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Select item 93563241.

ONECUT1 mutations and variants in diabetes

Anne Philippi, Sandra Heller, Ivan G. Costa, Valérie Senée, Markus Breunig, Zhijian Li, Gino Kwon, Ronan Russell, Anett Illing, Qiong Lin, Meike Hohwieler, Anne Degavre, Pierre Zalloua, Stefan Liebau, Michael Schuster, Johannes Krumm, Xi Zhang, Ryan Geusz, Jacqueline R. Benthuysen, Allen Wang, Joshua Chiou, Kyle Gaulton, Heike Neubauer, Eric Simon, Thomas Klein, Martin Wagner, Gopika Nair, Céline Besse, Claire Dandine-Roulland, Robert Olaso, Jean-François Deleuze, Bernhard Kuster, Matthias Hebrok, Thomas Seufferlein, Maike Sander, Bernhard O. Boehm, Franz Oswald, Marc Nicolino, Cécile Julier, Alexander Kleger

Nat Med. Author manuscript; available in PMC 2022 Aug 6.

Published in final edited form as: Nat Med. 2021 Nov; 27(11): 1928–1940. Published online 2021 Oct 18. doi: 10.1038/s41591-021-01502-7

PMCID:: PMC9356324

Abstract Article PDF–5.4M

Select item 85998462.

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation

Sandra Heller, Zhijian Li, Qiong Lin, Ryan Geusz, Markus Breunig, Meike Hohwieler, Xi Zhang, Gopika G. Nair, Thomas Seufferlein, Matthias Hebrok, Maike Sander, Cécile Julier, Alexander Kleger, Ivan G. Costa

Commun Biol. 2021; 4: 1298. Published online 2021 Nov 17. doi: 10.1038/s42003-021-02818-3

PMCID:: PMC8599846

Abstract Article PDF–2.3M

Select item 44423673.

Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6

Ruidong Hao, Jing He, Xing Liu, Guozhen Gao, Dan Liu, Lei Cui, Guojun Yu, Wenhui Yu, Yu Chen, Deyin Guo

J Virol. 2015 Apr 15; 89(8): 4345–4355. Published online 2015 Feb 4. doi: 10.1128/JVI.03094-14

PMCID:: PMC4442367

Abstract Article PDF–2.0M

Select item 40683394.

Loss of HNF6 expression correlates with human pancreatic cancer progression

Kelly R. Pekala, Xidi Ma, Peter A. Kropp, Christine P. Petersen, Courtney W. Hudgens, Christine H. Chung, Chanjuan Shi, Nipun Merchant, Anirban Maitra, Anna L. Means, Maureen Gannon

Lab Invest. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Lab Invest. 2014 May; 94(5): 517–527. Published online 2014 Mar 17. doi: 10.1038/labinvest.2014.47

PMCID:: PMC4068339

Abstract Article PDF–2.5M

Select item 38294315.

Hepatocyte Nuclear Factor 6 Suppresses the Migration and Invasive Growth of Lung Cancer Cells through p53 and the Inhibition of Epithelial-Mesenchymal Transition

Xin-Wang Yuan, Dong-Mei Wang, Ying Hu, Yun-Neng Tang, Wei-Wei Shi, Xiao-Jie Guo, Jian-Guo Song

J Biol Chem. 2013 Oct 25; 288(43): 31206–31216. Published online 2013 Sep 10. doi: 10.1074/jbc.M113.480285

PMCID:: PMC3829431

Abstract Article PDF–4.0M

Select item 29541836.

Inhibition of the Liver Enriched Protein FOXA2 Recovers HNF6 Activity in Human Colon Carcinoma and Liver Hepatoma Cells

Frank Lehner, Ulf Kulik, Juergen Klempnauer, Juergen Borlak

PLoS One. 2010; 5(10): e13344. Published online 2010 Oct 13. doi: 10.1371/journal.pone.0013344

PMCID:: PMC2954183

Abstract Article PDF–5.6M

Select item 12231017.

Hepatocyte nuclear factor-6 stimulates transcription of the alpha-fetoprotein gene and synergizes with the retinoic-acid-receptor-related orphan receptor alpha-4.

Habib Nacer-Cherif, Brigitte Bois-Joyeux, Guy G Rousseau, Frédéric P Lemaigre, Jean-Louis Danan

Biochem J. 2003 Feb 1; 369(Pt 3): 583–591. doi: 10.1042/BJ20021229

PMCID:: PMC1223101

Summary PDF–353K

Select item 384508.

Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain.

F P Lemaigre, S M Durviaux, O Truong, V J Lannoy, J J Hsuan, G G Rousseau

Proc Natl Acad Sci U S A. 1996 Sep 3; 93(18): 9460–9464. doi: 10.1073/pnas.93.18.9460

PMCID:: PMC38450

Summary Page Browse PDF–1.3M

Select item 177159.

Antiglucocorticoid activity of hepatocyte nuclear factor-6

Christophe E. Pierreux, John Stafford, Dominique Demonte, Donald K. Scott, Jean Vandenhaute, Richard M. O’Brien, Daryl K. Granner, Guy G. Rousseau, Frederic P. Lemaigre

Proc Natl Acad Sci U S A. 1999 Aug 3; 96(16): 8961–8966. doi: 10.1073/pnas.96.16.8961

PMCID:: PMC17715

Abstract Article PDF–358K

Select item 658231510.

ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility

Jori van der Raadt, Sebastianus H C van Gestel, Nael Nadif Kasri, Cornelis A Albers

Nucleic Acids Res. 2019 Jun 20; 47(11): 5587–5602. Published online 2019 May 3. doi: 10.1093/nar/gkz273

PMCID:: PMC6582315

Abstract Article PDF–8.9M

Select item 301262411.

Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

Duncan T. Odom, Nora Zizlsperger, D. Benjamin Gordon, George W. Bell, Nicola J. Rinaldi, Heather L. Murray, Tom L. Volkert, Jörg Schreiber, P. Alexander Rolfe, David K. Gifford, Ernest Fraenkel, Graeme I. Bell, Richard A. Young

Science. Author manuscript; available in PMC 2010 Dec 30.

Published in final edited form as: Science. 2004 Feb 27; 303(5662): 1378–1381. doi: 10.1126/science.1089769

PMCID:: PMC3012624

Abstract Article PDF–327K

Select item 52882012.

Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4α and HNF1β in a pancreatic β-cell line

Heike Thomas, Sabine Senkel, Silke Erdmann, Tanja Arndt, Gülüzar Turan, Ludger Klein-Hitpass, Gerhart U. Ryffel

Nucleic Acids Res. 2004; 32(19): e150. Published online 2004 Nov 1. doi: 10.1093/nar/gnh144

PMCID:: PMC528820

Abstract Article PDF–375K

Select item 23163013.

The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression.

U Samadani, R H Costa

Mol Cell Biol. 1996 Nov; 16(11): 6273–6284. doi: 10.1128/mcb.16.11.6273

PMCID:: PMC231630

Summary PDF–2.6M

Select item 389803414.

Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia

Pierre-Paul Prévot, Alexandru Simion, Adrien Grimont, Marta Colletti, Abed Khalaileh, Géraldine Van den Steen, Christine Sempoux, Xiaobo Xu, Véronique Roelants, Jacob Hald, Luc Bertrand, Harry Heimberg, Stephen F. Konieczny, Yuval Dor, Frédéric P. Lemaigre, Patrick Jacquemin

Gut. Author manuscript; available in PMC 2014 Jan 22.

Published in final edited form as: Gut. 2012 Dec; 61(12): 1723–1732. Published online 2012 Jan 22. doi: 10.1136/gutjnl-2011-300266

PMCID:: PMC3898034

Abstract Article PDF–4.8M

Select item 15153315.

Association between Hepatocyte Nuclear Factor 6 (HNF-6) and FoxA2 DNA Binding Domains Stimulates FoxA2 Transcriptional Activity but Inhibits HNF-6 DNA Binding

Francisco M. Rausa, Yongjun Tan, Robert H. Costa

Mol Cell Biol. 2003 Jan; 23(2): 437–449. doi: 10.1128/MCB.23.2.437-449.2003

PMCID:: PMC151533

Abstract Article PDF–538K

Select item 359184916.

A CpG Mutational Hotspot in a ONECUT Binding Site Accounts for the Prevalent Variant of Hemophilia B Leyden

Alister P.W. Funnell, Michael D. Wilson, Benoit Ballester, Ka Sin Mak, Jon Burdach, Natisha Magan, Richard C.M. Pearson, Frederic P. Lemaigre, Kathryn M. Stowell, Duncan T. Odom, Paul Flicek, Merlin Crossley

Am J Hum Genet. 2013 Mar 7; 92(3): 460–467. doi: 10.1016/j.ajhg.2013.02.003

PMCID:: PMC3591849

Abstract Article PDF–737K

Select item 8581217.

Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3

Patrick Jacquemin, Serge M. Durviaux, Jan Jensen, Catherine Godfraind, Gerard Gradwohl, François Guillemot, Ole D. Madsen, Peter Carmeliet, Mieke Dewerchin, Désiré Collen, Guy G. Rousseau, Frédéric P. Lemaigre

Mol Cell Biol. 2000 Jun; 20(12): 4445–4454. doi: 10.1128/mcb.20.12.4445-4454.2000

PMCID:: PMC85812

Abstract Article PDF–8.5M

Select item 490112718.

Homeodomain proteins: an update

Thomas R. Bürglin, Markus Affolter

Chromosoma. 2016; 125: 497–521. Published online 2015 Oct 13. doi: 10.1007/s00412-015-0543-8

PMCID:: PMC4901127

Abstract Article PDF–3.1M

Select item 800904819.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 570387820.

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C. O. Vertegaal

Nat Commun. 2017; 8: 1809. Published online 2017 Nov 27. doi: 10.1038/s41467-017-01900-x

PMCID:: PMC5703878

Abstract Article PDF–3.7M

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PMC Links for Gene (Select 3175) (25)
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Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/FL-...
Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/USA/FL-BPHL-15720/2021 ORF1ab polyprotein (ORF1ab), ORF1a polyprotein (ORF1ab), surface glycoprotein (S), ORF3a protein (ORF3a), envelope protein (E), membrane glycoprotein (M), ORF6 protein (ORF6), ORF7a protein (ORF7a), ORF7b (ORF7b), ORF8 protein (ORF8), nucleocapsid phosphoprotein (N), and ORF10 protein (ORF10) genes, complete cds
gi|2161117325|gb|OL746000.1|

Nucleotide

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