PMC Links for Gene (Select 285016) - PMC

Select item 89621791.

The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer

Martina Mazzeschi, Michela Sgarzi, Donatella Romaniello, Valerio Gelfo, Carola Cavallo, Francesca Ambrosi, Alessandra Morselli, Carmen Miano, Noemi Laprovitera, Cinzia Girone, Manuela Ferracin, Spartaco Santi, Karim Rihawi, Andrea Ardizzoni, Michelangelo Fiorentino, Gabriele D’Uva, Balázs Győrffy, Ruth Palmer, Mattia Lauriola

J Exp Clin Cancer Res. 2022; 41: 113. Published online 2022 Mar 29. doi: 10.1186/s13046-022-02309-1

PMCID:: PMC8962179

Article PDF–8.7M

Select item 78492942.

ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation

Marcus Borenäs, Ganesh Umapathy, Wei‐Yun Lai, Dan E Lind, Barbara Witek, Jikui Guan, Patricia Mendoza‐Garcia, Tafheem Masudi, Arne Claeys, Tzu‐Po Chuang, Abeer El Wakil, Badrul Arefin, Susanne Fransson, Jan Koster, Mathias Johansson, Jennie Gaarder, Jimmy Van den Eynden, Bengt Hallberg, Ruth H Palmer

EMBO J. 2021 Feb 1; 40(3): e105784. Published online 2021 Jan 7. doi: 10.15252/embj.2020105784

PMCID:: PMC7849294

Article PDF–3.1M

Select item 86397973.

Mechanism for the activation of the anaplastic lymphoma kinase receptor

Andrey V. Reshetnyak, Paolo Rossi, Alexander G. Myasnikov, Munia Sowaileh, Jyotidarsini Mohanty, Amanda Nourse, Darcie J. Miller, Irit Lax, Joseph Schlessinger, Charalampos G. Kalodimos

Nature. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Nature. 2021 Dec; 600(7887): 153–157. Published online 2021 Nov 24. doi: 10.1038/s41586-021-04140-8

PMCID:: PMC8639797

Article PDF–4.8M

Select item 60998724.

Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α)

Andrey V. Reshetnyak, Jyotidarsini Mohanty, Francisco Tomé, David E. Puleo, Alexander N. Plotnikov, Mansoor Ahmed, Navjot Kaur, Anton Poliakov, Arul M. Cinnaiyan, Irit Lax, Joseph Schlessinger

Proc Natl Acad Sci U S A. 2018 Aug 14; 115(33): 8340–8345. Published online 2018 Jul 30. doi: 10.1073/pnas.1807881115

PMCID:: PMC6099872

Article PDF–975K

Select item 93439675.

Structural basis of cytokine-mediated activation of ALK family receptors

Steven De Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J. Fernando Bazan, Akihide Yoshimi, Savvas N. Savvides

Nature. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Nature. 2021 Dec; 600(7887): 143–147. Published online 2021 Oct 13. doi: 10.1038/s41586-021-03959-5

PMCID:: PMC9343967

Article PDF–7.8M

Select item 47029556.

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand–receptor interactions

Andrey V. Reshetnyak, Phillip B. Murray, Xiarong Shi, Elizabeth S. Mo, Jyotidarsini Mohanty, Francisco Tome, Hanwen Bai, Murat Gunel, Irit Lax, Joseph Schlessinger

Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52): 15862–15867. Published online 2015 Nov 16. doi: 10.1073/pnas.1520099112

PMCID:: PMC4702955

Article PDF–1.2M

Select item 42261057.

Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome

Hongbing Zhang, Lily I. Pao, Aileen Zhou, Arthur D. Brace, Robert Halenbeck, Amy W. Hsu, Thomas L. Bray, Kevin Hestir, Elizabeth Bosch, Ernestine Lee, Gang Wang, Haixia Liu, Brian R. Wong, W. Michael Kavanaugh, Lewis T. Williams

Proc Natl Acad Sci U S A. 2014 Nov 4; 111(44): 15741–15745. Published online 2014 Oct 20. doi: 10.1073/pnas.1412009111

PMCID:: PMC4226105

Article PDF–996K

Select item 46581948.

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase

Jikui Guan, Ganesh Umapathy, Yasuo Yamazaki, Georg Wolfstetter, Patricia Mendoza, Kathrin Pfeifer, Ateequrrahman Mohammed, Fredrik Hugosson, Hongbing Zhang, Amy W Hsu, Robert Halenbeck, Bengt Hallberg, Ruth H Palmer

eLife. 2015; 4: e09811. Published online 2015 Sep 29. doi: 10.7554/eLife.09811

PMCID:: PMC4658194

Article PDF–3.8M

Select item 57899569.

ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells

Andrey Fadeev, Patricia Mendoza-Garcia, Uwe Irion, Jikui Guan, Kathrin Pfeifer, Stephanie Wiessner, Fabrizio Serluca, Ajeet Pratap Singh, Christiane Nüsslein-Volhard, Ruth H. Palmer

Proc Natl Acad Sci U S A. 2018 Jan 23; 115(4): E630–E638. Published online 2018 Jan 9. doi: 10.1073/pnas.1719137115

PMCID:: PMC5789956

Article PDF–2.1M

Select item 40369710.

The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment

Hilary F. Clark, Austin L. Gurney, Evangeline Abaya, Kevin Baker, Daryl Baldwin, Jennifer Brush, Jian Chen, Bernard Chow, Clarissa Chui, Craig Crowley, Bridget Currell, Bethanne Deuel, Patrick Dowd, Dan Eaton, Jessica Foster, Christopher Grimaldi, Qimin Gu, Philip E. Hass, Sherry Heldens, Arthur Huang, Hok Seon Kim, Laura Klimowski, Yisheng Jin, Stephanie Johnson, James Lee, Lhney Lewis, Dongzhou Liao, Melanie Mark, Edward Robbie, Celina Sanchez, Jill Schoenfeld, Somasekar Seshagiri, Laura Simmons, Jennifer Singh, Victoria Smith, Jeremy Stinson, Alicia Vagts, Richard Vandlen, Colin Watanabe, David Wieand, Kathryn Woods, Ming-Hong Xie, Daniel Yansura, Sothy Yi, Guoying Yu, Jean Yuan, Min Zhang, Zemin Zhang, Audrey Goddard, William I. Wood, Paul Godowski

Genome Res. 2003 Oct; 13(10): 2265–2270. doi: 10.1101/gr.1293003

Correction in:: Genome Res. 2003 Dec; 13(12): 2759.

PMCID:: PMC403697

Article PDF–120K

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Article PDF–2.2M

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Article PDF–1.0M

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