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Select item 101967521.

Xanthine oxidase mediates chronic stress-induced cerebrovascular dysfunction and cognitive impairment

Emily N Burrage, Tyler Coblentz, Saina S Prabhu, Ryan Childers, Randy W Bryner, Sarah E Lewis, Evan DeVallance, Eric E Kelley, Paul D Chantler

J Cereb Blood Flow Metab. 2023 Jun; 43(6): 905–920. Published online 2023 Jan 18. doi: 10.1177/0271678X231152551

PMCID:: PMC10196752

Abstract Article PDF–1.3M

Select item 100251332.

Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis

Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub

Redox Biol. 2023 Jun; 62: 102636. Published online 2023 Feb 13. doi: 10.1016/j.redox.2023.102636

PMCID:: PMC10025133

Abstract Article PDF–5.8M

Select item 78765053.

Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy

Takeo Ishii, Tomohiro Kumagae, Hiromichi Wakui, Shingo Urate, Shohei Tanaka, Eriko Abe, Toru Suzuki, Takahiro Yamaji, Sho Kinguchi, Ryu Kobayashi, Kotaro Haruhara, Takashi Nakamura, Shuzo Kobayashi, Kouichi Tamura

FEBS Open Bio. 2021 Feb; 11(2): 507–518. Published online 2021 Feb 1. doi: 10.1002/2211-5463.13083

PMCID:: PMC7876505

Abstract Article PDF–816K

Select item 68179044.

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

Teruo Kusano, Driss Ehirchiou, Tomohiro Matsumura, Veronique Chobaz, Sonia Nasi, Mariela Castelblanco, Alexander So, Christine Lavanchy, Hans Acha-Orbea, Takeshi Nishino, Ken Okamoto, Nathalie Busso

Nat Commun. 2019; 10: 4904. Published online 2019 Oct 28. doi: 10.1038/s41467-019-12565-z

PMCID:: PMC6817904

Abstract Article PDF–2.2M

Select item 66100255.

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities

Daniel B. Harmon, W. Kyle Mandler, Ian J. Sipula, Nikolaos Dedousis, Sara E. Lewis, Jeremy T. Eckels, Jianhai Du, Yekai Wang, Brydie R. Huckestein, Patrick J. Pagano, Eugenia Cifuentes-Pagano, Gregg E. Homanics, Thomas J. Van’t Erve, Maja Stefanovic-Racic, Michael J. Jurczak, Robert M. O’Doherty, Eric E. Kelley

Diabetes. 2019 Jun; 68(6): 1221–1229. Published online 2019 Apr 1. doi: 10.2337/db18-1198

PMCID:: PMC6610025

Abstract Article PDF–1.5M

Select item 55829526.

Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice

Guido Lastra, Camila Manrique, Guanghong Jia, Annayya R. Aroor, Melvin R. Hayden, Brady J. Barron, Brett Niles, Jaume Padilla, James R. Sowers

Am J Physiol Regul Integr Comp Physiol. 2017 Aug 1; 313(2): R67–R77. Published online 2017 May 24. doi: 10.1152/ajpregu.00483.2016

PMCID:: PMC5582952

Abstract Article

Select item 45036477.

Xanthine Oxidoreductase Function Contributes to Normal Wound Healing

Michael C Madigan, Ryan M McEnaney, Ankur J Shukla, Guiying Hong, Eric E Kelley, Margaret M Tarpey, Mark Gladwin, Brian S Zuckerbraun, Edith Tzeng

Mol Med. 2015; 21(1): 313–322. Prepublished online 2015 Apr 14. Published online 2015 Apr 14. doi: 10.2119/molmed.2014.00191

PMCID:: PMC4503647

Abstract Article PDF–4.0M

Select item 37385968.

Xanthine Oxidase Mediates Axonal and Myelin Loss in a Murine Model of Multiple Sclerosis

Josephe Archie Honorat, Makoto Kinoshita, Tatsusada Okuno, Kazushiro Takata, Toru Koda, Satoru Tada, Takashi Shirakura, Harutoshi Fujimura, Hideki Mochizuki, Saburo Sakoda, Yuji Nakatsuji

PLoS One. 2013; 8(8): e71329. Published online 2013 Aug 8. doi: 10.1371/journal.pone.0071329

PMCID:: PMC3738596

Abstract Article PDF–4.6M

Select item 36771779.

Functional characterization of voltage-dependent Ca²⁺ channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS

Eun A. Ko, Jun Wan, Aya Yamamura, Adriana M. Zimnicka, Hisao Yamamura, Hae Young Yoo, Haiyang Tang, Kimberly A. Smith, Premanand C. Sundivakkam, Amy Zeifman, Ramon J. Ayon, Ayako Makino, Jason X.-J. Yuan

Am J Physiol Cell Physiol. 2013 Jun 1; 304(11): C1042–C1052. Published online 2013 Feb 20. doi: 10.1152/ajpcell.00304.2012

PMCID:: PMC3677177

Abstract Article

Select item 337776210.

Untargeted Plasma Metabolite Profiling Reveals the Broad Systemic Consequences of Xanthine Oxidoreductase Inactivation in Mice

Qiuying Chen, Hyeong-Cheon Park, Michael S. Goligorsky, Praveen Chander, Steven M. Fischer, Steven S. Gross

PLoS One. 2012; 7(6): e37149. Published online 2012 Jun 18. doi: 10.1371/journal.pone.0037149

PMCID:: PMC3377762

Abstract Article PDF–1.3M

Select item 280620611.

Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation

M. C. Gomez-Cabrera, G. L. Close, A. Kayani, A. McArdle, J. Viña, M. J. Jackson

Am J Physiol Regul Integr Comp Physiol. 2010 Jan; 298(1): R2–R8. Published online 2009 Oct 14. doi: 10.1152/ajpregu.00142.2009

PMCID:: PMC2806206

Abstract Article

Select item 121785912.

Expression of xanthine oxidoreductase in mouse mammary epithelium during pregnancy and lactation: regulation of gene expression by glucocorticoids and prolactin.

M Kurosaki, S Zanotta, M Li Calzi, E Garattini, M Terao

Biochem J. 1996 Nov 1; 319(Pt 3): 801–810. doi: 10.1042/bj3190801

PMCID:: PMC1217859

Summary PDF–566K

Select item 113650513.

Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide.

M Kurosaki, M Li Calzi, E Scanziani, E Garattini, M Terao

Biochem J. 1995 Feb 15; 306(Pt 1): 225–234. doi: 10.1042/bj3060225

PMCID:: PMC1136505

Summary Page Browse PDF–3.2M

Select item 113096614.

Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo.

M Terao, G Cazzaniga, P Ghezzi, M Bianchi, F Falciani, P Perani, E Garattini

Biochem J. 1992 May 1; 283(Pt 3): 863–870. doi: 10.1042/bj2830863

PMCID:: PMC1130966

Summary Page Browse PDF–1.9M

Select item 976065715.

The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells

Teruo Kusano, Tomoko Nishino, Ken Okamoto, Russ Hille, Takeshi Nishino

Redox Biol. 2023 Feb; 59: 102573. Published online 2022 Dec 9. doi: 10.1016/j.redox.2022.102573

PMCID:: PMC9760657

Abstract Article PDF–6.4M

Select item 866404916.

The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation

Jaekwang Jeong, Anil K. G. Kadegowda, Thomas J. Meyer, Lisa M. Jenkins, Jerry C. Dinan, John J. Wysolmerski, Roberto Weigert, Ian H. Mather

FASEB Bioadv. 2021 Dec; 3(12): 971–997. Published online 2021 Sep 8. doi: 10.1096/fba.2021-00059

PMCID:: PMC8664049

Abstract Article PDF–3.0M

Select item 803734217.

Xanthine Oxidoreductase-Mediated Superoxide Production Is Not Involved in the Age-Related Pathologies in Sod1-Deficient Mice

Shuichi Shibuya, Kenji Watanabe, Yusuke Ozawa, Takahiko Shimizu

Int J Mol Sci. 2021 Apr; 22(7): 3542. Published online 2021 Mar 29. doi: 10.3390/ijms22073542

PMCID:: PMC8037342

Abstract Article PDF–1.1M

Select item 595287818.

Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: A mechanism involving calcium overload/XO/ROS/mPTP pathway

Pingjun Zhu, Shunying Hu, Qinhua Jin, Dandan Li, Feng Tian, Sam Toan, Yang Li, Hao Zhou, Yundai Chen

Redox Biol. 2018 Jun; 16: 157–168. Published online 2018 Mar 1. doi: 10.1016/j.redox.2018.02.019

PMCID:: PMC5952878

Abstract Article PDF–2.9M

Select item 576694619.

Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα

Takumi Kanemitsu, Yuya Tsurudome, Naoki Kusunose, Masayuki Oda, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo

J Biol Chem. 2017 Dec 29; 292(52): 21397–21406. Published online 2017 Nov 3. doi: 10.1074/jbc.M117.791285

PMCID:: PMC5766946

Abstract Article PDF–1.9M

Select item 438299520.

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

Annette Ives, Johji Nomura, Fabio Martinon, Thierry Roger, Didier LeRoy, Jeffrey N. Miner, Gregoire Simon, Nathalie Busso, Alexander So

Nat Commun. 2015 Mar 24; 6: 6555. Published online 2015 Mar 24. doi: 10.1038/ncomms7555

PMCID:: PMC4382995

Abstract Article PDF–1.1M

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