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Select item 112346131.

Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer

Claudia Cifuentes, Clara L. Oeste, Isabel Fernández-Pisonero, Alejandro M. Hortal, Carmen García-Macías, Jeanne Hochart, Regina Rubira, Lydia Horndler, Carlos Horndler, Xosé R. Bustelo, Balbino Alarcón

Mol Cancer. 2024; 23: 142. Published online 2024 Jul 10. doi: 10.1186/s12943-024-02054-3

PMCID:: PMC11234613

Abstract Article PDF–9.9M

Select item 107675932.

The RRAS2 pathogenic variant (c.67G>T; p. Gly23Cys) produces Noonan syndrome with embryonal rhabdomyosarcoma

Lan Zeng, Jin Wang, Hui Zhu, Yu Huang, Yi Deng, Ping Wei, Jing Nie, Bei Tang, Ai Chen, Shuyao Zhu

Mol Genet Genomic Med. 2024 Jan; 12(1): e2313. Published online 2023 Nov 9. doi: 10.1002/mgg3.2313

PMCID:: PMC10767593

Abstract Article PDF–2.4M

Select item 107053753.

Characterization of Three Somatic Mutations in the 3′UTR of RRAS2 and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia

Marta Lacuna, Alejandro M. Hortal, Claudia Cifuentes, Tania Gonzalo, Miguel Alcoceba, Miguel Bastos, Xosé R. Bustelo, Marcos González, Balbino Alarcón

Cells. 2023 Dec; 12(23): 2687. Published online 2023 Nov 22. doi: 10.3390/cells12232687

PMCID:: PMC10705375

Abstract Article PDF–4.8M

Select item 98831674.

Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors

Laura Clavaín, Isabel Fernández-Pisonero, Nieves Movilla, L. Francisco Lorenzo-Martín, Blanca Nieto, Antonio Abad, Rósula García-Navas, Clara Llorente-González, Manuel Sánchez-Martín, Miguel Vicente-Manzanares, Eugenio Santos, Balbino Alarcón, José M. García-Aznar, Mercedes Dosil, Xosé R. Bustelo

Oncogene. 2023; 42(5): 389–405. Published online 2022 Dec 7. doi: 10.1038/s41388-022-02563-9

PMCID:: PMC9883167

Abstract Article PDF–7.2M

Select item 65620055.

Germline-Activating RRAS2 Mutations Cause Noonan Syndrome

Tetsuya Niihori, Koki Nagai, Atsushi Fujita, Hirofumi Ohashi, Nobuhiko Okamoto, Satoshi Okada, Atsuko Harada, Hirotaka Kihara, Thomas Arbogast, Ryo Funayama, Matsuyuki Shirota, Keiko Nakayama, Taiki Abe, Shin-ichi Inoue, I-Chun Tsai, Naomichi Matsumoto, Erica E. Davis, Nicholas Katsanis, Yoko Aoki

Am J Hum Genet. 2019 Jun 6; 104(6): 1233–1240. Published online 2019 May 23. doi: 10.1016/j.ajhg.2019.04.014

PMCID:: PMC6562005

Abstract Article PDF–1.5M

Select item 65620036.

Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome

Yline Capri, Elisabetta Flex, Oliver H.F. Krumbach, Giovanna Carpentieri, Serena Cecchetti, Christina Lißewski, Soheila Rezaei Adariani, Denny Schanze, Julia Brinkmann, Juliette Piard, Francesca Pantaleoni, Francesca R. Lepri, Elaine Suk-Ying Goh, Karen Chong, Elliot Stieglitz, Julia Meyer, Alma Kuechler, Nuria C. Bramswig, Stephanie Sacharow, Marion Strullu, Yoann Vial, Cédric Vignal, George Kensah, Goran Cuturilo, Neda S. Kazemein Jasemi, Radovan Dvorsky, Kristin G. Monaghan, Lisa M. Vincent, Hélène Cavé, Alain Verloes, Mohammad R. Ahmadian, Marco Tartaglia, Martin Zenker

Am J Hum Genet. 2019 Jun 6; 104(6): 1223–1232. Published online 2019 May 23. doi: 10.1016/j.ajhg.2019.04.013

PMCID:: PMC6562003

Abstract Article PDF–1.4M

Select item 39002897.

R-RAS2 overexpression in tumors of the human central nervous system

Sylvia Gutierrez-Erlandsson, Pedro Herrero-Vidal, Marcos Fernandez-Alfara, Susana Hernandez-Garcia, Sandra Gonzalo-Flores, Alberto Mudarra-Rubio, Manuel Fresno, Beatriz Cubelos

Mol Cancer. 2013; 12: 127. Published online 2013 Oct 23. doi: 10.1186/1476-4598-12-127

PMCID:: PMC3900289

Abstract Article PDF–2.9M

Select item 444418.

A human oncogene of the RAS superfamily unmasked by expression cDNA cloning.

A M Chan, T Miki, K A Meyers, S A Aaronson

Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16): 7558–7562. doi: 10.1073/pnas.91.16.7558

PMCID:: PMC44441

Summary Page Browse PDF–1.3M

Select item 11712179.

Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells.

M Rosário, H F Paterson, C J Marshall

EMBO J. 1999 Mar 1; 18(5): 1270–1279. doi: 10.1093/emboj/18.5.1270

PMCID:: PMC1171217

Summary PDF–644K

Select item 844779310.

R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells

Shannon M. Weber, Nicole M. Brossier, Amanda Prechtl, Stephen Barnes, Landon S. Wilson, Stephanie N. Brosius, Jody Fromm Longo, Steven L. Carroll

Cell Commun Signal. 2021; 19: 95. Published online 2021 Sep 16. doi: 10.1186/s12964-021-00773-4

PMCID:: PMC8447793

Abstract Article PDF–3.9M

Select item 539120911.

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

Xiaoyu Zhang, Nicole A Spiegelman, Ornella D Nelson, Hui Jing, Hening Lin

eLife. 2017; 6: e25158. Published online 2017 Apr 13. doi: 10.7554/eLife.25158

PMCID:: PMC5391209

Abstract Article PDF–1.1M

Select item 514786212.

The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions

Hossein Nakhaeizadeh, Ehsan Amin, Saeideh Nakhaei-Rad, Radovan Dvorsky, Mohammad Reza Ahmadian

PLoS One. 2016; 11(12): e0167145. Published online 2016 Dec 9. doi: 10.1371/journal.pone.0167145

PMCID:: PMC5147862

Abstract Article PDF–2.3M

Select item 276214013.

Structural and Spatial Determinants Regulating TC21 Activation by RasGRF Family Nucleotide Exchange Factors

Fernando Calvo, Piero Crespo

Mol Biol Cell. 2009 Oct 15; 20(20): 4289–4302. doi: 10.1091/mbc.E09-03-0212

PMCID:: PMC2762140

Abstract Article PDF–3.8M

Select item 51508514.

A tagging-via-substrate technology for detection and proteomics of farnesylated proteins

Yoonjung Kho, Sung Chan Kim, Chen Jiang, Deb Barma, Sung Won Kwon, Jinke Cheng, Janis Jaunbergs, Carolyn Weinbaum, Fuyuhiko Tamanoi, John Falck, Yingming Zhao

Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34): 12479–12484. Published online 2004 Aug 12. doi: 10.1073/pnas.0403413101

PMCID:: PMC515085

Abstract Article PDF–395K

Select item 36228815.

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

G T Drivas, A Shih, E Coutavas, M G Rush, P D'Eustachio

Mol Cell Biol. 1990 Apr; 10(4): 1793–1798. doi: 10.1128/mcb.10.4.1793

PMCID:: PMC362288

Summary Page Browse PDF–1.2M

Select item 594811016.

Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative and HER2-enriched breast cancers

Sherona R. Sirkisoon, Richard L. Carpenter, Tadas Rimkus, Ashley Anderson, Alexandria Harrison, Allison M. Lange, Guangxu Jin, Kounosuke Watabe, Hui-Wen Lo

Oncogene. Author manuscript; available in PMC 2018 Aug 16.

Published in final edited form as: Oncogene. 2018 May; 37(19): 2502–2514. Published online 2018 Feb 16. doi: 10.1038/s41388-018-0132-4

Correction in:: Oncogene. 2024 Jun 12

PMCID:: PMC5948110

Abstract Article PDF–1.1M

Select item 31654117.

The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf

Weiquan Li, Min Han, Kun-Liang Guan

Genes Dev. 2000 Apr 15; 14(8): 895–900.

PMCID:: PMC316541

Abstract Article PDF–355K

Select item 244265318.

Neither Replication nor Simulation Supports a Role for the Axon Guidance Pathway in the Genetics of Parkinson's Disease

Yonghong Li, Charles Rowland, Georgia Xiromerisiou, Robert J. Lagier, Steven J. Schrodi, Efthimios Dradiotis, David Ross, Nam Bui, Joseph Catanese, Konstantinos Aggelakis, Andrew Grupe, Georgios Hadjigeorgiou

PLoS One. 2008; 3(7): e2707. Published online 2008 Jul 16. doi: 10.1371/journal.pone.0002707

PMCID:: PMC2442653

Abstract Article PDF–245K

Select item 975894919.

A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy

Dong He, Tao Xin, Bo Pang, Jun Sun, Zi Hao Liu, Zhen Qin, Xiao Shuai Ji, Fan Yang, Yan Bang Wei, Zi Xiao Wang, Jia Jia Gao, Qi Pang, Qian Liu

J Exp Clin Cancer Res. 2022; 41: 349. Published online 2022 Dec 17. doi: 10.1186/s13046-022-02543-7

PMCID:: PMC9758949

Abstract Article PDF–18M

Select item 376099520.

Genome Wide Association Study of the Rate of Cognitive Decline in Alzheimer’s Disease

Richard Sherva, Yorghos Tripodis, David Bennett, Lori B. Chibnik, Paul K. Crane, Philip de Jager, Lindsay A. Farrer, Andrew J. Saykin, Joshua Shulman, Robert C. Green, the Alzheimer’s Disease Neuroimaging Initiative

Alzheimers Dement. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Alzheimers Dement. 2014 Jan; 10(1): 10.1016/j.jalz.2013.01.008. Published online 2013 Mar 25. doi: 10.1016/j.jalz.2013.01.008

PMCID:: PMC3760995

Abstract Article PDF–589K

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PMC Links for Gene (Select 22800) (60)
PMC
Homo sapiens collagen type IV alpha 2 chain (COL4A2), mRNA
Homo sapiens collagen type IV alpha 2 chain (COL4A2), mRNA
gi|1653961724|ref|NM_001846.4|

Nucleotide
PREDICTED: Mus musculus ADAMTS-like 1 (Adamtsl1), transcript variant X4, mRNA
PREDICTED: Mus musculus ADAMTS-like 1 (Adamtsl1), transcript variant X4, mRNA
gi|1907157817|ref|XM_006538378.5|

Nucleotide
Mus musculus ADAMTS-like 1 (Adamtsl1), transcript variant 3, mRNA
Mus musculus ADAMTS-like 1 (Adamtsl1), transcript variant 3, mRNA
gi|1572616271|ref|NM_001368621.1|

Nucleotide
Homo sapiens KIAA1405 mRNA for KIAA1405 protein
Homo sapiens KIAA1405 mRNA for KIAA1405 protein
gi|27529872|dbj|AB037826.2|

Nucleotide

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