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Items: 1 to 20 of 55

1.
Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells
Skye A. Schmidt, Patricia L. Foley, Dong-Hoon Jeong, Linda A. Rymarquis, Francis Doyle, Scott A. Tenenbaum, Joel G. Belasco, Pamela J. Green
Nucleic Acids Res. 2015 Jan 9; 43(1): 309–323. Published online 2014 Nov 27. doi: 10.1093/nar/gku1258
PMCID:
PMC4288159
AbstractArticlePDF–2.9M
2.
Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A
Daijiro Takeshita, Shuhei Zenno, Woo Cheol Lee, Kaoru Saigo, Masaru Tanokura
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1; 62(Pt 7): 656–658. Published online 2006 Jun 10. doi: 10.1107/S1744309106020057
PMCID:
PMC2242961
AbstractArticlePDF–184K
3.
CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway
Edward J. Sanderlin, Melissa M. Keenan, Martin Mense, Alexey S. Revenko, Brett P. Monia, Shuling Guo, Lulu Huang
Nat Commun. 2022; 13: 2344. Published online 2022 Apr 29. doi: 10.1038/s41467-022-29935-9
PMCID:
PMC9054838
AbstractArticlePDF–1.6M
4.
Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay
Giuditta Annibaldis, Michal Domanski, René Dreos, Lara Contu, Sarah Carl, Nina Kläy, Oliver Mühlemann
Nucleic Acids Res. 2020 Oct 9; 48(18): 10259–10279. Published online 2020 Sep 17. doi: 10.1093/nar/gkaa758
PMCID:
PMC7544199
AbstractArticlePDF–4.7M
5.
SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy
Hua Tao, Xu Zhou, Qian Xie, Zhonghua Ma, Fuhai Sun, Lili Cui, Yujie Cai, Guoda Ma, Jiawu Fu, Zhou Liu, You Li, Haihong Zhou, Jianghao Zhao, Yanyan Chen, Hui Mai, Ying Chen, Jun Chen, Wei Qi, Chaowen Sun, Bin Zhao, Keshen Li
J Cell Mol Med. 2018 Mar; 22(3): 1883–1893. Published online 2018 Jan 24. doi: 10.1111/jcmm.13473
PMCID:
PMC5824374
AbstractArticlePDF–553K
6.
Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates
Franziska Ottens, Volker Boehm, Christopher R. Sibley, Jernej Ule, Niels H. Gehring
RNA. 2017 Aug; 23(8): 1224–1236. doi: 10.1261/rna.059659.116
PMCID:
PMC5513067
AbstractArticlePDF–604K
7.
Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways
Martino Colombo, Evangelos D. Karousis, Joël Bourquin, Rémy Bruggmann, Oliver Mühlemann
RNA. 2017 Feb; 23(2): 189–201. doi: 10.1261/rna.059055.116
PMCID:
PMC5238794
AbstractArticlePDF–738K
8.
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD
Pamela Nicholson, Christoph Josi, Hitomi Kurosawa, Akio Yamashita, Oliver Mühlemann
Nucleic Acids Res. 2014 Aug 18; 42(14): 9217–9235. Published online 2014 Jul 22. doi: 10.1093/nar/gku645
PMCID:
PMC4132754
AbstractArticlePDF–9.6M
9.
SMG6 Cleavage Generates Metastable Decay Intermediates from Nonsense-Containing β-Globin mRNA
Roshan Mascarenhas, Julie A. Dougherty, Daniel R. Schoenberg
PLoS One. 2013; 8(9): e74791. Published online 2013 Sep 25. doi: 10.1371/journal.pone.0074791
PMCID:
PMC3783490
AbstractArticlePDF–1.2M
10.
UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2
Lukas M Langer, Katharina Kurscheidt, Jérôme Basquin, Fabien Bonneau, Iuliia Iermak, Claire Basquin, Elena Conti
Nucleic Acids Res. 2024 Jun 10; 52(10): 6036–6048. Published online 2024 May 6. doi: 10.1093/nar/gkae323
PMCID:
PMC11162806
AbstractArticlePDF–1.9M
11.
Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6
Sutapa Chakrabarti, Fabien Bonneau, Steffen Schüssler, Elfriede Eppinger, Elena Conti
Nucleic Acids Res. 2014 Aug 18; 42(14): 9447–9460. Published online 2014 Jul 10. doi: 10.1093/nar/gku578
PMCID:
PMC4132714
AbstractArticlePDF–5.1M
12.
SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan
Eric Huntzinger, Isao Kashima, Maria Fauser, Jérôme Saulière, Elisa Izaurralde
RNA. 2008 Dec; 14(12): 2609–2617. doi: 10.1261/rna.1386208
PMCID:
PMC2590965
AbstractArticlePDF–1.0M
13.
Protein–RNA and protein–protein interactions mediate association of human EST1A/SMG6 with telomerase
Sophie Redon, Patrick Reichenbach, Joachim Lingner
Nucleic Acids Res. 2007 Nov; 35(20): 7011–7022. Published online 2007 Oct 16. doi: 10.1093/nar/gkm724
PMCID:
PMC2175296
AbstractArticlePDF–3.7M
14.
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex
Filip Glavan, Isabelle Behm-Ansmant, Elisa Izaurralde, Elena Conti
EMBO J. 2006 Nov 1; 25(21): 5117–5125. Published online 2006 Oct 19. doi: 10.1038/sj.emboj.7601377
PMCID:
PMC1630413
AbstractArticlePDF–488K
15.
The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis
David CF Sealey, Aleksandar D Kostic, Catherine LeBel, Fiona Pryde, Lea Harrington
BMC Mol Biol. 2011; 12: 45. Published online 2011 Oct 18. doi: 10.1186/1471-2199-12-45
PMCID:
PMC3215184
AbstractArticlePDF–3.5M
16.
Regulation of Cellular Immortalization and Steady-State Levels of the Telomerase Reverse Transcriptase through Its Carboxy-Terminal Domain
Elaine J. Middleman, Jinkuk Choi, Andrew S. Venteicher, Peggie Cheung, Steven E. Artandi
Mol Cell Biol. 2006 Mar; 26(6): 2146–2159. doi: 10.1128/MCB.26.6.2146-2159.2006
PMCID:
PMC1430280
AbstractArticlePDF–602K
17.
An Anchor Site–Type Defect in Human Telomerase That Disrupts Telomere Length Maintenance and Cellular Immortalization
Tara J. Moriarty, Ryan J. Ward, Michael A.S. Taboski, Chantal Autexier
Mol Biol Cell. 2005 Jul; 16(7): 3152–3161. doi: 10.1091/mbc.E05-02-0148
PMCID:
PMC1165400
AbstractArticlePDF–373K
18.
Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1
SHANG-YI CHIU, GUILLAUME SERIN, OSAMU OHARA, LYNNE E. MAQUAT
RNA. 2003 Jan; 9(1): 77–87. doi: 10.1261/rna.2137903
PMCID:
PMC1370372
AbstractArticlePDF–507K
19.
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense-mediated mRNA decay
Tobias M. Franks, Guramrit Singh, Jens Lykke-Andersen
Cell. Author manuscript; available in PMC 2012 May 21.
Published in final edited form as: Cell. 2010 Dec 10; 143(6): 938–950. doi: 10.1016/j.cell.2010.11.043
PMCID:
PMC3357093
AbstractArticlePDF–5.5M
20.
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
Isao Kashima, Stefanie Jonas, Uma Jayachandran, Gretel Buchwald, Elena Conti, Andrei N. Lupas, Elisa Izaurralde
Genes Dev. 2010 Nov 1; 24(21): 2440–2450. doi: 10.1101/gad.604610
PMCID:
PMC2964754
AbstractArticlePDF–1.2M

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