PMC Links for Gene (Select 268857) - PMC

Select item 110557301.

NLRC3 attenuates osteoclastogenesis by limiting TNFα⁺ Th17 cell response in osteoporosis

Lingyan Ren, Guangjun Liu, Yun Bai, Liling Gu, Yuan Wang, Li Sun

J Mol Med (Berl) 2024; 102(5): 655–665. Published online 2024 Mar 4. doi: 10.1007/s00109-024-02422-y

PMCID:: PMC11055730

Select item 98401172.

NLRC3 expression in macrophage impairs glycolysis and host immune defense by modulating the NF-κB-NFAT5 complex during septic immunosuppression

Jiqian Xu, Chenggang Gao, Yajun He, Xiangzhi Fang, Deyi Sun, Zhekang Peng, Hairong Xiao, Miaomiao Sun, Pei Zhang, Ting Zhou, Xiaobo Yang, Yuan Yu, Ruiting Li, Xiaojing Zou, Huaqing Shu, Yang Qiu, Xi Zhou, Shiying Yuan, Shanglong Yao, You Shang

Mol Ther. 2023 Jan 4; 31(1): 154–173. Published online 2022 Sep 6. doi: 10.1016/j.ymthe.2022.08.023

PMCID:: PMC9840117

Abstract Article PDF–5.2M

Select item 83229863.

Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection

Ruixue Ma, Xiaoxiao Zhang, Jiayi Shu, Ziyu Liu, Wenjie Sun, Shiyuan Hou, Yunhua Lv, Qikang Ying, Fang Wang, Xia Jin, Rongrong Liu, Xingan Wu

Front Immunol. 2021; 12: 692509. Published online 2021 Jul 16. doi: 10.3389/fimmu.2021.692509

PMCID:: PMC8322986

Abstract Article PDF–3.7M

Select item 77751634.

NLRC3 Delays the Progression of AD in APP/PS1 Mice via Inhibiting PI3K Activation

Lihuang Zha, Zaixin Yu, Jian Fang, Li Zhou, Wen Guo, Jun Zhou

Oxid Med Cell Longev. 2020; 2020: 5328031. Published online 2020 Dec 24. doi: 10.1155/2020/5328031

PMCID:: PMC7775163

Abstract Article PDF–2.4M

Select item 61228405.

NLRC3 negatively regulates CD4⁺ T cells and impacts protective immunity during Mycobacterium tuberculosis infection

Shengfeng Hu, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Xiaoxia Zhan, Wenting He, Qian Wen, Xinying Zhou, Chaoying Zhou, Xiao-Ping Zhong, Jiahui Yang, Wenjing Xiong, Ruining Wang, Yuchi Gao, Li Ma

PLoS Pathog. 2018 Aug; 14(8): e1007266. Published online 2018 Aug 22. doi: 10.1371/journal.ppat.1007266

PMCID:: PMC6122840

Abstract Article PDF–9.4M

Select item 55316216.

NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer

Rajendra Karki, R. K. Subbarao Malireddi, Qifan Zhu, Thirumala-Devi Kanneganti

Cell Cycle. 2017; 16(13): 1243–1251. Published online 2017 Jun 9. doi: 10.1080/15384101.2017.1317414

PMCID:: PMC5531621

Abstract Article PDF–1.0M

Select item 65326577.

The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity

Toru Uchimura, Yoshitaka Oyama, Meng Deng, Haitao Guo, Justin E. Wilson, Elena Rampanelli, Kevin D. Cook, Ichiro Misumi, Xianming Tan, Liang Chen, Brandon Johnson, Jason Tam, Wei-Chun Chou, W. June Brickey, Alex Petrucelli, Jason K. Whitmire, Jenny P.Y. Ting

Immunity. Author manuscript; available in PMC 2019 May 23.

Published in final edited form as: Immunity. 2018 Dec 18; 49(6): 1049–1061.e6. doi: 10.1016/j.immuni.2018.10.008

PMCID:: PMC6532657

Abstract Article PDF–2.4M

Select item 64695098.

Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon

Xin Li, Meng Deng, Alex S. Petrucelli, Cheng Zhu, Jinyao Mo, Lu Zhang, Jason W. Tam, Pablo Ariel, Baoyu Zhao, Song Zhang, Hengming Ke, Pingwei Li, Nikolay V. Dokholyan, Joseph A. Duncan, Jenny P.-Y. Ting

Immunity. Author manuscript; available in PMC 2019 Apr 17.

Published in final edited form as: Immunity. 2019 Mar 19; 50(3): 591–599.e6. doi: 10.1016/j.immuni.2019.02.009

PMCID:: PMC6469509

Abstract Article PDF–2.0M

Select item 66942209.

NLRC3 expression in dendritic cells attenuates CD4⁺ T cell response and autoimmunity

Yuling Fu, Xiaoxia Zhan, Yichong Wang, Xiaobing Jiang, Min Liu, Yalong Yang, Yulan Huang, Xialin Du, Xiao‐Ping Zhong, Laisheng Li, Li Ma, Shengfeng Hu

EMBO J. 2019 Aug 15; 38(16): e101397. Published online 2019 Jul 10. doi: 10.15252/embj.2018101397

PMCID:: PMC6694220

Abstract Article PDF–2.0M

Select item 546851610.

NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

Rajendra Karki, Si Ming Man, R.K. Subbarao Malireddi, Sannula Kesavardhana, Qifan Zhu, Amanda R. Burton, Bhesh Raj Sharma, Xiaopeng Qi, Stephane Pelletier, Peter Vogel, Philip Rosenstiel, Thirumala-Devi Kanneganti

Nature. Author manuscript; available in PMC 2017 Jun 13.

Published in final edited form as: Nature. 2016 Dec 22; 540(7634): 583–587. Published online 2016 Dec 12. doi: 10.1038/nature20597

PMCID:: PMC5468516

Abstract Article PDF–6.2M

Select item 401101411.

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING

Lu Zhang, Jinyao Mo, Karen V. Swanson, Haitao Wen, Alex Petrucelli, Sean M. Gregory, Zhigang Zhang, Monika Schneider, Yan Jiang, Katherine A. Fitzgerald, Songying Ouyang, Zhi-Jie Liu, Blossom A Damania, Hong-Bing Shu, Joseph A. Duncan, Jenny P-Y. Ting

Immunity. Author manuscript; available in PMC 2015 Mar 20.

Published in final edited form as: Immunity. 2014 Mar 20; 40(3): 329–341. Published online 2014 Feb 20. doi: 10.1016/j.immuni.2014.01.010

PMCID:: PMC4011014

Abstract Article PDF–2.5M

Select item 372119512.

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

Monika Schneider, Albert G Zimmermann, Reid A Roberts, Lu Zhang, Karen V Swanson, Haitao Wen, Beckley K Davis, Irving C Allen, Eda K Holl, Zhengmao Ye, Adeeb H Rahman, Brian J Conti, Timothy K Eitas, Beverly H Koller, Jenny P-Y Ting

Nat Immunol. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: Nat Immunol. 2012 Sep; 13(9): 823–831. Published online 2012 Aug 5. doi: 10.1038/ni.2378

PMCID:: PMC3721195

Abstract Article PDF–967K

Select item 456751013.

Canonical inflammasomes drive IFN-γ to prime caspase-11 in defense against a cytosol-invasive bacterium

Youssef Aachoui, Yuji Kajiwara, Irina A Leaf, Dat Mao, Jenny P-Y Ting, Jörn Coers, Alan Aderem, Joseph D Buxbaum, Edward A Miao

Cell Host Microbe. Author manuscript; available in PMC 2016 Sep 9.

Published in final edited form as: Cell Host Microbe. 2015 Sep 9; 18(3): 320–332. Published online 2015 Aug 27. doi: 10.1016/j.chom.2015.07.016

PMCID:: PMC4567510

Abstract Article PDF–1.7M

Select item 346420714.

A Mutation in the Srrm4 Gene Causes Alternative Splicing Defects and Deafness in the Bronx Waltzer Mouse

Yoko Nakano, Israt Jahan, Gregory Bonde, Xingshen Sun, Michael S. Hildebrand, John F. Engelhardt, Richard J. H. Smith, Robert A. Cornell, Bernd Fritzsch, Botond Bánfi

PLoS Genet. 2012 Oct; 8(10): e1002966. Published online 2012 Oct 4. doi: 10.1371/journal.pgen.1002966

PMCID:: PMC3464207

Abstract Article PDF–4.1M

Select item 461808615.

The Interleukin-2-mTORc1 Axis Defines the Reciprocal Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

John P. Ray, Matthew M. Staron, Justin A. Shyer, Ping-Chih Ho, Heather D. Marshall, Simon M. Gray, Brian J. Laidlaw, Koichi Araki, Rafi Ahmed, Susan M. Kaech, Joe Craft

Immunity. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Immunity. 2015 Oct 20; 43(4): 690–702. Published online 2015 Sep 22. doi: 10.1016/j.immuni.2015.08.017

PMCID:: PMC4618086

Abstract Article PDF–2.2M

Select item 255627016.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 31099217.

RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer

Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki

Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600

PMCID:: PMC310992

Abstract Article PDF–3.4M

Select item 31098018.

Normalization and Subtraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes

Piero Carninci, Yuko Shibata, Norihito Hayatsu, Yuichi Sugahara, Kazuhiro Shibata, Masayoshi Itoh, Hideaki Konno, Yasushi Okazaki, Masami Muramatsu, Yoshihide Hayashizaki

Genome Res. 2000 Oct; 10(10): 1617–1630. doi: 10.1101/gr.145100

PMCID:: PMC310980

Abstract Article PDF–1.4M

Select item 13924119.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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