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Select item 111594931.

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers

Mai Shimada, Kyoko Kitagawa, Yoh Dobashi, Tomoyasu Isobe, Takayuki Hattori, Chiharu Uchida, Kenji Abe, Yojiro Kotake, Toshiaki Oda, Hiroyuki Suzuki, Kenji Hashimoto, Masatoshi Kitagawa

Cancer Sci. 2009 May; 100(5): 866–872. Published online 2009 Mar 25. doi: 10.1111/j.1349-7006.2009.01122.x

PMCID:: PMC11159493

Abstract Article PDF–7.9M

Select item 105918462.

Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10

Pratik Rajendra Patil, A. Maxwell Burroughs, Mohit Misra, Federico Cerullo, Carlos Costas-Insua, Hao-Chih Hung, Ivan Dikic, L. Aravind, Claudio A.P. Joazeiro

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113100. Published online 2023 Sep 6. doi: 10.1016/j.celrep.2023.113100

PMCID:: PMC10591846

Abstract Article PDF–1.9M

Select item 92995393.

G6PD-mediated increase in de novo NADP⁺ biosynthesis promotes antioxidant defense and tumor metastasis

Yang Zhang, Yi Xu, Wenyun Lu, Jinyang Li, Sixiang Yu, Eric J. Brown, Ben Z. Stanger, Joshua D. Rabinowitz, Xiaolu Yang

Sci Adv. 2022 Jul; 8(29): eabo0404. Published online 2022 Jul 20. doi: 10.1126/sciadv.abo0404

PMCID:: PMC9299539

Abstract Article PDF–2.1M

Select item 44116734.

Human Pirh2 is A Novel Inhibitor of Prototype Foamy Virus Replication

Lanlan Dong, Qingqing Cheng, Zhihao Wang, Peipei Yuan, Zhi Li, Yan Sun, Song Han, Jun Yin, Biwen Peng, Xiaohua He, Wanhong Liu

Viruses. 2015 Apr; 7(4): 1668–1684. Published online 2015 Apr 2. doi: 10.3390/v7041668

PMCID:: PMC4411673

Abstract Article PDF–1001K

Select item 41305195.

Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase

Wensheng Yan, Yong-Sam Jung, Yanhong Zhang, Xinbin Chen

PLoS One. 2014; 9(8): e103497. Published online 2014 Aug 12. doi: 10.1371/journal.pone.0103497

PMCID:: PMC4130519

Abstract Article PDF–1.5M

Select item 36805366.

Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein

Asen Bagashev, Shongshan Fan, Ruma Mukerjee, Pier Paolo Claudio, Tinatin Chabrashvili, Roger P. Leng, Samuel Benchimol, Bassel E. Sawaya

Cell Cycle. 2013 May 15; 12(10): 1569–1577. Published online 2013 Apr 19. doi: 10.4161/cc.24733

PMCID:: PMC3680536

Abstract Article PDF–3.0M

Select item 31955997.

The p73 Tumor Suppressor Is Targeted by Pirh2 RING Finger E3 Ubiquitin Ligase for the Proteasome-dependent Degradation

Yong-Sam Jung, Yingjuan Qian, Xinbin Chen

J Biol Chem. 2011 Oct 14; 286(41): 35388–35395. Published online 2011 Aug 18. doi: 10.1074/jbc.M111.261537

PMCID:: PMC3195599

Abstract Article PDF–2.8M

Select item 28155608.

Pirh2 E3 Ubiquitin Ligase Targets DNA Polymerase Eta for 20S Proteasomal Degradation

Yong-Sam Jung, Gang Liu, Xinbin Chen

Mol Cell Biol. 2010 Feb; 30(4): 1041–1048. Published online 2009 Dec 14. doi: 10.1128/MCB.01198-09

PMCID:: PMC2815560

Abstract Article PDF–1.5M

Select item 27080949.

PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53

Gang Zheng, Jinying Ning, Yu-Chung Yang

Biochem Biophys Res Commun. Author manuscript; available in PMC 2009 Jul 9.

Published in final edited form as: Biochem Biophys Res Commun. 2007 Dec 14; 364(2): 344–350. Published online 2007 Oct 11. doi: 10.1016/j.bbrc.2007.10.003

PMCID:: PMC2708094

Abstract Article PDF–1.8M

Select item 808677210.

Pirh2, an E3 ligase, regulates the AIP4–p73 regulatory pathway by modulating AIP4 expression and ubiquitination

Rami Abou Zeinab, H Helena Wu, Yasser Abuetabh, Sarah Leng, Consolato Sergi, David D Eisenstat, Roger P Leng

Carcinogenesis. 2021 Apr; 42(4): 650–662. Published online 2021 Feb 11. doi: 10.1093/carcin/bgab009

PMCID:: PMC8086772

Abstract Article PDF–750K

Select item 680018411.

p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT

Yang Yang-Hartwich, Roslyn Tedja, Cai Roberts, Jamie Goodner-Bingham, Carlos Cardenas, Marta Gurea, Natalia J. Sumi, Ayesha B. Alvero, Carlotta A Glackin, Gil Mor

Mol Cancer Res. Author manuscript; available in PMC 2019 Oct 18.

Published in final edited form as: Mol Cancer Res. 2019 Jan; 17(1): 153–164. Published online 2018 Aug 21. doi: 10.1158/1541-7786.MCR-18-0238

PMCID:: PMC6800184

Abstract Article PDF–1.8M

Select item 361077412.

Pirh2 E3 Ubiquitin Ligase Modulates Keratinocyte Differentiation Through p63

Yong-Sam Jung, Yingjuan Qian, Wensheng Yan, Xinbin Chen

J Invest Dermatol. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: J Invest Dermatol. 2013 May; 133(5): 1178–1187. Published online 2012 Dec 13. doi: 10.1038/jid.2012.466

PMCID:: PMC3610774

Abstract Article PDF–836K

Select item 159284313.

Human PIRH2 Enhances Androgen Receptor Signaling through Inhibition of Histone Deacetylase 1 and Is Overexpressed in Prostate Cancer

Ian R. Logan, Luke Gaughan, Stuart R. C. McCracken, Vasileia Sapountzi, Hing Y. Leung, Craig N. Robson

Mol Cell Biol. 2006 Sep; 26(17): 6502–6510. doi: 10.1128/MCB.00147-06

PMCID:: PMC1592843

Abstract Article PDF–528K

Select item 814103514.

Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing

Anna Thrun, Aitor Garzia, Yu Kigoshi-Tansho, Pratik R. Patil, Charles S. Umbaugh, Teresa Dallinger, Jia Liu, Sylvia Kreger, Annarita Patrizi, Gregory A. Cox, Thomas Tuschl, Claudio A.P. Joazeiro

Mol Cell. Author manuscript; available in PMC 2022 May 20.

Published in final edited form as: Mol Cell. 2021 May 20; 81(10): 2112–2122.e7. Published online 2021 Apr 27. doi: 10.1016/j.molcel.2021.03.004

PMCID:: PMC8141035

Abstract Article PDF–1.3M

Select item 321959115.

Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

Anne Hakem, Miyuki Bohgaki, Bénédicte Lemmers, Elisabeth Tai, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Yong-Sam Jung, Jana Karaskova, Lilia Kaustov, Shili Duan, Jason Madore, Paul Boutros, Yi Sheng, Marta Chesi, P. Leif Bergsagel, Bayardo Perez-Ordonez, Anne-Marie Mes-Masson, Linda Penn, Jeremy Squire, Xinbin Chen, Igor Jurisica, Cheryl Arrowsmith, Otto Sanchez, Samuel Benchimol, Razqallah Hakem

PLoS Genet. 2011 Nov; 7(11): e1002360. Published online 2011 Nov 17. doi: 10.1371/journal.pgen.1002360

PMCID:: PMC3219591

Abstract Article PDF–6.4M

Select item 303934216.

Structural and Functional Comparison of the RING Domains of Two p53 E3 Ligases, Mdm2 and Pirh2

Jonathan Shloush, John E. Vlassov, Ian Engson, Shili Duan, Vivian Saridakis, Sirano Dhe-paganon, Brian Raught, Yi Sheng, Cheryl H. Arrowsmith

J Biol Chem. 2011 Feb 11; 286(6): 4796–4808. Published online 2010 Nov 17. doi: 10.1074/jbc.M110.157669

PMCID:: PMC3039342

Abstract Article PDF–2.5M

Select item 239872817.

Tip60 Is Required for DNA Interstrand Cross-link Repair in the Fanconi Anemia Pathway

James Hejna, Megan Holtorf, Jennie Hines, Lauren Mathewson, Aaron Hemphill, Muhsen Al-Dhalimy, Susan B. Olson, Robb E. Moses

J Biol Chem. 2008 Apr 11; 283(15): 9844–9851. doi: 10.1074/jbc.M709076200

PMCID:: PMC2398728

Abstract Article PDF–347K

Select item 502462818.

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PL^pro via E3 ubiquitin ligase RCHY1

Yue Ma-Lauer, Javier Carbajo-Lozoya, Marco Y. Hein, Marcel A. Müller, Wen Deng, Jian Lei, Benjamin Meyer, Yuri Kusov, Brigitte von Brunn, Dev Raj Bairad, Sabine Hünten, Christian Drosten, Heiko Hermeking, Heinrich Leonhardt, Matthias Mann, Rolf Hilgenfeld, Albrecht von Brunn

Proc Natl Acad Sci U S A. 2016 Aug 30; 113(35): E5192–E5201. Published online 2016 Aug 12. doi: 10.1073/pnas.1603435113

PMCID:: PMC5024628

Abstract Article PDF–1.7M

Select item 382056419.

The Homeodomain Transcription Factor Hoxa2 Interacts with and Promotes the Proteasomal Degradation of the E3 Ubiquitin Protein Ligase RCHY1

Isabelle Bergiers, Laure Bridoux, Nathan Nguyen, Jean-Claude Twizere, René Rezsöhazy

PLoS One. 2013; 8(11): e80387. Published online 2013 Nov 7. doi: 10.1371/journal.pone.0080387

PMCID:: PMC3820564

Abstract Article PDF–1.2M

Select item 318737120.

Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis

Yong-Sam Jung, Anne Hakem, Razqallah Hakem, Xinbin Chen

Mol Cell Biol. 2011 Oct; 31(19): 3997–4006. doi: 10.1128/MCB.05808-11

PMCID:: PMC3187371

Abstract Article PDF–2.5M

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