mol Genet Genomic Med. 2018 Sep; 6(5): 713–721. Published online 2018 Jul 21. doi: 10.1002/mgg3.391

PMCID:: PMC6160700

Abstract Article PDF–1.4M

Select item 614124213.

Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment

Federica Cattaneo, Mike Recher, Stefania Masneri, Sachin N. Baxi, Claudia Fiorini, Francesca Antonelli, Christian A. Wysocki, Jose G. Calderon, Hermann Eibel, Angela R. Smith, Francisco A. Bonilla, Erdyni Tsitsikov, Silvia Giliani, Luigi D. Notarangelo, Sung-Yun Pai

J Allergy Clin Immunol. Author manuscript; available in PMC 2018 Sep 17.

Published in final edited form as: J Allergy Clin Immunol. 2013 Apr; 131(4): 1136–1145. Published online 2013 Feb 4. doi: 10.1016/j.jaci.2012.12.667

PMCID:: PMC6141242

Abstract Article PDF–1.4M

Select item 579668314.

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

Sandrine Degryse, Simon Bornschein, Charles E. de Bock, Emilie Leroy, Marlies Vanden Bempt, Sofie Demeyer, Kris Jacobs, Ellen Geerdens, Olga Gielen, Jean Soulier, Christine J. Harrison, Stefan N. Constantinescu, Jan Cools

Blood. 2018 Jan 25; 131(4): 421–425. Prepublished online 2017 Nov 29. doi: 10.1182/blood-2017-07-797597

PMCID:: PMC5796683

Abstract Article

Select item 435987415.

Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Mercedes García-Bermúdez, Raquel López-Mejías, Fernanda Genre, Santos Castañeda, Alfonso Corrales, Javier Llorca, Carlos González-Juanatey, Begoña Ubilla, José A. Miranda-Filloy, Trinitario Pina, Carmen Gómez-Vaquero, Luis Rodríguez-Rodríguez, Benjamín Fernández-Gutiérrez, Alejandro Balsa, Dora Pascual-Salcedo, Francisco J. López-Longo, Patricia Carreira, Ricardo Blanco, Javier Martín, Miguel A. González-Gay

Biomed Res Int. 2015; 2015: 318364. Published online 2015 Mar 1. doi: 10.1155/2015/318364

PMCID:: PMC4359874

Abstract Article PDF–536K

Select item 433520016.

Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol

Eric R. Goedken, Maria A. Argiriadi, David L. Banach, Bryan A. Fiamengo, Sage E. Foley, Kristine E. Frank, Jonathan S. George, Christopher M. Harris, Adrian D. Hobson, David C. Ihle, Douglas Marcotte, Philip J. Merta, Mark E. Michalak, Sara E. Murdock, Medha J. Tomlinson, Jeffrey W. Voss

J Biol Chem. 2015 Feb 20; 290(8): 4573–4589. Published online 2014 Dec 31. doi: 10.1074/jbc.M114.595181