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Select item 109014631.

A genome-wide genetic screen uncovers determinants of human pigmentation

Vivek K. Bajpai, Tomek Swigut, Jaaved Mohammed, Sahin Naqvi, Martin Arreola, Josh Tycko, Tayne C. Kim, Jonathan K. Pritchard, Michael C. Bassik, Joanna Wysocka

Science. Author manuscript; available in PMC 2024 Feb 28.

Published in final edited form as: Science. 2023 Aug 11; 381(6658): eade6289. Published online 2023 Aug 11. doi: 10.1126/science.ade6289

PMCID:: PMC10901463

Abstract Article PDF–1.9M

Select item 103138962.

KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy

Jiye Li, Dongsheng Yu, Chenhui He, Qiwen Yu, Zhongkun Huo, Yi Zhang, Shuijun Zhang

Cell Death Dis. 2023 Jul; 14(7): 393. Published online 2023 Jul 1. doi: 10.1038/s41419-023-05872-3

PMCID:: PMC10313896

Abstract Article PDF–8.8M

Select item 43622573.

Krüppel-like factor 6 regulates mitochondrial function in the kidney

Sandeep K. Mallipattu, Sylvia J. Horne, Vivette D’Agati, Goutham Narla, Ruijie Liu, Michael A. Frohman, Kathleen Dickman, Edward Y. Chen, Avi Ma’ayan, Agnieszka B. Bialkowska, Amr M. Ghaleb, Mandayam O. Nandan, Mukesh K. Jain, Ilse Daehn, Peter Y. Chuang, Vincent W. Yang, John C. He

J Clin Invest. 2015 Mar 2; 125(3): 1347–1361. Published online 2015 Feb 17. doi: 10.1172/JCI77084

PMCID:: PMC4362257

Abstract Article PDF–7.4M

Select item 35227574.

Reduced Hepatic Stellate Cell Expression of KLF6 Tumor Suppressor Isoforms Amplifies Fibrosis During Acute and Chronic Rodent Liver Injury

Zahra Ghiassi-Nejad, Virginia Hernandez-Gea, Christopher Woodrell, Ursula E. Lang, Katja Dumic, Allison Kwong, Scott L. Friedman

Hepatology. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Hepatology. 2013 Feb; 57(2): 786–796. Published online 2012 Dec 6. doi: 10.1002/hep.26056

PMCID:: PMC3522757

Abstract Article PDF–1.2M

Select item 31449985.

Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma, associated with p53 pathway deregulation

Mirko Tarocchi, Rebekka Hannivoort, Yujin Hoshida, Ursula E. Lee, Diana Vetter, Goutham Narla, Augusto Villanueva, Moshe Oren, Josep M. Llovet, Scott L. Friedman

Hepatology. Author manuscript; available in PMC 2012 Aug 1.

Published in final edited form as: Hepatology. 2011 Aug; 54(2): 522–531. Published online 2011 Jun 26. doi: 10.1002/hep.24413

Correction in:: volume 54 on page 2280

PMCID:: PMC3144998

Abstract Article PDF–1.6M

Select item 86484636.

Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis

Xinbing Liu, Wei Gao, Wei Liu

Dis Markers. 2021; 2021: 2826609. Published online 2021 Nov 29. doi: 10.1155/2021/2826609

PMCID:: PMC8648463

Abstract Article PDF–5.6M

Select item 82018527.

Krüppel-like factor 6–mediated loss of BCAA catabolism contributes to kidney injury in mice and humans

Sian E. Piret, Yiqing Guo, Ahmed A. Attallah, Sylvia J. Horne, Amy Zollman, Daniel Owusu, Justina Henein, Viktoriya S. Sidorenko, Monica P. Revelo, Takashi Hato, Avi Ma’ayan, John Cijiang He, Sandeep K. Mallipattu

Proc Natl Acad Sci U S A. 2021 Jun 8; 118(23): e2024414118. Published online 2021 May 31. doi: 10.1073/pnas.2024414118

PMCID:: PMC8201852

Abstract Article PDF–3.1M

Select item 77740398.

Kruppel‐like factor 6 promotes macrophage inflammatory and hypoxia response

Gun‐Dong Kim, Hang Pong Ng, E. Ricky Chan, Ganapati H. Mahabeleshwar

FASEB J. 2020 Feb; 34(2): 3209–3223. Published online 2020 Jan 6. doi: 10.1096/fj.201902221R

PMCID:: PMC7774039

Abstract Article PDF–2.0M

Select item 70938129.

Klf6 protects β-cells against insulin resistance-induced dedifferentiation

Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens

Mol Metab. 2020 May; 35: 100958. Published online 2020 Feb 6. doi: 10.1016/j.molmet.2020.02.001

PMCID:: PMC7093812

Abstract Article PDF–2.7M

Select item 676664510.

Kruppel-like factor 6 and miR-223 signaling axis regulates macrophage-mediated inflammation

Gun-Dong Kim, Hang Pong Ng, Nibedita Patel, Ganapati H. Mahabeleshwar

FASEB J. 2019 Oct; 33(10): 10902–10915. Published online 2019 Jun 29. doi: 10.1096/fj.201900867RR

PMCID:: PMC6766645

Abstract Article

Select item 619834211.

Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease

Sylvia J. Horne, Jessica M. Vasquez, Yiqing Guo, Victoria Ly, Sian E. Piret, Alexandra R. Leonardo, Jason Ling, Monica P. Revelo, Daniel Bogenhagen, Vincent W. Yang, John C. He, Sandeep K. Mallipattu

Diabetes. 2018 Nov; 67(11): 2420–2433. Published online 2018 Aug 16. doi: 10.2337/db17-0958

PMCID:: PMC6198342

Abstract Article PDF–2.5M

Select item 610564512.

KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neurons

Zimei Wang, Vatsal Mehra, Matthew T. Simpson, Brian Maunze, Advaita Chakraborty, Lyndsey Holan, Erik Eastwood, Murray G. Blackmore, Ishwariya Venkatesh

Sci Rep. 2018; 8: 12565. Published online 2018 Aug 22. doi: 10.1038/s41598-018-31101-5

PMCID:: PMC6105645

Abstract Article PDF–4.4M

Select item 555611913.

Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

Svenja Sydor, Paul Manka, Jan Best, Sami Jafoui, Jan-Peter Sowa, Miguel Eugenio Zoubek, Virginia Hernandez-Gea, Francisco Javier Cubero, Julia Kälsch, Diana Vetter, Maria Isabel Fiel, Yujin Hoshida, C. Billie Bian, Leonard J. Nelson, Han Moshage, Klaas Nico Faber, Andreas Paul, Hideo A. Baba, Guido Gerken, Scott L. Friedman, Ali Canbay, Lars P. Bechmann

Sci Rep. 2017; 7: 8119. Published online 2017 Aug 14. doi: 10.1038/s41598-017-08680-w

PMCID:: PMC5556119

Abstract Article PDF–2.5M

Select item 507653314.

Kruppel-like Factor 6 Promotes Macrophage-mediated Inflammation by Suppressing B Cell Leukemia/Lymphoma 6 Expression

Gun-Dong Kim, Riku Das, Lediana Goduni, Sharon McClellan, Linda D. Hazlett, Ganapati H. Mahabeleshwar

J Biol Chem. 2016 Sep 30; 291(40): 21271–21282. Published online 2016 Aug 18. doi: 10.1074/jbc.M116.738617

PMCID:: PMC5076533

Abstract Article PDF–4.0M

Select item 497271515.

KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation

Wendy A. Goodman, Sara Omenetti, Dipali Date, Luca Di Martino, Carlo De Salvo, Gun-Dong Kim, Saleem Chowdhry, Giorgos Bamias, Fabio Cominelli, Theresa T. Pizarro, Ganapati H. Mahabeleshwar

Mucosal Immunol. Author manuscript; available in PMC 2016 Aug 22.

Published in final edited form as: Mucosal Immunol. 2016 Sep; 9(5): 1250–1262. Published online 2016 Feb 3. doi: 10.1038/mi.2016.1

PMCID:: PMC4972715

Abstract Article PDF–3.3M

Select item 454014216.

Modulation of cardiac fibrosis by Krüppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes

Daigo Sawaki, Lianguo Hou, Shota Tomida, Junqing Sun, Hong Zhan, Kenichi Aizawa, Bo-Kyung Son, Taro Kariya, Eiki Takimoto, Kinya Otsu, Simon J. Conway, Ichiro Manabe, Issei Komuro, Scott L. Friedman, Ryozo Nagai, Toru Suzuki

Cardiovasc Res. 2015 Sep 1; 107(4): 420–430. Published online 2015 May 18. doi: 10.1093/cvr/cvv155

PMCID:: PMC4540142

Abstract Article PDF–994K

Select item 329590617.

Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in non-alcoholic fatty liver disease

Lars P Bechmann, Amalia Gastaldelli, Diana Vetter, Gillian L Patman, Laura Pascoe, Rebekka A Hannivoort, Ursula E Lee, Isabel Fiel, Ursula Muñoz, Demetrio Ciociaro, Young-Min Lee, Emma Buzzigoli, Luca Miele, Kei Y Hui, Elisabetta Bugianesi, Alastair D Burt, Christopher P Day, Andrea Mari, Loranne Agius, Mark Walker, Scott L Friedman, Helen L Reeves

Hepatology. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: Hepatology. 2012 Apr; 55(4): 1083–1093. Published online 2012 Mar 1. doi: 10.1002/hep.24793

PMCID:: PMC3295906

Abstract Article PDF–2.7M

Select item 306076518.

Emerging Roles of Kruppel-Like Factor 6 and Kruppel-Like Factor 6 Splice Variant 1 in Ovarian Cancer Progression and Treatment

Analisa DiFeo, Goutham Narla, John A. Martignetti

Mt Sinai J Med. Author manuscript; available in PMC 2011 Mar 18.

Published in final edited form as: Mt Sinai J Med. 2009 Dec; 76(6): 557–566. doi: 10.1002/msj.20150

PMCID:: PMC3060765

Abstract Article PDF–1.1M

Select item 244185619.

KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis

Goutham Narla, Analisa DiFeo, Yolanda Fernandez, Saravana Dhanasekaran, Fei Huang, Jaya Sangodkar, Eldad Hod, Devin Leake, Scott L. Friedman, Simon J. Hall, Arul M. Chinnaiyan, William L. Gerald, Mark A. Rubin, John A. Martignetti

J Clin Invest. 2008 Aug 1; 118(8): 2711–2721. Published online 2008 Jul 1. doi: 10.1172/JCI34780

PMCID:: PMC2441856

Abstract Article PDF–1.4M

Select item 14852220.

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors.

S Philipsen, G Suske

Nucleic Acids Res. 1999 Aug 1; 27(15): 2991–3000. doi: 10.1093/nar/27.15.2991

PMCID:: PMC148522

Summary PDF–855K

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