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Select item 96294901.

Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8

Marco Preussner, Karine F. Santos, Jonathan Alles, Christina Heroven, Florian Heyd, Markus C. Wahl, Gert Weber

Acta Crystallogr D Struct Biol. 2022 Nov 1; 78(Pt 11): 1373–1383. Published online 2022 Oct 27. doi: 10.1107/S2059798322009755

PMCID:: PMC9629490

Article PDF–1.8M

Select item 95653722.

Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis

Lusheng Fan, Bin Gao, Ye Xu, Nora Flynn, Brandon Le, Chenjiang You, Shaofang Li, Natalia Achkar, Pablo A. Manavella, Zhenbiao Yang, Xuemei Chen

Proc Natl Acad Sci U S A. 2022 Oct 11; 119(41): e2208415119. Published online 2022 Oct 3. doi: 10.1073/pnas.2208415119

Correction in:: Proc Natl Acad Sci U S A. 2022 Dec 27; 119(52): e2219264119.

PMCID:: PMC9565372

Article PDF–2.3M

Select item 46315933.

Crystallization and biochemical characterization of the human spliceosomal Aar2–Prp8^RNaseH complex

Karine Santos, Marco Preussner, Anna Christina Heroven, Gert Weber

Acta Crystallogr F Struct Biol Commun. 2015 Nov 1; 71(Pt 11): 1421–1428. Published online 2015 Oct 23. doi: 10.1107/S2053230X15019202

PMCID:: PMC4631593

Article PDF–1.2M

Select item 82063484.

TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation

Klára Klimešová, Jitka Vojáčková, Nenad Radivojević, Franck Vandermoere, Edouard Bertrand, Celine Verheggen, David Staněk

Nat Commun. 2021; 12: 3646. Published online 2021 Jun 15. doi: 10.1038/s41467-021-23934-y

PMCID:: PMC8206348

Article PDF–5.5M

Select item 13701985.

The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p.

A Gottschalk, B Kastner, R Lührmann, P Fabrizio

RNA. 2001 Nov; 7(11): 1554–1565.

PMCID:: PMC1370198

Summary PDF–1.2M

Select item 59580996.

DNAJC17 is localized in nuclear speckles and interacts with splicing machinery components

A. Pascarella, G. Ferrandino, S. C. Credendino, C. Moccia, F. D’Angelo, B. Miranda, C. D’Ambrosio, P. Bielli, O. Spadaro, M. Ceccarelli, A. Scaloni, C. Sette, M. De Felice, G. De Vita, E. Amendola

Sci Rep. 2018; 8: 7794. Published online 2018 May 17. doi: 10.1038/s41598-018-26093-1

PMCID:: PMC5958099

Article PDF–2.0M

Select item 82257417.

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network

Yu-Kun Xia, Yi-Rong Zeng, Meng-Li Zhang, Peng Liu, Fang Liu, Hao Zhang, Chen-Xi He, Yi-Ping Sun, Jin-Ye Zhang, Cheng Zhang, Lei Song, Chen Ding, Yu-Jie Tang, Zhen Yang, Chen Yang, Pu Wang, Kun-Liang Guan, Yue Xiong, Dan Ye

Protein Cell. 2021 Jul; 12(7): 557–577. Published online 2020 Jul 18. doi: 10.1007/s13238-020-00754-2

PMCID:: PMC8225741

Article PDF–3.1M

Select item 34188448.

Methods for Quantification of in vivo Changes in Protein Ubiquitination following Proteasome and Deubiquitinase Inhibition

Namrata D. Udeshi, D. R. Mani, Thomas Eisenhaure, Philipp Mertins, Jacob D. Jaffe, Karl R. Clauser, Nir Hacohen, Steven A. Carr

Mol Cell Proteomics. 2012 May; 11(5): 148–159. Published online 2012 Apr 14. doi: 10.1074/mcp.M111.016857

PMCID:: PMC3418844

Article PDF–1.5M

Select item 32267199.

Global Identification of Modular Cullin-Ring Ligase Substrates

Michael J. Emanuele, Andrew E.H. Elia, Qikai Xu, Claudio R Thoma, Lior Izhar, Yumei Leng, Ailan Guo, Yi-Ning Chen, John Rush, Paul Wei-Che Hsu, Hsueh-Chi Sherry Yen, Stephen J Elledge

Cell. Author manuscript; available in PMC 2012 Apr 14.

Published in final edited form as: Cell. 2011 Oct 14; 147(2): 459–474. Published online 2011 Sep 29. doi: 10.1016/j.cell.2011.09.019

Correction in:: volume 148 on page 620

PMCID:: PMC3226719

Article PDF–5.9M

Select item 31087610.

Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics

Chun-Hung Lai, Chang-Yuan Chou, Lan-Yang Ch'ang, Chung-Shyan Liu, Wen-chang Lin

Genome Res. 2000 May; 10(5): 703–713. doi: 10.1101/gr.10.5.703

PMCID:: PMC310876

Article PDF–1.2M

Select item 320042711.

Systematic and quantitative assessment of the ubiquitin modified proteome

Woong Kim, Eric J. Bennett, Edward L. Huttlin, Ailan Guo, Jing Li, Anthony Possemato, Mathew E. Sowa, Ramin Rad, John Rush, Michael J. Comb, J. Wade Harper, Steven P. Gygi

Mol Cell. Author manuscript; available in PMC 2012 Oct 21.

Published in final edited form as: Mol Cell. 2011 Oct 21; 44(2): 325–340. Published online 2011 Sep 8. doi: 10.1016/j.molcel.2011.08.025

PMCID:: PMC3200427

Article PDF–3.1M

Select item 320587612.

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

Sebastian A. Wagner, Petra Beli, Brian T. Weinert, Michael L. Nielsen, Jürgen Cox, Matthias Mann, Chunaram Choudhary

Mol Cell Proteomics. 2011 Oct; 10(10): M111.013284. Published online 2011 Sep 1. doi: 10.1074/mcp.M111.013284

PMCID:: PMC3205876

Article PDF–4.8M

Select item 304715213.

Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level

Jannie M. R. Danielsen, Kathrine B. Sylvestersen, Simon Bekker-Jensen, Damian Szklarczyk, Jon W. Poulsen, Heiko Horn, Lars J. Jensen, Niels Mailand, Michael L. Nielsen

Mol Cell Proteomics. 2011 Mar; 10(3): M110.003590. Published online 2010 Dec 7. doi: 10.1074/mcp.M110.003590

PMCID:: PMC3047152

Article PDF–2.9M

Select item 962668814.

Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis

Xi Ling, Jiayi Lu, Xiaoyun Wang, Lan Liu, Lu Liu, Yadi Wang, Yujun Sun, Chune Ren, Chao Lu, Zhenhai Yu

iScience. 2022 Nov 18; 25(11): 105363. Published online 2022 Oct 14. doi: 10.1016/j.isci.2022.105363

PMCID:: PMC9626688

Article PDF–6.0M

Select item 546003515.

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein

Philippe Cloutier, Christian Poitras, Mathieu Durand, Omid Hekmat, Émilie Fiola-Masson, Annie Bouchard, Denis Faubert, Benoit Chabot, Benoit Coulombe

Nat Commun. 2017; 8: 15615. Published online 2017 May 31. doi: 10.1038/ncomms15615

PMCID:: PMC5460035

Article PDF–2.9M

Select item 743103016.

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Huettenhain, Robyn M. Kaake, Alicia L. Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J.P. Mathy, Tina Perica, Kala B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, Ramachandran Rakesh, Xi Liu, Sara B. Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, Jose Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A. Wankowicz, Markus Bohn, Maliheh Safari, Fatima S. Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J Fletcher, Michael C. O’Neal, Yiming Cai, Jason C.J.Chang, David J. Broadhurst, Saker Klippsten, Phillip P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu, Hao-Yuan Wang, Raphael Trenker, Janet M. Young, Devin A. Cavero, Joseph Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert M. Stroud, Alan D. Frankel, Oren S. Rosenberg, Kliment A Verba, David A. Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, Danica G. Fujimori, Trey Ideker, Charles S. Craik, Stephen N. Floor, James S. Fraser, John D. Gross, Andrej Sali, Bryan L. Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo García-Sastre, Kevan M. Shokat, Brian K. Shoichet, Nevan J. Krogan

Nature. Author manuscript; available in PMC 2020 Oct 30.

Published in final edited form as: Nature. 2020 Jul; 583(7816): 459–468. Published online 2020 Apr 30. doi: 10.1038/s41586-020-2286-9

PMCID:: PMC7431030

Article PDF–7.7M

Select item 910630317.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Article PDF–918K

Select item 420025218.

Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1

Joel W. Thompson, Jane Nagel, Sjouke Hoving, Bertran Gerrits, Andreas Bauer, Jason R. Thomas, Marc W. Kirschner, Markus Schirle, Sarah J. Luchansky

J Biol Chem. 2014 Oct 17; 289(42): 28942–28955. Published online 2014 Aug 21. doi: 10.1074/jbc.M114.573352

PMCID:: PMC4200252

Article PDF–1.6M

Select item 799307619.

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

Jin-Gu Lee, Weiliang Huang, Hangnoh Lee, Joyce van de Leemput, Maureen A. Kane, Zhe Han

Cell Biosci. 2021; 11: 58. Published online 2021 Mar 25. doi: 10.1186/s13578-021-00568-7

PMCID:: PMC7993076

Article PDF–2.0M

Select item 760600820.

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A

Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng

Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676

PMCID:: PMC7606008

Article PDF–2.5M

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