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Select item 109951491.

Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells

Syed S. Islam, Falah H. Al-Mohanna, Iman M. Yousef, Ismail A. Al-Badawi, Abdelilah Aboussekhra

Cell Death Dis. 2024 Apr; 15(4): 247. Published online 2024 Apr 4. doi: 10.1038/s41419-024-06512-0

PMCID:: PMC10995149

Article PDF–6.1M

Select item 74154282.

Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling

Yen-Ta Chen, Chi-Ruei Huang, Chia-Lo Chang, John Y. Chiang, Chi-Wen Luo, Hong-Hwa Chen, Hon-Kan Yip

Int J Biol Sci. 2020; 16(14): 2648–2662. Published online 2020 Jul 23. doi: 10.7150/ijbs.48358

PMCID:: PMC7415428

Article PDF–4.9M

Select item 71337353.

Overexpression of JAG2 is related to poor outcomes in oral squamous cell carcinoma

Kiichi Hatano, Chiemi Saigo, Yusuke Kito, Toshiyuki Shibata, Tamotsu Takeuchi

Clin Exp Dent Res. 2020 Apr; 6(2): 174–180. Published online 2019 Dec 5. doi: 10.1002/cre2.267

PMCID:: PMC7133735

Article PDF–1.1M

Select item 45859334.

Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells

Zhu Xishan, Zhang Bin, Zhao Haiyue, Dou Xiaowei, Bai Jingwen, Zhang Guojun

Sci Rep. 2015; 5: 14284. Published online 2015 Sep 28. doi: 10.1038/srep14284

PMCID:: PMC4585933

Article PDF–1.3M

Select item 40651825.

Notch signaling genes: Myogenic DNA hypomethylation and 5-hydroxymethylcytosine

Jolyon Terragni, Guoqiang Zhang, Zhiyi Sun, Sriharsa Pradhan, Lingyun Song, Gregory E Crawford, Michelle Lacey, Melanie Ehrlich

Epigenetics. 2014 Jun 1; 9(6): 842–850. Published online 2014 Mar 26. doi: 10.4161/epi.28597

PMCID:: PMC4065182

Article PDF–3.1M

Select item 39446446.

Activation of the NOTCH pathway in Head and Neck Cancer

Wenyue Sun, Daria A. Gaykalova, Michael F. Ochs, Elizabeth Mambo, Demetri Arnaoutakis, Yan Liu, Myriam Loyo, Nishant Agrawal, Jason Howard, Ryan Li, Sun Ahn, Elana Fertig, David Sidransky, Jeffery Houghton, Kalyan Buddavarapu, Tiffany Sanford, Ashish Choudhary, Will Darden, Alex Adai, Gary Latham, Justin Bishop, Rajni Sharma, William H. Westra, Patrick Hennessey, Christine H. Chung, Joseph A. Califano

Cancer Res. Author manuscript; available in PMC 2015 Feb 15.

Published in final edited form as: Cancer Res. 2014 Feb 15; 74(4): 1091–1104. Published online 2013 Dec 18. doi: 10.1158/0008-5472.CAN-13-1259

PMCID:: PMC3944644

Article PDF–1.5M

Select item 38168127.

High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder

Wei Li, Min Liu, Yuan Feng, Yan-Fei Huang, Yun-Fei Xu, Jian-Ping Che, Guang-Chun Wang, Jun-Hua Zheng

Int J Clin Exp Pathol. 2013; 6(11): 2430–2440. Published online 2013 Oct 15.

PMCID:: PMC3816812

Article PDF–1.4M

Select item 34377608.

TNFα and Endothelial Cells Modulate Notch Signaling in the Bone Marrow Microenvironment during Inflammation

Luis Fernandez, Sonia Rodriguez, Hui Huang, Angelo Chora, Christin Mumaw, Eugenia Cruz, Karen Pollok, Filipa Cristina, Joanne E. Price, Michael J. Ferkowicz, David T. Scadden, Matthias Clauss, Angelo A. Cardoso, Nadia Carlesso

Exp Hematol. Author manuscript; available in PMC 2012 Sep 10.

Published in final edited form as: Exp Hematol. 2008 May; 36(5): 545–558. doi: 10.1016/j.exphem.2007.12.012

PMCID:: PMC3437760

Article PDF–3.6M

Select item 31458249.

Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

Fei Xing, Hiroshi Okuda, Misako Watabe, Aya Kobayashi, Sudha K. Pai, Wen Liu, Puspa R. Pandey, Koji Fukuda, Shigeru Hirota, Tamotsu Sugai, Go Wakabayshi, Keisuke Koeda, Masahiro Kashiwaba, Kazuyuki Suzuki, Toshimi Chiba, Masaki Endo, Yin-Yuan Mo, Kounosuke Watabe

Oncogene. Author manuscript; available in PMC 2012 Mar 29.

Published in final edited form as: Oncogene. 2011 Sep 29; 30(39): 4075–4086. Published online 2011 Apr 18. doi: 10.1038/onc.2011.122

PMCID:: PMC3145824

Article PDF–2.5M

Select item 1089361710.

miR-541 is associated with the prognosis of liver cirrhosis and directly targets JAG2 to inhibit the activation of hepatic stellate cells

Jin-Pei Liu, Shao-Hua Song, Pei-Mei Shi, Xiao-Yu Qin, Bai-Nan Zheng, Shu-Qing Liu, Chen-Hong Ding, Xin Zhang, Wei-Fen Xie, Yi-Hai Shi, Wen-Ping Xu

BMC Gastroenterol. 2024; 24: 84. Published online 2024 Feb 23. doi: 10.1186/s12876-024-03174-2

PMCID:: PMC10893617

Article PDF–3.3M

Select item 441361211.

A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma

Fengfei Wang, Marc Remke, Kruttika Bhat, Eric T. Wong, Shuang Zhou, Vijay Ramaswamy, Adrian Dubuc, Ekokobe Fonkem, Saeed Salem, Hongbing Zhang, Tze-chen Hsieh, Stephen T. O'Rourke, Lizi Wu, David W. Li, Cynthia Hawkins, Isaac S. Kohane, Joseph M. Wu, Min Wu, Michael D. Taylor, Erxi Wu

Oncotarget. 2015 Feb; 6(5): 2709–2724. Published online 2014 Dec 17. doi: 10.18632/oncotarget.2779

PMCID:: PMC4413612

Article PDF–4.0M

Select item 402363012.

NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma

Giulio Fiaschetti, Christina Schroeder, Deborah Castelletti, Alexandre Arcaro, Frank Westermann, Martin Baumgartner, Tarek Shalaby, Michael A Grotzer

Acta Neuropathol Commun. 2014; 2: 39. Published online 2014 Apr 7. doi: 10.1186/2051-5960-2-39

PMCID:: PMC4023630

Article PDF–2.0M

Select item 284050013.

Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model

Jason T. Yustein, Yen-Chun Liu, Ping Gao, Chunfa Jie, Anne Le, Milena Vuica-Ross, Wee Joo Chng, Charles G. Eberhart, P. Leif Bergsagel, Chi V. Dang

Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8): 3534–3539. Published online 2010 Feb 2. doi: 10.1073/pnas.0901230107

PMCID:: PMC2840500

Article PDF–727K

Select item 160243114.

Skeletrophin, a Novel Ubiquitin Ligase to the Intracellular Region of Jagged-2, Is Aberrantly Expressed in Multiple Myeloma

Tamotsu Takeuchi, Yoshihiro Adachi, Yuji Ohtsuki

Am J Pathol. 2005 Jun; 166(6): 1817–1826. doi: 10.1016/S0002-9440(10)62491-1

PMCID:: PMC1602431

Article PDF–1.3M

Select item 820616015.

A form of muscular dystrophy associated with pathogenic variants in JAG2

Sandra Coppens, Alison M. Barnard, Sanna Puusepp, Sander Pajusalu, Katrin Õunap, Dorianmarie Vargas-Franco, Christine C. Bruels, Sandra Donkervoort, Lynn Pais, Katherine R. Chao, Julia K. Goodrich, Eleina M. England, Ben Weisburd, Vijay S. Ganesh, Sanna Gudmundsson, Anne O’Donnell-Luria, Mait Nigul, Pilvi Ilves, Payam Mohassel, Teepu Siddique, Margherita Milone, Stefan Nicolau, Reza Maroofian, Henry Houlden, Michael G. Hanna, Ros Quinlivan, Mehran Beiraghi Toosi, Ehsan Ghayoor Karimiani, Sabine Costagliola, Nicolas Deconinck, Hazim Kadhim, Erica Macke, Brendan C. Lanpher, Eric W. Klee, Anna Łusakowska, Anna Kostera-Pruszczyk, Andreas Hahn, Bertold Schrank, Ichizo Nishino, Masashi Ogasawara, Rasha El Sherif, Tanya Stojkovic, Isabelle Nelson, Gisèle Bonne, Enzo Cohen, Anne Boland-Augé, Jean-François Deleuze, Yao Meng, Ana Töpf, Catheline Vilain, Christina A. Pacak, Marie L. Rivera-Zengotita, Carsten G. Bönnemann, Volker Straub, Penny A. Handford, Isabelle Draper, Glenn A. Walter, Peter B. Kang

Am J Hum Genet. 2021 May 6; 108(5): 840–856. Published online 2021 Apr 15. doi: 10.1016/j.ajhg.2021.03.020

Correction in:: Am J Hum Genet. 2021 Jun 3; 108(6): 1164.

PMCID:: PMC8206160

Article PDF–2.8M

Select item 553876516.

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

Richard J Suckling, Boguslawa Korona, Pat Whiteman, Chandramouli Chillakuri, Laurie Holt, Penny A Handford, Susan M Lea

EMBO J. 2017 Aug 1; 36(15): 2204–2215. Published online 2017 Jun 1. doi: 10.15252/embj.201796632

PMCID:: PMC5538765

Article PDF–1.7M

Select item 367375117.

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

Inge Van de Walle, Greet De Smet, Martina Gärtner, Magda De Smedt, Els Waegemans, Bart Vandekerckhove, Georges Leclercq, Jean Plum, Jon C. Aster, Irwin D. Bernstein, Cynthia J. Guidos, Bruno Kyewski, Tom Taghon

Blood. 2011 Apr 28; 117(17): 4449–4459. Prepublished online 2011 Mar 3. doi: 10.1182/blood-2010-06-290049

PMCID:: PMC3673751

Article

Select item 23245518.

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.

B Luo, J C Aster, R P Hasserjian, F Kuo, J Sklar

Mol Cell Biol. 1997 Oct; 17(10): 6057–6067. doi: 10.1128/mcb.17.10.6057

PMCID:: PMC232455

Summary PDF–2.1M

Select item 427938119.

Notch signaling drives multiple myeloma induced osteoclastogenesis

Michela Colombo, Katja Thümmler, Leonardo Mirandola, Silvia Garavelli, Katia Todoerti, Luana Apicella, Elisa Lazzari, Marialuigia Lancellotti, Natalia Platonova, Moeed Akbar, Maurizio Chiriva-Internati, Richard Soutar, Antonino Neri, Carl S. Goodyear, Raffaella Chiaramonte

Oncotarget. 2014 Nov; 5(21): 10393–10406. Published online 2014 Jun 9. doi: 10.18632/oncotarget.2084

PMCID:: PMC4279381

Article PDF–7.3M

Select item 411027520.

β-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) Regulates Notch Signaling by Controlling the Cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) Proteins

Wanxia He, Jinxuan Hu, Yuxing Xia, Riqiang Yan

J Biol Chem. 2014 Jul 25; 289(30): 20630–20637. Published online 2014 Jun 6. doi: 10.1074/jbc.M114.579862

PMCID:: PMC4110275

Article PDF–1.8M

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