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Items: 1 to 20 of 68

1.
Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor
Andrea Piserchio, Eta A. Isiorho, Kevin N. Dalby, Ranajeet Ghose
J Biol Chem. 2023 Jun; 299(6): 104813. Published online 2023 May 11. doi: 10.1016/j.jbc.2023.104813
PMCID:
PMC10318512
AbstractArticlePDF–1.2M
2.
Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer’s disease
Tao Ma
J Neurochem. Author manuscript; available in PMC 2023 May 19.
Published in final edited form as: J Neurochem. 2023 Jul; 166(1): 47–57. Published online 2021 Nov 27. doi: 10.1111/jnc.15541
PMCID:
PMC9117558
AbstractArticlePDF–736K
3.
Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2
Rita Mateus-Seidl, Sebastian Stahl, Stefan Dengl, Fabian Birzele, Hedda Herrmuth, Klaus Mayer, Gerhard Niederfellner, Xiu-Fen Liu, Ira Pastan, Ulrich Brinkmann
Biol Chem. Author manuscript; available in PMC 2021 Jul 9.
Published in final edited form as: Biol Chem. 2019 Mar 26; 400(4): 501–512. doi: 10.1515/hsz-2018-0280
PMCID:
PMC8268772
AbstractArticlePDF–1.9M
4.
Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro
Pian Yu, Hai-yan Wang, Min Tian, Ao-xue Li, Xi-sha Chen, Xin-luan Wang, Yi Zhang, Yan Cheng
Acta Pharmacol Sin. 2019 Sep; 40(9): 1237–1244. Published online 2019 Mar 26. doi: 10.1038/s41401-019-0222-z
PMCID:
PMC6786479
AbstractArticlePDF–1.7M
5.
Solution Structure of the Carboxy-terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and its Role in Substrate Recognition
Andrea Piserchio, Nathan Will, David H. Giles, Fatlum Hajredini, Kevin N. Dalby, Ranajeet Ghose
J Mol Biol. Author manuscript; available in PMC 2020 Jul 12.
Published in final edited form as: J Mol Biol. 2019 Jul 12; 431(15): 2700–2717. Published online 2019 May 18. doi: 10.1016/j.jmb.2019.05.019
PMCID:
PMC6599559
AbstractArticlePDF–1.1M
6.
Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response
Michael B. Lazarus, Rebecca S. Levin, Kevan M. Shokat
Cell Signal. Author manuscript; available in PMC 2018 Jan 1.
Published in final edited form as: Cell Signal. 2017 Jan; 29: 78–83. Published online 2016 Oct 17. doi: 10.1016/j.cellsig.2016.10.006
PMCID:
PMC5138099
AbstractArticlePDF–1.0M
7.
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases
Rui Liu, Christopher G Proud
Acta Pharmacol Sin. 2016 Mar; 37(3): 285–294. Published online 2016 Jan 25. doi: 10.1038/aps.2015.123
PMCID:
PMC4775846
AbstractArticlePDF–1.3M
8.
Eukaryotic Elongation Factor 2 Kinase Activity Is Controlled by Multiple Inputs from Oncogenic Signaling
Xuemin Wang, Sergio Regufe da Mota, Rui Liu, Claire E. Moore, Jianling Xie, Francesco Lanucara, Usha Agarwala, Sébastien Pyr dit Ruys, Didier Vertommen, Mark H. Rider, Claire E. Eyers, Christopher G. Proud
Mol Cell Biol. 2014 Nov; 34(22): 4088–4103. doi: 10.1128/MCB.01035-14
PMCID:
PMC4248706
AbstractArticlePDF–3.1M
9.
The Molecular Mechanism of Eukaryotic Elongation Factor 2 Kinase Activation
Clint D. J. Tavares, Scarlett B. Ferguson, David H. Giles, Qiantao Wang, Rebecca M. Wellmann, John P. O'Brien, Mangalika Warthaka, Jennifer S. Brodbelt, Pengyu Ren, Kevin N. Dalby
J Biol Chem. 2014 Aug 22; 289(34): 23901–23916. Published online 2014 Jul 10. doi: 10.1074/jbc.M114.577148
PMCID:
PMC4156036
AbstractArticlePDF–3.0M
10.
A Conserved Loop in the Catalytic Domain of Eukaryotic Elongation Factor 2 Kinase Plays a Key Role in Its Substrate Specificity
Claire E. Moore, Sergio Regufe da Mota, Halina Mikolajek, Christopher G. Proud
Mol Cell Biol. 2014 Jun; 34(12): 2294–2307. doi: 10.1128/MCB.00388-14
PMCID:
PMC4054288
AbstractArticlePDF–3.0M
11.
Phosphorylation of elongation factor-2 kinase differentially regulates the enzyme’s stability under stress conditions
Kathryn J. Huber-Keener, Brad R. Evans, Xingcong Ren, Yan Cheng, Yi Zhang, William N. Hait, Jin-Ming Yang
Biochem Biophys Res Commun. Author manuscript; available in PMC 2013 Jul 27.
Published in final edited form as: Biochem Biophys Res Commun. 2012 Jul 27; 424(2): 308–314. Published online 2012 Jun 27. doi: 10.1016/j.bbrc.2012.06.112
PMCID:
PMC3614095
AbstractArticlePDF–1.4M
12.
Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells
Li Zhang, Yi Zhang, Xiao-yuan Liu, Zheng-hong Qin, Jin-ming Yang
Acta Pharmacol Sin. 2011 Mar; 32(3): 361–367. Published online 2011 Jan 31. doi: 10.1038/aps.2010.213
PMCID:
PMC3586188
AbstractArticlePDF–3.2M
13.
Calcium/Calmodulin Stimulates the Autophosphorylation of Elongation Factor 2 Kinase on Thr-348 and Ser-500 to Regulate its Activity and Calcium Dependence
Clint D. J. Tavares, John P. O’Brien, Olga Abramczyk, Ashwini K. Devkota, Kevin S. Shores, Scarlett B. Ferguson, Tamer S. Kaoud, Mangalika Warthaka, Kyle D. Marshall, Karin M. Keller, Yan Zhang, Jennifer S. Brodbelt, Bulent Ozpolat, Kevin N. Dalby
Biochemistry. Author manuscript; available in PMC 2013 Mar 20.
Published in final edited form as: Biochemistry. 2012 Mar 20; 51(11): 2232–2245. Published online 2012 Mar 6. doi: 10.1021/bi201788e
PMCID:
PMC3401519
AbstractArticlePDF–3.9M
14.
Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer
Ibrahim Tekedereli, S. Neslihan Alpay, Clint D. J. Tavares, Zehra E. Cobanoglu, Tamer S. Kaoud, Ibrahim Sahin, Anil K. Sood, Gabriel Lopez-Berestein, Kevin N. Dalby, Bulent Ozpolat
PLoS One. 2012; 7(7): e41171. Published online 2012 Jul 20. doi: 10.1371/journal.pone.0041171
PMCID:
PMC3401164
AbstractArticlePDF–1.3M
15.
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase
Sébastien Pyr Dit Ruys, Xuemin Wang, Ewan M. Smith, Gaëtan Herinckx, Nusrat Hussain, Mark H. Rider, Didier Vertommen, Christopher G. Proud
Biochem J. 2012 Mar 15; 442(Pt 3): 681–692. Prepublished online 2012 Jan 4. Published online 2012 Feb 24. doi: 10.1042/BJ20111530
Correction in:
Biochem J. 2012 Apr 1; 443(Pt 1): 328.
PMCID:
PMC3286862
AbstractArticlePDF–836K
16.
Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains
Craig R. Pigott, Halina Mikolajek, Claire E. Moore, Stephen J. Finn, Curtis W. Phippen, Jörn M. Werner, Christopher G. Proud
Biochem J. 2012 Feb 15; 442(Pt 1): 105–118. Prepublished online 2011 Nov 24. Published online 2012 Jan 27. doi: 10.1042/BJ20111536
PMCID:
PMC3268225
AbstractArticlePDF–1.1M
17.
Cytoprotective Effect of the Elongation Factor-2 Kinase-Mediated Autophagy in Breast Cancer Cells Subjected to Growth Factor Inhibition
Yan Cheng, Huaijun Li, Xingcong Ren, Tingkuang Niu, William N. Hait, Jinming Yang
PLoS One. 2010; 5(3): e9715. Published online 2010 Mar 16. doi: 10.1371/journal.pone.0009715
PMCID:
PMC2838786
AbstractArticlePDF–1.2M
18.
Immune Reactions Against Elongation Factor 2 Kinase: Specific Pathogenesis of Gastric Ulcer from Helicobacter pylori Infection
Kiyoshi Ayada, Kenji Yokota, Yoshiro Kawahara, Yumiko Yamamoto, Kazuyuki Hirai, Tomoki Inaba, Masahide Kita, Hiroyuki Okada, Kazuhide Yamamoto, Keiji Oguma
Clin Dev Immunol. 2009; 2009: 850623. Published online 2009 Jul 14. doi: 10.1155/2009/850623
PMCID:
PMC2712636
AbstractArticlePDF–665K
19.
eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma
Xisha Chen, Kuansong Wang, Shilong Jiang, Hongyin Sun, Xuanling Che, Minghui Zhang, Jiaying He, Ying Wen, Mengting Liao, Xiangling Li, Xiaoming Zhou, Jianxun Song, Xingcong Ren, Wenjun Yi, Jinming Yang, Xiang Chen, Mingzhu Yin, Yan Cheng
J Immunother Cancer. 2022; 10(3): e004026. Published online 2022 Mar 28. doi: 10.1136/jitc-2021-004026
PMCID:
PMC8961175
AbstractArticlePDF–4.1M
20.
Novel regulation of the eEF2K/eEF2 pathway: prospects of ‘PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation’
Yuqian Shen, Junhai Han, Zi Chao Zhang
J Mol Cell Biol. 2021 May; 13(5): 392–394. Published online 2021 Mar 18. doi: 10.1093/jmcb/mjab017
PMCID:
PMC8373267
ArticlePDF–170K

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