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Select item 33517931.

Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamn D₃ and is required for optimal cell differentiation

Xuening Wang, Tian-Tian Wang, John H. White, George P. Studzinski

Exp Cell Res. Author manuscript; available in PMC 2012 May 15.

Published in final edited form as: Exp Cell Res. 2007 Aug 15; 313(14): 3034–3045. Published online 2007 May 31. doi: 10.1016/j.yexcr.2007.05.021

PMCID:: PMC3351793

Abstract Article PDF–2.8M

Select item 75480072.

Splicing factor SF3B1 promotes endometrial cancer progression via regulating KSR2 RNA maturation

Pooja Popli, Megan M. Richters, Sangappa B. Chadchan, Tae Hoon Kim, Eric Tycksen, Obi Griffith, Premal H. Thaker, Malachi Griffith, Ramakrishna Kommagani

Cell Death Dis. 2020 Oct; 11(10): 842. Published online 2020 Oct 10. doi: 10.1038/s41419-020-03055-y

PMCID:: PMC7548007

Abstract Article PDF–3.2M

Select item 38987403.

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

Laura R. Pearce, Neli Atanassova, Matthew C. Banton, Bill Bottomley, Agatha A. van der Klaauw, Jean-Pierre Revelli, Audrey Hendricks, Julia M. Keogh, Elana Henning, Deon Doree, Sabrina Jeter-Jones, Sumedha Garg, Elena G. Bochukova, Rebecca Bounds, Sofie Ashford, Emma Gayton, Peter C. Hindmarsh, Julian P.H. Shield, Elizabeth Crowne, David Barford, Nick J. Wareham, UK10K consortium, Stephen O’Rahilly, Michael P. Murphy, David R. Powell, Ines Barroso, I. Sadaf Farooqi

Cell. 2013 Nov 7; 155(4): 765–777. doi: 10.1016/j.cell.2013.09.058

PMCID:: PMC3898740

Abstract Article PDF–2.1M

Select item 78944584.

MiR-3138 deteriorates the insulin resistance of HUVECs via KSR2/AMPK/GLUT4 signaling pathway

Yan Chen, Da Lin, Changxuan Shi, Liang Guo, Linhua Liu, Lin Chen, Ting Li, Ying Liu, Chengchao Zheng, Xintong Chi, Chun Meng, Yaoming Xue

Cell Cycle. 2021; 20(4): 353–368. Published online 2021 Jan 28. doi: 10.1080/15384101.2020.1870335

PMCID:: PMC7894458

Abstract Article PDF–3.2M

Select item 34401845.

Oncoprotein Cot1 Represses Kinase Suppressors of Ras1/2 and 1,25-Dihydroxyvitamin D₃-Induced Differentiation of Human Acute Myeloid Leukemia Cells

XUENING WANG, GEORGE P. STUDZINSKI

J Cell Physiol. Author manuscript; available in PMC 2012 Sep 12.

Published in final edited form as: J Cell Physiol. 2011 May; 226(5): 1232–1240. doi: 10.1002/jcp.22449

PMCID:: PMC3440184

Abstract Article PDF–2.3M

Select item 52799126.

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis

Lili Guo, Diane L. Costanzo-Garvey, Deandra R. Smith, Beth K. Neilsen, Richard G. MacDonald, Robert E. Lewis

Mol Metab. 2017 Feb; 6(2): 194–205. Published online 2016 Dec 18. doi: 10.1016/j.molmet.2016.12.004

PMCID:: PMC5279912

Abstract Article PDF–3.8M

Select item 40385037.

The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE)

E. Giurisato, A. Gamberucci, C. Ulivieri, S. Marruganti, E. Rossi, E. Giacomello, D. Randazzo, V. Sorrentino

Mol Biol Cell. 2014 Jun 1; 25(11): 1769–1781. doi: 10.1091/mbc.E13-05-0292

PMCID:: PMC4038503

Abstract Article PDF–5.2M

Select item 26575648.

Genome-wide Association Study of Biochemical Traits in Korčula Island, Croatia

Tatijana Zemunik, Mladen Boban, Gordan Lauc, Stipan Janković, Krešimir Rotim, Zoran Vatavuk, Goran Benčić, Zoran Đogaš, Vesna Boraska, Vesela Torlak, Jelena Sušac, Ivana Zobić, Diana Rudan, Dražen Pulanić, Darko Modun, Ivana Mudnić, Grgo Gunjača, Danijela Budimir, Caroline Hayward, Veronique Vitart, Alan F. Wright, Harry Campbell, Igor Rudan

Croat Med J. 2009 Feb; 50(1): 23–33. doi: 10.3325/cmj.2009.50.23

PMCID:: PMC2657564

Abstract Article PDF–4.7M

Select item 64331209.

MEK drives BRAF activation through allosteric control of KSR proteins

Hugo Lavoie, Malha Sahmi, Pierre Maisonneuve, Sara A. Marullo, Neroshan Thevakumaran, Ting Jin, Igor Kurinov, Frank Sicheri, Marc Therrien

Nature. Author manuscript; available in PMC 2019 Mar 25.

Published in final edited form as: Nature. 2018 Feb 22; 554(7693): 549–553. Published online 2018 Feb 12. doi: 10.1038/nature25478

PMCID:: PMC6433120

Abstract Article PDF–2.4M

Select item 358933310.

Genome-Wide Association Study Link Novel Loci to Endometriosis

Hans M. Albertsen, Rakesh Chettier, Pamela Farrington, Kenneth Ward

PLoS One. 2013; 8(3): e58257. Published online 2013 Mar 5. doi: 10.1371/journal.pone.0058257

PMCID:: PMC3589333

Abstract Article PDF–211K

Select item 934596911.

Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth

Rossella Delle Donne, Rosa Iannucci, Laura Rinaldi, Luca Roberto, Maria A. Oliva, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Francesco Chiuso, Salvatore Castaldo, Giovanni Scala, Virginia Campani, Valeria Nele, Giuseppe De Rosa, Chiara D’Ambrosio, Corrado Garbi, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Antonella Arcella, Antonio Feliciello

Commun Biol. 2022; 5: 780. Published online 2022 Aug 2. doi: 10.1038/s42003-022-03639-8

PMCID:: PMC9345969

Abstract Article PDF–2.3M

Select item 404112312.

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Verneri Anttila, Bendik S. Winsvold, Padhraig Gormley, Tobias Kurth, Francesco Bettella, George McMahon, Mikko Kallela, Rainer Malik, Boukje de Vries, Gisela Terwindt, Sarah E. Medland, Unda Todt, Wendy L. McArdle, Lydia Quaye, Markku Koiranen, M. Arfan Ikram, Terho Lehtimäki, Anine H. Stam, Lannie Ligthart, Juho Wedenoja, Ian Dunham, Benjamin M. Neale, Priit Palta, Eija Hamalainen, Markus Schürks, Lynda M Rose, Julie E. Buring, Paul M. Ridker, Stacy Steinberg, Hreinn Stefansson, Finnbogi Jakobsson, Debbie A. Lawlor, David M. Evans, Susan M. Ring, Markus Färkkilä, Ville Artto, Mari A Kaunisto, Tobias Freilinger, Jean Schoenen, Rune R. Frants, Nadine Pelzer, Claudia M. Weller, Ronald Zielman, Andrew C. Heath, Pamela A.F. Madden, Grant W. Montgomery, Nicholas G. Martin, Guntram Borck, Hartmut Göbel, Axel Heinze, Katja Heinze-Kuhn, Frances M.K. Williams, Anna-Liisa Hartikainen, Anneli Pouta, Joyce van den Ende, Andre G. Uitterlinden, Albert Hofman, Najaf Amin, Jouke-Jan Hottenga, Jacqueline M. Vink, Kauko Heikkilä, Michael Alexander, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Heinz Erich Wichmann, Arpo Aromaa, Johan G. Eriksson, Bryan Traynor, Daniah Trabzuni, North American Brain Expression Consortium, UK Brain Expression Consortium, Elizabeth Rossin, Kasper Lage, Suzanne B.R. Jacobs, J. Raphael Gibbs, Ewan Birney, Jaakko Kaprio, Brenda W. Penninx, Dorret I. Boomsma, Cornelia van Duijn, Olli Raitakari, Marjo-Riitta Jarvelin, John-Anker Zwart, Lynn Cherkas, David P. Strachan, Christian Kubisch, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Martin Dichgans, Maija Wessman, George Davey Smith, Kari Stefansson, Mark J. Daly, Dale R. Nyholt, Daniel Chasman, Aarno Palotie

Nat Genet. Author manuscript; available in PMC 2014 Jun 2.

Published in final edited form as: Nat Genet. 2013 Aug; 45(8): 912–917. Published online 2013 Jun 23. doi: 10.1038/ng.2676

PMCID:: PMC4041123

Article PDF–571K

Select item 672167013.

Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model

Zoë P. Van Acker, Geert A. Van Raemdonck, Emilie Logie, Sara I. Van Acker, Geert Baggerman, Wim Vanden Berghe, Peter Ponsaerts, Sylvia Dewilde

Cells. 2019 Aug; 8(8): 873. Published online 2019 Aug 11. doi: 10.3390/cells8080873

PMCID:: PMC6721670

Abstract Article PDF–4.1M

Select item 334973414.

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

Caroline S. Fox, Yongmei Liu, Charles C. White, Mary Feitosa, Albert V. Smith, Nancy Heard-Costa, Kurt Lohman, GIANT Consortium, MAGIC Consortium, GLGC Consortium, Andrew D. Johnson, Meredith C. Foster, Danielle M. Greenawalt, Paula Griffin, Jinghong Ding, Anne B. Newman, Fran Tylavsky, Iva Miljkovic, Stephen B. Kritchevsky, Lenore Launer, Melissa Garcia, Gudny Eiriksdottir, J. Jeffrey Carr, Vilmunder Gudnason, Tamara B. Harris, L. Adrienne Cupples, Ingrid B. Borecki

PLoS Genet. 2012 May; 8(5): e1002695. Published online 2012 May 10. doi: 10.1371/journal.pgen.1002695

PMCID:: PMC3349734

Abstract Article PDF–377K

Select item 410454415.

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

Mikko Taipale, George Tucker, Jian Peng, Irina Krykbaeva, Zhen-Yuan Lin, Brett Larsen, Hyungwon Choi, Bonnie Berger, Anne-Claude Gingras, Susan Lindquist

Cell. Author manuscript; available in PMC 2015 Jul 17.

Published in final edited form as: Cell. 2014 Jul 17; 158(2): 434–448. doi: 10.1016/j.cell.2014.05.039

PMCID:: PMC4104544

Abstract Article PDF–3.2M

Select item 389478616.

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D. Westover, Georgios I. Karras, Susan Lindquist

Cell. Author manuscript; available in PMC 2014 Jan 17.

Published in final edited form as: Cell. 2012 Aug 31; 150(5): 987–1001. doi: 10.1016/j.cell.2012.06.047

PMCID:: PMC3894786

Abstract Article PDF–5.0M

Select item 1003393717.

Assessment of community efforts to advance network-based prediction of protein–protein interactions

Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu

Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7

PMCID:: PMC10033937

Abstract Article PDF–1.5M

Select item 856647318.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 926261419.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 549522520.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

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