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Select item 110287811.

Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?

Bettina Weigelin, Elixabet Bolaños, Maria E. Rodriguez-Ruiz, Ivan Martinez-Forero, Peter Friedl, Ignacio Melero

Cancer Immunol Immunother. 2016 May; 65(5): 493–497. Published online 2016 Mar 12. doi: 10.1007/s00262-016-1818-5

PMCID:: PMC11028781

Article PDF–815K

Select item 109922392.

Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors

Mukul Prasad, Sashigala Ponnalagu, Qun Zeng, Khang Luu, Si Min Lang, Hiu Yi Wong, Man Si Cheng, Meihui Wu, Karthik Mallilankaraman, Radoslaw Mikolaj Sobota, Yan Ting Lim, Loo Chien Wang, Chuan Keng Goh, Kai Xun Joshua Tay, Kwok Seng Loh, Cheng-I. Wang, Wen-Hsien Lee, Boon Cher Goh, Chwee Ming Lim, Herbert Schwarz

Cancer Immunol Immunother. 2022 Nov; 71(11): 2583–2596. Published online 2022 Mar 17. doi: 10.1007/s00262-022-03183-8

PMCID:: PMC10992239

Article PDF–2.1M

Select item 107443193.

Soluble CD137: A Potential Prognostic Biomarker in Critically Ill Patients

Ulrich Räth, Patricia Mester, Herbert Schwarz, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel

Int J Mol Sci. 2023 Dec; 24(24): 17518. Published online 2023 Dec 15. doi: 10.3390/ijms242417518

PMCID:: PMC10744319

Article PDF–1.9M

Select item 86326784.

CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity

A. Stoll, H. Bruns, M. Fuchs, S. Völkl, F. Nimmerjahn, M. Kunz, M. Peipp, A. Mackensen, D. Mougiakakos

Leukemia. 2021; 35(12): 3482–3496. Published online 2021 May 21. doi: 10.1038/s41375-021-01287-1

PMCID:: PMC8632678

Article PDF–4.7M

Select item 83415295.

Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis

Lotte Lindgreen Eriksen, Morten Aagaard Nielsen, Tea Lund Laursen, Bent Deleuran, Hendrik Vilstrup, Sidsel Støy

PLoS One. 2021; 16(8): e0255574. Published online 2021 Aug 5. doi: 10.1371/journal.pone.0255574

PMCID:: PMC8341529

Article PDF–1.3M

Select item 78836336.

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

Benjamin I. Philipson, Roddy S. O’Connor, Michael J. May, Carl H. June, Steven M. Albelda, Michael C. Milone

Sci Signal. Author manuscript; available in PMC 2021 Feb 15.

Published in final edited form as: Sci Signal. 2020 Mar 31; 13(625): eaay8248. Published online 2020 Mar 31. doi: 10.1126/scisignal.aay8248

PMCID:: PMC7883633

Article PDF–1.3M

Select item 78720247.

Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting

Kang Yi Lee, Hiu Yi Wong, Qun Zeng, Jia Le Lin, Man Si Cheng, Chik Hong Kuick, Kenneth Tou En Chang, Amos Hong Pheng Loh, Herbert Schwarz

Oncoimmunology. 2021; 10(1): 1877459. Published online 2021 Feb 4. doi: 10.1080/2162402X.2021.1877459

PMCID:: PMC7872024

Article PDF–3.4M

Select item 78337358.

T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production

Saskia D. van Asten, Rosa de Groot, Marleen M. van Loenen, Suzanne M. Castenmiller, Jeroen de Jong, Kim Monkhorst, John B.A.G. Haanen, Derk Amsen, Axel Bex, Robbert M. Spaapen, Monika C. Wolkers

Oncoimmunology. 2021; 10(1): 1860482. Published online 2021 Jan 21. doi: 10.1080/2162402X.2020.1860482

PMCID:: PMC7833735

Article PDF–1.9M

Select item 71547539.

4‐1BB Delineates Distinct Activation Status of Exhausted Tumor‐Infiltrating CD8⁺ T Cells in Hepatocellular Carcinoma

Hyung‐Don Kim, Seongyeol Park, Seongju Jeong, Yong Joon Lee, Hoyoung Lee, Chang Gon Kim, Kyung Hwan Kim, Seung‐Mo Hong, Jung‐Yun Lee, Sunghoon Kim, Hong Kwan Kim, Byung Soh Min, Jong Hee Chang, Young Seok Ju, Eui‐Cheol Shin, Gi‐Won Song, Shin Hwang, Su‐Hyung Park

Hepatology. 2020 Mar; 71(3): 955–971. Published online 2019 Oct 18. doi: 10.1002/hep.30881

PMCID:: PMC7154753

Article PDF–1.7M

Select item 683994710.

CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis

Ido Somekh, Marini Thian, David Medgyesi, Nesrin Gülez, Thomas Magg, Alejandro Gallón Duque, Tali Stauber, Atar Lev, Ferah Genel, Ekrem Unal, Amos J. Simon, Yu Nee Lee, Artem Kalinichenko, Jasmin Dmytrus, Michael J. Kraakman, Ginette Schiby, Meino Rohlfs, Jeffrey M. Jacobson, Erdener Özer, Ömer Akcal, Raffaele Conca, Türkan Patiroglu, Musa Karakukcu, Alper Ozcan, Tala Shahin, Eliana Appella, Megumi Tatematsu, Catalina Martinez-Jaramillo, Ivan K. Chinn, Jordan S. Orange, Claudia Milena Trujillo-Vargas, José Luis Franco, Fabian Hauck, Raz Somech, Christoph Klein, Kaan Boztug

Blood. 2019 Oct 31; 134(18): 1510–1516. Prepublished online 2019 Sep 9. doi: 10.1182/blood.2019000644

PMCID:: PMC6839947

Article

Select item 661520711.

Regulation of CD137 expression through K-Ras signaling in pancreatic cancer cells

Christophe Glorieux, Peng Huang

Cancer Commun (Lond) 2019; 39: 41. Published online 2019 Jul 9. doi: 10.1186/s40880-019-0386-4

PMCID:: PMC6615207

Article PDF–3.4M

Select item 615515312.

Dendritic cell maturation in the corneal epithelium with onset of type 2 diabetes is associated with tumor necrosis factor receptor superfamily member 9

Neil S. Lagali, Reza A. Badian, Xu Liu, Tobias R. Feldreich, Johan Ärnlöv, Tor Paaske Utheim, Lars B. Dahlin, Olov Rolandsson

Sci Rep. 2018; 8: 14248. Published online 2018 Sep 24. doi: 10.1038/s41598-018-32410-5

PMCID:: PMC6155153

Article PDF–1.5M

Select item 603920613.

Increased Soluble CD137 Levels and CD4+ T‐Cell‐Associated Expression of CD137 in Acute Atherothrombotic Stroke

Yang He, Dong‐Hui Ao, Xiao‐Qing Li, Shan‐Shan Zhong, Rong A, Yang‐Yang Wang, Ya‐Juan Xiang, Bao‐Lei Xu, Ting‐Ting Yang, Xu‐Guang Gao, Guang‐Zhi Liu

Clin Transl Sci. 2018 Jul; 11(4): 428–434. Published online 2018 Apr 26. doi: 10.1111/cts.12553

PMCID:: PMC6039206

Article PDF–640K

Select item 529020014.

CD137 stimulation enhances cetuximab induced natural killer (NK): dendritic cell (DC) priming of anti-tumor T cell immunity in head and neck cancer patients

Raghvendra M. Srivastava, Sumita Trivedi, Fernando Concha-Benavente, Sandra P. Gibson, Carly Reeder, Soldano Ferrone, Robert L. Ferris

Clin Cancer Res. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Clin Cancer Res. 2017 Feb 1; 23(3): 707–716. Published online 2016 Aug 5. doi: 10.1158/1078-0432.CCR-16-0879

PMCID:: PMC5290200

Article PDF–931K

Select item 471700215.

Expression of co-stimulator 4-1BB molecule in hepatocellular carcinoma and adjacent non-tumor liver tissue, and its possible role in tumor immunity

Yun-Le Wan, Shu-Sen Zheng, Zhi-Cheng Zhao, Min-Wei Li, Chang-Ku Jia, Hao Zhang

World J Gastroenterol. 2004 Jan 15; 10(2): 195–199. Published online 2004 Jan 15. doi: 10.3748/wjg.v10.i2.195

PMCID:: PMC4717002

Article PDF–241K

Select item 421200916.

Human Genetic Evidence for Involvement of CD137 in Atherosclerosis

Leif Å Söderström, Karl Gertow, Lasse Folkersen, Maria Sabater-Lleal, Eva Sundman, Yuri Sheikine, Anuj Goel, Damiano Baldassarre, Steve E Humphries, Ulf de Faire, Hugh Watkins, Elena Tremoli, Fabrizio Veglia, Anders Hamsten, Göran K Hansson, Peder S Olofsson

Mol Med. 2014; 20(1): 456–465. Prepublished online 2014 Jul 14. Published online 2014 Oct 14. doi: 10.2119/molmed.2014.00004

PMCID:: PMC4212009

Article PDF–1.0M

Select item 394732617.

CD137 accurately identifies and enriches for naturally-occurring tumor-reactive T cells in tumor

Qunrui Ye, De-Gang Song, Mathilde Poussin, Tori Yamamoto, Andrew Best, Chunsheng Li, George Coukos, Daniel J. Powell, Jr.

Clin Cancer Res. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Clin Cancer Res. 2014 Jan 1; 20(1): 44–55. Published online 2013 Sep 17. doi: 10.1158/1078-0432.CCR-13-0945

PMCID:: PMC3947326

Article PDF–4.1M

Select item 378422518.

Activation-induced CD137 is a fast assay for identification and multi-parameter flow cytometric analysis of alloreactive T cells

N H R Litjens, E A de Wit, C C Baan, M G H Betjes

Clin Exp Immunol. 2013 Oct; 174(1): 179–191. Published online 2013 Sep 8. doi: 10.1111/cei.12152

PMCID:: PMC3784225

Article PDF–804K

Select item 361335519.

Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8⁺ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

Jessica Ann Chacon, Richard C. Wu, Pariya Sukhumalchandra, Jeffrey J. Molldrem, Amod Sarnaik, Shari Pilon-Thomas, Jeffrey Weber, Patrick Hwu, Laszlo Radvanyi

PLoS One. 2013; 8(4): e60031. Published online 2013 Apr 1. doi: 10.1371/journal.pone.0060031

PMCID:: PMC3613355

Article PDF–1.2M

Select item 357782120.

Bayesian Approach to Model CD137 Signaling in Human M. tuberculosis In Vitro Responses

Darío A. Fernández Do Porto, Jerónimo Auzmendi, Delfina Peña, Verónica E. García, Luciano Moffatt

PLoS One. 2013; 8(2): e55987. Published online 2013 Feb 20. doi: 10.1371/journal.pone.0055987

PMCID:: PMC3577821

Article PDF–1.2M

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