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Items: 1 to 20 of 59

1.
Erratum: Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner
E Theusch, K Kim, K Stevens, J D Smith, Y-DI Chen, J I Rotter, D A Nickerson, M W Medina
Pharmacogenomics J. 2016; 16(3): 301. Published online 2016 May 20. doi: 10.1038/tpj.2016.30
Corrects:
Pharmacogenomics J. 2017 Jun; 17(3): 222–229.
PMCID:
PMC7608431
CorrectionPDF–89K
2.
Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China
Jing Tao, Mayila Abudoukelimu, Xin Shen, Jun Liu, Feng-xia Wang, Jie Yuan, Pei-Pei Gu, Wei Zhu, Xiao-tian Zhang, Zhao Wang, Yi-tong Ma, Guo-qing Li
Biosci Rep. 2019 Dec 20; 39(12): BSR20190498. Published online 2019 Nov 28. doi: 10.1042/BSR20190498
PMCID:
PMC6893165
AbstractArticlePDF–447K
3.
Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner
E Theusch, K Kim, K Stevens, J D Smith, Y -D I Chen, J I Rotter, D A Nickerson, M W Medina
Pharmacogenomics J. 2017 Jun; 17(3): 222–229. Published online 2016 Mar 1. doi: 10.1038/tpj.2016.12
Correction in:
Pharmacogenomics J. 2016; 16(3): 301.
PMCID:
PMC5008997
AbstractArticlePDF–366K
4.
INSIG1 influences obesity-related hypertriglyceridemia in humans
E. M. Smith, Y. Zhang, T. M Baye, S. Gawrieh, R. Cole, J. Blangero, M. A. Carless, J. E. Curran, T. D. Dyer, L. J. Abraham, E. K. Moses, A. H. Kissebah, L. J. Martin, M. Olivier
J Lipid Res. 2010 Apr; 51(4): 701–708. doi: 10.1194/jlr.M001404
PMCID:
PMC2838707
AbstractArticlePDF–915K
5.
Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles
Christopher M. Adams, Joseph L. Goldstein, Michael S. Brown
Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19): 10647–10652. Published online 2003 Sep 8. doi: 10.1073/pnas.1534833100
PMCID:
PMC196858
AbstractArticlePDF–629K
6.
The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP
Bethany A. Janowski
Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20): 12675–12680. Published online 2002 Sep 19. doi: 10.1073/pnas.202471599
PMCID:
PMC130519
AbstractArticlePDF–349K
7.
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression
Vian Azzu, Michele Vacca, Ioannis Kamzolas, Zoe Hall, Jack Leslie, Stefania Carobbio, Samuel Virtue, Susan E. Davies, Agnes Lukasik, Martin Dale, Mohammad Bohlooly-Y, Animesh Acharjee, Daniel Lindén, Guillaume Bidault, Evangelia Petsalaki, Julian L. Griffin, Fiona Oakley, Michael E.D. Allison, Antonio Vidal-Puig
Mol Metab. 2021 Jun; 48: 101210. Published online 2021 Mar 17. doi: 10.1016/j.molmet.2021.101210
PMCID:
PMC8094910
AbstractArticlePDF–3.1M
8.
Genome-wide CRISPR analysis identifies substrate-specific conjugation modules in ER-associated degradation
Dara E. Leto, David W. Morgens, Lichao Zhang, Christopher P. Walczak, Joshua E. Elias, Michael C. Bassik, Ron R. Kopito
Mol Cell. Author manuscript; available in PMC 2020 Jan 17.
Published in final edited form as: Mol Cell. 2019 Jan 17; 73(2): 377–389.e11. Published online 2018 Dec 20. doi: 10.1016/j.molcel.2018.11.015
PMCID:
PMC6338494
AbstractArticlePDF–1.9M
9.
Precursor microRNA-122 inhibits synthesis of Insig1 isoform mRNA by modulating polyadenylation site usage
Kara L. Norman, Tzu-Chun Chen, Gusti Zeiner, Peter Sarnow
RNA. 2017 Dec; 23(12): 1886–1893. doi: 10.1261/rna.063099.117
PMCID:
PMC5689008
AbstractArticlePDF–1.6M
10.
Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi
Yinxin Zhang, Massoud Motamed, Joachim Seemann, Michael S. Brown, Joseph L. Goldstein
J Biol Chem. 2013 May 17; 288(20): 14059–14067. Published online 2013 Apr 5. doi: 10.1074/jbc.M113.469528
PMCID:
PMC3656263
AbstractArticlePDF–2.0M
11.
Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells
Peter C. W. Lee, Russell A. DeBose-Boyd
J Lipid Res. 2010 Jan; 51(1): 192–201. doi: 10.1194/jlr.M900336-JLR200
PMCID:
PMC2789779
AbstractArticlePDF–1.3M
12.
Insig-mediated, Sterol-accelerated Degradation of the Membrane Domain of Hamster 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase in Insect Cells
Andrew D. Nguyen, Soo Hee Lee, Russell A. DeBose-Boyd
J Biol Chem. 2009 Sep 25; 284(39): 26778–26788. Published online 2009 Jul 28. doi: 10.1074/jbc.M109.032342
PMCID:
PMC2785366
AbstractArticlePDF–1.5M
13.
Dislocation of HMG-CoA Reductase and Insig-1, Two Polytopic Endoplasmic Reticulum Proteins, En Route to Proteasomal Degradation
Gil S. Leichner, Rachel Avner, Dror Harats, Joseph Roitelman
Mol Biol Cell. 2009 Jul 15; 20(14): 3330–3341. doi: 10.1091/mbc.E08-09-0953
PMCID:
PMC2710830
AbstractArticlePDF–1.3M
14.
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer
Li Xiong, Hua-shan Liu, Chi Zhou, Xin Yang, Liang Huang, Hai-qing Jie, Zi-wei Zeng, Xiao-bin Zheng, Wen-xin Li, Zhan-zhen Liu, Liang Kang, Zhen-xing Liang
Mol Cancer. 2023; 22: 72. Published online 2023 Apr 22. doi: 10.1186/s12943-023-01773-3
PMCID:
PMC10122405
AbstractArticlePDF–12M
15.
Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK–eIF2α–ATF4 axis
Yuichi Watanabe, Takashi Sasaki, Shoko Miyoshi, Makoto Shimizu, Yoshio Yamauchi, Ryuichiro Sato
J Biol Chem. 2021 Aug; 297(2): 100989. Published online 2021 Jul 21. doi: 10.1016/j.jbc.2021.100989
PMCID:
PMC8363831
AbstractArticlePDF–2.7M
16.
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway
Zu-Guo Zheng, Si-Tong Zhu, Hui-Min Cheng, Xin Zhang, Gang Cheng, Pyone Myat Thu, Supeng Perry Wang, Hui-Jun Li, Ming Ding, Lei Qiang, Xiao-Wei Chen, Qing Zhong, Ping Li, Xiaojun Xu
Autophagy. 2021; 17(7): 1592–1613. Published online 2020 May 20. doi: 10.1080/15548627.2020.1757955
PMCID:
PMC8354609
AbstractArticlePDF–14M
17.
The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity
Flaminia Ferri, Simone Carotti, Guido Carpino, Monica Mischitelli, Alfredo Cantafora, Antonio Molinaro, Maria Eva Argenziano, Simona Parisse, Alessandro Corsi, Mara Riminucci, Quirino Lai, Gianluca Mennini, Gustavo Spadetta, Francesco Pugliese, Massimo Rossi, Sergio Morini, Eugenio Gaudio, Stefano Ginanni Corradini
Int J Mol Sci. 2021 Jun; 22(11): 6100. Published online 2021 Jun 5. doi: 10.3390/ijms22116100
PMCID:
PMC8200978
AbstractArticlePDF–1.3M
18.
HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages
Alexander N. Orekhov, Tatiana Pushkarsky, Yumiko Oishi, Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth, Igor A. Sobenin, Vasily N. Sukhorukov, Emile R. Zakiev, Anatol Kontush, Wilfried Le Goff, Michael Bukrinsky
Exp Mol Pathol. Author manuscript; available in PMC 2019 Oct 1.
Published in final edited form as: Exp Mol Pathol. 2018 Oct; 105(2): 202–207. Published online 2018 Aug 16. doi: 10.1016/j.yexmp.2018.08.003
PMCID:
PMC6247801
AbstractArticlePDF–563K
19.
Glucose-mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
Chunming Cheng, Peng Ru, Feng Geng, Junfeng Liu, Ji Young Yoo, Xiaoning Wu, Xiang Cheng, Vanessa Euthine, Peng Hu, Jeffrey Yunhua Guo, Etienne Lefai, Balveen Kaur, Axel Nohturfft, Jianjie Ma, Arnab Chakravarti, Deliang Guo
Cancer Cell. Author manuscript; available in PMC 2016 Nov 9.
Published in final edited form as: Cancer Cell. 2015 Nov 9; 28(5): 569–581. doi: 10.1016/j.ccell.2015.09.021
PMCID:
PMC4643405
AbstractArticlePDF–2.7M
20.
Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
Stefania Carobbio, Rachel M. Hagen, Christopher J. Lelliott, Marc Slawik, Gema Medina-Gomez, Chong-Yew Tan, Audrey Sicard, Helen J. Atherton, Nuria Barbarroja, Mikael Bjursell, Mohammad Bohlooly-Y, Sam Virtue, Antoinette Tuthill, Etienne Lefai, Martine Laville, Tingting Wu, Robert V. Considine, Hubert Vidal, Dominique Langin, Matej Oresic, Francisco J. Tinahones, Jose Manuel Fernandez-Real, Julian L. Griffin, Jaswinder K. Sethi, Miguel López, Antonio Vidal-Puig
Diabetes. 2013 Nov; 62(11): 3697–3708. Published online 2013 Oct 18. doi: 10.2337/db12-1748
PMCID:
PMC3806615
AbstractArticlePDF–1.2M

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