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Items: 1 to 20 of 65

1.
ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy inmetastatic colorectal cancer: ACACB is a biomarker for CTX therapy in metastatic CRC
Hi-Ju Hong, Yanfei Shao, Sen Zhang, Guang Yang, Hongtao Jia, Xiao Yang, Ling Huang, Shuchun Li, Batuer Aikemu, Luyang Zhang, Junjun Ma, Lu Zang, Jing Sun, Minhua Zheng
Acta Biochim Biophys Sin (Shanghai) 2022 Nov; 54(11): 1671–1683. Published online 2022 Sep 13. doi: 10.3724/abbs.2022121
PMCID:
PMC9828296
AbstractArticlePDF–10M
2.
An ACACB Variant Implicated in Diabetic Nephropathy Associates with Body Mass Index and Gene Expression in Obese Subjects
Lijun Ma, Mariana Murea, James A. Snipes, Alejandra Marinelarena, Jacqueline Krüger, Pamela J. Hicks, Kurt A. Langberg, Meredith A. Bostrom, Jessica N. Cooke, Daisuke Suzuki, Tetsuya Babazono, Takashi Uzu, Sydney C. W. Tang, Ashis K. Mondal, Neeraj K. Sharma, Sayuko Kobes, Peter A. Antinozzi, Matthew Davis, Swapan K. Das, Neda Rasouli, Philip A. Kern, Nathan J. Shores, Lawrence L. Rudel, Matthias Blüher, Michael Stumvoll, Donald W. Bowden, Shiro Maeda, John S. Parks, Peter Kovacs, Robert L. Hanson, Leslie J. Baier, Steven C. Elbein, Barry I. Freedman
PLoS One. 2013; 8(2): e56193. Published online 2013 Feb 27. doi: 10.1371/journal.pone.0056193
PMCID:
PMC3584087
AbstractArticlePDF–545K
3.
The Effect of ACACB cis-Variants on Gene Expression and Metabolic Traits
Lijun Ma, Ashis K. Mondal, Mariana Murea, Neeraj K. Sharma, Anke Tönjes, Kurt A. Langberg, Swapan K. Das, Paul W. Franks, Peter Kovacs, Peter A. Antinozzi, Michael Stumvoll, John S. Parks, Steven C. Elbein, Barry I. Freedman
PLoS One. 2011; 6(8): e23860. Published online 2011 Aug 26. doi: 10.1371/journal.pone.0023860
PMCID:
PMC3162605
AbstractArticlePDF–889K
4.
The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes
Sydney C.W. Tang, Violet T.M. Leung, Loretta Y.Y. Chan, Sunny S.H. Wong, Daniel W.S. Chu, Joseph C.K. Leung, Yiu Wing Ho, Kar Neng Lai, Lijun Ma, Steven C. Elbein, Donald W. Bowden, Pamela J. Hicks, Mary E. Comeau, Carl D. Langefeld, Barry I. Freedman
Nephrol Dial Transplant. 2010 Dec; 25(12): 3931–3934. Published online 2010 Jun 2. doi: 10.1093/ndt/gfq303
PMCID:
PMC3108368
AbstractArticlePDF–82K
5.
ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat
Catherine M. Phillips, Louisa Goumidi, Sandrine Bertrais, Martyn R. Field, L. Adrienne Cupples, Jose M. Ordovas, Jolene McMonagle, Catherine Defoort, Julie A. Lovegrove, Christian A. Drevon, Ellen E. Blaak, Beata Kiec-Wilk, Ulf Riserus, Jose Lopez-Miranda, Ross McManus, Serge Hercberg, Denis Lairon, Richard Planells, Helen M. Roche
J Lipid Res. 2010 Dec; 51(12): 3500–3507. doi: 10.1194/jlr.M008474
PMCID:
PMC2975722
AbstractArticlePDF–493K
6.
A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes
Shiro Maeda, Masa-aki Kobayashi, Shin-ichi Araki, Tetsuya Babazono, Barry I. Freedman, Meredith A. Bostrom, Jessica N. Cooke, Masao Toyoda, Tomoya Umezono, Lise Tarnow, Torben Hansen, Peter Gaede, Anders Jorsal, Daniel P. K. Ng, Minoru Ikeda, Toru Yanagimoto, Tatsuhiko Tsunoda, Hiroyuki Unoki, Koichi Kawai, Masahito Imanishi, Daisuke Suzuki, Hyoung Doo Shin, Kyong Soo Park, Atsunori Kashiwagi, Yasuhiko Iwamoto, Kohei Kaku, Ryuzo Kawamori, Hans-Henrik Parving, Donald W. Bowden, Oluf Pedersen, Yusuke Nakamura
PLoS Genet. 2010 Feb; 6(2): e1000842. Published online 2010 Feb 12. doi: 10.1371/journal.pgen.1000842
PMCID:
PMC2820513
AbstractArticlePDF–339K
7.
ACC2 Is Expressed at High Levels Human White Adipose and Has an Isoform with a Novel N-Terminus
John C. Castle, Yoshikazu Hara, Christopher K. Raymond, Philip Garrett-Engele, Kenji Ohwaki, Zhengyan Kan, Jun Kusunoki, Jason M. Johnson
PLoS One. 2009; 4(2): e4369. Published online 2009 Feb 3. doi: 10.1371/journal.pone.0004369
Correction in:
PLoS One. 2009; 4(2): 10.1371/annotation/c921dfce-9702-4632-abbe-f13d62fdfde0.
PMCID:
PMC2629817
AbstractArticlePDF–803K
8.
Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells
Jessica E. C. Jones, William P. Esler, Rushi Patel, Adhiraj Lanba, Nicholas B. Vera, Jeffrey A. Pfefferkorn, Cecile Vernochet
PLoS One. 2017; 12(1): e0169566. Published online 2017 Jan 12. doi: 10.1371/journal.pone.0169566
PMCID:
PMC5231342
AbstractArticlePDF–1.5M
9.
Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab
Jingtao Luo, Yun Hong, Yang Lu, Songbo Qiu, Bharat K. R. Chaganty, Lun Zhang, Xudong Wang, Qiang Li, Zhen Fan
Cancer Lett. Author manuscript; available in PMC 2018 Jan 1.
Published in final edited form as: Cancer Lett. 2017 Jan 1; 384: 39–49. Published online 2016 Sep 28. doi: 10.1016/j.canlet.2016.09.020
PMCID:
PMC5110372
AbstractArticlePDF–4.1M
10.
The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist
Kevin P. Madauss, William A. Burkhart, Thomas G. Consler, David J. Cowan, William K. Gottschalk, Aaron B. Miller, Steven A. Short, Thuy B. Tran, Shawn P. Williams
Acta Crystallogr D Biol Crystallogr. 2009 May 1; 65(Pt 5): 449–461. Published online 2009 Apr 18. doi: 10.1107/S0907444909008014
PMCID:
PMC2725780
AbstractArticlePDF–2.6M
11.
Identification of a second human acetyl-CoA carboxylase gene.
J Widmer, K S Fassihi, S C Schlichter, K S Wheeler, B E Crute, N King, N Nutile-McMenemy, W W Noll, S Daniel, J Ha, K H Kim, L A Witters
Biochem J. 1996 Jun 15; 316(Pt 3): 915–922. doi: 10.1042/bj3160915
PMCID:
PMC1217437
SummaryPDF–2.5M
12.
Cloning of human acetyl-CoA carboxylase-beta and its unique features.
J Ha, J K Lee, K S Kim, L A Witters, K H Kim
Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21): 11466–11470. doi: 10.1073/pnas.93.21.11466
PMCID:
PMC38080
SummaryPage BrowsePDF–1.5M
13.
Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion
Francis Rajamohan, Eric Marr, Allan R. Reyes, James A. Landro, Marie D. Anderson, Jeffrey W. Corbett, Kenneth J. Dirico, James H. Harwood, Meihua Tu, Felix F. Vajdos
J Biol Chem. 2011 Dec 2; 286(48): 41510–41519. Published online 2011 Sep 27. doi: 10.1074/jbc.M111.275396
PMCID:
PMC3308862
AbstractArticlePDF–2.5M
14.
Acetyl-coenzyme A carboxylase α gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels
Francisco J. Diaz, Alexander Meary, Maria J. Arranz, Gualberto Ruaño, Andreas Windemuth, Jose de Leon
Schizophr Res. Author manuscript; available in PMC 2010 Dec 1.
Published in final edited form as: Schizophr Res. 2009 Dec; 115(2-3): 136–140. Published online 2009 Oct 28. doi: 10.1016/j.schres.2009.09.038
PMCID:
PMC2784140
AbstractArticlePDF–61K
15.
Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest
Fabien Szabo de Edelenyi, Louisa Goumidi, Sandrine Bertrais, Catherine Phillips, Ross MacManus, Helen Roche, Richard Planells, Denis Lairon
Genes Nutr. 2008 Dec; 3(3-4): 173–176. Published online 2008 Nov 26. doi: 10.1007/s12263-008-0097-y
PMCID:
PMC2593021
AbstractArticlePDF–211K
16.
Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis
Zhiyong Dong, Xinyi Lei, Stacy A. Kujawa, NaciEmre Bolu, Hong Zhao, Cunchuan Wang
Adipocyte. 2021; 10(1): 310–321. Published online 2021 Jun 4. doi: 10.1080/21623945.2021.1933297
PMCID:
PMC8183531
AbstractArticlePDF–1.2M
17.
Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants
Kristen E. Boyle, Zachary W. Patinkin, Allison L.B. Shapiro, Carly Bader, Lauren Vanderlinden, Katerina Kechris, Rachel C. Janssen, Rebecca J. Ford, Brennan K. Smith, Gregory R. Steinberg, Elizabeth J. Davidson, Ivana V. Yang, Dana Dabelea, Jacob E. Friedman
Mol Metab. 2017 Nov; 6(11): 1503–1516. Published online 2017 Sep 1. doi: 10.1016/j.molmet.2017.08.012
PMCID:
PMC5681274
AbstractArticlePDF–1.6M
18.
Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival
Marin E. Nelson, Sujoy Lahiri, Jenny D. Y. Chow, Frances L. Byrne, Stefan R. Hargett, David S. Breen, Ellen M. Olzomer, Lindsay E. Wu, Gregory J. Cooney, Nigel Turner, David E. James, Jill K. Slack-Davis, Carolin Lackner, Stephen H. Caldwell, Kyle L. Hoehn
Nat Commun. 2017; 8: 14689. Published online 2017 Mar 14. doi: 10.1038/ncomms14689
PMCID:
PMC5424065
AbstractArticlePDF–1.6M
19.
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
Natalie J. German, Haejin Yoon, Rushdia Z. Yusuf, J. Patrick Murphy, Lydia W.S. Finley, Gaëlle Laurent, Wilhelm Haas, F. Kyle Satterstrom, Jlenia Guarnerio, Elma Zaganjor, Daniel Santos, Pier Paolo Pandolfi, Andrew H. Beck, Steven P. Gygi, David T. Scadden, William G. Kaelin, Jr., Marcia C. Haigis
Mol Cell. Author manuscript; available in PMC 2017 Sep 15.
Published in final edited form as: Mol Cell. 2016 Sep 15; 63(6): 1006–1020. doi: 10.1016/j.molcel.2016.08.014
PMCID:
PMC5040345
AbstractArticlePDF–2.4M
20.
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats
Geraldine Harriman, Jeremy Greenwood, Sathesh Bhat, Xinyi Huang, Ruiying Wang, Debamita Paul, Liang Tong, Asish K. Saha, William F. Westlin, Rosana Kapeller, H. James Harwood, Jr.
Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13): E1796–E1805. Published online 2016 Mar 14. doi: 10.1073/pnas.1520686113
PMCID:
PMC4822632
AbstractArticlePDF–1.5M

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