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Select item 97281431.

Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics

Jian Yang, John E. Hall, Pedro A. Jose, Ken Chen, Chunyu Zeng

Pharmacol Ther. Author manuscript; available in PMC 2022 Dec 7.

Published in final edited form as: Pharmacol Ther. 2022 Nov; 239: 108194. Published online 2022 Apr 27. doi: 10.1016/j.pharmthera.2022.108194

PMCID:: PMC9728143

Abstract Article PDF–591K

Select item 85651802.

Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients

Nian Cao, Hui Tang, Miao Tian, Xue Gong, Zaicheng Xu, Binqing Zhou, Cong Lan, Caiyu Chen, Shuang Qu, Shuo Zheng, Hongmei Ren, Chao Fan, Pedro A. Jose, Chunyu Zeng, Tianyang Xia

Clin Exp Hypertens. Author manuscript; available in PMC 2022 Apr 3.

Published in final edited form as: Clin Exp Hypertens. 2021 Oct 3; 43(7): 597–603. Published online 2021 Apr 25. doi: 10.1080/10641963.2021.1919357

PMCID:: PMC8565180

Abstract Article PDF–858K

Select item 80262793.

The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction

Liangpeng Li, Wenbin Fu, Xue Gong, Zhi Chen, Luxun Tang, Dezhong Yang, Qiao Liao, Xuewei Xia, Hao Wu, Chao Liu, Miao Tian, Andi Zeng, Lin Zhou, Pedro A Jose, Ken Chen, Wei Eric Wang, Chunyu Zeng

Eur Heart J. 2021 Apr 7; 42(14): 1415–1430. Published online 2020 Dec 6. doi: 10.1093/eurheartj/ehaa878

PMCID:: PMC8026279

Abstract Article PDF–1.7M

Select item 79104204.

Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension

Jian Yang, Van Anthony M. Villar, Pedro A. Jose, Chunyu Zeng

Antioxid Redox Signal. March 2021; 34(9): 716–735. Published online 2021 Feb 24. doi: 10.1089/ars.2020.8106

PMCID:: PMC7910420

Abstract Article PDF–619K

Select item 63505095.

G Protein-Coupled Receptor Kinase 4: Role in Hypertension

Jian Yang, Van Anthony M. Villar, John E. Jones, Pedro A. Jose, Chunyu Zeng

Hypertension. Author manuscript; available in PMC 2019 Jan 29.

Published in final edited form as: Hypertension. 2015 Jun; 65(6): 1148–1155. Published online 2015 Apr 13. doi: 10.1161/HYPERTENSIONAHA.115.05189

PMCID:: PMC6350509

Article PDF–511K

Select item 59443526.

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling

Pingping Xiao, Xishi Huang, Lanzhen Huang, Jing Yang, Ang Li, Ke Shen, Philip B. Wedegaertner, Xiaoshan Jiang

Exp Cell Res. Author manuscript; available in PMC 2018 Nov 15.

Published in final edited form as: Exp Cell Res. 2017 Nov 15; 360(2): 273–280. Published online 2017 Sep 11. doi: 10.1016/j.yexcr.2017.09.017

PMCID:: PMC5944352

Abstract Article PDF–945K

Select item 45594907.

Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade

Hironobu Sanada, Minoru Yoneda, Junichi Yatabe, Scott M. Williams, Jacquelaine Bartlett, Marquitta J. White, Lindsay N. Gordon, Robin A Felder, Gilbert M. Eisner, Ines Armando, Pedro A. Jose

Pharmacogenomics J. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Pharmacogenomics J. 2016 Feb; 16(1): 3–9. Published online 2015 Mar 3. doi: 10.1038/tpj.2015.6

PMCID:: PMC4559490

Abstract Article PDF–316K

Select item 45364428.

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4

Samantha J. Allen, Gopal Parthasarathy, Paul L. Darke, Ronald E. Diehl, Rachael E. Ford, Dawn L. Hall, Scott A. Johnson, John C. Reid, Keith W. Rickert, Jennifer M. Shipman, Stephen M. Soisson, Paul Zuck, Sanjeev K. Munshi, Kevin J. Lumb

J Biol Chem. 2015 Aug 14; 290(33): 20360–20373. Published online 2015 Jul 1. doi: 10.1074/jbc.M115.648907

PMCID:: PMC4536442

Abstract Article PDF–6.0M

Select item 28926329.

Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation

Pedro A. Jose, Patricio Soares-da-Silva, Gilbert M. Eisner, Robin A. Felder

Biochim Biophys Acta. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Biochim Biophys Acta. 2010 Dec; 1802(12): 1259–1267. Published online 2010 Feb 12. doi: 10.1016/j.bbadis.2010.02.004

PMCID:: PMC2892632

Abstract Article PDF–103K

Select item 271583710.

G-Protein-Coupled Receptor Kinase 4 Polymorphisms and Blood Pressure Response to Metoprolol Among African Americans: Sex-Specificity and Interactions

Vibha Bhatnagar, Daniel T. O’Connor, Victoria H. Brophy, Nicholas J. Schork, Erin Richard, Rany M. Salem, Caroline M. Nievergelt, George L. Bakris, John P. Middleton, Keith C. Norris, Jackson Wright, Leena Hiremath, Gabriel Contreras, Lawrence J. Appel, Michael S. Lipkowitz

Am J Hypertens. Author manuscript; available in PMC 2009 Jul 26.

Published in final edited form as: Am J Hypertens. 2009 Mar; 22(3): 332–338. Published online 2009 Jan 1. doi: 10.1038/ajh.2008.341

PMCID:: PMC2715837

Abstract Article PDF–1.0M

Select item 271382311.

Promoting regulatory gene variation in sodium reabsorption

Peter A. Doris

Hypertension. Author manuscript; available in PMC 2009 Jul 22.

Published in final edited form as: Hypertension. 2008 Oct; 52(4): 623–624. Published online 2008 Aug 18. doi: 10.1161/HYPERTENSIONAHA.108.116145

Correction in:: volume 52 on page e140

PMCID:: PMC2713823

Article PDF–22K

Select item 226506912.

G protein-coupled receptor kinase 4γ interacts with inactive Gα_s and Gα₁₃

Lindsay B. Keever, John E. Jones, Bradley T. Andresen

Biochem Biophys Res Commun. Author manuscript; available in PMC 2009 Mar 14.

Published in final edited form as: Biochem Biophys Res Commun. 2008 Mar 14; 367(3): 649–655. Published online 2008 Jan 9. doi: 10.1016/j.bbrc.2007.12.181

PMCID:: PMC2265069

Abstract Article PDF–1.5M

Select item 16905613.

Phosphorylation-independent desensitization of GABA_B receptor by GRK4

Julie Perroy, Lynda Adam, Riad Qanbar, Sébastien Chénier, Michel Bouvier

EMBO J. 2003 Aug 1; 22(15): 3816–3824. doi: 10.1093/emboj/cdg383

PMCID:: PMC169056

Abstract Article PDF–334K

Select item 830162114.

Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang

Wenxi Jiang, Xizi Wang, Ronghui Li, Panpan Wang, Guangle Shan, Xiaodong Jia, Mingliang Gu

PLoS One. 2021; 16(7): e0255311. Published online 2021 Jul 23. doi: 10.1371/journal.pone.0255311

PMCID:: PMC8301621

Abstract Article PDF–1.3M

Select item 471326215.

HUMAN GRK4γ^142V VARIANT PROMOTES AT₁R-MEDIATED HYPERTENSION VIA RENAL HDAC1 INHIBITION

Zheng Wang, Chunyu Zeng, Van Anthony M. Villar, Shi-You Chen, Prasad Konkalmatt, Xiaoyan Wang, Laureano D. Asico, John E. Jones, Yu Yang, Hironobu Sanada, Robin A. Felder, Gilbert M. Eisner, Matthew R. Weir, Ines Armando, Pedro A. Jose

Hypertension. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Hypertension. 2016 Feb; 67(2): 325–334. Published online 2015 Dec 14. doi: 10.1161/HYPERTENSIONAHA.115.05962

PMCID:: PMC4713262

Abstract Article PDF–3.1M

Select item 469467316.

Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

He Zhang, Zhao-qing Sun, Shuang-shuang Liu, Li-na Yang

Clin Interv Aging. 2016; 11: 17–27. Published online 2015 Dec 23. doi: 10.2147/CIA.S94510

PMCID:: PMC4694673

Abstract Article PDF–792K

Select item 435895517.

Gender-Based Differences on the Association between Salt-Sensitive Genes and Obesity in Korean Children Aged between 8 and 9 Years

Myoungsook Lee, Mi Kyung Kim, Seon-Mee Kim, Hyesoon Park, Chang gyu Park, Hye Kyung Park

PLoS One. 2015; 10(3): e0120111. Published online 2015 Mar 13. doi: 10.1371/journal.pone.0120111

PMCID:: PMC4358955

Abstract Article PDF–321K

Select item 336043118.

Pooled Analyses of the Associations of Polymorphisms in the GRK4 and EMILIN1 Genes with Hypertension Risk

Chibo Liu, Bo Xi

Int J Med Sci. 2012; 9(4): 274–279. Published online 2012 May 24. doi: 10.7150/ijms.4171

PMCID:: PMC3360431

Abstract Article PDF–562K

Select item 275586719.

G Protein-coupled Receptor Kinase 4 (GRK4) Regulates the Phosphorylation and Function of the Dopamine D₃ Receptor

Van Anthony M. Villar, John E. Jones, Ines Armando, Cynthia Palmes-Saloma, Peiying Yu, Annabelle M. Pascua, Lindsay Keever, Francis B. Arnaldo, Zheng Wang, Yingjin Luo, Robin A. Felder, Pedro A. Jose

J Biol Chem. 2009 Aug 7; 284(32): 21425–21434. Published online 2009 Jun 11. doi: 10.1074/jbc.M109.003665

PMCID:: PMC2755867

Abstract Article PDF–1.8M

Select item 704505820.

Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing

EITAN FRIEDMAN, DANIEL S. MORAN, DANNY BEN-AVRAHAM, RAN YANOVICH, GIL ATZMON

Genet Res (Camb) 2014; 96: e004. Published online 2014 May 28. doi: 10.1017/S001667231400007X

PMCID:: PMC7045058

Abstract Article PDF–424K

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PMC Links for Gene (Select 2868) (41)
PMC
PREDICTED: Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript v...
PREDICTED: Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant X6, mRNA
gi|2217350327|ref|XM_011513450.3|

Nucleotide
Homo sapiens basic helix-loop-helix ARNT like 1 (BMAL1), transcript variant 12, ...
Homo sapiens basic helix-loop-helix ARNT like 1 (BMAL1), transcript variant 12, mRNA
gi|1890341941|ref|NM_001351819.2|

Nucleotide
AU146809 HEMBB1 Homo sapiens cDNA clone HEMBB1001564 3', mRNA sequence
AU146809 HEMBB1 Homo sapiens cDNA clone HEMBB1001564 3', mRNA sequence
gi|11008330|gnl|dbEST|6575824|dbj|A 09.1|

Nucleotide
PREDICTED: Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript v...
PREDICTED: Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant X5, mRNA
gi|2462596722|ref|XM_054349797.1|

Nucleotide

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