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Items: 1 to 20 of 139

1.
IFI16 phase separation via multi-phosphorylation drives innate immune signaling
Dawei Liu, Krystal K Lum, Nicholas Treen, Corazón T Núñez, Jinhang Yang, Timothy R Howard, Michael Levine, Ileana M Cristea
Nucleic Acids Res. 2023 Jul 21; 51(13): 6819–6840. Published online 2023 Jun 7. doi: 10.1093/nar/gkad449
PMCID:
PMC10359621
AbstractArticlePDF–3.4M
2.
IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection
Gloria Griffante, Weronika Hewelt-Belka, Camilla Albano, Francesca Gugliesi, Selina Pasquero, Sergio Fernando Castillo Pacheco, Greta Bajetto, Paolo Ettore Porporato, Erica Mina, Marta Vallino, Christian Krapp, Martin Roelsgaard Jakobsen, John Purdy, Jens von Einem, Santo Landolfo, Valentina Dell’Oste, Matteo Biolatti
mBio. 2022 May-Jun; 13(3): e00435-22. Published online 2022 Apr 14. doi: 10.1128/mbio.00435-22
PMCID:
PMC9239058
AbstractArticlePDF–3.3M
3.
Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA
Krystal K. Lum, Timothy R. Howard, Catherina Pan, Ileana M. Cristea
mBio. 2019 Jul-Aug; 10(4): e01428-19. Published online 2019 Jul 23. doi: 10.1128/mBio.01428-19
PMCID:
PMC6650555
AbstractArticlePDF–3.8M
4.
IFI16 restoration in hepatocellular carcinoma induces tumour inhibition via activation of p53 signals and inflammasome
Wei Lin, Zhiguang Zhao, Zhonglin Ni, Yaxin Zhao, Wenjun Du, Shijun Chen
Cell Prolif. 2017 Dec; 50(6): e12392. Published online 2017 Oct 8. doi: 10.1111/cpr.12392
PMCID:
PMC6529087
AbstractArticlePDF–1.7M
5.
Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection
Philipp E. Merkl, David M. Knipe
mBio. 2019 Jan-Feb; 10(1): e02621-18. Published online 2019 Jan 22. doi: 10.1128/mBio.02621-18
PMCID:
PMC6343039
AbstractArticlePDF–6.6M
6.
The Absent in Melanoma 2-Like Receptor IFN-Inducible Protein 16 as an Inflammasome Regulator in Systemic Lupus Erythematosus: The Dark Side of Sensing Microbes
Valeria Caneparo, Santo Landolfo, Marisa Gariglio, Marco De Andrea
Front Immunol. 2018; 9: 1180. Published online 2018 May 28. doi: 10.3389/fimmu.2018.01180
PMCID:
PMC5985366
AbstractArticlePDF–3.5M
7.
Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency
Gina Pisano, Arunava Roy, Mairaj Ahmed Ansari, Binod Kumar, Leela Chikoti, Bala Chandran
Virol J. 2017; 14: 221. Published online 2017 Nov 13. doi: 10.1186/s12985-017-0891-5
PMCID:
PMC5683537
AbstractArticlePDF–2.3M
8.
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
K. L. Jønsson, A. Laustsen, C. Krapp, K. A. Skipper, K. Thavachelvam, D. Hotter, J. H. Egedal, M. Kjolby, P. Mohammadi, T. Prabakaran, L. K. Sørensen, C. Sun, S. B. Jensen, C. K. Holm, R. J. Lebbink, M. Johannsen, M. Nyegaard, J. G. Mikkelsen, F. Kirchhoff, S. R. Paludan, M. R. Jakobsen
Nat Commun. 2017; 8: 14391. Published online 2017 Feb 10. doi: 10.1038/ncomms14391
PMCID:
PMC5309897
AbstractArticlePDF–4.7M
9.
Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency
Arunava Roy, Dipanjan Dutta, Jawed Iqbal, Gina Pisano, Olsi Gjyshi, Mairaj Ahmed Ansari, Binod Kumar, Bala Chandran
J Virol. 2016 Oct 1; 90(19): 8822–8841. Prepublished online 2016 Jul 27. Published online 2016 Sep 12. doi: 10.1128/JVI.01003-16
PMCID:
PMC5021400
AbstractArticlePDF–4.3M
10.
Antibodies to interferon-inducible protein-16 in primary Sjögren's syndrome are associated with markers of more severe disease
Alan N. Baer, Michelle Petri, Jungsan Sohn, Antony Rosen, Livia Casciola-Rosen
Arthritis Care Res (Hoboken) Author manuscript; available in PMC 2017 Feb 1.
Published in final edited form as: Arthritis Care Res (Hoboken). 2016 Feb; 68(2): 254–260. doi: 10.1002/acr.22632
PMCID:
PMC4847427
AbstractArticlePDF–171K
11.
The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex
Sarah A Stratmann, Seamus R Morrone, Antoine M van Oijen, Jungsan Sohn
eLife. 2015; 4: e11721. Published online 2015 Dec 16. doi: 10.7554/eLife.11721
PMCID:
PMC4829420
AbstractArticlePDF–2.4M
12.
Interferon gamma-inducible protein 16 in primary Sjögren’s syndrome: a novel player in disease pathogenesis?
Alessia Alunno, Valeria Caneparo, Francesco Carubbi, Onelia Bistoni, Sara Caterbi, Elena Bartoloni, Roberto Giacomelli, Marisa Gariglio, Santo Landolfo, Roberto Gerli
Arthritis Res Ther. 2015; 17(1): 208. Published online 2015 Aug 14. doi: 10.1186/s13075-015-0722-2
PMCID:
PMC4536589
AbstractArticlePDF–1.4M
13.
The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters
Irene Lo Cigno, Marco De Andrea, Cinzia Borgogna, Silvia Albertini, Manuela M. Landini, Alberto Peretti, Karen E. Johnson, Bala Chandran, Santo Landolfo, Marisa Gariglio
J Virol. 2015 Aug 1; 89(15): 7506–7520. Published online 2015 May 13. doi: 10.1128/JVI.00013-15
PMCID:
PMC4505635
AbstractArticlePDF–2.0M
14.
IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation
Pier Paolo Piccaluga, Claudio Agostinelli, Fabio Fuligni, Simona Righi, Claudio Tripodo, Maria Carla Re, Alberto Clò, Anna Miserocchi, Silvia Morini, Marisa Gariglio, Gian Gaetano Ferri, Alberto Rinaldi-Ceroni, Ottavio Piccin, Marco De Andrea, Stefano A. Pileri, Santo Landolfo, Davide Gibellini
J Immunol Res. 2015; 2015: 747645. Published online 2015 Jun 22. doi: 10.1155/2015/747645
PMCID:
PMC4491573
AbstractArticlePDF–9.2M
15.
Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses
Mairaj Ahmed Ansari, Sujoy Dutta, Mohanan Valiya Veettil, Dipanjan Dutta, Jawed Iqbal, Binod Kumar, Arunava Roy, Leela Chikoti, Vivek Vikram Singh, Bala Chandran
PLoS Pathog. 2015 Jul; 11(7): e1005019. Published online 2015 Jul 2. doi: 10.1371/journal.ppat.1005019
PMCID:
PMC4489722
AbstractArticlePDF–7.5M
16.
IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications
Karen E. Johnson, Virginie Bottero, Stephanie Flaherty, Sujoy Dutta, Vivek Vikram Singh, Bala Chandran
PLoS Pathog. 2014 Nov; 10(11): e1004503. Published online 2014 Nov 6. doi: 10.1371/journal.ppat.1004503
Correction in:
PLoS Pathog. 2018 Jun; 14(6): e1007113.
PMCID:
PMC4223080
AbstractArticlePDF–5.9M
17.
Interferon γ-inducible Protein (IFI) 16 Transcriptionally Regulates Type I Interferons and Other Interferon-stimulated Genes and Controls the Interferon Response to both DNA and RNA Viruses
Mikayla R. Thompson, Shruti Sharma, Maninjay Atianand, Søren B. Jensen, Susan Carpenter, David M. Knipe, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones
J Biol Chem. 2014 Aug 22; 289(34): 23568–23581. Published online 2014 Jul 7. doi: 10.1074/jbc.M114.554147
PMCID:
PMC4156042
AbstractArticlePDF–1.9M
18.
Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation
S K Nissen, J F Højen, K L D Andersen, E Kofod-Olsen, R K Berg, S R Paludan, L Østergaard, M R Jakobsen, M Tolstrup, T H Mogensen
Clin Exp Immunol. 2014 Jul; 177(1): 295–309. Published online 2014 Jun 9. doi: 10.1111/cei.12317
PMCID:
PMC4089180
AbstractArticlePDF–462K
19.
Innate Nuclear Sensor IFI16 Translocates into the Cytoplasm during the Early Stage of In Vitro Human Cytomegalovirus Infection and Is Entrapped in the Egressing Virions during the Late Stage
Valentina Dell'Oste, Deborah Gatti, Francesca Gugliesi, Marco De Andrea, Mandar Bawadekar, Irene Lo Cigno, Matteo Biolatti, Marta Vallino, Manfred Marschall, Marisa Gariglio, Santo Landolfo
J Virol. 2014 Jun; 88(12): 6970–6982. doi: 10.1128/JVI.00384-14
PMCID:
PMC4054358
AbstractArticlePDF–2.4M
20.
IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T-cells Abortively Infected with HIV
Kathryn M. Monroe, Zhiyuan Yang, Jeffrey R. Johnson, Xin Geng, Gilad Doitsh, Nevan J. Krogan, Warner C. Greene
Science. Author manuscript; available in PMC 2014 Jul 24.
Published in final edited form as: Science. 2014 Jan 24; 343(6169): 428–432. Published online 2013 Dec 19. doi: 10.1126/science.1243640
PMCID:
PMC3976200
AbstractArticlePDF–596K

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