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Select item 61914181.

Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity

Susobhan Sarkar, Candice C. Poon, Reza Mirzaei, Khalil S. Rawji, Walter Hader, Pinaki Bose, John Kelly, Jeffrey F. Dunn, V. Wee Yong

Sci Rep. 2018; 8: 15286. Published online 2018 Oct 16. doi: 10.1038/s41598-018-33306-0

PMCID:: PMC6191418

Abstract Article PDF–2.7M

Select item 43496062.

Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1

Katja Rosti, Adrian Goldman, Tommi Kajander

BMC Biochem. 2015; 16: 8. Published online 2015 Feb 28. doi: 10.1186/s12858-015-0037-6

PMCID:: PMC4349606

Abstract Article PDF–2.5M

Select item 36956223.

Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH

Daniel E. Pineda-Alvarez, Erich Roessler, Ping Hu, Kshitij Srivastava, Benjamin D. Solomon, C. Evan Siple, Chen-Ming Fan, Maximilian Muenke

Hum Genet. Author manuscript; available in PMC 2013 Jun 28.

Published in final edited form as: Hum Genet. 2012 Feb; 131(2): 301–310. Published online 2011 Aug 13. doi: 10.1007/s00439-011-1078-6

PMCID:: PMC3695622

Abstract Article PDF–697K

Select item 33094234.

Gas1 Interferes with AβPP Trafficking by Facilitating the Accumulation of Immature AβPP in Endoplasmic Reticulum-Associated Raft Subdomains

Julien Chapuis, Valérie Vingtdeux, Hemachander Capiralla, Peter Davies, Philippe Marambaud

J Alzheimers Dis. Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as: J Alzheimers Dis. 2012 Jan; 28(1): 127–135. doi: 10.3233/JAD-2011-110434

PMCID:: PMC3309423

Abstract Article PDF–1.6M

Select item 27853155.

Identification of GAS1 as an Epirubicin Resistance-related Gene in Human Gastric Cancer Cells with a Partially Randomized Small Interfering RNA Library

Lina Zhao, Yanglin Pan, Yi Gang, Honghong Wang, Haifeng Jin, Jun Tie, Lin Xia, Yongguo Zhang, Lijie He, Liping Yao, Taidong Qiao, Tingting Li, Zhiguo Liu, Daiming Fan

J Biol Chem. 2009 Sep 25; 284(39): 26273–26285. Published online 2009 Jul 28. doi: 10.1074/jbc.M109.028068

PMCID:: PMC2785315

Abstract Article PDF–2.3M

Select item 25777906.

A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene

Stephane Gobeil, Xiaochun Zhu, Charles J. Doillon, Michael R. Green

Genes Dev. 2008 Nov 1; 22(21): 2932–2940. doi: 10.1101/gad.1714608

PMCID:: PMC2577790

Abstract Article PDF–629K

Select item 32790487.

Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-β precursor protein

Julien Chapuis, Valérie Vingtdeux, Fabien Campagne, Peter Davies, Philippe Marambaud

Hum Mol Genet. 2011 May 15; 20(10): 2026–2036. Published online 2011 Feb 28. doi: 10.1093/hmg/ddr085

PMCID:: PMC3279048

Abstract Article PDF–465K

Select item 432618.

Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene.

G Del Sal, L Collavin, M E Ruaro, P Edomi, S Saccone, G D Valle, C Schneider

Proc Natl Acad Sci U S A. 1994 Mar 1; 91(5): 1848–1852. doi: 10.1073/pnas.91.5.1848

PMCID:: PMC43261

Summary Page Browse PDF–1.3M

Select item 587329.

Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite

Catherine S. Lee, Laura Buttitta, Chen-Ming Fan

Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20): 11347–11352. doi: 10.1073/pnas.201418298

PMCID:: PMC58732

Abstract Article PDF–1.9M

Select item 893546410.

Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog

M. Seppala, B. Thivichon-Prince, G.M. Xavier, N. Shaffie, I. Sangani, A.A. Birjandi, J. Rooney, J.N.S. Lau, R. Dhaliwal, O. Rossi, M.A. Riaz, D. Stonehouse-Smith, Y. Wang, S.N. Papageorgiou, L. Viriot, M.T. Cobourne

J Dent Res. 2022 Apr; 101(4): 473–482. Published online 2021 Nov 19. doi: 10.1177/00220345211049403

PMCID:: PMC8935464

Abstract Article PDF–4.4M

Select item 316202511.

Genome-Wide Detection of Allele Specific Copy Number Variation Associated with Insulin Resistance in African Americans from the HyperGEN Study

Marguerite R. Irvin, Nathan E. Wineinger, Treva K. Rice, Nicholas M. Pajewski, Edmond K. Kabagambe, Charles C. Gu, Jim Pankow, Kari E. North, Jemma B. Wilk, Barry I. Freedman, Nora Franceschini, Uli Broeckel, Hemant K. Tiwari, Donna K. Arnett

PLoS One. 2011; 6(8): e24052. Published online 2011 Aug 25. doi: 10.1371/journal.pone.0024052

PMCID:: PMC3162025

Abstract Article PDF–119K

Select item 40646712.

HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy

Yan Xu, Joseph Kulkosky, Edward Acheampong, Giuseppe Nunnari, Julie Sullivan, Roger J. Pomerantz

Proc Natl Acad Sci U S A. 2004 May 4; 101(18): 7070–7075. Published online 2004 Apr 21. doi: 10.1073/pnas.0304859101

PMCID:: PMC406467

Abstract Article PDF–362K

Select item 957870713.

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

Dirk H Siepe, Lukas T Henneberg, Steven C Wilson, Gaelen T Hess, Michael C Bassik, Kai Zinn, K Christopher Garcia

eLife. 2022; 11: e81398. Published online 2022 Sep 30. doi: 10.7554/eLife.81398

PMCID:: PMC9578707

Abstract Article PDF–3.3M

Select item 287244314.

Mig-6 controls EGFR trafficking and suppresses gliomagenesis

Haoqiang Ying, Hongwu Zheng, Kenneth Scott, Ruprecht Wiedemeyer, Haiyan Yan, Carol Lim, Joseph Huang, Sabin Dhakal, Elena Ivanova, Yonghong Xiao, Hailei Zhang, Jian Hu, Jayne M. Stommel, Michelle A. Lee, An-Jou Chen, Ji-Hye Paik, Oreste Segatto, Cameron Brennan, Lisa A. Elferink, Y. Alan Wang, Lynda Chin, Ronald A. DePinho

Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15): 6912–6917. Published online 2010 Mar 29. doi: 10.1073/pnas.0914930107

PMCID:: PMC2872443

Abstract Article PDF–967K

Select item 901632015.

A Hypoxia-Induced SCF^FBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis

Jun Zeng, Xiao-qing Xiao, Zhi-yong Zhou

Cancer Res Treat. 2022 Apr; 54(2): 525–540. Published online 2021 Jun 29. doi: 10.4143/crt.2021.373

PMCID:: PMC9016320

Abstract Article PDF–3.0M

Select item 290029516.

Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”

Sharon E. Johnatty, Jonathan Beesley, Xiaoqing Chen, Stuart Macgregor, David L. Duffy, Amanda B. Spurdle, Anna deFazio, Natalie Gava, Penelope M. Webb, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer), Mary Anne Rossing, Jennifer Anne Doherty, Marc T. Goodman, Galina Lurie, Pamela J. Thompson, Lynne R. Wilkens, Roberta B. Ness, Kirsten B. Moysich, Jenny Chang-Claude, Shan Wang-Gohrke, Daniel W. Cramer, Kathryn L. Terry, Susan E. Hankinson, Shelley S. Tworoger, Montserrat Garcia-Closas, Hannah Yang, Jolanta Lissowska, Stephen J. Chanock, Paul D. Pharoah, Honglin Song, Alice S. Whitemore, Celeste L. Pearce, Daniel O. Stram, Anna H. Wu, Malcolm C. Pike, Simon A. Gayther, Susan J. Ramus, Usha Menon, Aleksandra Gentry-Maharaj, Hoda Anton-Culver, Argyrios Ziogas, Estrid Hogdall, Susanne K. Kjaer, Claus Hogdall, Andrew Berchuck, Joellen M. Schildkraut, Edwin S. Iversen, Patricia G. Moorman, Catherine M. Phelan, Thomas A. Sellers, Julie M. Cunningham, Robert A. Vierkant, David N. Rider, Ellen L. Goode, Izhak Haviv, Georgia Chenevix-Trench, Ovarian Cancer Association Consortium

PLoS Genet. 2010 Jul; 6(7): e1001016. Published online 2010 Jul 8. doi: 10.1371/journal.pgen.1001016

PMCID:: PMC2900295

Abstract Article PDF–587K

Select item 589826617.

ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest

Aya Noguchi, Shungo Adachi, Naoto Yokota, Tomohisa Hatta, Tohru Natsume, Hiroyuki Kawahara

Biol Open. 2018 Mar 15; 7(3): bio031575. Published online 2018 Feb 15. doi: 10.1242/bio.031575

PMCID:: PMC5898266

Abstract Article PDF–3.4M

Select item 509804118.

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions

Charles A. S. Banks, Gina Boanca, Zachary T. Lee, Cassandra G. Eubanks, Gaye L. Hattem, Allison Peak, Lauren E. Weems, Juliana J. Conkright, Laurence Florens, Michael P. Washburn

Mol Cell Proteomics. 2016 Nov; 15(11): 3435–3449. Published online 2016 Sep 8. doi: 10.1074/mcp.M116.060509

PMCID:: PMC5098041

Abstract Article PDF–2.1M

Select item 923162319.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 268304720.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

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