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Select item 101867521.

Implications of Peptidyl Arginine Deiminase 4 gene transcription and polymorphisms in susceptibility to rheumatoid arthritis in an Iranian population

Zahra Bagheri-Hosseinabadi, Mohammad Reza Mirzaei, Ozrasadat Esmaeili, Fatemeh Asadi, Hassan Ahmadinia, Banafshe Shamsoddini, Mitra Abbasifard

BMC Med Genomics. 2023; 16: 104. Published online 2023 May 16. doi: 10.1186/s12920-023-01532-9

PMCID:: PMC10186752

Abstract Article PDF–1.3M

Select item 100383522.

Neutrophil PAD4: how does it function in cancer beyond promoting NETosis?

Laura Garcia-Gerique, Yulia Nefedova

Oncotarget. 2023; 14: 258–260. Published online 2023 Mar 24. doi: 10.18632/oncotarget.28369

PMCID:: PMC10038352

Article PDF–617K

Select item 85584743.

PADI4 Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With HLA-DRB1*04 and Smoking

Laura Massarenti, Christian Enevold, Dres Damgaard, Niels Ødum, Peter Garred, Morten Frisch, Miriam A. Shelef, Søren Jacobsen, Claus Henrik Nielsen

Front Immunol. 2021; 12: 707690. Published online 2021 Oct 18. doi: 10.3389/fimmu.2021.707690

PMCID:: PMC8558474

Abstract Article PDF–1.1M

Select item 83972724.

Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization

Yufeng Wang, Yajing Lyu, Kangsheng Tu, Qiuran Xu, Yongkang Yang, Shaima Salman, Nguyet Le, Haiquan Lu, Chelsey Chen, Yayun Zhu, Ru Wang, Qingguang Liu, Gregg L. Semenza

Sci Adv. 2021 Aug; 7(35): eabe3771. Published online 2021 Aug 27. doi: 10.1126/sciadv.abe3771

PMCID:: PMC8397272

Abstract Article PDF–10M

Select item 83600665.

PAD4 takes charge during neutrophil activation: Impact of PAD4 mediated NET formation on immune‐mediated disease

Xiaosong Liu, Tom Arfman, Kanin Wichapong, Chris P. M. Reutelingsperger, Jan Voorberg, Gerry A. F. Nicolaes

J Thromb Haemost. 2021 Jul; 19(7): 1607–1617. Published online 2021 May 12. doi: 10.1111/jth.15313

PMCID:: PMC8360066

Abstract Article PDF–1.3M

Select item 82941676.

Peptidylarginine deiminase IV (PADI4) regulates breast cancer stem cells via a novel tumor cell-autonomous suppressor role

Nellie Moshkovich, Humberto J. Ochoa, Binwu Tang, Howard H. Yang, Yuan Yang, Jing Huang, Maxwell P. Lee, Lalage M. Wakefield

Cancer Res. Author manuscript; available in PMC 2021 Jul 21.

Published in final edited form as: Cancer Res. 2020 Jun 1; 80(11): 2125–2137. Published online 2020 Apr 7. doi: 10.1158/0008-5472.CAN-19-3018

PMCID:: PMC8294167

Abstract Article PDF–2.2M

Select item 79623377.

Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang, Lining Wei

Cell Mol Biol Lett. 2021; 26: 9. Published online 2021 Mar 16. doi: 10.1186/s11658-021-00251-2

Correction in:: Cell Mol Biol Lett. 2021; 26: 55.

Correction in:: Cell Mol Biol Lett. 2023; 28: 29.

PMCID:: PMC7962337

Abstract Article PDF–5.1M

Select item 78559888.

Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4- and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14^hi monocytes

Yuko Okamato, Tusharkanti Ghosh, Tsukasa Okamoto, Ronald P. Schuyler, Jennifer Seifert, Laura Lenis Charry, Ashley Visser, Marie Feser, Chelsie Fleischer, Chong Pedrick, Justin August, Laurakay Moss, Elizabeth A. Bemis, Jill M. Norris, Kristine A. Kuhn, M. Kristen Demoruelle, Kevin D. Deane, Debashis Ghosh, V. Michael Holers, Elena W.Y. Hsieh

J Autoimmun. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: J Autoimmun. 2021 Feb; 117: 102581. Published online 2020 Dec 9. doi: 10.1016/j.jaut.2020.102581

PMCID:: PMC7855988

Abstract Article PDF–1.2M

Select item 73199629.

Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation

Qingfei Zheng, Adewola Osunsade, Yael David

Nat Commun. 2020; 11: 3241. Published online 2020 Jun 26. doi: 10.1038/s41467-020-17066-y

PMCID:: PMC7319962

Abstract Article PDF–1.0M

Select item 713227710.

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

Hawa Racine Thiam, Siu Ling Wong, Rong Qiu, Mark Kittisopikul, Amir Vahabikashi, Anne E. Goldman, Robert D. Goldman, Denisa D. Wagner, Clare M. Waterman

Proc Natl Acad Sci U S A. 2020 Mar 31; 117(13): 7326–7337. Published online 2020 Mar 13. doi: 10.1073/pnas.1909546117

PMCID:: PMC7132277

Abstract Article PDF–3.9M

Select item 642358511.

PADI4-mediated epithelial-mesenchymal transition in lung cancer cells

Meiyan Liu, Yang Qu, Xue Teng, Ying Xing, Dandan Li, Chunhong Li, Li Cai

Mol Med Rep. 2019 Apr; 19(4): 3087–3094. Published online 2019 Feb 19. doi: 10.3892/mmr.2019.9968

PMCID:: PMC6423585

Abstract Article PDF–1.7M

Select item 615644712.

Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients

Nara Aline Costa, Ana Lúcia Gut, Paula Schmidt Azevedo, Bertha Furlan Polegato, Eloá Siqueira Magalhães, Larissa Lumi Watanabe Ishikawa, Rita de Cassia Siqueira Bruder, Evelyn Aparecida da Silva, Renan Braga Gonçalves, Suzana Erico Tanni, Marcelo Macedo Rogero, Marina Maintinguer Norde, Natália Baraldi Cunha, Leonardo Antonio Mamede Zornoff, Sergio Alberto Rupp de Paiva, Marcos Ferreira Minicucci

J Cell Mol Med. 2018 Oct; 22(10): 4732–4737. Published online 2018 Jul 25. doi: 10.1111/jcmm.13717

PMCID:: PMC6156447

Abstract Article PDF–198K

Select item 615495713.

Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation

Stéfanie P. Muraro, Gabriela F. De Souza, Stephanie W. Gallo, Bruna K. Da Silva, Sílvia D. De Oliveira, Marco Aurélio R. Vinolo, Elvira M. Saraiva, Bárbara N. Porto

Sci Rep. 2018; 8: 14166. Published online 2018 Sep 21. doi: 10.1038/s41598-018-32576-y

PMCID:: PMC6154957

Abstract Article PDF–1.7M

Select item 586597614.

Hypoxia-induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis

Tingting Fan, Changsong Zhang, Ming Zong, Lieying Fan

Mol Med Rep. 2018 Apr; 17(4): 5116–5124. Published online 2018 Jan 26. doi: 10.3892/mmr.2018.8501

PMCID:: PMC5865976

Abstract Article PDF–2.2M

Select item 584321715.

Peptidylarginine deiminase 4 -104C/T polymorphism and risk of rheumatoid arthritis: A pooled analysis based on different populations

Jiong Hua, Weijie Huang

PLoS One. 2018; 13(3): e0193674. Published online 2018 Mar 8. doi: 10.1371/journal.pone.0193674

PMCID:: PMC5843217

Abstract Article PDF–2.5M

Select item 556180516.

Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population

Z.Y. Guo, J.X. Zhang, M. Wu, Y.F. Mei, X.J. Lin, C. Bu, Y. Xie, J. Wang

Braz J Med Biol Res. 2017; 50(10): e6115. Published online 2017 Aug 17. doi: 10.1590/1414-431X20176115

PMCID:: PMC5561805

Abstract Article PDF–782K

Select item 537044317.

PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients

Lieying Fan, Ming Zong, Ruhan Gong, Dongyi He, Niu Li, Li shan Sun, Qin Ye, Shanshan Yu

Int J Biol Sci. 2017; 13(3): 358–366. Published online 2017 Feb 25. doi: 10.7150/ijbs.16879

PMCID:: PMC5370443

Abstract Article PDF–1.3M

Select item 531440718.

Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4

Chien-Yun Lee, Chu-Cheng Lin, Yi-Liang Liu, Guang-Yaw Liu, Jyung-Hurng Liu, Hui-Chih Hung

Sci Rep. 2017; 7: 42662. Published online 2017 Feb 17. doi: 10.1038/srep42662

PMCID:: PMC5314407

Abstract Article PDF–2.5M

Select item 482309619.

A novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells

Guanhua Song, Lulu Shi, Yuqi Guo, Linchang Yu, Lin Wang, Xiaoyu Zhang, Lianlian Li, Yang Han, Xia Ren, Qiang Guo, Kehong Bi, Guosheng Jiang

Oncotarget. 2016 Jan 19; 7(3): 3144–3157. Published online 2015 Dec 10. doi: 10.18632/oncotarget.6551

PMCID:: PMC4823096

Abstract Article PDF–6.8M

Select item 405025720.

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation

Stephan Kolodziej, Olga N. Kuvardina, Thomas Oellerich, Julia Herglotz, Ingo Backert, Nicole Kohrs, Estel.la Buscató, Sandra K. Wittmann, Gabriela Salinas-Riester, Halvard Bonig, Michael Karas, Hubert Serve, Ewgenij Proschak, Jörn Lausen

Nat Commun. 2014 May 29; 5: 3995. Published online 2014 May 29. doi: 10.1038/ncomms4995

PMCID:: PMC4050257

Abstract Article PDF–1.5M

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PMC Links for Gene (Select 23569) (96)
PMC
PADI4[gene] (88)
ClinVar
PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), transcript varian...
PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), transcript variant X2, mRNA
gi|2462507335|ref|XM_054335713.1|

Nucleotide
PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), transcript varian...
PREDICTED: Homo sapiens peptidyl arginine deiminase 4 (PADI4), transcript variant X3, mRNA
gi|767903523|ref|XM_011541152.1|

Nucleotide

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