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Select item 61871181.

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

Timo E. S. Kauppila, Ana Bratic, Martin Borch Jensen, Francesca Baggio, Linda Partridge, Heinrich Jasper, Sebastian Grönke, Nils-Göran Larsson

Proc Natl Acad Sci U S A. 2018 Oct 9; 115(41): E9620–E9629. Published online 2018 Sep 24. doi: 10.1073/pnas.1721683115

PMCID:: PMC6187118

Abstract Article PDF–2.0M

Select item 94057052.

Downregulating Mitochondrial DNA Polymerase γ in the Muscle Stimulated Autophagy, Apoptosis, and Muscle Aging-Related Phenotypes in Drosophila Adults

Mika Ozaki, Tuan Dat Le, Yoshihiro H. Inoue

Biomolecules. 2022 Aug; 12(8): 1105. Published online 2022 Aug 11. doi: 10.3390/biom12081105

PMCID:: PMC9405705

Abstract Article PDF–23M

Select item 60520433.

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase

Ana Paula C. Rodrigues, André F. Camargo, Ana Andjelković, Howard T. Jacobs, Marcos T. Oliveira

Sci Rep. 2018; 8: 10882. Published online 2018 Jul 18. doi: 10.1038/s41598-018-29150-x

PMCID:: PMC6052043

Abstract Article PDF–1.1M

Select item 44197894.

Evolution of the Metazoan Mitochondrial Replicase

Marcos T. Oliveira, Jani Haukka, Laurie S. Kaguni

Genome Biol Evol. 2015 Apr; 7(4): 943–959. Published online 2015 Mar 3. doi: 10.1093/gbe/evv042

PMCID:: PMC4419789

Abstract Article PDF–2.6M

Select item 27734085.

Disruption of Mitochondrial DNA Replication in Drosophila Increases Mitochondrial Fast Axonal Transport In Vivo

Rehan M. Baqri, Brittany A. Turner, Mary B. Rheuben, Bradley D. Hammond, Laurie S. Kaguni, Kyle E. Miller

PLoS One. 2009; 4(11): e7874. Published online 2009 Nov 17. doi: 10.1371/journal.pone.0007874

PMCID:: PMC2773408

Abstract Article PDF–2.2M

Select item 2978656.

Mismatch-specific 3'----5' exonuclease associated with the mitochondrial DNA polymerase from Drosophila embryos.

L S Kaguni, M W Olson

Proc Natl Acad Sci U S A. 1989 Sep; 86(17): 6469–6473. doi: 10.1073/pnas.86.17.6469

PMCID:: PMC297865

Summary Page Browse PDF–1.2M

Select item 1236747.

The accessory subunit of DNA polymerase γ is essential for mitochondrial DNA maintenance and development in Drosophilamelanogaster

Balaji Iyengar, Ningguang Luo, Carol L. Farr, Laurie S. Kaguni, Ana Regina Campos

Proc Natl Acad Sci U S A. 2002 Apr 2; 99(7): 4483–4488. Published online 2002 Mar 26. doi: 10.1073/pnas.072664899

PMCID:: PMC123674

Abstract Article PDF–363K

Select item 62894498.

Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ

Colby L. Samstag, Jake G. Hoekstra, Chiu-Hui Huang, Mark J. Chaisson, Richard J. Youle, Scott R. Kennedy, Leo J. Pallanck

PLoS Genet. 2018 Nov; 14(11): e1007805. Published online 2018 Nov 19. doi: 10.1371/journal.pgen.1007805

PMCID:: PMC6289449

Abstract Article PDF–2.4M

Select item 47031069.

MUSCLE-SPECIFIC OVEREXPRESSION OF THE CATALYTIC SUBUNIT OF DNA POLYMERASE γ INDUCES PUPAL LETHALITY IN Drosophila melanogaster

Francisco Martínez-Azorín, Manuel Calleja, Rosana Hernández-Sierra, Carol L. Farr, Laurie S. Kaguni, Rafael Garesse

Arch Insect Biochem Physiol. Author manuscript; available in PMC 2016 Jan 6.

Published in final edited form as: Arch Insect Biochem Physiol. 2013 Jul; 83(3): 127–137. Published online 2013 May 31. doi: 10.1002/arch.21101

PMCID:: PMC4703106

Abstract Article PDF–702K

Select item 377801310.

Mitochondrial Transcription Terminator Family Members mTTF and mTerf5 Have Opposing Roles in Coordination of mtDNA Synthesis

Priit Jõers, Samantha C. Lewis, Atsushi Fukuoh, Mikael Parhiala, Simo Ellilä, Ian J. Holt, Howard T. Jacobs

PLoS Genet. 2013 Sep; 9(9): e1003800. Published online 2013 Sep 19. doi: 10.1371/journal.pgen.1003800

PMCID:: PMC3778013

Abstract Article PDF–2.1M

Select item 935137711.

Mitigation of age-dependent accumulation of defective mitochondrial genomes

Pei-I Tsai, Ekaterina Korotkevich, Patrick H. O’Farrell

Proc Natl Acad Sci U S A. 2022 Aug 2; 119(31): e2119009119. Published online 2022 Jul 26. doi: 10.1073/pnas.2119009119

PMCID:: PMC9351377

Abstract Article PDF–1.2M

Select item 665041712.

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth

Nat Commun. 2019; 10: 3280. Published online 2019 Jul 23. doi: 10.1038/s41467-019-10857-y

PMCID:: PMC6650417

Abstract Article PDF–2.6M

Select item 603284513.

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency

Marie‐Lune Simard, Arnaud Mourier, Laura C Greaves, Robert W Taylor, James B Stewart

J Pathol. 2018 Jul; 245(3): 311–323. Published online 2018 May 14. doi: 10.1002/path.5084

PMCID:: PMC6032845

Abstract Article PDF–11M

Select item 588611514.

A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma

Triinu Siibak, Paula Clemente, Ana Bratic, Helene Bruhn, Timo E.S. Kauppila, Bertil Macao, Florian A. Rosenberger, Nicole Lesko, Rolf Wibom, Karin Naess, Inger Nennesmo, Anna Wedell, Bradley Peter, Christoph Freyer, Maria Falkenberg, Anna Wredenberg

Hum Mol Genet. 2017 Jul 1; 26(13): 2515–2525. Published online 2017 Apr 17. doi: 10.1093/hmg/ddx146

PMCID:: PMC5886115

Abstract Article PDF–958K

Select item 438861815.

The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM

Fan Zhang, Yun Qi, Kiet Zhou, Guofeng Zhang, Kaari Linask, Hong Xu

EMBO Rep. 2015 Apr; 16(4): 520–527. Published online 2015 Feb 3. doi: 10.15252/embr.201439636

PMCID:: PMC4388618

Abstract Article PDF–2.5M

Select item 539169116.

The mitochondrial DNA-polymerase promotes elimination of paternal mitochondrial genomes

Zhongsheng Yu, Patrick H. O’Farrell, Nikita Yakubovich, Steven Z. DeLuca

Curr Biol. Author manuscript; available in PMC 2018 Apr 3.

Published in final edited form as: Curr Biol. 2017 Apr 3; 27(7): 1033–1039. Published online 2017 Mar 16. doi: 10.1016/j.cub.2017.02.014

PMCID:: PMC5391691

Abstract Article PDF–1.6M

Select item 477388717.

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

Ana Bratic, Timo E. S. Kauppila, Bertil Macao, Sebastian Grönke, Triinu Siibak, James B. Stewart, Francesca Baggio, Jacqueline Dols, Linda Partridge, Maria Falkenberg, Anna Wredenberg, Nils-Göran Larsson

Nat Commun. 2015; 6: 8808. Published online 2015 Nov 10. doi: 10.1038/ncomms9808

PMCID:: PMC4773887

Abstract Article PDF–1.8M

Select item 692647618.

A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations

Ason C.-Y. Chiang, Eleanor McCartney, Patrick H. O'Farrell, Hansong Ma

Curr Biol. 2019 Dec 16; 29(24): 4330–4336.e3. doi: 10.1016/j.cub.2019.10.060

PMCID:: PMC6926476

Abstract Article

Select item 733750519.

Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation

Zhe Chen, Zong-Heng Wang, Guofeng Zhang, Christopher K.E. Bleck, Dillon J. Chung, Grey P. Madison, Eric Lindberg, Christian Combs, Robert S. Balaban, Hong Xu

J Cell Biol. 2020 Jul 6; 219(7): e201905160. Published online 2020 May 6. doi: 10.1083/jcb.201905160