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Select item 70275541.

Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression

Malgorzata A. Komor, Meike de Wit, Jose van den Berg, Sanne R. Martens de Kemp, Pien M. Delis‐van Diemen, Anne S. Bolijn, Marianne Tijssen, Tim Schelfhorst, Sander R. Piersma, Davide Chiasserini, Joyce Sanders, Christian Rausch, Youri Hoogstrate, Andrew P. Stubbs, Mark de Jong, Guido Jenster, Beatriz Carvalho, Gerrit A. Meijer, Connie R. Jimenez, Remond J.A. Fijneman, In collaboration with the NGS‐ProToCol Consortium

Int J Cancer. 2020 Apr 1; 146(7): 1979–1992. Published online 2019 Aug 30. doi: 10.1002/ijc.32627

PMCID:: PMC7027554

Abstract Article PDF–5.8M

Select item 67870572.

poFUT1 promotes uterine angiogenesis and vascular remodeling via enhancing the O-fucosylation on uPA

Dandan Zhang, Yu Yang, Caixia Liang, Jianwei Liu, Hao Wang, Shuai Liu, Qiu Yan

Cell Death Dis. 2019 Oct; 10(10): 775. Published online 2019 Oct 10. doi: 10.1038/s41419-019-2005-3

PMCID:: PMC6787057

Abstract Article PDF–3.6M

Select item 66069273.

poFUT1 promotes endometrial decidualization by enhancing the O-fucosylation of Notch1

Yu Yang, Dandan Zhang, Huamin Qin, Shuai Liu, Qiu Yan

EBioMedicine. 2019 Jun; 44: 563–573. Published online 2019 Jun 11. doi: 10.1016/j.ebiom.2019.05.027

Correction in:: eBioMedicine. 2023 Sep; 95: 104761.

PMCID:: PMC6606927

Abstract Article PDF–4.9M

Select item 61551994.

POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling

Yuheng Du, Daojiang Li, Nanpeng Li, Chen Su, Chunxing Yang, Changwei Lin, Miao Chen, Runliu Wu, Xiaorong Li, Gui Hu

Cell Death Dis. 2018 Oct; 9(10): 995. Published online 2018 Sep 24. doi: 10.1038/s41419-018-1055-2

PMCID:: PMC6155199

Abstract Article PDF–2.6M

Select item 60575295.

Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features

Hideyuki Takeuchi, Derek Wong, Michael Schneider, Hudson H Freeze, Megumi Takeuchi, Steven J Berardinelli, Atsuko Ito, Hane Lee, Stanley F Nelson, Robert S Haltiwanger

Glycobiology. 2018 May; 28(5): 276–283. Published online 2018 Feb 14. doi: 10.1093/glycob/cwy014

PMCID:: PMC6057529

Abstract Article PDF–710K

Select item 44543106.

LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal–maternal interface

S Liu, J Wang, H-M Qin, X-M Yan, X-S Yang, C Liu, Q Yan

Cell Death Dis. 2014 Aug; 5(8): e1396. Published online 2014 Aug 28. doi: 10.1038/cddis.2014.335

PMCID:: PMC4454310

Abstract Article PDF–3.7M

Select item 41448017.

Analysis of POFUT1 Gene Mutation in a Chinese Family with Dowling-Degos Disease

Mingfei Chen, Yi Li, Hong Liu, Xi'an Fu, Yiongxiang Yu, Gongqi Yu, Chuan Wang, Fangfang Bao, Herty Liany, Zhenzhen Wang, Zhongxiang Shi, Dizhan Zhang, Guizhi Zhou, Jianjun Liu, Furen Zhang

PLoS One. 2014; 9(8): e104496. Published online 2014 Aug 26. doi: 10.1371/journal.pone.0104496

PMCID:: PMC4144801

Abstract Article PDF–401K

Select item 98297168.

Circular RNA circPOFUT1 enhances malignant phenotypes and autophagy-associated chemoresistance via sequestrating miR-488-3p to activate the PLAG1-ATG12 axis in gastric cancer

Ming Luo, Xiaofeng Deng, Zonglin Chen, Yongjun Hu

Cell Death Dis. 2023 Jan; 14(1): 10. Published online 2023 Jan 9. doi: 10.1038/s41419-022-05506-0

PMCID:: PMC9829716

Abstract Article PDF–6.9M

Select item 68263229.

Weighted gene coexpression analysis indicates that PLAGL2 and POFUT1 are related to the differential features of proximal and distal colorectal cancer

Yiming Lv, Binbin Xie, Bingjun Bai, Lina Shan, Wenqian Zheng, Xuefeng Huang, Hongbo Zhu

Oncol Rep. 2019 Dec; 42(6): 2473–2485. Published online 2019 Oct 14. doi: 10.3892/or.2019.7368

PMCID:: PMC6826322

Abstract Article PDF–1.7M

Select item 664233410.

PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness

Daojiang Li, Changwei Lin, Nanpeng Li, Yuheng Du, Chunxing Yang, Yang Bai, Zhicai Feng, Chen Su, Runliu Wu, Shenglei Song, Peicheng Yan, Miao Chen, Arad Jain, Lihua Huang, Yi Zhang, Xiaorong Li

EBioMedicine. 2019 Jul; 45: 124–138. Published online 2019 Jul 4. doi: 10.1016/j.ebiom.2019.06.051

PMCID:: PMC6642334

Abstract Article PDF–5.5M

Select item 588168211.

Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations

Brian J McMillan, Brandon Zimmerman, Emily D Egan, Michael Lofgren, Xiang Xu, Anthony Hesser, Stephen C Blacklow

Glycobiology. 2017 Aug; 27(8): 777–786. Published online 2017 Mar 17. doi: 10.1093/glycob/cwx020

PMCID:: PMC5881682

Abstract Article PDF–1.0M

Select item 237623812.

Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling

Mark Stahl, Kazuhide Uemura, Changhui Ge, Shaolin Shi, Yuko Tashima, Pamela Stanley

J Biol Chem. 2008 May 16; 283(20): 13638–13651. doi: 10.1074/jbc.M802027200

PMCID:: PMC2376238

Abstract Article PDF–809K

Select item 367523513.

Mutations in POFUT1, Encoding Protein O-fucosyltransferase 1, Cause Generalized Dowling-Degos Disease

Ming Li, Ruhong Cheng, Jianying Liang, Heng Yan, Hui Zhang, Lijia Yang, Chengrang Li, Qingqing Jiao, Zhiyong Lu, Jianhui He, Jin Ji, Zhu Shen, Chunqi Li, Fei Hao, Hong Yu, Zhirong Yao

Am J Hum Genet. 2013 Jun 6; 92(6): 895–903. doi: 10.1016/j.ajhg.2013.04.022

Correction in:: Am J Hum Genet. 2013 Jun 6; 92(6): 1014.

PMCID:: PMC3675235

Abstract Article PDF–2.3M

Select item 15432814.

Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways

Shaolin Shi, Pamela Stanley

Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9): 5234–5239. Published online 2003 Apr 15. doi: 10.1073/pnas.0831126100

PMCID:: PMC154328

Abstract Article PDF–519K

Select item 603073015.

AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation

Julia Hülsmann, Bojana Kravic, Matthias Weith, Matthias Gstaiger, Ruedi Aebersold, Ben C. Collins, Hemmo Meyer

Mol Cell Proteomics. 2018 Jul; 17(7): 1295–1307. Published online 2018 Mar 29. doi: 10.1074/mcp.RA117.000471

PMCID:: PMC6030730

Abstract Article PDF–3.8M

Select item 367060416.

Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma

Xiaoli Yang, Peng Zou, Jun Yao, Dong Yun, Huimin Bao, Ruyun Du, Jing Long, Xian Chen

J Proteome Res. Author manuscript; available in PMC 2013 Jun 3.

Published in final edited form as: J Proteome Res. 2010 Mar 5; 9(3): 1402–1415. doi: 10.1021/pr900932y

PMCID:: PMC3670604

Abstract Article PDF–1.5M

Select item 739249117.

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination

Gangliang Wang, Shuai Chen, Ziang Xie, Shuying Shen, Wenbin Xu, Wenxiang Chen, Xiang Li, Yizheng Wu, Liangping Li, Bin Liu, Xianjun Ding, An Qin, Shunwu Fan

Ann Rheum Dis. 2020 Aug; 79(8): 1111–1120. Published online 2020 May 14. doi: 10.1136/annrheumdis-2019-216911

PMCID:: PMC7392491

Abstract Article PDF–14M

Select item 723200918.

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress

Jiaojiao Yu, Tao Li, Yu Liu, Xi Wang, Jianchao Zhang, Xi'e Wang, Guizhi Shi, Jizhong Lou, Likun Wang, Chih‐chen Wang, Lei Wang

EMBO J. 2020 May 18; 39(10): e103841. Published online 2020 Mar 9. doi: 10.15252/embj.2019103841

PMCID:: PMC7232009

Abstract Article PDF–5.5M

Select item 818479619.

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells

Nadia Habel, Najla El-Hachem, Frédéric Soysouvanh, Hanene Hadhiri-Bzioueche, Serena Giuliano, Sophie Nguyen, Pavel Horák, Anne-Sophie Gay, Delphine Debayle, Nicolas Nottet, Guillaume Béranger, Brigitte Bressac-de Paillerets, Corine Bertolotto, Robert Ballotti

Cell Death Differ. 2021 Jun; 28(6): 1837–1848. Published online 2021 Jan 18. doi: 10.1038/s41418-020-00710-x

PMCID:: PMC8184796

Abstract Article PDF–2.4M

Select item 828276420.

N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

Yuanming Cheng, Wei Xie, Brian F Pickering, Karen L Chu, Angela M Savino, Xuejing Yang, Hanzhi Luo, Diu TT Nguyen, Shanlan Mo, Ersilia Barin, Anthony Velleca, Thomas Rohwetter, Dinshaw J Patel, Samie R Jaffrey, Michael G Kharas

Cancer Cell. Author manuscript; available in PMC 2022 Jul 12.

Published in final edited form as: Cancer Cell. 2021 Jul 12; 39(7): 958–972.e8. Published online 2021 May 27. doi: 10.1016/j.ccell.2021.04.017

PMCID:: PMC8282764

Abstract Article PDF–3.4M

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PMC Links for Gene (Select 23509) (42)
PMC
GDP-fucose protein O-fucosyltransferase 1 isoform X1 [Homo sapiens]
GDP-fucose protein O-fucosyltransferase 1 isoform X1 [Homo sapiens]
gi|2462580065|ref|XP_054179274.1|

Protein
Homo sapiens protein O-fucosyltransferase 1 (POFUT1), transcript variant 1, mRNA
Homo sapiens protein O-fucosyltransferase 1 (POFUT1), transcript variant 1, mRNA
gi|1519499509|ref|NM_015352.2|

Nucleotide

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