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Select item 79864611.

Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology

Vijay K. Ramanan, Timothy G. Lesnick, Scott A. Przybelski, Michael G. Heckman, David S. Knopman, Jonathan Graff-Radford, Val J. Lowe, Mary M. Machulda, Michelle M. Mielke, Clifford R. Jack, Jr., Ronald C. Petersen, Owen A. Ross, Prashanthi Vemuri, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Acta Neuropathol Commun. 2021; 9: 48. Published online 2021 Mar 23. doi: 10.1186/s40478-021-01154-1

PMCID:: PMC7986461

Abstract Article PDF–1.8M

Select item 71931742.

CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma

Chongren Ren, Xiaojing Ren, Dujuan Cao, Haichao Zhao, Zhensheng Zhai, Huiyu Li, Yanjun Li, Xifeng Fu, Jiefeng He, Haoliang Zhao

FEBS Open Bio. 2020 May; 10(5): 847–860. Published online 2020 Apr 2. doi: 10.1002/2211-5463.12836

PMCID:: PMC7193174

Abstract Article PDF–3.7M

Select item 57376583.

Alternative splicing of CNOT7 diversifies CCR4–NOT functions

Clément Chapat, Kamel Chettab, Pierre Simonet, Peng Wang, Pierre De La Grange, Muriel Le Romancer, Laura Corbo

Nucleic Acids Res. 2017 Aug 21; 45(14): 8508–8523. Published online 2017 Jun 7. doi: 10.1093/nar/gkx506

PMCID:: PMC5737658

Abstract Article PDF–7.1M

Select item 46562134.

Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach

Yuwei Bai, Shinya Tashiro, Satoru Nagatoishi, Toru Suzuki, Dongke Yan, Ruihua Liu, Kouhei Tsumoto, Mark Bartlam, Tadashi Yamamoto

Protein Cell. 2015 Dec; 6(12): 924–928. Published online 2015 Oct 30. doi: 10.1007/s13238-015-0225-6

PMCID:: PMC4656213

Article PDF–918K

Select item 45777315.

Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1

Gopal P. Jadhav, Ishwinder Kaur, Maryati Maryati, Blessing Airhihen, Peter M. Fischer, G. Sebastiaan Winkler

Bioorg Med Chem Lett. 2015 Oct 1; 25(19): 4219–4224. doi: 10.1016/j.bmcl.2015.07.095

PMCID:: PMC4577731

Abstract Article

Select item 39507236.

A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity

Maryati Maryati, Ishwinder Kaur, Gopal P. Jadhav, Loyin Olotu-Umoren, Blessing Oveh, Lubna Hashmi, Peter M. Fischer, G. Sebastiaan Winkler

Nucleic Acids Res. 2014 Mar; 42(5): e30. Published online 2013 Oct 28. doi: 10.1093/nar/gkt972

PMCID:: PMC3950723

Abstract Article PDF–4.0M

Select item 38702827.

Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex

G. Sebastiaan Winkler, Dario L. Balacco

Front Genet. 2013; 4: 296. Published online 2013 Dec 23. doi: 10.3389/fgene.2013.00296

PMCID:: PMC3870282

Abstract Article PDF–2.3M

Select item 34763038.

Human Pumilio Proteins Recruit Multiple Deadenylases to Efficiently Repress Messenger RNAs

Jamie Van Etten, Trista L. Schagat, Joel Hrit, Chase A. Weidmann, Justin Brumbaugh, Joshua J. Coon, Aaron C. Goldstrohm

J Biol Chem. 2012 Oct 19; 287(43): 36370–36383. Published online 2012 Sep 6. doi: 10.1074/jbc.M112.373522

PMCID:: PMC3476303

Abstract Article PDF–1.4M

Select item 82164649.

Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex

Ying Chen, Elena Khazina, Elisa Izaurralde, Oliver Weichenrieder

Nucleic Acids Res. 2021 Jun 21; 49(11): 6489–6510. Published online 2021 May 26. doi: 10.1093/nar/gkab414

PMCID:: PMC8216464

Abstract Article PDF–3.6M

Select item 733266610.

Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility

Wei Zheng, Zhou Zhou, Qianqian Sha, Xiangli Niu, Xiaoxi Sun, Juanzi Shi, Lei Zhao, Shuoping Zhang, Jing Dai, Sufen Cai, Fei Meng, Liang Hu, Fei Gong, Xiaoran Li, Jing Fu, Rong Shi, Guangxiu Lu, Biaobang Chen, Hengyu Fan, Lei Wang, Ge Lin, Qing Sang

Am J Hum Genet. 2020 Jul 2; 107(1): 24–33. Published online 2020 Jun 4. doi: 10.1016/j.ajhg.2020.05.010

PMCID:: PMC7332666

Abstract Article PDF–1.5M

Select item 673604311.

DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity

Hedda A Meijer, Tobias Schmidt, Sarah L Gillen, Claudia Langlais, Rebekah Jukes-Jones, Cornelia H de Moor, Kelvin Cain, Ania Wilczynska, Martin Bushell

Nucleic Acids Res. 2019 Sep 5; 47(15): 8224–8238. Published online 2019 Jun 10. doi: 10.1093/nar/gkz509

PMCID:: PMC6736043

Abstract Article PDF–4.6M

Select item 644399612.

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg²⁺‐dependent binding

Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler

FEBS Open Bio. 2019 Apr; 9(4): 717–727. Published online 2019 Mar 7. doi: 10.1002/2211-5463.12605

PMCID:: PMC6443996

Abstract Article PDF–903K

Select item 448883413.

Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA

Meng Shen, Meng-Yao Wu, Long-Pei Chen, Qiaoming Zhi, Fei-Ran Gong, Kai Chen, Dao-Ming Li, Yadi Wu, Min Tao, Wei Li

Sci Rep. 2015; 5: 11836. Published online 2015 Jul 2. doi: 10.1038/srep11836

Correction in:: Sci Rep. 2021; 11: 5063.

PMCID:: PMC4488834

Abstract Article PDF–2.2M

Select item 234410914.

Crystallization and preliminary crystallographic analysis of the Tob–hCaf1 complex

Kinya Nishida, Masataka Horiuchi, Nobuo N. Noda, Kiyohiro Takahasi, Norimasa Iwasaki, Akio Minami, Fuyuhiko Inagaki

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1; 63(Pt 12): 1061–1063. Published online 2007 Nov 30. doi: 10.1107/S1744309107057466

PMCID:: PMC2344109

Abstract Article PDF–193K

Select item 463560915.

Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression

Panagiotis Maragozidis, Eirini Papanastasi, Diana Scutelnic, Athina Totomi, Ioanna Kokkori, Sotirios G. Zarogiannis, Theodora Kerenidi, Konstantinos I. Gourgoulianis, Nikolaos A. A. Balatsos

Mol Cancer. 2015; 14: 187. Published online 2015 Nov 5. doi: 10.1186/s12943-015-0457-3