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Items: 1 to 20 of 46

1.
Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma
Alex Frias, Luca Di Leo, Asier Antoranz, Loulieta Nazerai, Marco Carretta, Valérie Bodemeyer, Chiara Pagliuca, Christina Dahl, Giuseppina Claps, Giulio Eugenio Mandelli, Madhavi Dipak Andhari, Maria Pires Pacheco, Thomas Sauter, Caroline Robert, Per Guldberg, Daniel Hargbøl Madsen, Francesco Cecconi, Francesca Maria Bosisio, Daniela De Zio
J Immunother Cancer. 2023; 11(3): e006389. Published online 2023 Mar 3. doi: 10.1136/jitc-2022-006389
PMCID:
PMC9990656
AbstractArticlePDF–11M
2.
Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration
Ignacio Ramírez-Pardo, Beatriz Villarejo-Zori, Juan Ignacio Jiménez-Loygorri, Elena Sierra-Filardi, Sandra Alonso-Gil, Guillermo Mariño, Pedro de la Villa, Patrick S Fitze, José Manuel Fuentes, Ramón García-Escudero, Deborah A. Ferrington, Raquel Gomez-Sintes, Patricia Boya
Autophagy. 2023; 19(3): 784–804. Published online 2022 Jul 24. doi: 10.1080/15548627.2022.2103307
PMCID:
PMC9980615
AbstractArticlePDF–7.8M
3.
Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice
Roberto Coccurello, Francesca Nazio, Claudia Rossi, Federica De Angelis, Valentina Vacca, Giacomo Giacovazzo, Patrizia Procacci, Valerio Magnaghi, Domenico Ciavardelli, Sara Marinelli
PLoS One. 2018; 13(12): e0208596. Published online 2018 Dec 10. doi: 10.1371/journal.pone.0208596
PMCID:
PMC6287902
AbstractArticlePDF–5.3M
4.
Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival
Rossella Russo, Giuseppe Pasquale Varano, Annagrazia Adornetto, Francesca Nazio, Gianluca Tettamanti, Rossana Girardello, Valentina Cianfanelli, Federica Cavaliere, Luigi Antonio Morrone, Maria Tiziana Corasaniti, Francesco Cecconi, Giacinto Bagetta, Carlo Nucci
Cell Death Dis. 2018 Oct; 9(10): 981. Published online 2018 Sep 24. doi: 10.1038/s41419-018-1044-5
PMCID:
PMC6155349
AbstractArticlePDF–7.8M
5.
Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female Gender
Ekrem Dere, Liane Dahm, Derek Lu, Kurt Hammerschmidt, Anes Ju, Martesa Tantra, Anne Kästner, Kamal Chowdhury, Hannelore Ehrenreich
Front Behav Neurosci. 2014; 8: 181. Published online 2014 May 16. doi: 10.3389/fnbeh.2014.00181
PMCID:
PMC4032889
AbstractArticlePDF–2.8M
6.
The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes
Christina Schoenherr, Adam Byron, Billie Griffith, Alexander Loftus, Jimi C. Wills, Alison F. Munro, Alex von Kriegsheim, Margaret C. Frame
J Biol Chem. 2020 Aug 21; 295(34): 12045–12057. Published online 2020 Jul 2. doi: 10.1074/jbc.RA120.012565
PMCID:
PMC7443501
AbstractArticlePDF–3.4M
7.
MicroRNA‐30a ameliorates hepatic fibrosis by inhibiting Beclin1‐mediated autophagy
Jianliang Chen, Yue Yu, Shu Li, Yuting Liu, Shu Zhou, Shouji Cao, Jie Yin, Guoqiang Li
J Cell Mol Med. 2017 Dec; 21(12): 3679–3692. Published online 2017 Aug 1. doi: 10.1111/jcmm.13278
PMCID:
PMC5706581
AbstractArticlePDF–7.1M
8.
Sexual dimorphism of AMBRA1-related autistic features in human and mouse
M Mitjans, M Begemann, A Ju, E Dere, L Wüstefeld, S Hofer, I Hassouna, J Balkenhol, B Oliveira, S van der Auwera, R Tammer, K Hammerschmidt, H Völzke, G Homuth, F Cecconi, K Chowdhury, H Grabe, J Frahm, S Boretius, T Dandekar, H Ehrenreich
Transl Psychiatry. 2017 Oct; 7(10): e1247. Published online 2017 Oct 10. doi: 10.1038/tp.2017.213
PMCID:
PMC5682605
AbstractArticlePDF–2.7M
9.
Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor‐dependent apoptosis
Mauro Corrado, Francesca R Mariotti, Laura Trapani, Lucia Taraborrelli, Francesca Nazio, Valentina Cianfanelli, Maria Eugenia Soriano, Emilie Schrepfer, Francesco Cecconi, Luca Scorrano, Silvia Campello
EMBO J. 2016 Aug 15; 35(16): 1793–1809. Published online 2016 Jul 7. doi: 10.15252/embj.201593727
PMCID:
PMC5010050
AbstractArticlePDF–2.5M
10.
The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone
M Yazdankhah, S Farioli-Vecchioli, A B Tonchev, A Stoykova, F Cecconi
Cell Death Dis. 2014 Sep; 5(9): e1403. Published online 2014 Sep 4. doi: 10.1038/cddis.2014.358
PMCID:
PMC4540193
AbstractArticlePDF–2.6M
11.
GIT1 contributes to autophagy in osteoclast through disruption of the binding of Beclin1 and Bcl2 under starvation condition
Shu-Jie Zhao, Fan-Qi Kong, Wei Cai, Tao Xu, Zhi-Min Zhou, Zi-Bin Wang, An-Di Xu, Ya-Qing Yang, Jian Chen, Peng-Yu Tang, Qian Wang, Lin Cheng, Yong-Jun Luo, Zheng Zhou, Lin-Wei Li, Yi-Fan Huang, Xuan Zhao, Guo-Yong Yin, Ming-Xin Xue, Jin Fan
Cell Death Dis. 2018 Dec; 9(12): 1195. Published online 2018 Dec 13. doi: 10.1038/s41419-018-1256-8
PMCID:
PMC6294144
AbstractArticlePDF–2.3M
12.
Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks
Christina Schoenherr, Adam Byron, Emma Sandilands, Ketevan Paliashvili, George S Baillie, Amaya Garcia-Munoz, Cristina Valacca, Francesco Cecconi, Bryan Serrels, Margaret C Frame
eLife. 2017; 6: e23172. Published online 2017 Mar 31. doi: 10.7554/eLife.23172
PMCID:
PMC5376188
AbstractArticlePDF–5.0M
13.
Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy
Christopher C. Pan, Sanjay Kumar, Nirav Shah, Jeffrey C. Bloodworth, Lukas J. A. C. Hawinkels, Karthikeyan Mythreye, Dale G. Hoyt, Nam Y. Lee
J Biol Chem. 2015 Jun 12; 290(24): 14884–14892. Published online 2015 Apr 30. doi: 10.1074/jbc.M114.630178
PMCID:
PMC4463436
AbstractArticlePDF–1.8M
14.
Insights from DEspR-deficiency and haploinsufficiency
Victoria L.M. Herrera, Julius L. Decano, Martin Steffen, Nelson Ruiz-Opazo
Autophagy. Author manuscript; available in PMC 2010 Feb 22.
Published in final edited form as: Autophagy. 2009 Feb; 5(2): 259–262. Published online 2009 Feb 12. doi: 10.4161/auto.5.2.7617
PMCID:
PMC2825871
AbstractArticlePDF–1.2M
15.
Loss of Ambra1 promotes melanoma growth and invasion
Luca Di Leo, Valérie Bodemeyer, Francesca M. Bosisio, Giuseppina Claps, Marco Carretta, Salvatore Rizza, Fiorella Faienza, Alex Frias, Shawez Khan, Matteo Bordi, Maria P. Pacheco, Julie Di Martino, Jose J. Bravo-Cordero, Colin J. Daniel, Rosalie C. Sears, Marco Donia, Daniel H. Madsen, Per Guldberg, Giuseppe Filomeni, Thomas Sauter, Caroline Robert, Daniela De Zio, Francesco Cecconi
Nat Commun. 2021; 12: 2550. Published online 2021 May 5. doi: 10.1038/s41467-021-22772-2
PMCID:
PMC8100102
AbstractArticlePDF–4.7M
16.
AMBRA1, a novel α‐synuclein‐binding protein, is implicated in the pathogenesis of multiple system atrophy
Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Yota Tatara, Jun Utsumi, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Gian Maria Fimia, Koichi Wakabayashi
Brain Pathol. 2018 Jan; 28(1): 28–42. Published online 2017 Mar 15. doi: 10.1111/bpa.12461
PMCID:
PMC8028368
AbstractArticlePDF–936K
17.
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-MYC dephosphorylation and degradation
Valentina Cianfanelli, Claudia Fuoco, Mar Lorente, Maria Salazar, Fabio Quondamatteo, Pier Federico Gherardini, Daniela De Zio, Francesca Nazio, Manuela Antonioli, Melania D’Orazio, Tatjana Skobo, Matteo Bordi, Mikkel Rohde, Luisa Dalla Valle, Manuela Helmer-Citterich, Christine Gretzmeier, Joern Dengjel, Gian Maria Fimia, Mauro Piacentini, Sabrina Di Bartolomeo, Guillermo Velasco, Francesco Cecconi
Nat Cell Biol. Author manuscript; available in PMC 2016 Aug 8.
Published in final edited form as: Nat Cell Biol. 2015 Jan; 17(1): 20–30. Published online 2014 Dec 1. doi: 10.1038/ncb3072
Correction in:
Nat Cell Biol. 2015 May; 17(5): 706.
PMCID:
PMC4976803
AbstractArticlePDF–2.2M
18.
Microglia ablation alleviates myelin-associated catatonic signs in mice
Hana Janova, Sahab Arinrad, Evan Balmuth, Marina Mitjans, Johannes Hertel, Mohamad Habes, Robert A. Bittner, Hong Pan, Sandra Goebbels, Martin Begemann, Ulrike C. Gerwig, Sönke Langner, Hauke B. Werner, Sarah Kittel-Schneider, Georg Homuth, Christos Davatzikos, Henry Völzke, Brian L. West, Andreas Reif, Hans Jörgen Grabe, Susann Boretius, Hannelore Ehrenreich, Klaus-Armin Nave
J Clin Invest. 2018 Feb 1; 128(2): 734–745. Published online 2017 Dec 18. doi: 10.1172/JCI97032
PMCID:
PMC5785265
AbstractArticlePDF–9.0M
19.
Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains
M. Di Rienzo, M. Antonioli, C. Fusco, Y. Liu, M. Mari, I. Orhon, G. Refolo, F. Germani, M. Corazzari, A. Romagnoli, F. Ciccosanti, B. Mandriani, M. T. Pellico, R. De La Torre, H. Ding, M. Dentice, M. Neri, A. Ferlini, F. Reggiori, M. Kulesz-Martin, M. Piacentini, G. Merla, G. M. Fimia
Sci Adv. 2019 May; 5(5): eaau8857. Published online 2019 May 8. doi: 10.1126/sciadv.aau8857
PMCID:
PMC6527439
AbstractArticlePDF–4.3M
20.
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
Sabrina Di Bartolomeo, Marco Corazzari, Francesca Nazio, Serafina Oliverio, Gaia Lisi, Manuela Antonioli, Vittoria Pagliarini, Silvia Matteoni, Claudia Fuoco, Luigi Giunta, Marcello D'Amelio, Roberta Nardacci, Alessandra Romagnoli, Mauro Piacentini, Francesco Cecconi, Gian Maria Fimia
J Cell Biol. 2010 Oct 4; 191(1): 155–168. doi: 10.1083/jcb.201002100
PMCID:
PMC2953445
AbstractArticlePDF–6.9M

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