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Select item 104914921.

JMJD6 in tumor-associated macrophage regulates macrophage polarization and cancer progression via STAT3/IL-10 axis

Siyuan Chen, Manni Wang, Tianqi Lu, Yu Liu, Weiqi Hong, Xuemei He, Yuan Cheng, Jian Liu, Yuquan Wei, Xiawei Wei

Oncogene. 2023; 42(37): 2737–2750. Published online 2023 Aug 11. doi: 10.1038/s41388-023-02781-9

PMCID:: PMC10491492

Abstract Article PDF–4.9M

Select item 102333592.

JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization in Breast Cancer

Bianca Cioni, Silvia Ratti, Annamaria Piva, Irene Tripodi, Matteo Milani, Francesca Menichetti, Tiziana Langella, Laura Botti, Loris De Cecco, Claudia Chiodoni, Daniele Lecis, Mario P. Colombo

Mol Cancer Res. 2023 Jun 1; 21(6): 614–627. Published online 2023 Mar 3. doi: 10.1158/1541-7786.MCR-22-0370

PMCID:: PMC10233359

Abstract Article PDF–12M

Select item 101855483.

Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer’s disease

Julie P. Merchant, Kuixi Zhu, Marc Y. R. Henrion, Syed S. A. Zaidi, Branden Lau, Sara Moein, Melissa L. Alamprese, Richard V. Pearse, II, David A. Bennett, Nilüfer Ertekin-Taner, Tracy L. Young-Pearse, Rui Chang

Commun Biol. 2023; 6: 503. Published online 2023 May 15. doi: 10.1038/s42003-023-04791-5

PMCID:: PMC10185548

Abstract Article PDF–7.1M

Select item 96780794.

JMJD6 orchestrates a transcriptional program in favor of endocrine resistance in ER+ breast cancer cells

Partha Das, Aritra Gupta, Kartiki V. Desai

Front Endocrinol (Lausanne) 2022; 13: 1028616. Published online 2022 Nov 7. doi: 10.3389/fendo.2022.1028616

PMCID:: PMC9678079

Abstract Article PDF–3.6M

Select item 93717145.

Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6

Matthew E. Cockman, Yoichiro Sugimoto, Hamish B. Pegg, Norma Masson, Eidarus Salah, Anthony Tumber, Helen R. Flynn, Joanna M. Kirkpatrick, Christopher J. Schofield, Peter J. Ratcliffe

Proc Natl Acad Sci U S A. 2022 Aug 9; 119(32): e2201483119. Published online 2022 Aug 5. doi: 10.1073/pnas.2201483119

PMCID:: PMC9371714

Abstract Article PDF–1.9M

Select item 89639616.

Role of the Epigenetic Modifier JMJD6 in Tumor Development and Regulation of Immune Response

Kai Wang, Chao Yang, Haibin Li, Xiaoyan Liu, Meiling Zheng, Zixue Xuan, Zhiqiang Mei, Haiyong Wang

Front Immunol. 2022; 13: 859893. Published online 2022 Mar 14. doi: 10.3389/fimmu.2022.859893

PMCID:: PMC8963961

Abstract Article PDF–7.4M

Select item 83473027.

Computational and Mass Spectrometry-Based Approach Identify Deleterious Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) in JMJD6

Tianqi Gong, Lujie Yang, Fenglin Shen, Hao Chen, Ziyue Pan, Quanqing Zhang, Yan Jiang, Fan Zhong, Pengyuan Yang, Yang Zhang

Molecules. 2021 Aug; 26(15): 4653. Published online 2021 Jul 31. doi: 10.3390/molecules26154653

PMCID:: PMC8347302

Abstract Article PDF–1.9M

Select item 78820988.

Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma

Chuanjie Zhang, Xuan Lu, Jingyi Huang, Hongchao He, Li Chen, Yihan Liu, Haofei Wang, Yang Xu, Siwei Xing, Xiaohao Ruan, Xiaoqun Yang, Lu Chen, Danfeng Xu

Clin Transl Med. 2021 Feb; 11(2): e328. Published online 2021 Feb 14. doi: 10.1002/ctm2.328

PMCID:: PMC7882098

Abstract Article PDF–16M

Select item 75558459.

JMJD6 Regulates Splicing of Its Own Gene Resulting in Alternatively Spliced Isoforms with Different Nuclear Targets

Nikoleta Raguz, Astrid Heim, Eden Engal, Juste Wesche, Juliane Merl-Pham, Stefanie M. Hauck, Steffen Erkelenz, Heiner Schaal, Olivier Bensaude, Alexander Wolf, Maayan Salton, Angelika Böttger

Int J Mol Sci. 2020 Sep; 21(18): 6618. Published online 2020 Sep 10. doi: 10.3390/ijms21186618

PMCID:: PMC7555845

Abstract Article PDF–2.9M

Select item 735122410.

JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage

Jérémie Fages, Catherine Chailleux, Jonathan Humbert, Suk-Min Jang, Jérémy Loehr, Jean-Philippe Lambert, Jacques Côté, Didier Trouche, Yvan Canitrot

PLoS Genet. 2020 Jun; 16(6): e1008511. Published online 2020 Jun 29. doi: 10.1371/journal.pgen.1008511

PMCID:: PMC7351224

Abstract Article PDF–4.4M

Select item 720609111.

JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity

Dawei Huo, Hao Chen, Yiming Cheng, Xin Song, Kai Zhang, Mulin Jun Li, Chenghao Xuan

Cell Death Differ. 2020 Mar; 27(3): 1052–1066. Published online 2019 Jul 29. doi: 10.1038/s41418-019-0397-3

PMCID:: PMC7206091

Abstract Article PDF–6.0M

Select item 670175312.

Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function

Pablo Reyes-Gutierrez, Jake W. Carrasquillo-Rodríguez, Anthony N. Imbalzano

PLoS One. 2019; 14(8): e0216015. Published online 2019 Aug 20. doi: 10.1371/journal.pone.0216015

PMCID:: PMC6701753

Abstract Article PDF–2.7M

Select item 666387913.

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6

Md. Saiful Islam, Michael A. McDonough, Rasheduzzaman Chowdhury, Joseph Gault, Amjad Khan, Elisabete Pires, Christopher J. Schofield

J Biol Chem. 2019 Jul 26; 294(30): 11637–11652. Published online 2019 May 30. doi: 10.1074/jbc.RA119.008693

PMCID:: PMC6663879

Abstract Article PDF–6.7M

Select item 608571014.

Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells

Chongyang Shen, Qingli Quan, Chuan Yang, Yueqiang Wen, Hong Li

Stem Cell Res Ther. 2018; 9: 212. Published online 2018 Aug 9. doi: 10.1186/s13287-018-0949-3

PMCID:: PMC6085710

Abstract Article PDF–3.3M

Select item 500620715.

Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties

Chang-Ryul Lee, Sung Hee Lee, Nicole Kristina Rigas, Reuben H. Kim, Mo K. Kang, No-Hee Park, Ki-Hyuk Shin

Carcinogenesis. 2016 Feb; 37(2): 119–128. Published online 2015 Dec 8. doi: 10.1093/carcin/bgv169

PMCID:: PMC5006207

Abstract Article PDF–14M

Select item 442388816.

Role of JMJD6 in Breast Tumourigenesis

Coralie Poulard, Juliette Rambaud, Emilie Lavergne, Julien Jacquemetton, Jack-Michel Renoir, Olivier Trédan, Sylvie Chabaud, Isabelle Treilleux, Laura Corbo, Muriel Le Romancer

PLoS One. 2015; 10(5): e0126181. Published online 2015 May 7. doi: 10.1371/journal.pone.0126181

PMCID:: PMC4423888

Abstract Article PDF–5.8M

Select item 416367317.

Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection

Cai-Feng Chen, Xia Feng, Hui-Yu Liao, Wen-Jing Jin, Jian Zhang, Yu Wang, Lu-Lu Gong, Jing-Jun Liu, Xiao-Hui Yuan, Bin-Bin Zhao, Ding Zhang, Guo-Feng Chen, Ying Wan, Jian Guo, Hui-Ping Yan, You-Wen He

Sci Rep. 2014; 4: 6359. Published online 2014 Sep 15. doi: 10.1038/srep06359

PMCID:: PMC4163673

Abstract Article PDF–1.4M

Select item 344634818.

JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer

Yi Fang Lee, Lance David Miller, Xiu Bin Chan, Michael A Black, Brendan Pang, Chee Wee Ong, Manuel Salto-Tellez, Edison T Liu, Kartiki V Desai

Breast Cancer Res. 2012; 14(3): R85. Published online 2012 May 23. doi: 10.1186/bcr3200

Correction in:: Breast Cancer Res. 2017; 19: 42.

PMCID:: PMC3446348

Abstract Article PDF–2.6M

Select item 135685719.

Phosphatidylserine Receptor in Chronic Pancreatitis: Evidence for a Macrophage Independent Role

Jörg Köninger, Peter Balaz, Markus Wagner, Xin Shi, Igor Cima, Arthur Zimmermann, Pierluigi di Sebastiano, Markus W. Büchler, Helmut Friess

Ann Surg. 2005 Jan; 241(1): 144–151. doi: 10.1097/01.sla.0000149304.89456.5a

PMCID:: PMC1356857

Abstract Article PDF–1.1M

Select item 15088920.

Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis

R. William Vandivier, Valerie A. Fadok, Peter R. Hoffmann, Donna L. Bratton, Churee Penvari, Kevin K. Brown, Joseph D. Brain, Frank J. Accurso, Peter M. Henson

J Clin Invest. 2002 Mar 1; 109(5): 661–670. doi: 10.1172/JCI13572

PMCID:: PMC150889

Abstract Article PDF–1.8M

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PMC Links for Gene (Select 23210) (80)
PMC
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1 [Homo s...
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1 [Homo sapiens]
gi|2217310911|ref|XP_047291644.1|

Protein
Homo sapiens mitochondrial fission regulator 1 (MTFR1), transcript variant 17, m...
Homo sapiens mitochondrial fission regulator 1 (MTFR1), transcript variant 17, mRNA; nuclear gene for mitochondrial product
gi|2321224062|ref|NM_001413082.1|

Nucleotide
mitochondrial fission regulator 1 isoform 4 precursor [Homo sapiens]
mitochondrial fission regulator 1 isoform 4 precursor [Homo sapiens]
gi|2321224047|ref|NP_001400003.1|

Protein

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