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Select item 109451751.

Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment

Jiali Qian, Chuxin Huang, Mimi Wang, Ying Liu, Yingying Zhao, Miao Li, Xi Zhang, Xiangyu Gao, Yawen Zhang, Yi Wang, Jinya Huang, Jiajun Li, Qiwen Zhou, Rui Liu, Xuanchun Wang, Jiefeng Cui, Yehong Yang

Redox Biol. 2024 May; 71: 103103. Published online 2024 Mar 4. doi: 10.1016/j.redox.2024.103103

PMCID:: PMC10945175

Abstract Article PDF–19M

Select item 107020132.

M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics

Lizhe Guo, Lu Wang, Gang Qin, Junjie Zhang, Jin Peng, Longyan Li, Xiang Chen, Dandan Wang, Jian Qiu, E. Wang

J Transl Med. 2023; 21: 888. Published online 2023 Dec 7. doi: 10.1186/s12967-023-04780-6

PMCID:: PMC10702013

Abstract Article PDF–5.0M

Select item 99362593.

Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arterial hypertension via regulation of PKM2

Wenfeng Li, Wenjuan Chen, Hongyan Peng, Zhenghui Xiao, Jinqiao Liu, Yunhong Zeng, Ting Huang, Qingqing Song, Xun Wang, Yunbin Xiao

Mol Med Rep. 2023 Mar; 27(3): 60. Published online 2023 Feb 1. doi: 10.3892/mmr.2023.12947

PMCID:: PMC9936259

Abstract Article PDF–8.4M

Select item 99169474.

Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy

Yeon Su Park, Joo Hee Han, Jae Hyeon Park, Ji Soo Choi, Seung Hyeon Kim, Hyung Sik Kim

Int J Mol Sci. 2023 Feb; 24(3): 2683. Published online 2023 Jan 31. doi: 10.3390/ijms24032683

PMCID:: PMC9916947

Abstract Article PDF–3.0M

Select item 87952555.

Bile acids attenuate PKM2 pathway activation in proinflammatory microglia

Lorenzo Romero-Ramírez, Concepción García-Rama, Siyu Wu, Jörg Mey

Sci Rep. 2022; 12: 1459. Published online 2022 Jan 27. doi: 10.1038/s41598-022-05408-3

Correction in:: Sci Rep. 2022; 12: 3399.

PMCID:: PMC8795255

Abstract Article PDF–4.3M

Select item 24510406.

Regulation of M₂-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation

H Ryu, J K L Walker, S Kim, N Koo, L S Barak, T Noguchi, B Y Kang, K-M Kim

Br J Pharmacol. 2008 Jul; 154(5): 1035–1046. Published online 2008 Apr 21. doi: 10.1038/bjp.2008.148

PMCID:: PMC2451040

Abstract Article PDF–262K

Select item 3184407.

The nucleotide sequence of a full length cDNA encoding rat pituitary pyruvate kinase.

C Parkison, H Kato, S Y Cheng

Nucleic Acids Res. 1989 Sep 12; 17(17): 7106. doi: 10.1093/nar/17.17.7106

PMCID:: PMC318440

Summary Page Browse PDF–101K

Select item 64873768.

Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions

Yang-Hui Bi, Wen-Qi Han, Ruo-Fei Li, Yun-Jiao Wang, Zun-Shu Du, Xue-Jiang Wang, Ying Jiang

World J Gastroenterol. 2019 Apr 28; 25(16): 1936–1949. Published online 2019 Apr 28. doi: 10.3748/wjg.v25.i16.1936

PMCID:: PMC6487376

Abstract Article PDF–21M

Select item 46131699.

Nuclear translocation of PKM2 modulates astrocyte proliferation via p27 and β-catenin pathway after spinal cord injury

Jinlong Zhang, Guijuan Feng, Guofeng Bao, Guanhua Xu, Yuyu Sun, Weidong Li, Lingling Wang, Jiajia Chen, Huricha Jin, Zhiming Cui

Cell Cycle. 2015 Aug 18; 14(16): 2609–2618. Published online 2015 Jul 7. doi: 10.1080/15384101.2015.1064203

PMCID:: PMC4613169

Abstract Article PDF–1010K

Select item 282399110.

Identification of small molecule inhibitors of pyruvate kinase M2

Matthew G. Vander Heiden, Heather R. Christofk, Eli Schuman, Alexander O. Subtelny, Hadar Sharfi, Edward E. Harlow, Jun Xian, Lewis C. Cantley

Biochem Pharmacol. Author manuscript; available in PMC 2011 Apr 15.

Published in final edited form as: Biochem Pharmacol. 2010 Apr 15; 79(8): 1118–1124. Published online 2009 Dec 11. doi: 10.1016/j.bcp.2009.12.003

PMCID:: PMC2823991

Abstract Article PDF–406K

Select item 910152011.

Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis

Yosuke Inomata, Jae-Won Oh, Kohei Taniguchi, Nobuhiko Sugito, Nao Kawaguchi, Fumitoshi Hirokawa, Sang-Woong Lee, Yukihiro Akao, Shinji Takai, Kwang-Pyo Kim, Kazuhisa Uchiyama

Int J Mol Sci. 2022 May; 23(9): 5230. Published online 2022 May 7. doi: 10.3390/ijms23095230

PMCID:: PMC9101520

Abstract Article PDF–4.4M

Select item 404071112.

Control of glioma cell death and differentiation by PKM2–Oct4 interaction

M Morfouace, L Lalier, L Oliver, M Cheray, C Pecqueur, P-F Cartron, F M Vallette

Cell Death Dis. 2014 Jan; 5(1): e1036. Published online 2014 Jan 30. doi: 10.1038/cddis.2013.561

PMCID:: PMC4040711

Abstract Article PDF–1.7M

Select item 116598013.

Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo

J. M. Gunn, C. B. Taylor

Biochem J. 1973 Nov; 136(3): 455–465. doi: 10.1042/bj1360455

PMCID:: PMC1165980

Summary Page Browse PDF–1.6M

Select item 674904314.

Effects of Tianshu Capsule on Spontaneously Hypertensive Rats as Revealed by ¹H-NMR-Based Metabolic Profiling

Jian Gao, Tieshan Wang, Chao Wang, Shuai Wang, Wei Wang, Di Ma, Yongbiao Li, Haibin Zhao, Jianxin Chen

Front Pharmacol. 2019; 10: 989. Published online 2019 Sep 11. doi: 10.3389/fphar.2019.00989

PMCID:: PMC6749043

Abstract Article PDF–2.0M

Select item 425060315.

Gene expression profile in rat small intestinal allografts after cold preservation/reperfusion

Shu-Feng Wang, Qi Liang, Guo-Wei Li, Kun Gao

World J Gastroenterol. 2005 Feb 14; 11(6): 885–889. Published online 2005 Feb 14. doi: 10.3748/wjg.v11.i6.885

PMCID:: PMC4250603

Abstract Article PDF–479K

Select item 381102216.

Isolation of Mammalian 26S Proteasomes and p97/VCP Complexes Using the Ubiquitin-like Domain from HHR23B Reveals Novel Proteasome-Associated Proteins

Henrike C. Besche, Wilhelm Haas, Steven P. Gygi, Alfred L. Goldberg

Biochemistry. Author manuscript; available in PMC 2013 Oct 29.

Published in final edited form as: Biochemistry. 2009 Mar 24; 48(11): 10.1021/bi802198q. doi: 10.1021/bi802198q

PMCID:: PMC3811022

Abstract Article PDF–3.7M

Select item 269865517.

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

Mehmet Kesimer, Margaret Scull, Brian Brighton, Genevieve DeMaria, Kimberlie Burns, Wanda O'Neal, Raymond J. Pickles, John K. Sheehan

FASEB J. 2009 Jun; 23(6): 1858–1868. doi: 10.1096/fj.08-119131

PMCID:: PMC2698655

Abstract Article

Select item 308558418.

Protein Profile of Exosomes from Trabecular Meshwork Cells

WD Stamer, EA Hoffman, JM Luther, DL Hachey, KL Schey

J Proteomics. Author manuscript; available in PMC 2012 May 16.

Published in final edited form as: J Proteomics. 2011 May 16; 74(6): 796–804. Published online 2011 Mar 8. doi: 10.1016/j.jprot.2011.02.024

PMCID:: PMC3085584

Abstract Article PDF–1.3M

Select item 369664619.

Comparative Proteomic Analysis of Supportive and Unsupportive Extracellular Matrix Substrates for Human Embryonic Stem Cell Maintenance

Despina Soteriou, Banu Iskender, Adam Byron, Jonathan D. Humphries, Simon Borg-Bartolo, Marie-Claire Haddock, Melissa A. Baxter, David Knight, Martin J. Humphries, Susan J. Kimber

J Biol Chem. 2013 Jun 28; 288(26): 18716–18731. Published online 2013 May 8. doi: 10.1074/jbc.M113.463372