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Select item 92391001.

Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner

Rebecca L. Casazza, Drake T. Philip, Helen M. Lazear

mBio. 2022 May-Jun; 13(3): e03857-21. Published online 2022 Apr 26. doi: 10.1128/mbio.03857-21

PMCID:: PMC9239100

Abstract Article PDF–3.1M

Select item 70718912.

Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus

Rishi R. Goel, Xinghao Wang, Liam J. O’Neil, Shuichiro Nakabo, Kowser Hasneen, Sarthak Gupta, Gustaf Wigerblad, Luz P. Blanco, Jeffrey B. Kopp, Maria I. Morasso, Sergei V. Kotenko, Zu-Xi Yu, Carmelo Carmona-Rivera, Mariana J. Kaplan

Proc Natl Acad Sci U S A. 2020 Mar 10; 117(10): 5409–5419. Published online 2020 Feb 24. doi: 10.1073/pnas.1916897117

PMCID:: PMC7071891

Abstract Article PDF–1.8M

Select item 63367863.

Interferon lambda protects the female reproductive tract against Zika virus infection

Elizabeth A. Caine, Suzanne M. Scheaffer, Nitin Arora, Konstantin Zaitsev, Maxim N. Artyomov, Carolyn B. Coyne, Kelle H. Moley, Michael S. Diamond

Nat Commun. 2019; 10: 280. Published online 2019 Jan 17. doi: 10.1038/s41467-018-07993-2

PMCID:: PMC6336786

Abstract Article PDF–2.2M

Select item 59555434.

Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection

Silvia Gimeno Brias, Morgan Marsden, Jessica Forbester, Mathew Clement, Cordelia Brandt, Katherine Harcourt, Leanne Kane, Lucy Chapman, Simon Clare, Ian R. Humphreys

PLoS One. 2018; 13(5): e0197596. Published online 2018 May 16. doi: 10.1371/journal.pone.0197596

PMCID:: PMC5955543

Abstract Article PDF–3.9M

Select item 90213575.

Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron

Zhenlu Chong, Courtney E. Karl, Peter J. Halfmann, Yoshihiro Kawaoka, Emma S. Winkler, Shamus P. Keeler, Michael J. Holtzman, Jinsheng Yu, Michael S. Diamond

Cell Rep. 2022 May 10; 39(6): 110799. Published online 2022 Apr 21. doi: 10.1016/j.celrep.2022.110799

PMCID:: PMC9021357

Abstract Article PDF–6.2M

Select item 81132466.

Critical role of interferons in gastrointestinal injury repair

Constance McElrath, Vanessa Espinosa, Jian-Da Lin, Jianya Peng, Raghavendra Sridhar, Orchi Dutta, Hsiang-Chi Tseng, Sergey V. Smirnov, Heidi Risman, Marvin J. Sandoval, Viralkumar Davra, Yun-Juan Chang, Brian P. Pollack, Raymond B. Birge, Mark Galan, Amariliz Rivera, Joan E. Durbin, Sergei V. Kotenko

Nat Commun. 2021; 12: 2624. Published online 2021 May 11. doi: 10.1038/s41467-021-22928-0

PMCID:: PMC8113246

Abstract Article PDF–4.0M

Select item 75499507.

B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria

William O. Hahn, Marion Pepper, W. Conrad Liles

Virulence. 2020; 11(1): 594–606. Published online 2020 Jun 7. doi: 10.1080/21505594.2020.1768329

PMCID:: PMC7549950

Abstract Article PDF–4.0M

Select item 72174878.

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells

Deanna M. Santer, Gillian E. S. Minty, Dominic P. Golec, Julia Lu, Julia May, Afshin Namdar, Juhi Shah, Shokrollah Elahi, David Proud, Michael Joyce, D. Lorne Tyrrell, Michael Houghton

PLoS Pathog. 2020 Apr; 16(4): e1008515. Published online 2020 Apr 30. doi: 10.1371/journal.ppat.1008515

PMCID:: PMC7217487

Abstract Article PDF–2.7M

Select item 63764069.

The Effects of IFN-λ on Epithelial Barrier Function Contribute to Klebsiella pneumoniae ST258 Pneumonia

Danielle Ahn, Matthew Wickersham, Sebastian Riquelme, Alice Prince

Am J Respir Cell Mol Biol. 2019 Feb; 60(2): 158–166. doi: 10.1165/rcmb.2018-0021OC

PMCID:: PMC6376406

Abstract Article PDF–1.2M

Select item 595354210.

IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

Jonas Klinkhammer, Daniel Schnepf, Liang Ye, Marilena Schwaderlapp, Hans Henrik Gad, Rune Hartmann, Dominique Garcin, Tanel Mahlakõiv, Peter Staeheli

eLife. 2018; 7: e33354. Published online 2018 Apr 13. doi: 10.7554/eLife.33354

PMCID:: PMC5953542

Abstract Article PDF–1.9M

Select item 570151311.

IFN-? suppresses intestinal inflammation by non-translational regulation of neutrophil function

Achille Broggi, Yunhao Tan, Francesca Granucci, Ivan Zanoni

Nat Immunol. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Nat Immunol. 2017 Oct; 18(10): 1084–1093. Published online 2017 Aug 28. doi: 10.1038/ni.3821

PMCID:: PMC5701513

Abstract Article PDF–2.3M

Select item 535559412.

Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus

Megan T. Baldridge, Sanghyun Lee, Judy J. Brown, Nicole McAllister, Kelly Urbanek, Terence S. Dermody, Timothy J. Nice, Herbert W. Virgin

J Virol. 2017 Apr 1; 91(7): e02079-16. Prepublished online 2017 Jan 11. Published online 2017 Mar 13. doi: 10.1128/JVI.02079-16

PMCID:: PMC5355594

Abstract Article PDF–459K

Select item 447903813.

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

Mahima Swamy, Lucie Abeler-Dörner, James Chettle, Tanel Mahlakõiv, Delphine Goubau, Probir Chakravarty, George Ramsay, Caetano Reis e Sousa, Peter Staeheli, Barbara A. Blacklaws, Jonathan L. Heeney, Adrian C. Hayday

Nat Commun. 2015; 6: 7090. Published online 2015 May 19. doi: 10.1038/ncomms8090

PMCID:: PMC4479038

Abstract Article PDF–1.1M

Select item 443572414.

Interferon-? restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

Helen M. Lazear, Brian P. Daniels, Amelia K. Pinto, Albert C. Huang, Sarah C. Vick, Sean E. Doyle, Michael Gale, Jr, Robyn S. Klein, Michael S. Diamond

Sci Transl Med. Author manuscript; available in PMC 2015 May 18.

Published in final edited form as: Sci Transl Med. 2015 Apr 22; 7(284): 284ra59. doi: 10.1126/scitranslmed.aaa4304

PMCID:: PMC4435724

Abstract Article PDF–1.7M

Select item 442642815.

NK cells require IL-28R for optimal in vivo activity

Fernando Souza-Fonseca-Guimaraes, Arabella Young, Deepak Mittal, Ludovic Martinet, Claudia Bruedigam, Kazuyoshi Takeda, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Geoffrey R. Hill, Mark J. Smyth

Proc Natl Acad Sci U S A. 2015 May 5; 112(18): E2376–E2384. Published online 2015 Apr 21. doi: 10.1073/pnas.1424241112

PMCID:: PMC4426428

Abstract Article PDF–1.2M

Select item 438847016.

Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

Tanel Mahlakõiv, Pedro Hernandez, Konrad Gronke, Andreas Diefenbach, Peter Staeheli

PLoS Pathog. 2015 Apr; 11(4): e1004782. Published online 2015 Apr 7. doi: 10.1371/journal.ppat.1004782

PMCID:: PMC4388470

Abstract Article PDF–9.9M

Select item 415733117.

IFN-lambda Exerts Opposing Effects on T cell Responses Depending on the Chronicity of the Virus Infection

Ichiro Misumi, Jason K. Whitmire

J Immunol. Author manuscript; available in PMC 2015 Apr 15.

Published in final edited form as: J Immunol. 2014 Apr 15; 192(8): 3596–3606. Published online 2014 Mar 19. doi: 10.4049/jimmunol.1301705

PMCID:: PMC4157331

Abstract Article PDF–1.7M

Select item 325236818.

Replication in Cells of Hematopoietic Origin Is Necessary for Dengue Virus Dissemination

Alissa M. Pham, Ryan A. Langlois, Benjamin R. tenOever

PLoS Pathog. 2012 Jan; 8(1): e1002465. Published online 2012 Jan 5. doi: 10.1371/journal.ppat.1002465

PMCID:: PMC3252368

Abstract Article PDF–1.9M

Select item 1109576919.

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

Somya Aggarwal, Forrest C. Walker, James S. Weagley, Broc T. McCune, Xiaofen Wu, Lawrence A. Schriefer, Heyde Makimaa, Dylan Lawrence, Pratyush Sridhar, Megan T. Baldridge

PLoS Pathog. 2024 May; 20(5): e1011961. Published online 2024 May 3. doi: 10.1371/journal.ppat.1011961