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Select item 112282271.

Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability

Claire E L Smith, Virginie Laugel-Haushalter, Ummey Hany, Sunayna Best, Rachel L Taylor, James A Poulter, Saskia B Wortmann, Rene G Feichtinger, Johannes A Mayr, Suhaila Al Bahlani, Georgios Nikolopoulos, Alice Rigby, Graeme C Black, Christopher M Watson, Sahar Mansour, Chris F Inglehearn, Alan J Mighell, Agnès Bloch-Zupan

J Med Genet. 2024 Jul; 61(7): 689–698. Published online 2024 Mar 8. doi: 10.1136/jmg-2023-109728

PMCID:: PMC11228227

Abstract Article PDF–3.7M

Select item 85170242.

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion

Chrystian Junqueira Alves, Rafael Dariolli, Jonathan Haydak, Sangjo Kang, Theodore Hannah, Robert J. Wiener, Stefanie DeFronzo, Rut Tejero, Gabriele L. Gusella, Aarthi Ramakrishnan, Rodrigo Alves Dias, Alexandre Wojcinski, Santosh Kesari, Li Shen, Eric A. Sobie, José Paulo Rodrigues Furtado de Mendonça, Evren U. Azeloglu, Hongyan Zou, Roland H. Friedel

Nat Commun. 2021; 12: 6019. Published online 2021 Oct 14. doi: 10.1038/s41467-021-26296-7

PMCID:: PMC8517024

Abstract Article PDF–20M

Select item 78466103.

Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

Yong Huang, Rut Tejero, Vivian K. Lee, Concetta Brusco, Theodore Hannah, Taylor B. Bertucci, Chrystian Junqueira Alves, Igor Katsyv, Michael Kluge, Ramsey Foty, Bin Zhang, Caroline C. Friedel, Guohao Dai, Hongyan Zou, Roland H. Friedel

Commun Biol. 2021; 4: 145. Published online 2021 Jan 29. doi: 10.1038/s42003-021-01667-4

PMCID:: PMC7846610

Abstract Article PDF–8.8M

Select item 44666854.

Plexin-B2 promotes invasive growth of malignant glioma

Audrey P. Le, Yong Huang, Sandeep C. Pingle, Santosh Kesari, Huaien Wang, Raymund L. Yong, Hongyan Zou, Roland H. Friedel

Oncotarget. 2015 Mar 30; 6(9): 7293–7304. Published online 2015 Jan 31. doi: 10.18632/oncotarget.3421

PMCID:: PMC4466685

Abstract Article PDF–7.3M

Select item 113061115.

In vivo interaction screening reveals liver-derived constraints to metastasis

Costanza Borrelli, Morgan Roberts, Davide Eletto, Marie-Didiée Hussherr, Hassan Fazilaty, Tomas Valenta, Atefeh Lafzi, Jonas A. Kretz, Elena Guido Vinzoni, Andromachi Karakatsani, Srivathsan Adivarahan, Ardian Mannhart, Shoichiro Kimura, Ab Meijs, Farah Baccouche Mhamedi, Ilhan E. Acar, Kristina Handler, Xenia Ficht, Randall J. Platt, Salvatore Piscuoglio, Andreas E. Moor

Nature. 2024; 632(8024): 411–418. Published online 2024 Jul 24. doi: 10.1038/s41586-024-07715-3

PMCID:: PMC11306111

Abstract Article PDF–37M

Select item 84354586.

Increased airway epithelial cell–derived exosomes activate macrophage‐mediated allergic inflammation via CD100 shedding

Yi Yu, Yao Zhou, Caixia Di, Caiqi Zhao, Jie Chen, Wen Su, Qun Wu, Min Wu, Xiao Su, Zhenwei Xia

J Cell Mol Med. 2021 Sep; 25(18): 8850–8862. Published online 2021 Aug 20. doi: 10.1111/jcmm.16843

PMCID:: PMC8435458

Abstract Article PDF–1.5M

Select item 60301767.

Sema4C/PlexinB2 signaling controls breast cancer cell growth, hormonal dependence and tumorigenic potential

Sreeharsha Gurrapu, Emanuela Pupo, Giulia Franzolin, Letizia Lanzetti, Luca Tamagnone

Cell Death Differ. 2018 Jul; 25(7): 1259–1275. Published online 2018 Mar 19. doi: 10.1038/s41418-018-0097-4

PMCID:: PMC6030176

Abstract Article PDF–3.8M

Select item 51172108.

Rnd3-induced cell rounding requires interaction with Plexin-B2

Brad McColl, Ritu Garg, Philippe Riou, Kirsi Riento, Anne J. Ridley

J Cell Sci. 2016 Nov 1; 129(21): 4046–4056. doi: 10.1242/jcs.192211

PMCID:: PMC5117210

Abstract Article

Select item 93458929.

Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival

Hailing Yang, Liang Yuan, Soichiro Ibaragi, Shuping Li, Robert Shapiro, Nil Vanli, Kevin A. Goncalves, Wenhao Yu, Hiroko Kishikawa, Yuxiang Jiang, Alexander J. Hu, Daniel Jay, Brent Cochran, Eric C. Holland, Guo-fu Hu

Br J Cancer. 2022 Aug 1; 127(3): 422–435. Published online 2022 Apr 13. doi: 10.1038/s41416-022-01814-6

PMCID:: PMC9345892

Abstract Article PDF–4.1M

Select item 467277310.

Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ–RhoGEF

Heath G. Pascoe, Stephen Gutowski, Hua Chen, Chad A. Brautigam, Zhe Chen, Paul C. Sternweis, Xuewu Zhang

Proc Natl Acad Sci U S A. 2015 Dec 1; 112(48): 14852–14857. Published online 2015 Nov 16. doi: 10.1073/pnas.1508931112

PMCID:: PMC4672773

Abstract Article PDF–1.9M

Select item 382959211.

Experimental validation of 5 in-silico predicted glioma biomarkers

Rheal A. Towner, Randy L. Jensen, Brian Vaillant, Howard Colman, Debra Saunders, Cory B. Giles, Jonathan D. Wren

Neuro Oncol. 2013 Dec; 15(12): 1625–1634. Published online 2013 Oct 24. doi: 10.1093/neuonc/not124

PMCID:: PMC3829592

Abstract Article PDF–922K

Select item 732749512.

Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin‐B2 axis

Rongpan Bai, Desen Sun, Muxiong Chen, Xiaoliang Shi, Liang Luo, Zhengrong Yao, Yaxin Liu, Xiaolong Ge, Xiangwei Gao, Guo‐fu Hu, Wei Zhou, Jinghao Sheng, Zhengping Xu

EMBO J. 2020 Jul 1; 39(13): e103325. Published online 2020 Jun 8. doi: 10.15252/embj.2019103325

PMCID:: PMC7327495

Abstract Article PDF–9.2M

Select item 969204113.

HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi

Redox Biol. 2022 Dec; 58: 102546. Published online 2022 Nov 19. doi: 10.1016/j.redox.2022.102546

PMCID:: PMC9692041

Abstract Article PDF–13M

Select item 584737714.

Plexin-B2 mediates physiologic and pathologic functions of angiogenin

Wenhao Yu, Kevin A. Goncalves, Hiroko Kishikawa, Shuping Li, Guangjie Sun, Hailing Yang, Nil Vanli, Yunxia Wu, Yuxiang Jiang, Miaofen G. Hu, Roland H. Friedel, Guo-fu Hu

Cell. Author manuscript; available in PMC 2018 Nov 2.

Published in final edited form as: Cell. 2017 Nov 2; 171(4): 849–864.e25. doi: 10.1016/j.cell.2017.10.005

PMCID:: PMC5847377

Abstract Article PDF–3.0M

Select item 564508615.

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins

Thomas Wylie, Ritu Garg, Anne J. Ridley, Maria R. Conte

PLoS One. 2017; 12(10): e0185899. Published online 2017 Oct 17. doi: 10.1371/journal.pone.0185899

PMCID:: PMC5645086

Abstract Article PDF–5.0M

Select item 121548616.

Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin

Christine Hartwig, Andres Veske, Sarka Krejcova, Georg Rosenberger, Ulrich Finckh

BMC Neurosci. 2005; 6: 53. Published online 2005 Aug 25. doi: 10.1186/1471-2202-6-53

PMCID:: PMC1215486

Abstract Article PDF–3.5M

Select item 278669517.

Semaphorin 4D Signaling Requires the Recruitment of Phospholipase Cγ into the Plexin-B1 Receptor Complex

Jakub M. Swiercz, Thomas Worzfeld, Stefan Offermanns

Mol Cell Biol. 2009 Dec; 29(23): 6321–6334. Published online 2009 Oct 5. doi: 10.1128/MCB.00103-09

PMCID:: PMC2786695

Abstract Article PDF–2.9M

Select item 271299218.

Quantitative proteomics identifies a Dab2/integrin module regulating cell migration

Anjali Teckchandani, Natalie Toida, Jake Goodchild, Christine Henderson, Julian Watts, Bernd Wollscheid, Jonathan A. Cooper

J Cell Biol. 2009 Jul 13; 186(1): 99–111. doi: 10.1083/jcb.200812160

PMCID:: PMC2712992

Abstract Article PDF–6.0M

Select item 702154919.

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential

Leena Yadav, Elina Pietilä, Tiina Öhman, Xiaonan Liu, Arun K. Mahato, Yulia Sidorova, Kaisa Lehti, Mart Saarma, Markku Varjosalo

iScience. 2020 Feb 21; 23(2): 100871. Published online 2020 Jan 31. doi: 10.1016/j.isci.2020.100871

PMCID:: PMC7021549

Abstract Article PDF–8.1M

Select item 711512820.

Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan

Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525

PMCID:: PMC7115128

Abstract Article PDF–1.6M

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PMC Links for Gene (Select 23654) (51)
PMC
leucine-rich repeat transmembrane protein FLRT2 precursor [Homo sapiens]
leucine-rich repeat transmembrane protein FLRT2 precursor [Homo sapiens]
gi|7019381|ref|NP_037363.1|

Protein
Mus musculus WAPL cohesin release factor (Wapl), transcript variant 1, mRNA
Mus musculus WAPL cohesin release factor (Wapl), transcript variant 1, mRNA
gi|671696009|ref|NM_001004436.4|

Nucleotide
Myopathy caused by variation in POMGNT1
Myopathy caused by variation in POMGNT1

MedGen
CN305639[conceptid] (1)
MedGen

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