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Select item 85226341.

A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge–Weber syndrome

Roar Fjær, Katarzyna Marciniak, Olav Sundnes, Hanne Hjorthaug, Ying Sheng, Clara Hammarström, Jan Cezary Sitek, Magnus Dehli Vigeland, Paul Hoff Backe, Ane-Marte Øye, Johanna Hol Fosse, Tor Espen Stav-Noraas, Yuri Uchiyama, Naomichi Matsumoto, Anne Comi, Jonathan Pevsner, Guttorm Haraldsen, Kaja Kristine Selmer

Hum Mol Genet. 2021 Nov 1; 30(21): 1919–1931. Published online 2021 Jun 14. doi: 10.1093/hmg/ddab144

PMCID:: PMC8522634

Abstract Article PDF–959K

Select item 527712.

Direct selection: a method for the isolation of cDNAs encoded by large genomic regions.

M Lovett, J Kere, L M Hinton

Proc Natl Acad Sci U S A. 1991 Nov 1; 88(21): 9628–9632. doi: 10.1073/pnas.88.21.9628

PMCID:: PMC52771

Summary Page Browse PDF–1.2M

Select item 42891153.

Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance

Akinori Yoda, Guillaume Adelmant, Jerome Tamburini, Bjoern Chapuy, Nobuaki Shindoh, Yuka Yoda, Oliver Weigert, Nadja Kopp, Shuo-Chieh Wu, Sunhee S. Kim, Huiyun Liu, Trevor Tivey, Amanda L. Christie, Kutlu G. Elpek, Joseph Card, Kira Gritsman, Jason Gotlib, Michael W. Deininger, Hideki Makishima, Shannon J. Turley, Nathalie Javidi-Sharifi, Jaroslaw P. Maciejewski, Siddhartha Jaiswal, Benjamin L. Ebert, Scott J. Rodig, Jeffrey W. Tyner, Jarrod A. Marto, David M. Weinstock, Andrew A. Lane

Nat Med. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Nat Med. 2015 Jan; 21(1): 71–75. Published online 2014 Dec 8. doi: 10.1038/nm.3751

PMCID:: PMC4289115

Abstract Article PDF–913K

Select item 16000044.

The molecular basis for T-type Ca²⁺ channel inhibition by G protein β₂γ₂ subunits

Seth D. DePuy, Junlan Yao, Changlong Hu, William McIntire, Isabelle Bidaud, Philippe Lory, Fraydoon Rastinejad, Carlos Gonzalez, James C. Garrison, Paula Q. Barrett

Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39): 14590–14595. Published online 2006 Sep 14. doi: 10.1073/pnas.0603945103

PMCID:: PMC1600004

Abstract Article PDF–831K

Select item 3049625.

Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning.

H K Fong, T T Amatruda, 3rd, B W Birren, M I Simon

Proc Natl Acad Sci U S A. 1987 Jun; 84(11): 3792–3796. doi: 10.1073/pnas.84.11.3792

PMCID:: PMC304962

Summary Page Browse PDF–1.2M

Select item 2990206.

A second form of the beta subunit of signal-transducing G proteins.

B Gao, A G Gilman, J D Robishaw

Proc Natl Acad Sci U S A. 1987 Sep; 84(17): 6122–6125. doi: 10.1073/pnas.84.17.6122

PMCID:: PMC299020

Summary Page Browse PDF–870K

Select item 21716377.

G protein β interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus

Tomoshige Kino, Anatoly Tiulpakov, Takamasa Ichijo, Ly Chheng, Tohru Kozasa, George P. Chrousos

J Cell Biol. 2005 Jun 20; 169(6): 885–896. doi: 10.1083/jcb.200409150

PMCID:: PMC2171637

Abstract Article PDF–2.8M

Select item 47483088.

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy

Jacy L. Wagnon, Bryan S. Barker, James A. Hounshell, Charlotte A. Haaxma, Amy Shealy, Timothy Moss, Sumit Parikh, Ricka D. Messer, Manoj K. Patel, Miriam H. Meisler

Ann Clin Transl Neurol. 2016 Feb; 3(2): 114–123. Published online 2015 Dec 21. doi: 10.1002/acn3.276

PMCID:: PMC4748308

Abstract Article PDF–514K

Select item 13250049.

Giα and Gβ subunits both define selectivity of G protein activation by α2-adrenergic receptors

Scott K. Gibson, Alfred G. Gilman

Proc Natl Acad Sci U S A. 2006 Jan 3; 103(1): 212–217. Published online 2005 Dec 21. doi: 10.1073/pnas.0509763102

PMCID:: PMC1325004

Abstract Article PDF–457K

Select item 2317210.

Direct interaction of Gβγ with a C-terminal Gβγ-binding domain of the Ca²⁺ channel α₁ subunit is responsible for channel inhibition by G protein-coupled receptors

Ning Qin, Daniela Platano, Riccardo Olcese, Enrico Stefani, Lutz Birnbaumer

Proc Natl Acad Sci U S A. 1997 Aug 5; 94(16): 8866–8871. doi: 10.1073/pnas.94.16.8866

PMCID:: PMC23172

Abstract Article PDF–408K

Select item 806309011.

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1

Roger Belizaire, Sebastian H. J. Koochaki, Namrata D. Udeshi, Alexis Vedder, Lei Sun, Tanya Svinkina, Christina Hartigan, Marie McConkey, Veronica Kovalcik, Amanuel Bizuayehu, Caroline Stanclift, Monica Schenone, Steven A. Carr, Eric Padron, Benjamin L. Ebert

Blood. 2021 Apr 22; 137(16): 2209–2220. Prepublished online 2021 Jan 7. doi: 10.1182/blood.2020006528

PMCID:: PMC8063090

Abstract Article

Select item 2379312.

A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G_β5 subunits

Bryan E. Snow, Andrejs M. Krumins, Greg M. Brothers, Sheu-Fen Lee, Mark A. Wall, Stephen Chung, Joan Mangion, Sudha Arya, Alfred G. Gilman, David P. Siderovski

Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22): 13307–13312. doi: 10.1073/pnas.95.22.13307

PMCID:: PMC23793

Abstract Article PDF–542K

Select item 2690913.

Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11

Bryan E. Snow, Laurie Betts, Joan Mangion, John Sondek, David P. Siderovski

Proc Natl Acad Sci U S A. 1999 May 25; 96(11): 6489–6494. doi: 10.1073/pnas.96.11.6489

PMCID:: PMC26909

Abstract Article PDF–545K

Select item 445823814.

A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation

Zhengyu Zha, Xiaoran Han, Matthew D. Smith, Yang Liu, Patrick M. Giguère, Dragana Kopanja, Pradip Raychaudhuri, David P. Siderovski, Kun-Liang Guan, Qun-Ying Lei, Yue Xiong

Mol Cell. Author manuscript; available in PMC 2016 Jun 4.

Published in final edited form as: Mol Cell. 2015 Jun 4; 58(5): 794–803. Published online 2015 May 14. doi: 10.1016/j.molcel.2015.04.017

PMCID:: PMC4458238

Abstract Article PDF–4.0M

Select item 31078815.

Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes

Gernot Glöckner, Stephen Scherer, Ruben Schattevoy, Andrew Boright, Jacqueline Weber, Lap-Chee Tsui, André Rosenthal

Genome Res. 1998 Oct; 8(10): 1060–1073. doi: 10.1101/gr.8.10.1060

PMCID:: PMC310788

Abstract Article PDF–3.7M

Select item 709285816.

VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability

Xiao Yu, Shuliang Chen, Panpan Hou, Min Wang, Yu Chen, Deyin Guo

Biochem Biophys Res Commun. 2015 Apr 3; 459(2): 270–276. Published online 2015 Feb 27. doi: 10.1016/j.bbrc.2015.02.097

PMCID:: PMC7092858

Abstract Article PDF–1.4M

Select item 354136817.

Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR-Dependent Gene Regulation

Anushree Bhatnagar, Hamiyet Unal, Rajaganapathi Jagannathan, Suma Kaveti, Zhong-Hui Duan, Sandro Yong, Amit Vasanji, Michael Kinter, Russell Desnoyer, Sadashiva S. Karnik

PLoS One. 2013; 8(1): e52689. Published online 2013 Jan 9. doi: 10.1371/journal.pone.0052689