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Select item 109791011.

The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain

Mariana Di Felice, Livia Pagano, Valeria Pennacchietti, Awa Diop, Paola Pietrangeli, Lucia Marcocci, Sara Di Matteo, Francesca Malagrinò, Angelo Toto, Stefano Gianni

J Biol Chem. 2024 Apr; 300(4): 107129. Published online 2024 Mar 1. doi: 10.1016/j.jbc.2024.107129

PMCID:: PMC10979101

Abstract Article PDF–1.8M

Select item 79526952.

A new bioinformatics approach identifies overexpression of GRB2 as a poor prognostic biomarker for prostate cancer

Teppei Iwata, Anna S. Sedukhina, Manabu Kubota, Shigeko Oonuma, Ichiro Maeda, Miki Yoshiike, Wataru Usuba, Kimino Minagawa, Eleina Hames, Rei Meguro, Sunny Cho, Stephen H. H. Chien, Shiro Urabe, Sookhee Pae, Kishore Palanisamy, Toshio Kumai, Kazuo Yudo, Eiji Kikuchi, Ko Sato

Sci Rep. 2021; 11: 5696. Published online 2021 Mar 11. doi: 10.1038/s41598-021-85086-9

PMCID:: PMC7952695

Abstract Article PDF–1.0M

Select item 66371483.

Evaluation of genetic susceptibility between systemic lupus erythematosus and GRB2 gene

Meifeng Xu, Yan Liu, Xiaoli Li, Chuantao Cheng, Yale Liu, Wei Dong, Shaoyi Du, Shengxiang Xiao

Sci Rep. 2019; 9: 10335. Published online 2019 Jul 17. doi: 10.1038/s41598-019-46827-z

PMCID:: PMC6637148

Abstract Article PDF–1.3M

Select item 59801544.

Integrated transcriptomic and proteomic analyses reveal ɑ‐lipoic acid‐regulated cell proliferation via Grb2‐mediated signalling in hepatic cancer cells

Lan Yang, Xiliang Wang, Juan Xu, Ya Wen, Manqiao Zhang, Jingxiao Lu, Rongfu Wang, Xiaojuan Sun

J Cell Mol Med. 2018 Jun; 22(6): 2981–2992. Published online 2018 Mar 25. doi: 10.1111/jcmm.13447

PMCID:: PMC5980154

Abstract Article PDF–1.0M

Select item 48154105.

Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide

Danai Papaioannou, Sebastian Geibel, Micha B. A. Kunze, Christopher W. M. Kay, Gabriel Waksman

Protein Sci. 2016 Mar; 25(3): 627–637. Published online 2015 Dec 29. doi: 10.1002/pro.2856

PMCID:: PMC4815410

Abstract Article PDF–1.2M

Select item 45583426.

Regions Outside of Conserved PxxPxR Motifs Drive the High Affinity Interaction of GRB2 with SH3 Domain Ligands

Rebekah R. Bartelt, Jonathan Light, Aldo Vacaflores, Alayna Butcher, Madhana Pandian, Piers Nash, Jon C.D. Houtman

Biochim Biophys Acta. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Biochim Biophys Acta. 2015 Oct; 1853(10 0 0): 2560–2569. Published online 2015 Jun 12. doi: 10.1016/j.bbamcr.2015.06.002

PMCID:: PMC4558342

Abstract Article PDF–4.1M

Select item 40972507.

Overexpression of GRB2 is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma

Li-Yan Li, En-Min Li, Zhi-Yong Wu, Hui-Hui Cao, Jin-Hui Shen, Xiu-E Xu, Bo Chen, Jian-Yi Wu, Li-Yan Xu

Int J Clin Exp Pathol. 2014; 7(6): 3132–3140. Published online 2014 May 15.

PMCID:: PMC4097250

Abstract Article PDF–1.6M

Select item 36948908.

A Novel Phosphopeptide Microarray Based Interactome Map in Breast Cancer Cells Reveals Phosphoprotein-GRB2 Cell Signaling Networks

Srinivasan Krishnamoorthy, Zhonghua Liu, Ailing Hong, Ruijuan Zhu, Haosi Chen, Tongbin Li, Xiaochuan Zhou, Xiaolian Gao

PLoS One. 2013; 8(6): e67634. Published online 2013 Jun 27. doi: 10.1371/journal.pone.0067634

Correction in:: PLoS One. 2013; 8(9): 10.1371/annotation/a05f0793-f1af-409d-984e-79444877aec3.

PMCID:: PMC3694890

Abstract Article PDF–2.1M

Select item 36683409.

Grb2, a Double-Edged Sword of Receptor Tyrosine Kinase Signaling

Artur A. Belov, Moosa Mohammadi

Sci Signal. Author manuscript; available in PMC 2013 May 31.

Published in final edited form as: Sci Signal. 2012 Nov 6; 5(249): pe49. Published online 2012 Nov 6. doi: 10.1126/scisignal.2003576

PMCID:: PMC3668340

Abstract Article PDF–687K

Select item 357554410.

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

Zamal Ahmed, Chi-Chuan Lin, Kin M. Suen, Fernando A. Melo, James A Levitt, Klaus Suhling, John E. Ladbury

J Cell Biol. 2013 Feb 18; 200(4): 493–504. doi: 10.1083/jcb.201204106

PMCID:: PMC3575544

Abstract Article PDF–2.4M

Select item 303172211.

Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample

Jingchun Sun, Chunling Wan, Peilin Jia, Ayman H. Fanous, Kenneth S. Kendler, Brien P. Riley, Zhongming Zhao

Schizophr Res. Author manuscript; available in PMC 2012 Feb 1.

Published in final edited form as: Schizophr Res. 2011 Feb; 125(2-3): 201–208. Published online 2010 Dec 30. doi: 10.1016/j.schres.2010.12.002

PMCID:: PMC3031722

Abstract Article PDF–742K

Select item 194794512.

Structural and Energetic Aspects of Grb2-SH2 Domain-Swapping

Aaron P. Benfield, Benjamin B. Whiddon, John H. Clements, Stephen F. Martin

Arch Biochem Biophys. Author manuscript; available in PMC 2008 Jun 1.

Published in final edited form as: Arch Biochem Biophys. 2007 Jun 1; 462(1): 47–53. Published online 2007 Apr 2. doi: 10.1016/j.abb.2007.03.010

PMCID:: PMC1947945

Abstract Article PDF–644K

Select item 1077034113.

GRB2 is a BECN1 interacting protein that regulates autophagy

Jetsy Montero-Vergara, Kira Plachetta, Lisa Kinch, Stephan Bernhardt, Kriti Kashyap, Beth Levine, Lipi Thukral, Martina Vetter, Christoph Thomssen, Stefan Wiemann, Samuel Peña-Llopis, Verena Jendrossek, Silvia Vega-Rubin-de-Celis

Cell Death Dis. 2024 Jan; 15(1): 14. Published online 2024 Jan 5. doi: 10.1038/s41419-023-06387-7

PMCID:: PMC10770341

Abstract Article PDF–3.2M

Select item 1046404814.

RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma

Jie Zhou, Daoyuan Tu, Rui Peng, Yuhong Tang, Qiangwei Deng, Bingbing Su, Shunyi Wang, Hao Tang, Shengjie Jin, Guoqing Jiang, Qian Wang, Xin Jin, Chi Zhang, Jun Cao, Dousheng Bai

Cell Commun Signal. 2023; 21: 224. Published online 2023 Aug 25. doi: 10.1186/s12964-023-01241-x

PMCID:: PMC10464048

Abstract Article PDF–14M

Select item 801684415.

Grb2 binding induces phosphorylation-independent activation of Shp2

Chi-Chuan Lin, Lukasz Wieteska, Kin Man Suen, Arnout P. Kalverda, Zamal Ahmed, John E. Ladbury

Commun Biol. 2021; 4: 437. Published online 2021 Apr 1. doi: 10.1038/s42003-021-01969-7

PMCID:: PMC8016844

Abstract Article PDF–2.1M

Select item 786281316.

Loss of GRB2 associated binding protein 1 in arteriosclerosis obliterans promotes host autophagy

Meng Ye, Xiang-Jiang Guo, Ke-Jia Kan, Qi-Hong Ni, Jia-Quan Chen, Han Wang, Xin Qian, Guan-Hua Xue, Hao-Yu Deng, Lan Zhang

Chin Med J (Engl) 2021 Jan 5; 134(1): 73–80. Published online 2020 Dec 8. doi: 10.1097/CM9.0000000000001255

PMCID:: PMC7862813

Abstract Article PDF–996K

Select item 769516717.

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2

Francesca Malagrinò, Antonio Coluccia, Marianna Bufano, Giuseppe La Regina, Michela Puxeddu, Angelo Toto, Lorenzo Visconti, Alessio Paone, Maria Chiara Magnifico, Francesca Troilo, Francesca Cutruzzolà, Romano Silvestri, Stefano Gianni

Cells. 2020 Nov; 9(11): 2435. Published online 2020 Nov 7. doi: 10.3390/cells9112435