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Select item 94482881.

Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function

Pei-Wen Liu, Gregory L. Martin, Weiyu Lin, Wanting Huang, Suchita Pande, Mark J. Aronovitz, Roger J. Davis, Robert M. Blanton

Am J Physiol Heart Circ Physiol. 2022 Sep 1; 323(3): H513–H522. Published online 2022 Jul 22. doi: 10.1152/ajpheart.00660.2021

PMCID:: PMC9448288

Abstract Article

Select item 84923232.

MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms

Timothy D. Calamaras, Suchita Pande, Robert A.U. Baumgartner, Seung Kyum Kim, Joseph C. McCarthy, Gregory L. Martin, Kelly Tam, Angela L. McLaughlin, Guang-rong Wang, Mark J. Aronovitz, Weiyu Lin, Jonathan I. Aguirre, Paulina Baca, Peiwen Liu, Daniel A. Richards, Roger J. Davis, Richard H. Karas, Iris Z. Jaffe, Robert M. Blanton

JCI Insight. 2021 Sep 22; 6(18): e149075. Published online 2021 Sep 22. doi: 10.1172/jci.insight.149075

PMCID:: PMC8492323

Abstract Article PDF–3.6M

Select item 73824803.

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

Junyan Wang, Bo Deng, Qing Liu, Yusheng Huang, Weitao Chen, Jing Li, Zheng Zhou, Lu Zhang, Birong Liang, Jiaqi He, Zixin Chen, Cui Yan, Zhongqi Yang, Shaoxiang Xian, Lingjun Wang

Cell Death Dis. 2020 Jul; 11(7): 574. Published online 2020 Jul 24. doi: 10.1038/s41419-020-02777-3

PMCID:: PMC7382480

Abstract Article PDF–4.9M

Select item 63833564.

Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload

Timothy D. Calamaras, Robert A. Baumgartner, Mark J. Aronovitz, Angela L. McLaughlin, Kelly Tam, Daniel A. Richards, Craig W. Cooper, Nathan Li, Wendy E. Baur, Xiaoying Qiao, Guang-Rong Wang, Roger J. Davis, Navin K. Kapur, Richard H. Karas, Robert M. Blanton

Am J Physiol Heart Circ Physiol. 2019 Jan 1; 316(1): H145–H159. Published online 2018 Oct 26. doi: 10.1152/ajpheart.00029.2018

PMCID:: PMC6383356

Abstract Article

Select item 39468115.

MLK3 regulates fMLP-stimulated neutrophil motility

Oksana Polesskaya, Christopher Wong, Luis Lebron, Jeffrey M. Chamberlain, Harris A. Gelbard, Val Goodfellow, Minsoo Kim, John L. Daiss, Stephen Dewhurst

Mol Immunol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Mol Immunol. 2014 Apr; 58(2): 214–222. Published online 2014 Jan 3. doi: 10.1016/j.molimm.2013.11.016

PMCID:: PMC3946811

Abstract Article PDF–1.2M

Select item 38912206.

MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet

Vidya Gadang, Rohit Kohli, Andriy Myronovych, David Y. Hui, Diego Perez-Tilve, Anja Jaeschke

Am J Physiol Endocrinol Metab. 2013 Aug 15; 305(4): E549–E556. Published online 2013 Jul 16. doi: 10.1152/ajpendo.00197.2013

PMCID:: PMC3891220

Abstract Article

Select item 34696927.

Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa

Pavlo L. Kovalenko, Lyudmyla Kunovska, Jian Chen, Kathleen A. Gallo, Marc D. Basson

Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15; 303(8): G951–G960. Published online 2012 Aug 23. doi: 10.1152/ajpgi.00158.2012

PMCID:: PMC3469692

Abstract Article

Select item 29978838.

Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure

Oksana Polesskaya, Lisa L. Cunningham, Shimon P. Francis, Anne E. Luebke, Xiaoxia Zhu, David Collins, Olga N. Vasilyeva, Julie Sahler, Emily A. Desmet, Harris A. Gelbard, Sanjay B. Maggirwar, Joseph P. Walton, Robert D. Frisina, Jr., Stephen Dewhurst

Hear Res. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Hear Res. 2010 Dec 1; 270(1-2): 21–27. Published online 2010 Oct 27. doi: 10.1016/j.heares.2010.10.008

PMCID:: PMC2997883

Abstract Article PDF–1.8M

Select item 28444759.

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells

Emily A. Desmet, Joseph A. Hollenbaugh, Patricia J. Sime, Terry W. Wright, David J. Topham, Andrea J. Sant, Toru Takimoto, Stephen Dewhurst, Sanjay B. Maggirwar

Virology. Author manuscript; available in PMC 2011 May 10.

Published in final edited form as: Virology. 2010 May 10; 400(2): 224–232. Published online 2010 Feb 25. doi: 10.1016/j.virol.2010.02.001

PMCID:: PMC2844475

Abstract Article PDF–2.0M

Select item 108431210.

Role of MLK3 in the Regulation of Mitogen-Activated Protein Kinase Signaling Cascades

Deborah Brancho, Juan-Jose Ventura, Anja Jaeschke, Beth Doran, Richard A. Flavell, Roger J. Davis

Mol Cell Biol. 2005 May; 25(9): 3670–3681. doi: 10.1128/MCB.25.9.3670-3681.2005

PMCID:: PMC1084312

Abstract Article PDF–1.0M

Select item 950121811.

MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells

Anh Thu Ha, Jae Youl Cho, Daewon Kim

Int J Mol Sci. 2022 Sep; 23(18): 10874. Published online 2022 Sep 17. doi: 10.3390/ijms231810874

PMCID:: PMC9501218

Abstract Article PDF–2.0M

Select item 714938912.

Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity

Sandeep Kumar, Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Subhash C. Sinha, Rajyasree Emmadi, Kent Hoskins, Oana Danciu, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana

Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7961–7970. Published online 2020 Mar 24. doi: 10.1073/pnas.1921325117

PMCID:: PMC7149389

Abstract Article PDF–2.4M

Select item 408468313.

Mixed Lineage Kinase 3 Deficiency Promotes Neointima Formation through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells

Vidya Gadang, Eddy Konaniah, David Y. Hui, Anja Jaeschke

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7): 1429–1436. Published online 2014 May 1. doi: 10.1161/ATVBAHA.114.303439

PMCID:: PMC4084683

Abstract Article PDF–1.3M

Select item 376911514.

Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity

Shashi Kant, Tamera Barrett, Anastassiia Vertii, Yun Hee Noh, Dae Young Jung, Jason K. Kim, Roger J. Davis

Cell Rep. Author manuscript; available in PMC 2013 Sep 10.

Published in final edited form as: Cell Rep. 2013 Aug 29; 4(4): 681–688. Published online 2013 Aug 15. doi: 10.1016/j.celrep.2013.07.019

PMCID:: PMC3769115

Abstract Article PDF–2.5M

Select item 320484615.

MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice

Weiguo Zou, Matthew B. Greenblatt, Jae-Hyuck Shim, Shashi Kant, Bo Zhai, Sutada Lotinun, Nicholas Brady, Dorothy Zhang Hu, Steven P. Gygi, Roland Baron, Roger J. Davis, Dallas Jones, Laurie H. Glimcher

J Clin Invest. 2011 Nov 1; 121(11): 4383–4392. Published online 2011 Oct 3. doi: 10.1172/JCI59041

PMCID:: PMC3204846

Abstract Article PDF–1.4M

Select item 290336316.

Mixed Lineage Kinase-3 Stabilizes and Functionally Cooperates with TRIBBLES-3 to Compromise Mitochondrial Integrity in Cytokine-induced Death of Pancreatic Beta Cells

Rohan K. Humphrey, Christina J. Newcomb, Shu-Mei A. Yu, Ergeng Hao, Doris Yu, Stan Krajewski, Keyong Du, Ulupi S. Jhala

J Biol Chem. 2010 Jul 16; 285(29): 22426–22436. Published online 2010 Apr 26. doi: 10.1074/jbc.M110.123786

PMCID:: PMC2903363

Abstract Article PDF–3.6M

Select item 280177217.

TRAF2-MLK3 interaction is essential for TNF-a-induced MLK3 activation

Gautam Sondarva, Chanakya N. Kundu, Suneet Mehrotra, Rajakishore Mishra, Velusamy Rangasamy, Pradeep Sathyanarayana, Rajarshi S. Ray, Basabi Rana, Ajay Rana

Cell Res. Author manuscript; available in PMC 2010 Jul 1.

Published in final edited form as: Cell Res. 2010 Jan; 20(1): 89–98. Published online 2009 Nov 17. doi: 10.1038/cr.2009.125

PMCID:: PMC2801772

Abstract Article PDF–789K

Select item 278801018.

Mixed Lineage Kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death

Eric T. Cole, Yu Zhan, Widian F. Abi Saab, Amanda C. Korchnak, Brian P. Ashburner, Deborah N. Chadee

Biochim Biophys Acta. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Biochim Biophys Acta. 2009 Dec; 1793(12): 1811–1818. Published online 2009 Sep 25. doi: 10.1016/j.bbamcr.2009.09.014