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Select item 105170191.

FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis

Ganesh Kumar Barik, Osheen Sahay, Anindya Mukhopadhyay, Rajesh Kumar Manne, Sehbanul Islam, Anup Roy, Somsubhra Nath, Manas Kumar Santra

Cell Death Dis. 2023 Sep; 14(9): 623. Published online 2023 Sep 22. doi: 10.1038/s41419-023-06127-x

PMCID:: PMC10517019

Abstract Article PDF–5.0M

Select item 90616862.

FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation

Tao Zhou, Tingting Chen, Bin Lai, Wenfeng Zhang, Xi Luo, Ding Xia, Weihua Fu, Jie Xu

Cell Mol Life Sci. 2022 May; 79(5): 268. Published online 2022 May 2. doi: 10.1007/s00018-022-04320-3

PMCID:: PMC9061686

Abstract Article PDF–8.4M

Select item 75788603.

E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis

Cheng Wang, Wenjing Xu, Yuelin Chao, Minglu Liang, Fengxiao Zhang, Kai Huang

Adv Sci (Weinh) 2020 Oct; 7(20): 2001800. Published online 2020 Aug 26. doi: 10.1002/advs.202001800

PMCID:: PMC7578860

Abstract Article PDF–5.3M

Select item 88169404.

Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance

Chune Ren, Xue Han, Chao Lu, Tingting Yang, Pengyun Qiao, Yonghong Sun, Zhenhai Yu

Cell Death Differ. 2022 Feb; 29(2): 381–392. Published online 2021 Aug 31. doi: 10.1038/s41418-021-00862-4

PMCID:: PMC8816940

Abstract Article PDF–7.2M

Select item 67899105.

The FBXW2–MSX2–SOX2 axis regulates stem cell property and drug resistance of cancer cells

Yuan Yin, Chuan-Ming Xie, Hua Li, Mingjia Tan, Guoan Chen, Rachel Schiff, Xiufang Xiong, Yi Sun

Proc Natl Acad Sci U S A. 2019 Oct 8; 116(41): 20528–20538. Published online 2019 Sep 23. doi: 10.1073/pnas.1905973116

PMCID:: PMC6789910

Abstract Article PDF–1.7M

Select item 26760366.

The F-box Protein β-TrCp1/Fbw1a Interacts with p300 to Enhance β-Catenin Transcriptional Activity

Erin A. Kimbrel, Andrew L. Kung

J Biol Chem. 2009 May 8; 284(19): 13033–13044. doi: 10.1074/jbc.M901248200

PMCID:: PMC2676036

Abstract Article PDF–1.6M

Select item 868537.

ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCF^βTrCP Ubiquitin Ligase

Irina Lassot, Emmanuel Ségéral, Clarisse Berlioz-Torrent, Herve Durand, Lionel Groussin, Tsonwin Hai, Richard Benarous, Florence Margottin-Goguet

Mol Cell Biol. 2001 Mar; 21(6): 2192–2202. doi: 10.1128/MCB.21.6.2192-2202.2001

PMCID:: PMC86853

Abstract Article PDF–3.2M

Select item 64371518.

FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation

Fei Yang, Jie Xu, Hua Li, Mingjia Tan, Xiufang Xiong, Yi Sun

Nat Commun. 2019; 10: 1382. Published online 2019 Mar 27. doi: 10.1038/s41467-019-09289-5

PMCID:: PMC6437151

Abstract Article PDF–3.2M

Select item 52418249.

The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor

Jie Xu, Weihua Zhou, Fei Yang, Guoan Chen, Haomin Li, Yongchao Zhao, Pengyuan Liu, Hua Li, Mingjia Tan, Xiufang Xiong, Yi Sun

Nat Commun. 2017; 8: 14002. Published online 2017 Jan 16. doi: 10.1038/ncomms14002

PMCID:: PMC5241824

Abstract Article PDF–5.3M

Select item 656758010.

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells

Zhou-hua Jiang, Tao Peng, Hai-long Qian, Cai-de Lu, Feng Qiu, Su-zhan Zhang

Cancer Cell Int. 2019; 19: 162. Published online 2019 Jun 14. doi: 10.1186/s12935-019-0878-y

PMCID:: PMC6567580

Abstract Article PDF–1.1M

Select item 835019611.

TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance

Shunjie Xia, Lin Ji, Liye Tao, Yu Pan, Zhongjie Lin, Zhe Wan, Haoqi Pan, Jie Zhao, Liuxin Cai, Junjie Xu, Xiujun Cai

Cell Mol Gastroenterol Hepatol. 2021; 12(3): 1121–1143. Published online 2021 May 5. doi: 10.1016/j.jcmgh.2021.04.016

PMCID:: PMC8350196

Abstract Article PDF–9.2M

Select item 270776812.

Control of chromosome stability by the β-TrCP–REST–Mad2 axis

Daniele Guardavaccaro, David Frescas, N. Valerio Dorrello, Angelo Peschiaroli, Asha S. Multani, Timothy Cardozo, Anna Lasorella, Antonio Iavarone, Sandy Chang, Eva Hernando, Michele Pagano

Nature. Author manuscript; available in PMC 2009 Jul 9.

Published in final edited form as: Nature. 2008 Mar 20; 452(7185): 365–369. doi: 10.1038/nature06641

PMCID:: PMC2707768

Abstract Article PDF–856K

Select item 467319813.

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

Xin Tian, Shundong Dai, Jing Sun, Guojiang Jin, Shenyi Jiang, Fandong Meng, Yan Li, Di Wu, Youhong Jiang

Oncotarget. 2015 Sep 8; 6(26): 22767–22775. Published online 2015 May 28. doi: 10.18632/oncotarget.4082

PMCID:: PMC4673198

Abstract Article PDF–1.5M

Select item 333902914.

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

Luca Busino, Scott E. Millman, Luigi Scotto, Christos A. Kyratsous, Venkatesha Basrur, Owen O’Connor, Alexander Hoffmann, Kojo S. Elenitoba-Johnson, Michele Pagano

Nat Cell Biol. Author manuscript; available in PMC 2012 Oct 1.

Published in final edited form as: Nat Cell Biol. 2012 Mar 4; 14(4): 375–385. Published online 2012 Mar 4. doi: 10.1038/ncb2463

PMCID:: PMC3339029

Abstract Article PDF–4.9M

Select item 38476215.

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF^β-TrCP

Nobumoto Watanabe, Harumi Arai, Yoshifumi Nishihara, Makoto Taniguchi, Naoko Watanabe, Tony Hunter, Hiroyuki Osada

Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4419–4424. Published online 2004 Mar 22. doi: 10.1073/pnas.0307700101

PMCID:: PMC384762

Abstract Article PDF–526K

Select item 361632516.

The Cyclin F-Ribonucleotide Reductase M2 axis controls genome integrity and DNA repair

Vincenzo D’Angiolella, Valerio Donato, Frances M. Forrester, Yeon-Tae Jeong, Claudia Pellacani, Yasusei Kudo, Anita Saraf, Laurence Florens, Michael P. Washburn, Michele Pagano

Cell. Author manuscript; available in PMC 2013 Apr 4.

Published in final edited form as: Cell. 2012 May 25; 149(5): 1023–1034. doi: 10.1016/j.cell.2012.03.043

PMCID:: PMC3616325

Abstract Article PDF–2.3M

Select item 741719517.

FBXW7 triggers degradation of KMT2D to favor growth of diffuse large B-cell lymphoma cells

Rizwan Saffie, Nan Zhou, Delphine Rolland, Özlem Önder, Venkatesha Basrur, Sydney Campbell, Kathryn E. Wellen, Kojo S.J. Elenitoba-Johnson, Brian C. Capell, Luca Busino

Cancer Res. Author manuscript; available in PMC 2021 Jun 15.

Published in final edited form as: Cancer Res. 2020 Jun 15; 80(12): 2498–2511. Published online 2020 Apr 29. doi: 10.1158/0008-5472.CAN-19-2247