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Select item 85337791.

The Interplay between Histamine H₄ Receptor and the Kidney Function: The Lesson from H₄ Receptor Knockout Mice

Roberta Verta, Maura Gurrieri, Sara Borga, Elisa Benetti, Paolo Pollicino, Roberta Cavalli, Robin L. Thurmond, Paul L. Chazot, Alessandro Pini, Arianna Carolina Rosa, Cristina Grange

Biomolecules. 2021 Oct; 11(10): 1517. Published online 2021 Oct 15. doi: 10.3390/biom11101517

PMCID:: PMC8533779

Abstract Article PDF–4.8M

Select item 72260352.

Genetic Deficiency of the Histamine H₄-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice

Bastian Schirmer, Tamina Rother, Inga Bruesch, Andre Bleich, Christopher Werlein, Danny Jonigk, Roland Seifert, Detlef Neumann

Cancers (Basel) 2020 Apr; 12(4): 912. Published online 2020 Apr 8. doi: 10.3390/cancers12040912

PMCID:: PMC7226035

Abstract Article PDF–1.8M

Select item 61674653.

In vivo Evidence for Partial Activation of Eosinophils via the Histamine H₄-Receptor: Adoptive Transfer Experiments Using Eosinophils From H₄R^−/− and H₄R^+/+ Mice

Bastian Schirmer, Luisa Bringmann, Roland Seifert, Detlef Neumann

Front Immunol. 2018; 9: 2119. Published online 2018 Sep 25. doi: 10.3389/fimmu.2018.02119

PMCID:: PMC6167465

Abstract Article PDF–1.4M

Select item 56013864.

Lack of Histamine H₄-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice

Eva J. Wunschel, Bastian Schirmer, Roland Seifert, Detlef Neumann

Front Pharmacol. 2017; 8: 642. Published online 2017 Sep 13. doi: 10.3389/fphar.2017.00642

PMCID:: PMC5601386

Abstract Article PDF–1.7M

Select item 41515225.

The histamine H₄ receptor mediates inflammation and Th17 responses in preclinical models of arthritis

Jeffery M Cowden, Fuqu Yu, Homayon Banie, Mandana Farahani, Ping Ling, Steven Nguyen, Jason P Riley, Mai Zhang, Jian Zhu, Paul J Dunford, Robin L Thurmond

Ann Rheum Dis. 2014 Mar; 73(3): 600–608. Published online 2013 Oct 14. doi: 10.1136/annrheumdis-2013-203832

PMCID:: PMC4151522

Abstract Article PDF–22M

Select item 37648506.

Antagonism of histamine H₄ receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis

C Ballerini, A Aldinucci, I Luccarini, A Galante, C Manuelli, P Blandina, M Katebe, P L Chazot, E Masini, M B Passani

Br J Pharmacol. 2013 Sep; 170(1): 67–77. Published online 2013 Aug 15. doi: 10.1111/bph.12263

PMCID:: PMC3764850

Abstract Article PDF–1.7M

Select item 29147357.

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

Jeffery M Cowden, Jason P Riley, Jing Ying Ma, Robin L Thurmond, Paul J Dunford

Respir Res. 2010; 11(1): 86. Published online 2010 Jun 24. doi: 10.1186/1465-9921-11-86

PMCID:: PMC2914735

Abstract Article PDF–1.4M

Select item 44478938.

Histamine induces proliferation in keratinocytes from atopic dermatitis patients

Franziska Glatzer, Maria Gschwandtner, Sarah Ehling, Kristine Rossbach, Katrin Janik, Andreas Klos, Wolfgang Bäumer, Manfred Kietzmann, Thomas Werfel, Ralf Gutzmer

J Allergy Clin Immunol. Author manuscript; available in PMC 2015 May 29.

Published in final edited form as: J Allergy Clin Immunol. 2013 Dec; 132(6): 1358–1367. Published online 2013 Aug 9. doi: 10.1016/j.jaci.2013.06.023

PMCID:: PMC4447893

Abstract Article PDF–1.8M

Select item 41280719.

Histamine H₄ receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration

Hiroki Kaneko, Fuxiang Ye, Ryo Ijima, Shu Kachi, Seiichi Kato, Masatoshi Nagaya, Akiko Higuchi, Hiroko Terasaki

Br J Pharmacol. 2014 Aug; 171(15): 3754–3763. Published online 2014 Jul 17. doi: 10.1111/bph.12737

PMCID:: PMC4128071

Abstract Article PDF–1.0M

Select item 391358810.

Delineating the Role of Histamine-1- and -4-Receptors in a Mouse Model of Th2-Dependent Antigen-Specific Skin Inflammation

Subhashree Mahapatra, Melanie Albrecht, Barbara Behrens, Adan Jirmo, Georg Behrens, Christina Hartwig, Detlef Neumann, Ulrike Raap, Heike Bähre, Christina Herrick, Anna-Maria Dittrich

PLoS One. 2014; 9(2): e87296. Published online 2014 Feb 4. doi: 10.1371/journal.pone.0087296

PMCID:: PMC3913588

Abstract Article PDF–4.6M

Select item 358318711.

Histamine modulates microglia function

Raquel Ferreira, Tiago Santos, Joana Gonçalves, Graça Baltazar, Lino Ferreira, Fabienne Agasse, Liliana Bernardino

J Neuroinflammation. 2012; 9: 90. Published online 2012 May 8. doi: 10.1186/1742-2094-9-90

PMCID:: PMC3583187

Abstract Article PDF–1.2M

Select item 326027912.

Opposite Effects of Mepyramine on JNJ 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation

Silke Beermann, Silke Glage, Danny Jonigk, Roland Seifert, Detlef Neumann

PLoS One. 2012; 7(1): e30285. Published online 2012 Jan 17. doi: 10.1371/journal.pone.0030285

PMCID:: PMC3260279

Abstract Article PDF–2.1M

Select item 272060613.

H4 Histamine Receptors Mediate Cell Cycle Arrest in Growth Factor-Induced Murine and Human Hematopoietic Progenitor Cells

Anne-France Petit-Bertron, François Machavoine, Marie Paule Defresne, Michel Gillard, Pierre Chatelain, Prakash Mistry, Elke Schneider, Michel Dy

PLoS One. 2009; 4(8): e6504. Published online 2009 Aug 7. doi: 10.1371/journal.pone.0006504

PMCID:: PMC2720606

Abstract Article PDF–676K

Select item 269778314.

The histamine H₄ receptor is functionally expressed on neurons in the mammalian CNS

WM Connelly, FC Shenton, N Lethbridge, R Leurs, HJ Waldvogel, RLM Faull, G Lees, PL Chazot

Br J Pharmacol. 2009 May; 157(1): 55–63. doi: 10.1111/j.1476-5381.2009.00227.x

PMCID:: PMC2697783

Abstract Article PDF–456K

Select item 853307315.

The Histamine H₄ Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A₃ Receptor Agonist IB-MECA: Role of CD4⁺ T Cells

Laura Micheli, Mariaconcetta Durante, Elena Lucarini, Silvia Sgambellone, Laura Lucarini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Emanuela Masini

Biomolecules. 2021 Oct; 11(10): 1447. Published online 2021 Oct 2. doi: 10.3390/biom11101447

PMCID:: PMC8533073

Abstract Article PDF–1.7M

Select item 700040116.

Study of the antitumour effects and the modulation of immune response by histamine in breast cancer

Melisa B. Nicoud, Helena A. Sterle, Noelia A. Massari, Mónica A. Táquez Delgado, Karina Formoso, María V. Herrero Ducloux, Diego Martinel Lamas, Graciela A. Cremaschi, Vanina A. Medina

Br J Cancer. 2020 Feb 4; 122(3): 348–360. Published online 2019 Nov 21. doi: 10.1038/s41416-019-0636-x

PMCID:: PMC7000401

Abstract Article PDF–1.4M

Select item 597651617.

Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis

Joshua B. Wechsler, Alison Szabo, Chia-Lin Hsu, Rebecca Krier-Burris, Holly Schroeder, Ming Y. Wang, Roderick Carter, Tania Velez, Lizath M. Aguiniga, Jeff B. Brown, Mendy L. Miller, Barry K. Wershil, Terrence A. Barrett, Paul J. Bryce

Mucosal Immunol. Author manuscript; available in PMC 2018 Jul 24.

Published in final edited form as: Mucosal Immunol. 2018 May; 11(3): 861–870. Published online 2018 Jan 24. doi: 10.1038/mi.2017.121

PMCID:: PMC5976516

Abstract Article PDF–807K

Select item 353889318.

Sequential Engagement of FcεRI on Mast Cells and Basophil Histamine H₄ Receptor and FcεRI in Allergic Rhinitis

Yoshiki Shiraishi, Yi Jia, Joanne Domenico, Anthony Joetham, Hajime Karasuyama, Katsuyuki Takeda, Erwin W. Gelfand

J Immunol. Author manuscript; available in PMC 2014 Jan 15.

Published in final edited form as: J Immunol. 2013 Jan 15; 190(2): 539–548. Published online 2012 Dec 14. doi: 10.4049/jimmunol.1202049

PMCID:: PMC3538893

Abstract Article PDF–1.5M

Select item 325320919.

Histamine H₄ receptor optimizes T_R cell frequency and facilitates anti-inflammatory responses within the CNS

Roxana del Rio, Rajkumar Noubade, Naresha Saligrama, Emma H. Wall, Dimitry N. Krementsov, Matthew E. Poynter, James F. Zachary, Robin L. Thurmond, Cory Teuscher

J Immunol. Author manuscript; available in PMC 2013 Jan 15.

Published in final edited form as: J Immunol. 2012 Jan 15; 188(2): 541–547. Published online 2011 Dec 5. doi: 10.4049/jimmunol.1101498