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Select item 89868651.

HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells

Cha Kyung Youn, Jung-Hee Lee, Gurusamy Hariharasudhan, Hong Beum Kim, Jeeho Kim, Sumi Lee, Sung-Chul Lim, Sang-Pil Yoon, Sang-Gon Park, In-Youb Chang, Ho Jin You

Cell Death Dis. 2022 Apr; 13(4): 309. Published online 2022 Apr 6. doi: 10.1038/s41419-022-04766-0

PMCID:: PMC8986865

Abstract Article PDF–3.9M

Select item 72268072.

The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation

Hicham Mahboubi, Ossama Moujaber, Mohamed Kodiha, Ursula Stochaj

Cells. 2020 Apr; 9(4): 825. Published online 2020 Mar 29. doi: 10.3390/cells9040825

PMCID:: PMC7226807

Abstract Article PDF–5.3M

Select item 47702123.

HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression

Priyanka Chaudhary, Sohrab Zafar Khan, Pratima Rawat, Tracy Augustine, Deborah A. Raynes, Vince Guerriero, Debashis Mitra

Nucleic Acids Res. 2016 Feb 29; 44(4): 1613–1629. Published online 2015 Nov 3. doi: 10.1093/nar/gkv1151

PMCID:: PMC4770212

Abstract Article PDF–9.5M

Select item 43898374.

Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1

Anna S. Chalova, Maria V. Sudnitsyna, Pavel I. Semenyuk, Victor N. Orlov, Nikolai B. Gusev

Cell Stress Chaperones. 2014 Nov; 19(6): 963–972. Published online 2014 Jun 5. doi: 10.1007/s12192-014-0520-9

PMCID:: PMC4389837

Abstract Article PDF–542K

Select item 27794615.

HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease¹

Joanna L Howarth, Colin P J Glover, James B Uney

J Neurochem. 2009 Feb; 108(4): 945–951. doi: 10.1111/j.1471-4159.2008.05847.x

PMCID:: PMC2779461

Abstract Article PDF–549K

Select item 27282666.

HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness

Ana Paula Souza, Caroline Albuquerque, Carolina Torronteguy, Antonio Frasson, Fabio Maito, Luciana Pereira, Vinícius Duval da Silva, Felipe Zerwes, Deborah Raynes, Vince Guerriero, Cristina Bonorino

Cell Stress Chaperones. 2009 May; 14(3): 301–310. Published online 2008 Nov 6. doi: 10.1007/s12192-008-0085-6

PMCID:: PMC2728266

Abstract Article PDF–246K

Select item 38918537.

Hsp70 Cochaperones HspBP1 and BAG-1M Differentially Regulate Steroid Hormone Receptor Function

Regina T. Knapp, Michael J. H. Wong, Lorenz K. Kollmannsberger, Nils C. Gassen, Anja Kretzschmar, Jürgen Zschocke, Kathrin Hafner, Jason C. Young, Theo Rein

PLoS One. 2014; 9(1): e85415. Published online 2014 Jan 14. doi: 10.1371/journal.pone.0085415

PMCID:: PMC3891853

Abstract Article PDF–1.9M

Select item 56040398.

Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins

Ting Zhao, Yan Hong, Peng Yin, Shihua Li, Xiao-Jiang Li

Proc Natl Acad Sci U S A. 2017 Sep 12; 114(37): E7803–E7811. Published online 2017 Aug 28. doi: 10.1073/pnas.1710549114

PMCID:: PMC5604039

Abstract Article PDF–2.1M

Select item 30604809.

The Heat Shock-binding Protein (HspBP1) Protects Cells against the Cytotoxic Action of the Tag7-Hsp70 Complex

Denis V. Yashin, Elena A. Dukhanina, Olga D. Kabanova, Elena A. Romanova, Tamara I. Lukyanova, Alexsander G. Tonevitskii, Deborah A. Raynes, Nikolai V. Gnuchev, Vince Guerriero, Georgii P. Georgiev, Lidia P. Sashchenko

J Biol Chem. 2011 Mar 25; 286(12): 10258–10264. Published online 2011 Jan 19. doi: 10.1074/jbc.M110.163436

PMCID:: PMC3060480

Abstract Article PDF–1.2M

Select item 368009910.

Heat shock protein 70‐binding protein 1 is highly expressed in high‐grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces

Michael W. Graner, Deborah A. Raynes, Darell D. Bigner, Vince Guerriero

Cancer Sci. 2009 Oct; 100(10): 1870–1879. Published online 2009 Jul 1. doi: 10.1111/j.1349-7006.2009.01269.x

PMCID:: PMC3680099

Abstract Article PDF–4.8M

Select item 51533511.

The Cochaperone HspBP1 Inhibits the CHIP Ubiquitin Ligase and Stimulates the Maturation of the Cystic Fibrosis Transmembrane Conductance Regulator

Simon Alberti, Karsten Böhse, Verena Arndt, Anton Schmitz, Jörg Höhfeld

Mol Biol Cell. 2004 Sep; 15(9): 4003–4010. doi: 10.1091/mbc.E04-04-0293

PMCID:: PMC515335

Abstract Article PDF–304K

Select item 128943012.

BAG-2 Acts as an Inhibitor of the Chaperone-associated Ubiquitin Ligase CHIP

Verena Arndt, Christina Daniel, Wolfgang Nastainczyk, Simon Alberti, Jörg Höhfeld

Mol Biol Cell. 2005 Dec; 16(12): 5891–5900. doi: 10.1091/mbc.E05-07-0660

PMCID:: PMC1289430

Abstract Article PDF–420K

Select item 450556713.

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

Sarah N. Fontaine, Jennifer N. Rauch, Bryce A. Nordhues, Victoria A. Assimon, Andrew R. Stothert, Umesh K. Jinwal, Jonathan J. Sabbagh, Lyra Chang, Stanley M. Stevens, Jr., Erik R. P. Zuiderweg, Jason E. Gestwicki, Chad A. Dickey

J Biol Chem. 2015 May 22; 290(21): 13115–13127. Published online 2015 Apr 11. doi: 10.1074/jbc.M115.637595

PMCID:: PMC4505567

Abstract Article PDF–3.2M

Select item 952570314.

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Zhuoyao Chen, Rafael M. Ioris, Stacey Richardson, Ava N. Van Ess, Iolanda Vendrell, Benedikt M. Kessler, Francesca M. Buffa, Luca Busino, Steven C. Clifford, Alex N. Bullock, Vincenzo D’Angiolella

Cell Death Differ. 2022 Oct; 29(10): 1955–1969. Published online 2022 Apr 4. doi: 10.1038/s41418-022-00983-4

PMCID:: PMC9525703

Abstract Article PDF–4.4M

Select item 583609715.

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration

Ella Fung, Carmen Richter, Hong‐Bin Yang, Isabell Schäffer, Roman Fischer, Benedikt M Kessler, Florian Bassermann, Vincenzo D'Angiolella

EMBO Rep. 2018 Mar; 19(3): e44799. Published online 2018 Jan 18. doi: 10.15252/embr.201744799

PMCID:: PMC5836097

Abstract Article PDF–1.9M

Select item 713853716.

Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism

Johanna Hietamäki, Louise C Gregory, Sandy Ayoub, Anna-Pauliina Iivonen, Kirsi Vaaralahti, Xiaonan Liu, Nina Brandstack, Andrew J Buckton, Tiina Laine, Johanna Känsäkoski, Matti Hero, Päivi J Miettinen, Markku Varjosalo, Emma Wakeling, Mehul T Dattani, Taneli Raivio

J Clin Endocrinol Metab. 2020 Jun; 105(6): 1748–1758. Published online 2020 Feb 15. doi: 10.1210/clinem/dgaa078

PMCID:: PMC7138537

Abstract Article

Select item 596114117.

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells

Benoit Miotto, Claire Marchal, Guillaume Adelmant, Nadège Guinot, Ping Xie, Jarrod A Marto, Lingqiang Zhang, Pierre-Antoine Defossez

Nucleic Acids Res. 2018 May 18; 46(9): 4392–4404. Published online 2018 Feb 27. doi: 10.1093/nar/gky149

PMCID:: PMC5961141

Abstract Article PDF–2.1M

Select item 613844118.

CRL4^AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling

Si‐Han Chen, Gwendolyn M Jang, Ruth Hüttenhain, David E Gordon, Dan Du, Billy W Newton, Jeffrey R Johnson, Joseph Hiatt, Judd F Hultquist, Tasha L Johnson, Yi‐Liang Liu, Lily A Burton, Jordan Ye, Kurt M Reichermeier, Robert M Stroud, Alexander Marson, Jayanta Debnath, John D Gross, Nevan J Krogan

EMBO J. 2018 Sep 14; 37(18): e97508. Published online 2018 Aug 30. doi: 10.15252/embj.201797508

PMCID:: PMC6138441

Abstract Article PDF–1.7M

Select item 741748019.

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

Erik L. Friesen, Yu Tong Zhang, Rebecca Earnshaw, Mitch L. De Snoo, Darren M. O’Hara, Victoria Agapova, Hien Chau, Sophie Ngana, Kevin S. Chen, Lorraine V. Kalia, Suneil K. Kalia

Front Cell Dev Biol. 2020; 8: 716. Published online 2020 Aug 4. doi: 10.3389/fcell.2020.00716