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Select item 111477671.

Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR^low/neg monocytes in lower-risk myelodysplastic neoplasms

Susann Winter, Marie Schneider, Uta Oelschlaegel, Giulia Maggioni, Elena Riva, Marco Gabriele Raddi, Sara Bencini, Benedetta Peruzzi, Desmond Choy, Rita Antunes Dos Reis, Esther Güse, Christopher Lischer, Julio Vera, Jessica A. Timms, Nicolas Sompairac, Katja Sockel, Antonella Poloni, Antje Tunger, Matteo Giovanni Della Porta, Valeria Santini, Marc Schmitz, Uwe Platzbecker, Shahram Kordasti

Leukemia. 2024; 38(6): 1427–1431. Published online 2024 Apr 17. doi: 10.1038/s41375-024-02249-z

PMCID:: PMC11147767

Article PDF–2.4M

Select item 109594132.

SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia

Céline Moison, Deanne Gracias, Julie Schmitt, Simon Girard, Jean-François Spinella, Simon Fortier, Isabel Boivin, Rodrigo Mendoza-Sanchez, Bounkham Thavonekham, Tara MacRae, Nadine Mayotte, Eric Bonneil, Mark Wittman, James Carmichael, Réjean Ruel, Pierre Thibault, Josée Hébert, Anne Marinier, Guy Sauvageau

Sci Adv. 2024 Mar 22; 10(12): eadl4018. Published online 2024 Mar 22. doi: 10.1126/sciadv.adl4018

PMCID:: PMC10959413

Abstract Article PDF–2.0M

Select item 107901303.

Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts

Pedro L. Moura, Teresa Mortera-Blanco, Isabel J. Hofman, Gabriele Todisco, Warren W. Kretzschmar, Ann-Charlotte Björklund, Maria Creignou, Michael Hagemann-Jensen, Christoph Ziegenhain, David Cabrerizo Granados, Indira Barbosa, Gunilla Walldin, Monika Jansson, Neil Ashley, Adam J. Mead, Vanessa Lundin, Marios Dimitriou, Tetsuichi Yoshizato, Petter S. Woll, Seishi Ogawa, Rickard Sandberg, Sten Eirik W. Jacobsen, Eva Hellström-Lindberg

Cancer Res. 2024 Jan 16; 84(2): 211–225. Published online 2023 Nov 3. doi: 10.1158/0008-5472.CAN-23-3038

PMCID:: PMC10790130

Abstract Article PDF–16M

Select item 107017704.

Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1

Iva Trsova, Andrea Hrustincova, Zdenek Krejcik, David Kundrat, Aleš Holoubek, Karolina Staflova, Lucie Janstova, Sarka Vanikova, Katarina Szikszai, Jiri Klema, Petr Rysavy, Monika Belickova, Monika Kaisrlikova, Jitka Vesela, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Jan Fric, Jan Musil, Michaela Dostalova Merkerova

Mol Oncol. 2023 Dec; 17(12): 2565–2583. Published online 2023 Jul 17. doi: 10.1002/1878-0261.13486

PMCID:: PMC10701770

Abstract Article PDF–2.4M

Select item 104124595.

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

Philip Bland, Harry Saville, Patty T. Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E. Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N. Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Guy Pratt, Ceri Oldreive, Tatjana Stankovic, Samantha Barlow, Helen Kalirai, Sarah E. Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti S. Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher J. Lord, Rachael Natrajan

Nat Genet. 2023; 55(8): 1311–1323. Published online 2023 Jul 31. doi: 10.1038/s41588-023-01460-5

PMCID:: PMC10412459

Abstract Article PDF–23M

Select item 103792126.

SF3B1 Mutations Are Associated with Resistance to Non-Genotoxic MDM2 Inhibition in Chronic Lymphocytic Leukemia

Erhan Aptullahoglu, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec

Int J Mol Sci. 2023 Jul; 24(14): 11335. Published online 2023 Jul 12. doi: 10.3390/ijms241411335

PMCID:: PMC10379212

Abstract Article PDF–3.4M

Select item 100159777.

Only SF3B1 Mutation involving K700E Independently Predicts Overall Survival in Myelodysplastic Syndromes

Rashmi Kanagal-Shamanna, Guillermo Montalban-Bravo, Koji Sasaki, Faezeh Darbaniyan, Elias Jabbour, Carlos Bueso-Ramos, Yue Wei, Kelly Chien, Tapan Kadia, Farhad Ravandi, Gautam Borthakur, Kelly A. Soltysiak, Mark Routbort, Keyur Patel, Sherry Pierce, L. Jeffrey Medeiros, Hagop Kantarjian, Guillermo Garcia-Manero

Cancer. Author manuscript; available in PMC 2023 Mar 15.

Published in final edited form as: Cancer. 2021 Oct 1; 127(19): 3552–3565. Published online 2021 Jun 23. doi: 10.1002/cncr.33745

PMCID:: PMC10015977

Abstract Article PDF–1.4M

Select item 97120898.

SF3B1 mutated MDS: Blast count, genetic co-abnormalities and their impact on classification and prognosis

Sandra Huber, Torsten Haferlach, Manja Meggendorfer, Stephan Hutter, Gregor Hoermann, Constance Baer, Wolfgang Kern, Claudia Haferlach

Leukemia. 2022; 36(12): 2894–2902. Published online 2022 Oct 19. doi: 10.1038/s41375-022-01728-5

PMCID:: PMC9712089

Abstract Article PDF–1.6M

Select item 94271039.

Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations

Gaurav S Choudhary, Andrea Pellagatti, Bogos Agianian, Molly A Smith, Tushar D Bhagat, Shanisha Gordon-Mitchell, Srabani Sahu, Sanjay Pandey, Nishi Shah, Srinivas Aluri, Ritesh Aggarwal, Sarah Aminov, Leya Schwartz, Violetta Steeples, Robert N Booher, Murali Ramachandra, Maria Samson, Milagros Carbajal, Kith Pradhan, Teresa V Bowman, Manoj M Pillai, Britta Will, Amittha Wickrema, Aditi Shastri, Robert K Bradley, Robert E Martell, Ulrich G Steidl, Evripidis Gavathiotis, Jacqueline Boultwood, Daniel T Starczynowski, Amit Verma

eLife. 2022; 11: e78136. Published online 2022 Aug 30. doi: 10.7554/eLife.78136

PMCID:: PMC9427103

Abstract Article PDF–6.0M

Select item 941822310.

Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome

Tetsuro Ochi, Tohru Fujiwara, Koya Ono, Chie Suzuki, Maika Nikaido, Daichi Inoue, Hiroki Kato, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Yukio Nakamura, Hideo Harigae

Sci Rep. 2022; 12: 14562. Published online 2022 Aug 26. doi: 10.1038/s41598-022-18921-2

PMCID:: PMC9418223

Abstract Article PDF–2.5M

Select item 904628111.

Mutation in SF3B1 gene promotes formation of polyploid giant cells in Leukemia cells

Sanjay Mukherjee, Abdullah Mahmood Ali, Vundavalli V. Murty, Azra Raza

Med Oncol. 2022; 39(6): 65. Published online 2022 Apr 28. doi: 10.1007/s12032-022-01652-9

PMCID:: PMC9046281

Abstract Article PDF–5.6M

Select item 878244812.

SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia

Cuijuan Han, Alireza Khodadadi-Jamayran, Adam H. Lorch, Qi Jin, Valentina Serafin, Ping Zhu, Yuliya Politanska, Limin Sun, Blanca T. Gutierrez-Diaz, Marina V. Pryzhkova, Hiam Abdala-Valencia, Elizabeth Thomas Bartom, Barbara Buldini, Giuseppe Basso, Sadanandan E. Velu, Kavitha Sarma, Basil B. Mattamana, Byoung-Kyu Cho, Rebecca C. Obeng, Young Ah Goo, Philip W. Jordan, Aristotelis Tsirigos, Yalu Zhou, Panagiotis Ntziachristos

Sci Adv. 2022 Jan; 8(3): eabj8357. Published online 2022 Jan 21. doi: 10.1126/sciadv.abj8357

PMCID:: PMC8782448

Abstract Article PDF–5.2M

Select item 867244813.

Analysis of distinct SF3B1 hotspot mutations in relation to clinical phenotypes and response to therapy in myeloid neoplasia

Vera Adema, Jack Khouri, Ying Ni, Heesun J. Rogers, Cassandra M. Kerr, Hassan Awada, Yasunobu Nagata, Teodora Kuzmanovic, Anjali S. Advani, Aaron T. Gerds, Sudipto Mukherjee, Aziz Nazha, Yogen Saunthararajah, Yazan Madanat, Bhumika J. Patel, Francesc Solé, Steffan T. Nawrocki, Jennifer S. Carew, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Valeria Visconte, Hetty E. Carraway

Leuk Lymphoma. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Leuk Lymphoma. 2021 Mar; 62(3): 735–738. Published online 2020 Nov 3. doi: 10.1080/10428194.2020.1839647

PMCID:: PMC8672448

Article PDF–536K

Select item 863419114.

SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation

Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei

Haematologica. 2021 Dec 1; 106(12): 3125–3135. Published online 2020 Oct 29. doi: 10.3324/haematol.2020.261891

PMCID:: PMC8634191

Abstract Article PDF–1.1M

Select item 861280915.

MDS-associated SF3B1 Mutations Enhance Pro-Inflammatory Gene Expression in Patient Blast Cells

Daniel A. Pollyea, Hyun Min Kim, Brett M. Stevens, Frank Fang-Yao Lee, Chelsea Harris, Brenna R. Hedin, Jennifer R. Knapp, Brian P. O’Connor, Craig T. Jordan, Eric M. Pietras, Aik Choon Tan, Scott Alper

J Leukoc Biol. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: J Leukoc Biol. 2021 Jul; 110(1): 197–205. Published online 2020 Nov 6. doi: 10.1002/JLB.6AB0520-318RR

PMCID:: PMC8612809

Abstract Article PDF–1.4M

Select item 856464716.

SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis

Jian‐Yu Yang, Yan‐Miao Huo, Min‐Wei Yang, Yang Shen, De‐Jun Liu, Xue‐Liang Fu, Ling‐Ye Tao, Rui‐Zhe He, Jun‐Feng Zhang, Rong Hua, Shu‐Heng Jiang, Yong‐Wei Sun, Wei Liu

Mol Oncol. 2021 Nov; 15(11): 3076–3090. Published online 2021 May 3. doi: 10.1002/1878-0261.12970

PMCID:: PMC8564647

Abstract Article PDF–4.3M

Select item 843148417.

Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients

Alicja Pacholewska, Christina Grimm, Carmen D. Herling, Matthias Lienhard, Anja Königs, Bernd Timmermann, Janine Altmüller, Oliver Mücke, Hans Christian Reinhardt, Christoph Plass, Ralf Herwig, Michael Hallek, Michal R. Schweiger

Int J Mol Sci. 2021 Sep; 22(17): 9337. Published online 2021 Aug 28. doi: 10.3390/ijms22179337

PMCID:: PMC8431484

Abstract Article PDF–1.4M

Select item 841058218.

SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia

Inge van der Werf, Anna Wojtuszkiewicz, Huilan Yao, Rocco Sciarrillo, Manja Meggendorfer, Stephan Hutter, Wencke Walter, Jeroen Janssen, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach, Gerrit Jansen, Gertjan J. L. Kaspers, Richard Groen, Gert Ossenkoppele, Jacqueline Cloos

Leukemia. 2021; 35(9): 2698–2702. Published online 2021 May 17. doi: 10.1038/s41375-021-01273-7

Correction in:: Leukemia. 2021; 35(9): 2735.

PMCID:: PMC8410582

Article PDF–591K

Select item 837109519.

Clonal trajectories and cellular dynamics of myeloid neoplasms with SF3B1 mutations

Hassan Awada, Cassandra M. Kerr, Arda Durmaz, Vera Adema, Carmelo Gurnari, Simona Pagliuca, Misam Zawit, Sunisa Kongkiatkamon, Heesun J. Rogers, Yogen Saunthararajah, Mikkael A. Sekeres, Hetty Carraway, Jaroslaw P. Maciejewski, Valeria Visconte

Leukemia. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Leukemia. 2021 Nov; 35(11): 3324–3328. Published online 2021 Feb 18. doi: 10.1038/s41375-021-01176-7

PMCID:: PMC8371095

Article PDF–754K

Select item 825273620.

Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 (SF3B1)‐mutant myelodysplastic syndromes subtype

Carolien Duetz, Theresia M. Westers, Florentien E. M. in ’t Hout, Eline M. P. Cremers, Canan Alhan, Bianca Venniker‐Punt, Heleen A. Visser‐Wisselaar, Dana A. Chitu, Aniek O. de Graaf, Linda Smit, Joop H. Jansen, Arjan A. van de Loosdrecht

Br J Haematol. 2021 May; 193(4): 798–803. Published online 2021 Mar 25. doi: 10.1111/bjh.17414

PMCID:: PMC8252736

Abstract Article PDF–229K

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