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Items: 1 to 20 of 36

1.
Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption
Keiko Unno, Kyoko Taguchi, Yoshiichi Takagi, Tadashi Hase, Shinichi Meguro, Yoriyuki Nakamura
Int J Mol Sci. 2023 Apr; 24(7): 6278. Published online 2023 Mar 27. doi: 10.3390/ijms24076278
PMCID:
PMC10094282
AbstractArticlePDF–447K
2.
SGLT2 Inhibition by Intraperitoneal Dapagliflozin Mitigates Peritoneal Fibrosis and Ultrafiltration Failure in a Mouse Model of Chronic Peritoneal Exposure to High-Glucose Dialysate
Michael S. Balzer, Song Rong, Johannes Nordlohne, Jan D. Zemtsovski, Sonja Schmidt, Britta Stapel, Maria Bartosova, Sibylle von Vietinghoff, Hermann Haller, Claus P. Schmitt, Nelli Shushakova
Biomolecules. 2020 Nov; 10(11): 1573. Published online 2020 Nov 19. doi: 10.3390/biom10111573
PMCID:
PMC7699342
AbstractArticlePDF–4.0M
3.
Sodium-Glucose Co-Transporter 2 Inhibitors Correct Metabolic Maladaptation of Proximal Tubular Epithelial Cells in High-Glucose Conditions
Kohsuke Shirakawa, Motoaki Sano
Int J Mol Sci. 2020 Oct; 21(20): 7676. Published online 2020 Oct 16. doi: 10.3390/ijms21207676
PMCID:
PMC7589591
AbstractArticlePDF–4.6M
4.
Gene knockout of the Na+-glucose cotransporter SGLT2 in a murine model of acute kidney injury induced by ischemia-reperfusion
Josselin Nespoux, Rohit Patel, Haiyan Zhang, Winnie Huang, Brent Freeman, Paul W. Sanders, Young Chul Kim, Volker Vallon
Am J Physiol Renal Physiol. 2020 May 1; 318(5): F1100–F1112. Published online 2020 Mar 2. doi: 10.1152/ajprenal.00607.2019
PMCID:
PMC7294332
AbstractArticle
5.
Genetic ablation of SGLT2 function in mice impairs tissue mineral density but does not affect fracture resistance of bone
Kathryn M. Thrailkill, R. Clay Bunn, Sasidhar Uppuganti, Philip Ray, Kate Garrett, Iuliana Popescu, Jacquelyn S. Pennings, John L. Fowlkes, Jeffry S. Nyman
Bone. Author manuscript; available in PMC 2021 Apr 1.
Published in final edited form as: Bone. 2020 Apr; 133: 115254. Published online 2020 Jan 25. doi: 10.1016/j.bone.2020.115254
PMCID:
PMC7059549
AbstractArticlePDF–839K
6.
Sodium-Glucose Cotransporter 2 Inhibitor and a Low Carbohydrate Diet Affect Gluconeogenesis and Glycogen Content Differently in the Kidney and the Liver of Non-Diabetic Mice
Kuralay Atageldiyeva, Yukihiro Fujita, Tsuyoshi Yanagimachi, Katsutoshi Mizumoto, Yasutaka Takeda, Jun Honjo, Yumi Takiyama, Atsuko Abiko, Yuichi Makino, Masakazu Haneda
PLoS One. 2016; 11(6): e0157672. Published online 2016 Jun 21. doi: 10.1371/journal.pone.0157672
PMCID:
PMC4915669
AbstractArticlePDF–4.1M
7.
Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice
Yumiko Chiba, Tetsuya Yamada, Sohei Tsukita, Kei Takahashi, Yuichiro Munakata, Yuta Shirai, Shinjiro Kodama, Yoichiro Asai, Takashi Sugisawa, Kenji Uno, Shojiro Sawada, Junta Imai, Kazuhiro Nakamura, Hideki Katagiri
PLoS One. 2016; 11(3): e0150756. Published online 2016 Mar 10. doi: 10.1371/journal.pone.0150756
PMCID:
PMC4786146
AbstractArticlePDF–2.4M
8.
Sodium-Glucose Transporter-2 (SGLT2; SLC5A2) Enhances Cellular Uptake of Aminoglycosides
Meiyan Jiang, Qi Wang, Takatoshi Karasawa, Ja-Won Koo, Hongzhe Li, Peter S. Steyger
PLoS One. 2014; 9(9): e108941. Published online 2014 Sep 30. doi: 10.1371/journal.pone.0108941
PMCID:
PMC4182564
AbstractArticlePDF–3.8M
9.
Expression of Na+-d-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences
Ivan Sabolić, Ivana Vrhovac, Daniela Balen Eror, Maria Gerasimova, Michael Rose, Davorka Breljak, Marija Ljubojević, Hrvoje Brzica, Anne Sebastiani, Serge C. Thal, Christoph Sauvant, Helmut Kipp, Volker Vallon, Hermann Koepsell
Am J Physiol Cell Physiol. 2012 Apr 15; 302(8): C1174–C1188. Published online 2012 Jan 18. doi: 10.1152/ajpcell.00450.2011
PMCID:
PMC3774553
AbstractArticle
10.
SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule
Volker Vallon, Kenneth A. Platt, Robyn Cunard, Jana Schroth, Jean Whaley, Scott C. Thomson, Hermann Koepsell, Timo Rieg
J Am Soc Nephrol. 2011 Jan; 22(1): 104–112. doi: 10.1681/ASN.2010030246
PMCID:
PMC3014039
AbstractArticle
11.
Col4a3-/- Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds
Camila I. Irion, Monique Williams, Jose Condor Capcha, Trevor Eisenberg, Guerline Lambert, Lauro M. Takeuchi, Grace Seo, Keyvan Yousefi, Rosemeire Kanashiro-Takeuchi, Keith A. Webster, Karen C. Young, Joshua M. Hare, Lina A. Shehadeh
Int J Mol Sci. 2022 Jun; 23(12): 6674. Published online 2022 Jun 15. doi: 10.3390/ijms23126674
PMCID:
PMC9223785
AbstractArticlePDF–7.7M
12.
Sodium/glucose cotransporter 2 is expressed in choroid plexus epithelial cells and ependymal cells in human and mouse brains
Yoichi Chiba, Yasunori Sugiyama, Nozomu Nishi, Wakako Nonaka, Ryuta Murakami, Masaki Ueno
Neuropathology. 2020 Oct; 40(5): 482–491. Published online 2020 Jun 2. doi: 10.1111/neup.12665
PMCID:
PMC7587001
AbstractArticlePDF–17M
13.
Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age
Keiko Unno, Yoshiichi Takagi, Tomokazu Konishi, Mitsuhiro Suzuki, Akiyuki Miyake, Takumi Kurotaki, Tadashi Hase, Shinichi Meguro, Atsuyoshi Shimada, Sanae Hasegawa-Ishii, Monira Pervin, Kyoko Taguchi, Yoriyuki Nakamura
Int J Mol Sci. 2020 Aug; 21(15): 5579. Published online 2020 Aug 4. doi: 10.3390/ijms21155579
PMCID:
PMC7432872
AbstractArticlePDF–1.1M
14.
No direct effect of sodium-glucose transporter-2 (SGLT2) activity on glucagon secretion
Rune E. Kuhre, Seyed M. Ghiasi, Alice E. Adriaenssens, Nicolai J. Wewer Albrechtsen, Daniel B. Andersen, Alexander Aivazidis, Lihua Chen, Thomas Mandrup-Poulsen, Cathrine Ørskov, Fiona M. Gribble, Frank Reimann, Nils Wierup, Björn Tyrberg, Jens J. Holst
Diabetologia. Author manuscript; available in PMC 2020 May 11.
Published in final edited form as: Diabetologia. 2019 Jun 1; 62(6): 1011–1023. Published online 2019 Mar 22. doi: 10.1007/s00125-019-4849-6
PMCID:
PMC7212061
AbstractArticlePDF–2.1M
15.
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Nat Commun. 2019; 10: 139. Published online 2019 Jan 11. doi: 10.1038/s41467-018-08193-8
PMCID:
PMC6329806
AbstractArticlePDF–985K
16.
Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia
Timo Rieg, Takahiro Masuda, Maria Gerasimova, Eric Mayoux, Kenneth Platt, David R. Powell, Scott C. Thomson, Hermann Koepsell, Volker Vallon
Am J Physiol Renal Physiol. 2014 Jan 15; 306(2): F188–F193. Published online 2013 Nov 13. doi: 10.1152/ajprenal.00518.2013
PMCID:
PMC3920019
AbstractArticle
17.
SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function
Michael J. Jurczak, Hui-Young Lee, Andreas L. Birkenfeld, Francois R. Jornayvaz, David W. Frederick, Rebecca L. Pongratz, Xiaoxian Zhao, Gilbert W. Moeckel, Varman T. Samuel, Jean M. Whaley, Gerald I. Shulman, Richard G. Kibbey
Diabetes. 2011 Mar; 60(3): 890–898. Published online 2011 Feb 21. doi: 10.2337/db10-1328
PMCID:
PMC3046850
AbstractArticlePDF–1.6M
18.
Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2
Mitsunori Fujino, Naoki Morito, Takuto Hayashi, Masami Ojima, Shun Ishibashi, Akihiro Kuno, Seizo Koshiba, Kunihiro Yamagata, Satoru Takahashi
JCI Insight. 2023 Mar 22; 8(6): e163306. Published online 2023 Mar 22. doi: 10.1172/jci.insight.163306
PMCID:
PMC10070115
AbstractArticlePDF–14M
19.
Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin
Shih-Jie Jhuo, I-Hsin Liu, Wei-Chung Tasi, Te-Wu Chou, Yi-Hsiung Lin, Bin-Nan Wu, Kun-Tai Lee, Wen-Ter Lai
Int J Mol Sci. 2021 Jun; 22(11): 6105. Published online 2021 Jun 5. doi: 10.3390/ijms22116105
PMCID:
PMC8200966
AbstractArticlePDF–4.4M
20.
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans
Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Nancy Antoine, Firas Khattab, Bao-Khanh Lai, Davide Brusa, Birgit Stierstorfer, Holger Klein, Bilal Singh, Lucie Ruiz, Michael Pieper, Michael Mark, Pedro L. Herrera, Fiona M. Gribble, Frank Reimann, Anne Wojtusciszyn, Christophe Broca, Nano Rita, Lorenzo Piemonti, Patrick Gilon
Mol Metab. 2020 Dec; 42: 101071. Published online 2020 Sep 5. doi: 10.1016/j.molmet.2020.101071
PMCID:
PMC7554656
AbstractArticlePDF–5.0M

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