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Select item 107754221.

LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells

Hongjin Shi, Zhiyong Tan, Bowen Duan, Chunming Guo, Chong Li, Ting Luan, Ning Li, Yinglong Huang, Shi Chen, Jixian Gao, Wei Feng, Haole Xu, Jiansong Wang, Shi Fu, Haifeng Wang

BMC Med. 2024; 22: 19. Published online 2024 Jan 9. doi: 10.1186/s12916-023-03243-5

PMCID:: PMC10775422

Article PDF–7.3M

Select item 82772142.

Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study

Rebekah J Nicholson, Annelise M Poss, J Alan Maschek, James E Cox, Paul N Hopkins, Steven C Hunt, Mary C Playdon, William L Holland, Scott A Summers

J Clin Endocrinol Metab. 2021 Aug; 106(8): e3098–e3109. Published online 2021 Mar 11. doi: 10.1210/clinem/dgab155

PMCID:: PMC8277214

Article

Select item 82374073.

Ceramide synthase 2-C_24:1-ceramide axis limits the metastatic potential of ovarian cancer cells

Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E. Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A. Hannun, Takeshi Nabe, Kazuyuki Kitatani

FASEB J. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: FASEB J. 2021 Feb; 35(2): e21287. doi: 10.1096/fj.202001504RR

PMCID:: PMC8237407

Article PDF–1.1M

Select item 79491264.

Ceramide synthase 2 deletion decreases the infectivity of HIV-1

Eric Barklis, Ayna Alfadhli, Jennifer E. Kyle, Lisa M. Bramer, Kent J. Bloodsworth, Robin Lid Barklis, Hans C. Leier, R. Max Petty, Iris D. Zelnik, Thomas O. Metz, Anthony H. Futerman, Fikadu G. Tafesse

J Biol Chem. 2021 Jan-Jun; 296: 100340. Published online 2021 Jan 28. doi: 10.1016/j.jbc.2021.100340

PMCID:: PMC7949126

Article PDF–2.0M

Select item 78761505.

Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype

Trishna Pani, Kajal Rajput, Animesh Kar, Harsh Sharma, Rituparna Basak, Nihal Medatwal, Sandhini Saha, Gagan Dev, Sharwan Kumar, Siddhi Gupta, Arnab Mukhopadhyay, Dipankar Malakar, Tushar Kanti Maiti, Aneeshkumar G. Arimbasseri, S. V. S. Deo, Ravi Datta Sharma, Avinash Bajaj, Ujjaini Dasgupta

Cell Death Dis. 2021 Feb; 12(2): 171. Published online 2021 Feb 10. doi: 10.1038/s41419-021-03436-x

PMCID:: PMC7876150

Article PDF–3.0M

Select item 74412126.

肿瘤转移抑制基因LASS2/TMSG1 S248A突变体通过增加ATP6V0C表达促进前列腺癌的侵袭

张宽根, 周雨禾, 邵雅昆, 梅放, 由江峰, 刘北英, 裴斐

Beijing Da Xue Xue Bao Yi Xue Ban. 2019 Apr 18; 51(2): 210–220. Chinese. doi: 10.19723/j.issn.1671-167X.2019.02.003

PMCID:: PMC7441212

Article PDF–6.2M

Select item 67661337.

Evaluation of CERS2 Gene as a Potential Biomarker for Bladder Cancer

Ahmed Faris Aldoghachi, Aminuddin Baharudin, Umar Ahmad, Soon Choy Chan, Teng Aik Ong, Rosna Yunus, Azad Hassan Razack, Khatijah Yusoff, Abhi Veerakumarasivam

Dis Markers. 2019; 2019: 3875147. Published online 2019 Sep 15. doi: 10.1155/2019/3875147

PMCID:: PMC6766133

Article PDF–1.9M

Select item 65046598.

Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers

Qian Zhang, Jin-yan Wang, Wei Yan, Dan-dan Wang, Su-jin Yang, Si-ying Zhou, Shan-liang Zhong, Jin-hai Tang

Biosci Rep. 2019 May 31; 39(5): BSR20181743. Prepublished online 2019 Apr 15. Published online 2019 May 7. doi: 10.1042/BSR20181743

PMCID:: PMC6504659

Article PDF–478K

Select item 46036479.

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

Stefka D. Spassieva, Thomas D. Mullen, Danyelle M. Townsend, Lina M. Obeid

Biochem J. Author manuscript; available in PMC 2015 Oct 13.

Published in final edited form as: Biochem J. 2009 Dec 1; 424(2): 273–283. Published online 2009 Nov 11. doi: 10.1042/BJ20090699

PMCID:: PMC4603647

Article PDF–1.0M

Select item 439621010.

Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer

Yuan Zi, Wenjian Zhao, Jun Zhou, Hanjiang He, Ming Xie

Int J Clin Exp Pathol. 2015; 8(2): 1312–1320. Published online 2015 Feb 1.

PMCID:: PMC4396210

Article PDF–1.0M

Select item 1003454011.

LASS2/TMSG1过表达抑制人肺癌A549细胞增殖和促进A549细胞凋亡：基于上调神经酰胺和p38 MAPK进而启动级联信号传导通路

刘峥璐, 宣成睿, 韩希然, 郑泽泽, 肖瑞, 宝鲁日, 徐晓艳

Nan Fang Yi Ke Da Xue Xue Bao. 2023 Feb 20; 43(2): 166–174. Chinese. doi: 10.12122/j.issn.1673-4254.2023.02.02

PMCID:: PMC10034540

Article PDF–3.2M

Select item 570657712.

Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate‐induced colitis in mice due to increased intestinal permeability

Ye‐Ryung Kim, Giora Volpert, Kyong‐Oh Shin, So‐Yeon Kim, Sun‐Hye Shin, Younghay Lee, Sun Hee Sung, Yong‐Moon Lee, Jung‐Hyuck Ahn, Yael Pewzner‐Jung, Woo‐Jae Park, Anthony H. Futerman, Joo‐Won Park

J Cell Mol Med. 2017 Dec; 21(12): 3565–3578. Published online 2017 Jul 12. doi: 10.1111/jcmm.13267

PMCID:: PMC5706577

Article PDF–2.2M

Select item 500752513.

Co-expression of LASS2 and TGF-β1 predicts poor prognosis in hepatocellular carcinoma

Haoyu Ruan, Ting Wang, Chen Yang, Guangzhi Jin, Dishui Gu, Xuan Deng, Cun Wang, Wenxin Qin, Haojie Jin

Sci Rep. 2016; 6: 32421. Published online 2016 Sep 1. doi: 10.1038/srep32421

PMCID:: PMC5007525

Article PDF–1.2M

Select item 365389114.

Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models

Irina Petrache, Krzysztof Kamocki, Christophe Poirier, Yael Pewzner-Jung, Elad L. Laviad, Kelly S. Schweitzer, Mary Van Demark, Matthew J. Justice, Walter C. Hubbard, Anthony H. Futerman

PLoS One. 2013; 8(5): e62968. Published online 2013 May 14. doi: 10.1371/journal.pone.0062968

PMCID:: PMC3653891

Article PDF–2.3M

Select item 880419615.

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L. Kim, Jason S. Pierce, Besim Ogretmen, Anthony H. Futerman, Frank Thévenod

J Biol Chem. 2022 Feb; 298(2): 101492. Published online 2021 Dec 13. doi: 10.1016/j.jbc.2021.101492

PMCID:: PMC8804196

Article PDF–13M

Select item 434800516.

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

Judith Mesicek, Hyunmi Lee, Taya Feldman, Xuejun Jiang, Anastasia Skobeleva, Evgeny V. Berdyshev, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick

Cell Signal. Author manuscript; available in PMC 2015 Mar 3.

Published in final edited form as: Cell Signal. 2010 Sep; 22(9): 1300–1307. Published online 2010 Apr 18. doi: 10.1016/j.cellsig.2010.04.006